المؤلفون: Knight KM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Krumm BE; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Kapolka NJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ludlam WG; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Cui M; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Mani S; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Prytkova I; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Obarow EG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lefevre TJ; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Wei W; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Ma N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Huang XP; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Fay JF; Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Smrcka AV; Department of Pharmacology, University of Michigan, Ann Arbor, MI, USA., Slesinger PA; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Logothetis DE; Department of Pharmaceutical Sciences Northeastern University, Boston, MA, USA., Martemyanov KA; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA., Roth BL; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dohlman HG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. hdohlman@med.unc.edu.

المصدر: Nature communications [Nat Commun] 2024 Aug 05; Vol. 15 (1), pp. 6643. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Cryoelectron Microscopy* , Guanosine Diphosphate*/metabolism , Guanosine Triphosphate*/metabolism, Humans ; HEK293 Cells ; Neurodevelopmental Disorders/genetics ; Neurodevelopmental Disorders/metabolism ; Receptors, Dopamine D2/metabolism ; Receptors, Dopamine D2/genetics ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go/genetics ; GTP-Binding Protein alpha Subunits, Gi-Go/chemistry ; Protein Binding ; GTP-Binding Proteins/metabolism ; GTP-Binding Proteins/genetics ; GTP-Binding Protein gamma Subunits/metabolism ; GTP-Binding Protein gamma Subunits/genetics

المؤلفون: Lefevre TJ; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA., Wei W; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Mukhaleva E; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Meda Venkata SP; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Chandan NR; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA; Genentech, South San Francisco, California, USA., Abraham S; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Li Y; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, Texas, USA., Dessauer CW; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, Texas, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, California, USA., Smrcka AV; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: avsmrcka@umich.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 May; Vol. 300 (5), pp. 107211. Date of Electronic Publication: 2024 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: GTP-Binding Protein alpha Subunits, Gi-Go*/metabolism , GTP-Binding Protein alpha Subunits, Gi-Go*/chemistry , GTP-Binding Protein alpha Subunits, Gi-Go*/genetics , Signal Transduction*, Humans ; Molecular Dynamics Simulation ; GTP-Binding Protein alpha Subunit, Gi2/metabolism ; GTP-Binding Protein alpha Subunit, Gi2/genetics ; GTP-Binding Protein alpha Subunit, Gi2/chemistry ; HEK293 Cells ; Protein Domains ; Protein Stability ; Protein Binding

المؤلفون: Lefevre TJ; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.; Program in Chemical Biology, University of Michigan, Ann Arbor, MI., Wei W; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, TX., Mukhaleva E; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, TX., Venkata SPM; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Chandan NR; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.; Genentech, South San Francisco, CA., Abraham S; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI., Li Y; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, TX., Dessauer CW; Department of Integrative Biology and Pharmacology McGovern Medical School, UTHealth, Houston, TX., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA., Smrcka AV; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 06. Date of Electronic Publication: 2023 Apr 06.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Knight KM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Ghosh S; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA., Campbell SL; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Lefevre TJ; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Olsen RHJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Smrcka AV; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA., Valentin NH; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Yin G; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Vaidehi N; Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address: nvaidehi@coh.org., Dohlman HG; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: hdohlman@med.unc.edu.

المصدر: Molecular cell [Mol Cell] 2021 Apr 01; Vol. 81 (7), pp. 1384-1396.e6. Date of Electronic Publication: 2021 Feb 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Guanosine Triphosphate*/chemistry , Guanosine Triphosphate*/metabolism , Heterotrimeric GTP-Binding Proteins*/chemistry , Heterotrimeric GTP-Binding Proteins*/metabolism , Molecular Dynamics Simulation* , Saccharomyces cerevisiae Proteins*/chemistry , Saccharomyces cerevisiae Proteins*/metabolism, Saccharomyces cerevisiae/*enzymology, Allosteric Regulation ; Amino Acid Motifs ; HEK293 Cells ; Humans