المؤلفون: Anand RP; eGenesis, Cambridge, MA, USA., Layer JV; eGenesis, Cambridge, MA, USA., Heja D; eGenesis, Cambridge, MA, USA., Hirose T; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lassiter G; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Firl DJ; eGenesis, Cambridge, MA, USA.; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Paragas VB; eGenesis, Cambridge, MA, USA., Akkad A; eGenesis, Cambridge, MA, USA., Chhangawala S; eGenesis, Cambridge, MA, USA., Colvin RB; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ernst RJ; eGenesis, Cambridge, MA, USA., Esch N; eGenesis, Cambridge, MA, USA., Getchell K; eGenesis, Cambridge, MA, USA., Griffin AK; eGenesis, Cambridge, MA, USA., Guo X; eGenesis, Cambridge, MA, USA., Hall KC; eGenesis, Cambridge, MA, USA., Hamilton P; eGenesis, Cambridge, MA, USA., Kalekar LA; eGenesis, Cambridge, MA, USA., Kan Y; eGenesis, Cambridge, MA, USA., Karadagi A; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Li F; eGenesis, Cambridge, MA, USA., Low SC; eGenesis, Cambridge, MA, USA., Matheson R; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Nehring C; eGenesis, Cambridge, MA, USA., Otsuka R; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Pandelakis M; eGenesis, Cambridge, MA, USA., Policastro RA; eGenesis, Cambridge, MA, USA., Pols R; eGenesis, Cambridge, MA, USA., Queiroz L; eGenesis, Cambridge, MA, USA., Rosales IA; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Serkin WT; eGenesis, Cambridge, MA, USA., Stiede K; eGenesis, Cambridge, MA, USA., Tomosugi T; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Xue Y; eGenesis, Cambridge, MA, USA., Zentner GE; eGenesis, Cambridge, MA, USA., Angeles-Albores D; eGenesis, Cambridge, MA, USA., Chris Chao J; eGenesis, Cambridge, MA, USA., Crabtree JN; eGenesis, Cambridge, MA, USA., Harken S; eGenesis, Cambridge, MA, USA., Hinkle N; eGenesis, Cambridge, MA, USA., Lemos T; eGenesis, Cambridge, MA, USA., Li M; eGenesis, Cambridge, MA, USA., Pantano L; eGenesis, Cambridge, MA, USA., Stevens D; eGenesis, Cambridge, MA, USA., Subedar OD; eGenesis, Cambridge, MA, USA., Tan X; eGenesis, Cambridge, MA, USA., Yin S; eGenesis, Cambridge, MA, USA., Anwar IJ; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA., Aufhauser D; Department of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Capuano S; Wisconsin National Primate Research Center, Madison, WI, USA., Kaufman DB; Department of Surgery, Division of Transplantation, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Knechtle SJ; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA., Kwun J; Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC, USA., Shanmuganayagam D; Department of Animal and Dairy Science, University of Wisconsin, Madison, WI, USA., Markmann JF; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Wyss Institute of Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA., Curtis M; eGenesis, Cambridge, MA, USA., Kawai T; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Youd ME; eGenesis, Cambridge, MA, USA. michele.youd@egenesisbio.com., Qin W; eGenesis, Cambridge, MA, USA. wenning.qin@egenesisbio.com.

المصدر: Nature [Nature] 2023 Oct; Vol. 622 (7982), pp. 393-401. Date of Electronic Publication: 2023 Oct 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Graft Rejection*/immunology , Graft Rejection*/prevention & control , Kidney Transplantation*/methods , Macaca fascicularis* , Swine*/genetics , Transplantation, Heterologous*/methods, Animals ; Humans ; Animals, Genetically Modified ; Endothelial Cells/immunology ; Endothelial Cells/metabolism ; Polysaccharides/deficiency ; Transgenes/genetics

المؤلفون: Petitpas K; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Habibabady Z; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Ritchie V; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Connolly MR; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Burdorf L; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Qin W; eGenesis Inc., Cambridge, Massachusetts, USA., Kan Y; eGenesis Inc., Cambridge, Massachusetts, USA., Layer JV; eGenesis Inc., Cambridge, Massachusetts, USA., Crabtree JN; eGenesis Inc., Cambridge, Massachusetts, USA., Youd ME; eGenesis Inc., Cambridge, Massachusetts, USA., Westlin WF; eGenesis Inc., Cambridge, Massachusetts, USA., Magnani DM; MassBiologics of UMMS, Boston, Massachusetts, USA., Pierson RN 3rd; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA., Azimzadeh AM; MGH, Center for Transplantation Sciences, Boston, Massachusetts, USA.

