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3دورية أكاديمية
المؤلفون: Leśniak RK; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA. Electronic address: r.k.lesniak@stanford.edu., Nichols RJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Schonemann M; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Zhao J; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Gajera CR; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Lam G; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Nguyen KC; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Langston JW; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA; Department of Neurology and Neuroscience, 300 Pasteur Drive, Stanford University, Stanford, CA, 94304, USA., Smith M; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA, 94305, USA., Montine TJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Nov 15; Vol. 242, pp. 114693. Date of Electronic Publication: 2022 Aug 24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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4Editorial & Opinion
المؤلفون: Leśniak RK; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA., Nichols RJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA., Smith M; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, CA 94305, USA., Montine TJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA 94305, USA.
المصدر: Future medicinal chemistry [Future Med Chem] 2022 Aug; Vol. 14 (16), pp. 1167-1170. Date of Electronic Publication: 2022 Jun 22.
نوع المنشور: Editorial
بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Parkinson Disease*/genetics, Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mutation
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5دورية أكاديمية
المؤلفون: Leśniak RK; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States.; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States., Nichols RJ; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States., Schonemann M; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States., Zhao J; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States., Gajera CR; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States., Lam G; Departments of Medicine and Microbiology and Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, United States., Nguyen KC; Departments of Medicine and Microbiology and Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California 94305, United States., Langston JW; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States.; Department of Neurology and Neuroscience, Stanford University, 300 Pasteur Drive, Stanford, California 94304, United States., Smith M; Medicinal Chemistry Knowledge Center, Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States., Montine TJ; Department of Pathology, Stanford University, 300 Pasteur Drive, Stanford, California 94305, United States.
المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 May 23; Vol. 13 (6), pp. 981-988. Date of Electronic Publication: 2022 May 23 (Print Publication: 2022).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
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6دورية أكاديميةDiscovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
المؤلفون: Leśniak RK; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford University, Stanford CA, 94305, USA; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Nichols RJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Schonemann M; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Zhao J; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Gajera CR; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA., Fitch WL; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Lam G; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Nguyen KC; Departments of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Smith M; Medicinal Chemistry Knowledge Center, Stanford ChEM-H, Stanford University, Stanford CA, 94305, USA. Electronic address: mxsmith@stanford.edu., Montine TJ; Department of Pathology, 300 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA. Electronic address: tmontine@stanford.edu.
المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Feb 05; Vol. 229, pp. 114080. Date of Electronic Publication: 2021 Dec 28.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Indazoles/*chemical synthesis , Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*antagonists & inhibitors , Neuroprotective Agents/*chemical synthesis , Parkinson Disease/*drug therapy , Protein Kinase Inhibitors/*chemical synthesis, Animals ; Brain ; Disease Models, Animal ; Drug Discovery ; Humans ; Indazoles/pharmacokinetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Lung ; Male ; Mice ; Molecular Docking Simulation ; Mutation ; Neuroprotective Agents/pharmacokinetics ; Phenotype ; Protein Binding ; Protein Conformation ; Protein Kinase Inhibitors/pharmacokinetics ; Rodentia ; Structure-Activity Relationship
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7دورية أكاديمية
المؤلفون: Brem J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk., Panduwawala T; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Hansen JU; Statens Serum Institut, Copenhagen, Denmark., Hewitt J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Liepins E; Latvian Institute of Organic Synthesis, Riga, Latvia., Donets P; Latvian Institute of Organic Synthesis, Riga, Latvia., Espina L; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Farley AJM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Shubin K; Latvian Institute of Organic Synthesis, Riga, Latvia., Campillos GG; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Kiuru P; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Shishodia S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA., Krahn D; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Leśniak RK; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Schmidt Adrian J; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Calvopiña K; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Turrientes MC; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Kavanagh ME; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Lubriks D; Latvian Institute of Organic Synthesis, Riga, Latvia., Hinchliffe P; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Langley GW; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Charles River Laboratories, Saffron Walden, UK., Aboklaish AF; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Eneroth A; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Backlund M; Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden., Baran AG; Latvian Institute of Organic Synthesis, Riga, Latvia., Nielsen EI; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Speake M; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Kuka J; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson J; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Grinberga S; Latvian Institute of Organic Synthesis, Riga, Latvia., Robinson L; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., McDonough MA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Rydzik AM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.; Research and Early Development, Respiratory & Immunology, AstraZeneca, Mölndal, Sweden., Leissing TM; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Jimenez-Castellanos JC; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.; Chemical Biology of Antibiotics, Centre for Infection & Immunity (CIIL), Pasteur Institute, INSERM U1019 - CNRS UMR 9017, Lille, France., Avison MB; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Da Silva Pinto S; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Pannifer AD; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Martjuga M; Latvian Institute of Organic Synthesis, Riga, Latvia., Widlake E; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Priede M; Latvian Institute of Organic Synthesis, Riga, Latvia., Hopkins Navratilova I; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK., Gniadkowski M; Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland., Belfrage AK; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden., Brandt P; Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.; Beactica Therapeutics AB, Uppsala, Sweden., Yli-Kauhaluoma J; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Bacque E; Evotec Infectious Diseases Lyon, Marcy l'Etoile, France., Page MGP; Jacobs University Bremen gGmbH, Bremen, Germany., Björkling F; Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark., Tyrrell JM; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Spencer J; School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Lang PA; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK., Baranczewski P; Department of Pharmacy, SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics Facility, Uppsala University, Uppsala, Sweden., Cantón R; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., McElroy SP; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Jones PS; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Baquero F; Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain., Suna E; Latvian Institute of Organic Synthesis, Riga, Latvia., Morrison A; University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.; BioAscent Discovery Ltd, Newhouse, UK., Walsh TR; Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK., Schofield CJ; Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.
