المؤلفون: Prawira A; Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Ho RZW; Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Huynh H; Laboratory of Molecular Endocrinology, Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore. cmrhth@nccs.com.sg.

المصدر: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Oct; Vol. 147 (10), pp. 2955-2968. Date of Electronic Publication: 2021 Jun 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7902060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1335 (Electronic) Linking ISSN: 01715216 NLM ISO Abbreviation: J Cancer Res Clin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Carcinoma, Hepatocellular/*drug therapy , Drug Resistance, Neoplasm/*drug effects , Enhancer of Zeste Homolog 2 Protein/*metabolism , Gene Expression Regulation, Neoplastic/*drug effects , Receptor, ErbB-2/*metabolism , Receptor, Fibroblast Growth Factor, Type 1/*antagonists & inhibitors, Animals ; Antibodies, Monoclonal, Humanized/administration & dosage ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Proliferation ; Enhancer of Zeste Homolog 2 Protein/genetics ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, SCID ; Phenylurea Compounds/administration & dosage ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/administration & dosage ; Receptor, ErbB-2/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Tai DWM; Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Ho RZW; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore., Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore, 169610, Singapore. cmrhth@nccs.com.sg.

المصدر: Hepatology international [Hepatol Int] 2021 Oct; Vol. 15 (5), pp. 1236-1246. Date of Electronic Publication: 2021 Jul 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101304009 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-0541 (Electronic) Linking ISSN: 19360533 NLM ISO Abbreviation: Hepatol Int Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/drug therapy, Animals ; Cell Line, Tumor ; Fibroblast Growth Factors ; Humans ; Mice ; Mice, SCID ; Phenylurea Compounds ; Signal Transduction

المؤلفون: Millet-Boureima C; Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada., He S; Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada., Le TBU; Department of Biology, Concordia University, Montreal, QC H4B 1R6, Canada.; Haematology-Oncology Research Group, National University Cancer Institute, Singapore 119228, Singapore., Gamberi C; Department of Biology, Coastal Carolina University, Conway, SC 29528-6054, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 10; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 10.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Carcinogenesis/*genetics , Carcinoma, Renal Cell/*genetics , Polycystic Kidney, Autosomal Dominant/*genetics , Vascular Endothelial Growth Factor A/*genetics, Animals ; Carcinoma, Renal Cell/pathology ; Cell Proliferation/genetics ; Disease Models, Animal ; Drosophila/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Kidney/metabolism ; Kidney/pathology ; Neovascularization, Pathologic/genetics ; Neovascularization, Pathologic/pathology ; Polycystic Kidney, Autosomal Dominant/pathology

المؤلفون: Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore., Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore., Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore.

المصدر: Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2021 Mar; Vol. 41 (3), pp. 608-620. Date of Electronic Publication: 2020 Nov 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 101160857 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-3231 (Electronic) Linking ISSN: 14783223 NLM ISO Abbreviation: Liver Int Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines*/pharmacology , Carcinoma, Hepatocellular*/drug therapy , Liver Neoplasms*/drug therapy , Phenylurea Compounds*/pharmacology , Purines*/pharmacology , Pyrimidines*/pharmacology, Animals ; Cell Differentiation ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Male ; Mice ; Mice, SCID ; Xenograft Model Antitumor Assays

المؤلفون: Tran A; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore., Koh TS; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore., Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore., Ho RZW; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore., Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore., Hartano S; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore., Teo XQ; Functional Metabolism Group, Agency for Science, Technology and Research, Singapore BioImaging Consortium, Singapore, Singapore., Chen WC; Bruker Singapore Pte Ltd, Singapore, Singapore., Lee P; Functional Metabolism Group, Agency for Science, Technology and Research, Singapore BioImaging Consortium, Singapore, Singapore., Thng CH; Department of Oncologic Imaging, National Cancer Centre, Singapore, Singapore. thng.choon.hua@singhealth.com.sg., Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore. cmrhth@nccs.com.sg.