المصدر: Xenotransplantation [Xenotransplantation] 2022 Nov; Vol. 29 (6), pp. e12780. Date of Electronic Publication: 2022 Sep 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Munksgaard International Publishers Country of Publication: Denmark NLM ID: 9438793 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-3089 (Electronic) Linking ISSN: 0908665X NLM ISO Abbreviation: Xenotransplantation Subsets: MEDLINE

مواضيع طبية MeSH: Sialic Acid Binding Ig-like Lectin 1*/genetics , N-Acetylneuraminic Acid*/metabolism, Humans ; Swine ; Animals ; Transplantation, Heterologous/methods ; Macrophages ; Erythrocytes/metabolism

المؤلفون: Ma D; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Hirose T; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Lassiter G; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Sasaki H; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rosales I; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Coe TM; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Rickert CG; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Matheson R; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Colvin RB; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Qin W; eGenesis Inc., Cambridge, Massachusetts, USA., Kan Y; eGenesis Inc., Cambridge, Massachusetts, USA., Layer JV; eGenesis Inc., Cambridge, Massachusetts, USA., Paragas VB; eGenesis Inc., Cambridge, Massachusetts, USA., Stiede K; eGenesis Inc., Cambridge, Massachusetts, USA., Hall KC; eGenesis Inc., Cambridge, Massachusetts, USA., Youd ME; eGenesis Inc., Cambridge, Massachusetts, USA., Queiroz LM; eGenesis Inc., Cambridge, Massachusetts, USA., Westlin WF; eGenesis Inc., Cambridge, Massachusetts, USA., Curtis M; eGenesis Inc., Cambridge, Massachusetts, USA., Yang L; eGenesis Inc., Cambridge, Massachusetts, USA., Markmann JF; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.; eGenesis Inc., Cambridge, Massachusetts, USA., Kawai T; Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

المصدر: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2022 Jan; Vol. 22 (1), pp. 46-57. Date of Electronic Publication: 2021 Aug 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE

مواضيع طبية MeSH: Kidney Transplantation*, Animals ; Animals, Genetically Modified ; Graft Rejection/genetics ; Humans ; Macaca fascicularis ; Swine ; Transplantation, Heterologous

المؤلفون: Yue Y; Qihan Bio Inc, Hangzhou, China., Xu W; Qihan Bio Inc, Hangzhou, China., Kan Y; eGenesis Inc, Cambridge, MA, USA., Zhao HY; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Zhou Y; Qihan Bio Inc, Hangzhou, China., Song X; Qihan Bio Inc, Hangzhou, China., Wu J; Qihan Bio Inc, Hangzhou, China., Xiong J; Qihan Bio Inc, Hangzhou, China., Goswami D; eGenesis Inc, Cambridge, MA, USA., Yang M; Qihan Bio Inc, Hangzhou, China., Lamriben L; eGenesis Inc, Cambridge, MA, USA., Xu M; Qihan Bio Inc, Hangzhou, China., Zhang Q; Qihan Bio Inc, Hangzhou, China., Luo Y; Qihan Bio Inc, Hangzhou, China., Guo J; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Mao S; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Jiao D; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Nguyen TD; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Li Z; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Layer JV; eGenesis Inc, Cambridge, MA, USA., Li M; eGenesis Inc, Cambridge, MA, USA., Paragas V; eGenesis Inc, Cambridge, MA, USA., Youd ME; eGenesis Inc, Cambridge, MA, USA., Sun Z; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Ding Y; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Wang W; Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Dou H; Qihan Bio Inc, Hangzhou, China., Song L; Qihan Bio Inc, Hangzhou, China., Wang X; Qihan Bio Inc, Hangzhou, China., Le L; Qihan Bio Inc, Hangzhou, China., Fang X; Qihan Bio Inc, Hangzhou, China., George H; eGenesis Inc, Cambridge, MA, USA., Anand R; eGenesis Inc, Cambridge, MA, USA., Wang SY; eGenesis Inc, Cambridge, MA, USA., Westlin WF; eGenesis Inc, Cambridge, MA, USA., Güell M; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain., Markmann J; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Qin W; eGenesis Inc, Cambridge, MA, USA., Gao Y; Qihan Bio Inc, Hangzhou, China., Wei HJ; Key Laboratory of Animal Gene Editing and Animal Cloning in Yunnan Province, Yunnan Agricultural University, Kunming, China., Church GM; Department of Genetics, Harvard Medical School, Boston, MA, USA., Yang L; Qihan Bio Inc, Hangzhou, China. luhan.yang@qihanbio.com.