المصدر: Nature chemistry [Nat Chem] 2022 Jan; Vol. 14 (1), pp. 15-24. Date of Electronic Publication: 2021 Dec 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE
مواضيع طبية MeSH: beta-Lactamase Inhibitors/*pharmacology , beta-Lactams/*metabolism, Animals ; Gram-Negative Bacteria/drug effects ; Humans ; Mice ; Microbial Sensitivity Tests ; Protein Binding ; Structure-Activity Relationship ; beta-Lactamase Inhibitors/chemistry ; beta-Lactamase Inhibitors/metabolism
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8دورية أكاديمية
المؤلفون: Wawro AM; Department of Pathology, Stanford University, Stanford, CA, USA., Gajera CR; Department of Pathology, Stanford University, Stanford, CA, USA., Baker SA; Department of Pathology, Stanford University, Stanford, CA, USA., Leśniak RK; ChEM-H, Stanford University, Stanford, CA, USA., Montine KS; Department of Pathology, Stanford University, Stanford, CA, USA., Fischer CR; ChEM-H, Stanford University, Stanford, CA, USA., Saw NL; Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, CA, USA., Shamloo M; Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, CA, USA.; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Montine TJ; Department of Pathology, Stanford University, Stanford, CA, USA.
المصدر: Journal of neurochemistry [J Neurochem] 2021 Sep; Vol. 158 (5), pp. 1074-1082. Date of Electronic Publication: 2021 Aug 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE
مواضيع طبية MeSH: Exploratory Behavior/*physiology , Locomotion/*physiology , Neurotransmitter Agents/*chemistry , Pentanoic Acids/*chemistry , gamma-Aminobutyric Acid/*chemistry, Animals ; Brain/metabolism ; Brain Chemistry ; Dose-Response Relationship, Drug ; Exploratory Behavior/drug effects ; Locomotion/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Neurotransmitter Agents/metabolism ; Pentanoic Acids/metabolism ; Pentanoic Acids/pharmacology ; Receptors, GABA-A/chemistry ; Receptors, GABA-A/metabolism ; Stereoisomerism ; Synaptosomes/metabolism ; gamma-Aminobutyric Acid/metabolism
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9دورية أكاديمية
المؤلفون: Wawro AM; Department of Pathology, Stanford University, Stanford, USA., Gajera CR; Department of Pathology, Stanford University, Stanford, USA., Baker SA; Department of Pathology, Stanford University, Stanford, USA., Leśniak RK; ChEM-H, Stanford University, Stanford, USA., Fischer CR; ChEM-H, Stanford University, Stanford, USA., Saw NL; Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, USA., Shamloo M; Behavioral and Functional Neuroscience Laboratory, Stanford University, Stanford, USA.; Department of Neurosurgery, Stanford University, Stanford, USA., Montine TJ; Department of Pathology, Stanford University, Stanford, USA. tmontine@stanford.edu.
المصدر: Scientific reports [Sci Rep] 2021 Apr 14; Vol. 11 (1), pp. 8138. Date of Electronic Publication: 2021 Apr 14.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
مواضيع طبية MeSH: Brain/*metabolism , Glutamates/*administration & dosage , Glutamine/*administration & dosage , Synaptosomes/*metabolism, Animals ; Behavior, Animal/drug effects ; Chromatography, Liquid ; Dose-Response Relationship, Drug ; Female ; Glutamates/chemistry ; Glutamates/pharmacokinetics ; Glutamine/chemistry ; Glutamine/pharmacokinetics ; Male ; Mice ; Primary Cell Culture ; Stereoisomerism ; Tandem Mass Spectrometry ; gamma-Aminobutyric Acid/metabolism
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10دورية أكاديمية
المؤلفون: Leśniak RK; The Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. tim.claridge@chem.ox.ac.uk christopher.schofield@chem.ox.ac.uk., Rydzik AM, Kamps JJAG, Kahn A, Claridge TDW, Schofield CJ
المصدر: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Dec 05; Vol. 55 (98), pp. 14717-14720.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE
مواضيع طبية MeSH: Magnetic Resonance Spectroscopy*, Enzyme Inhibitors/*chemistry , gamma-Butyrobetaine Dioxygenase/*metabolism, Betaine/analogs & derivatives ; Betaine/chemical synthesis ; Betaine/chemistry ; Betaine/metabolism ; Carnitine/biosynthesis ; Carnitine/chemical synthesis ; Carnitine/chemistry ; Carnitine/metabolism ; Drug Design ; Enzyme Inhibitors/chemical synthesis ; Fluorine/chemistry ; gamma-Butyrobetaine Dioxygenase/antagonists & inhibitors
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