المصدر: Molecular imaging and biology [Mol Imaging Biol] 2021 Feb; Vol. 23 (1), pp. 70-83. Date of Electronic Publication: 2020 Sep 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 101125610 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-2002 (Electronic) Linking ISSN: 15361632 NLM ISO Abbreviation: Mol Imaging Biol Subsets: MEDLINE

مواضيع طبية MeSH: Magnetic Resonance Imaging*, Biomarkers, Tumor/*metabolism , Carcinoma, Hepatocellular/*drug therapy , Contrast Media/*chemistry , Liver Neoplasms/*drug therapy , Neovascularization, Pathologic/*drug therapy , Phenylurea Compounds/*therapeutic use , Pyrimidines/*therapeutic use , Receptors, Fibroblast Growth Factor/*metabolism, Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/blood supply ; Cell Proliferation/drug effects ; Humans ; Kinetics ; Liver Neoplasms/blood supply ; Mice, SCID ; Perfusion ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Tumor Microenvironment/drug effects ; Xenograft Model Antitumor Assays ; Mice

المؤلفون: Sparapani S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Millet-Boureima C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Oliver J; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Mu K; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Hadavi P; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Kalostian T; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Ali N; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Avelar CM; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Bardies M; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Barrow B; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Benedikt M; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Biancardi G; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Bindra R; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Bui L; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Chihab Z; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Cossitt A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Costa J; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Daigneault T; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Dault J; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Davidson I; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Dias J; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Dufour E; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., El-Khoury S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Farhangdoost N; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Forget A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Fox A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Gebrael M; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Gentile MC; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Geraci O; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Gnanapragasam A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Gomah E; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Haber E; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Hamel C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Iyanker T; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Kalantzis C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Kamali S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Kassardjian E; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Kontos HK; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Le TBU; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., LoScerbo D; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Low YF; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Mac Rae D; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Maurer F; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Mazhar S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Nguyen A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Nguyen-Duong K; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Osborne-Laroche C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Park HW; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Parolin E; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Paul-Cole K; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Peer LS; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Philippon M; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Plaisir CA; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Porras Marroquin J; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Prasad S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Ramsarun R; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Razzaq S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Rhainds S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Robin D; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Scartozzi R; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Singh D; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Fard SS; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Soroko M; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Soroori Motlagh N; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Stern K; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Toro L; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Toure MW; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Tran-Huynh S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Trépanier-Chicoine S; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Waddingham C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Weekes AJ; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Wisniewski A; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada., Gamberi C; Biology Department, Concordia University, Montreal, QC H4B 1R6, Canada.

المصدر: Biomedicines [Biomedicines] 2021 Jan 18; Vol. 9 (1). Date of Electronic Publication: 2021 Jan 18.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE

المؤلفون: Le TBU; Department of Haematology-Oncology, National University Health System, Singapore 119074, Singapore., Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Ho RZW; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Wang L; Department of Haematology-Oncology, National University Health System, Singapore 119074, Singapore.; Cancer Science Institute of Singapore, National University Hospital, Singapore 117599, Singapore., Goh BC; Department of Haematology-Oncology, National University Health System, Singapore 119074, Singapore.; Cancer Science Institute of Singapore, National University Hospital, Singapore 117599, Singapore., Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 Dec 10; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Angiogenesis Inhibitors/*therapeutic use , Antineoplastic Agents, Immunological/*therapeutic use , Bevacizumab/*therapeutic use , Carcinoma, Hepatocellular/*drug therapy , Liver Neoplasms/*drug therapy , Phenylurea Compounds/*therapeutic use , Pyrimidines/*therapeutic use, Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Angiogenesis Inhibitors/administration & dosage ; Animals ; Antineoplastic Agents, Immunological/administration & dosage ; Apoptosis ; Bevacizumab/administration & dosage ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Drug Synergism ; Extracellular Signal-Regulated MAP Kinases/genetics ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, SCID ; Neoplasm Metastasis ; Phenylurea Compounds/administration & dosage ; Pyrimidines/administration & dosage ; Ribosomal Protein S6 Kinases, 70-kDa/genetics ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Survivin/genetics ; Survivin/metabolism ; Tumor Hypoxia ; cdc25 Phosphatases/genetics ; cdc25 Phosphatases/metabolism

المؤلفون: Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore, Singapore. cmrhth@nccs.com.sg., Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore, Singapore., Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore, Singapore., Hao HX; Oncology Drug Discovery Pharmacology, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA., Huang A; Oncology Drug Discovery Pharmacology, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA., Wang Y; Oncology Drug Discovery Pharmacology, Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA., Porta DG; Oncology Translational Research, Novartis Institutes for Biomedical Research at Basel, Basel, Switzerland.