المصدر: Nature biomedical engineering [Nat Biomed Eng] 2021 Feb; Vol. 5 (2), pp. 134-143. Date of Electronic Publication: 2020 Sep 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Transplantation, Heterologous*, Genetic Engineering/*methods , Germ Cells/*metabolism , Sus scrofa/*genetics , Sus scrofa/*virology, Animals ; CRISPR-Associated Protein 9/genetics ; Cells, Cultured ; Galactosyltransferases/genetics ; Gene Knockout Techniques ; Mixed Function Oxygenases/genetics ; N-Acetylgalactosaminyltransferases/genetics ; Sus scrofa/immunology

المؤلفون: House NCM; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America., Parasuram R; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America., Layer JV; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America., Price BD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States of America.

المصدر: PloS one [PLoS One] 2020 Dec 17; Vol. 15 (12), pp. e0237759. Date of Electronic Publication: 2020 Dec 17 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems/*genetics , Clustered Regularly Interspaced Short Palindromic Repeats/*genetics , DNA/*genetics , DNA Damage/*genetics , DNA Repair/*genetics , Oxidative Stress/*genetics, Cell Line ; Chromatin/genetics ; DNA Breaks, Double-Stranded ; Endonucleases/genetics ; Genome/genetics ; HEK293 Cells ; Humans ; Light ; RNA, Guide, CRISPR-Cas Systems/genetics

المؤلفون: Layer JV; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Debaize L; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Van Scoyk A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., House NC; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Brown AJ; School of Molecular Biosciences, Washington State University, Pullman, WA 99164., Liu Y; The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139., Stevenson KE; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215., Hemann M; The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139., Roberts SA; School of Molecular Biosciences, Washington State University, Pullman, WA 99164., Price BD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; dweinstock@partners.org t.day@northeastern.edu.; Cancer Biology Program, Broad Institute of MIT and Harvard University, Cambridge, MA 02142.; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA 02215., Day TA; Department of Biology, Northeastern University, Boston, MA 02115 dweinstock@partners.org t.day@northeastern.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 03; Vol. 117 (44), pp. 27566-27577. Date of Electronic Publication: 2020 Oct 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA End-Joining Repair* , Translocation, Genetic*, DNA Polymerase III/*metabolism, DNA Breaks, Double-Stranded ; DNA Polymerase III/genetics ; Gene Knockdown Techniques ; HEK293 Cells ; HeLa Cells ; Humans ; RNA, Small Interfering/metabolism

المؤلفون: Layer JV; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Cleary JP; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Brown AJ; School of Molecular Biosciences, Washington State University, Pullman, WA 99164., Stevenson KE; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215., Morrow SN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Van Scoyk A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Blasco RB; Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA., Karaca E; Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA., Meng FL; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02215.; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02215.; Department of Genetics, Harvard Medical School, Boston, MA 02215., Frock RL; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02215.; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02215.; Department of Genetics, Harvard Medical School, Boston, MA 02215., Tivey T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Kim S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Fuchs H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215., Chiarle R; Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA.; Department of Molecular Biotechnology and Health Sciences, University of Turin, 10124 Turin, Italy., Alt FW; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02215.; Program in Cellular and Molecular Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02215.; Department of Genetics, Harvard Medical School, Boston, MA 02215., Roberts SA; School of Molecular Biosciences, Washington State University, Pullman, WA 99164., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; davidm_weinstock@dfci.harvard.edu tovah_day@dfci.harvard.edu.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Day TA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215; davidm_weinstock@dfci.harvard.edu tovah_day@dfci.harvard.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Oct 02; Vol. 115 (40), pp. 10076-10081. Date of Electronic Publication: 2018 Sep 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: B-Lymphocytes/*metabolism , DNA End-Joining Repair/*physiology , Immunoglobulin Class Switching/*physiology , Mouse Embryonic Stem Cells/*metabolism , Poly(ADP-ribose) Polymerases/*metabolism, Anaplastic Lymphoma Kinase ; Animals ; Fibroblasts/metabolism ; Mice ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Poly(ADP-ribose) Polymerases/genetics ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism

المؤلفون: Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM

المصدر: Nature communications [Nat Commun] 2017 Jun 13; Vol. 8, pp. 15918. Date of Electronic Publication: 2017 Jun 13.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE

المؤلفون: Day TA; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Layer JV; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Cleary JP; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Guha S; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Stevenson KE; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Tivey T; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Kim S; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Schinzel AC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA., Izzo F; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA., Doench J; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA., Root DE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA., Price BD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, Massachusetts 02215, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.; Genetic Perturbation Platform, Broad Institute of MIT and Harvard University, 415 Main Street, Cambridge, Massachusetts 02142, USA.

المصدر: Nature communications [Nat Commun] 2017 Apr 27; Vol. 8, pp. 15110. Date of Electronic Publication: 2017 Apr 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: G-Quadruplexes*, Cell Cycle Proteins/*genetics , DNA/*metabolism , DNA Repair Enzymes/*genetics , DNA-Binding Proteins/*genetics , Poly(ADP-ribose) Polymerases/*genetics , Translocation, Genetic/*genetics , Tumor Suppressor p53-Binding Protein 1/*genetics , Ubiquitin-Conjugating Enzymes/*genetics, A549 Cells ; Acid Anhydride Hydrolases ; Cell Line, Tumor ; Chromosomes/metabolism ; DNA Breaks, Double-Stranded ; DNA Damage ; DNA End-Joining Repair/genetics ; Gene Knockout Techniques ; HEK293 Cells ; HeLa Cells ; Homologous Recombination ; Humans ; Models, Genetic ; Synthetic Lethal Mutations

المؤلفون: Jacobson C; Department of Medical Oncology and., Kopp N; Department of Medical Oncology and., Layer JV; Department of Medical Oncology and., Redd RA; Department of Biostatistics & Computational Biology, Dana-Farber Cancer Institute, Boston, MA., Tschuri S; Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research, Ludwig-Maximilians University, Munich, Germany.; German Cancer Consortium, Heidelberg, Germany.; German Cancer Research Center, Heidelberg, Germany., Haebe S; Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research, Ludwig-Maximilians University, Munich, Germany.; German Cancer Consortium, Heidelberg, Germany.; German Cancer Research Center, Heidelberg, Germany., van Bodegom D; Department of Medical Oncology and., Bird L; Department of Medical Oncology and., Christie AL; Department of Medical Oncology and.; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA., Christodoulou A; Department of Medical Oncology and., Saur A; Lurie Family Imaging Center, Dana-Farber Cancer Institute, Boston, MA., Tivey T; Department of Medical Oncology and., Zapf S; Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health, Munich, Germany., Bararia D; Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research, Ludwig-Maximilians University, Munich, Germany.; German Cancer Consortium, Heidelberg, Germany.; German Cancer Research Center, Heidelberg, Germany., Zimber-Strobl U; Department of Gene Vectors, Helmholtz Zentrum München, German Research Center for Environment and Health, Munich, Germany., Rodig SJ; Department of Pathology, Brigham and Women's Hospital, Boston, MA; and., Weigert O; Department of Medicine III, Laboratory for Experimental Leukemia and Lymphoma Research, Ludwig-Maximilians University, Munich, Germany.; German Cancer Consortium, Heidelberg, Germany.; German Cancer Research Center, Heidelberg, Germany., Weinstock DM; Department of Medical Oncology and.; Broad Institute, Harvard University and Massachusetts Institute of Technology, Cambridge, MA.

المصدر: Blood [Blood] 2016 Nov 24; Vol. 128 (21), pp. 2517-2526. Date of Electronic Publication: 2016 Oct 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm/*drug effects , HSP90 Heat-Shock Proteins/*antagonists & inhibitors , Isoxazoles/*pharmacology , Lymphoma, Mantle-Cell/*drug therapy , Pyrazoles/*pharmacology , Pyrimidines/*pharmacology , Resorcinols/*pharmacology, Adenine/analogs & derivatives ; Agammaglobulinaemia Tyrosine Kinase ; Amino Acid Substitution ; Animals ; Cell Line, Tumor ; Drug Resistance, Neoplasm/genetics ; HSP90 Heat-Shock Proteins/genetics ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Lymphoma, Mantle-Cell/genetics ; Lymphoma, Mantle-Cell/metabolism ; Lymphoma, Mantle-Cell/pathology ; Mice ; Mutation, Missense ; Piperidines ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Xenograft Model Antitumor Assays