المصدر: Experimental & molecular medicine [Exp Mol Med] 2020 Nov; Vol. 52 (11), pp. 1857-1868. Date of Electronic Publication: 2020 Nov 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*pharmacology , Carcinoma, Hepatocellular/*metabolism , Fibroblast Growth Factors/*metabolism , Liver Neoplasms/*metabolism , Piperazines/*pharmacology , Pyridines/*pharmacology , Vinorelbine/*pharmacology, Animals ; Apoptosis ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/pathology ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Drug Synergism ; Fibroblast Growth Factors/antagonists & inhibitors ; Fibroblast Growth Factors/genetics ; Gene Expression ; Humans ; Immunohistochemistry ; Liver Neoplasms/drug therapy ; Liver Neoplasms/etiology ; Liver Neoplasms/pathology ; Mice ; Receptor, Fibroblast Growth Factor, Type 4/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 4/genetics ; Receptor, Fibroblast Growth Factor, Type 4/metabolism ; Xenograft Model Antitumor Assays

المؤلفون: Kong LR; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiklr@nus.edu.sg.; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK. csiklr@nus.edu.sg., Ong RW; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, Singapore., Tan TZ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Mohamed Salleh NAB; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Thangavelu M; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore., Chan JV; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore., Koh LYJ; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore., Periyasamy G; Genome Institute of Singapore, Agency for Science, Technology & Research (A*STAR), Singapore, 138672, Singapore., Lau JA; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Le TBU; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, Singapore., Wang L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore., Lee M; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Kannan S; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore., Verma CS; Bioinformatics Institute, Agency for Science, Technology, and Research (A*STAR), Singapore, 138671, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, 639798, Singapore., Lim CM; Division of Surgical Oncology (Head and Neck Surgery), National University Cancer Institute, Singapore (NCIS), Singapore, 119074, Singapore., Chng WJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Lane DP; p53 Laboratory (p53Lab), Agency for Science, Technology, and Research (A*STAR), Singapore, 138648, Singapore., Venkitaraman A; Medical Research Council Cancer Unit, University of Cambridge, Cambridge, CB2 0XZ, UK., Hung HT; Laboratory of Molecular Endocrinology, National Cancer Centre Singapore, Singapore, Singapore., Cheok CF; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology, and Research (A*STAR), Singapore, 138673, Singapore.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore., Goh BC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. phcgbc@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. phcgbc@nus.edu.sg.; Department of Haematology-Oncology, National University Cancer Institute, Singapore, 119074, Singapore. phcgbc@nus.edu.sg.

المصدر: Nature communications [Nat Commun] 2020 Apr 29; Vol. 11 (1), pp. 2086. Date of Electronic Publication: 2020 Apr 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Codon/*genetics , Mutation/*genetics , Neoplasms/*genetics , Tumor Suppressor Protein p53/*genetics, Acetylation/drug effects ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Epigenesis, Genetic/drug effects ; Gain of Function Mutation/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydroxamic Acids/pharmacology ; Mice, SCID ; Models, Biological ; Mutant Proteins/metabolism ; NF-kappa B/metabolism ; Neoplasms/drug therapy ; Nucleotide Motifs/genetics ; Poly(ADP-ribose) Polymerases/metabolism ; Protein Binding/drug effects ; Protein Isoforms/genetics ; Sulfonamides/pharmacology ; Topotecan/pharmacology ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Xenograft Model Antitumor Assays

المؤلفون: Yeoh KW; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Prawira A; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Saad MZB; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Lee KM; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Lee EMH; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Low GK; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Mohd Nasir MHB; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Phua JH; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Chow WWL; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Lim IJH; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Omar YB; Department of Radiation Oncology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore., Ho RZW; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Le TBU; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Vu TC; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore., Soo KC; Tan Chin Tuan Laboratory of Optical Imaging and Photodynamic & Proton Therapy, Division of Medical Sciences, National Cancer Centre, Singapore 169610, Singapore., Huynh H; Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, National Cancer Centre, Singapore 169610, Singapore.

المصدر: Cancers [Cancers (Basel)] 2020 Apr 03; Vol. 12 (4). Date of Electronic Publication: 2020 Apr 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE