المؤلفون: Bruno PM; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Timms RT; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK., Abdelfattah NS; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Leng Y; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Lelis FJN; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Wesemann DR; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Yu XG; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA., Elledge SJ; Department of Genetics, Harvard Medical School and Division of Genetics, Brigham and Women's Hospital, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. selledge@genetics.med.harvard.edu.

المصدر: Nature biotechnology [Nat Biotechnol] 2023 Jul; Vol. 41 (7), pp. 980-992. Date of Electronic Publication: 2023 Jan 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine* , Histocompatibility Antigens Class I*/genetics , Histocompatibility Antigens Class I*/metabolism, Ligands ; Peptides/metabolism ; Epitopes, T-Lymphocyte/genetics ; Protein Binding

المؤلفون: Tong P; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Gautam A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Windsor IW; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Travers M; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Chen Y; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Garcia N; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Whiteman NB; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., McKay LGA; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Storm N; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Malsick LE; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Honko AN; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Lelis FJN; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Habibi S; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Jenni S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Cai Y; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Rennick LJ; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Duprex WP; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., McCarthy KR; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Zuo T; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lin J; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zuiani A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., MacDonald EA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Griffths A; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Chen B; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Neuberg D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Bajic G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Harrison SC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA., Wesemann DR; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA. Electronic address: dwesemann@bwh.harvard.edu.

المصدر: Cell [Cell] 2021 Sep 16; Vol. 184 (19), pp. 4969-4980.e15. Date of Electronic Publication: 2021 Jul 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Tong P; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Gautam A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Windsor I; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Travers M; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Chen Y; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Garcia N; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Whiteman NB; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., McKay LGA; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Lelis FJN; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Habibi S; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Cai Y; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Rennick LJ; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh PA., Duprex WP; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh PA., McCarthy KR; The Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.; The Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh PA., Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Zuo T; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lin J; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zuiani A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., MacDonald EA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Griffths A; Department of Microbiology, Boston University School of Medicine, Boston, MA 02115, USA.; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02115, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Department of Microbiology, Harvard Medical School, Boston MA 02115.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Chen B; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Neuberg D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Bajic G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA., Harrison SC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.; Laboratory of Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.; Howard Hughes Medical Institute, Boston, MA 02115, USA., Wesemann DR; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2021 Mar 10. Date of Electronic Publication: 2021 Mar 10.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Chen Y; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zuiani A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Mullur J; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Atyeo C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Travers M; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lelis FJN; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pullen KM; Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Martin H; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Tong P; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Gautam A; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Habibi S; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Bensko J; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Gakpo D; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Feldman J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Hauser BM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Caradonna TM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Cai Y; Boston Children's Hospital, Boston, MA 02115, USA., Burke JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Lin J; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lederer JA; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Lam EC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Lavine CL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Chen B; Boston Children's Hospital, Boston, MA 02115, USA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Balazs AB; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Lauffenburger DA; Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Wesemann DR; Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA. Electronic address: dwesemann@bwh.harvard.edu.

المصدر: Cell [Cell] 2020 Dec 10; Vol. 183 (6), pp. 1496-1507.e16. Date of Electronic Publication: 2020 Nov 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Antibody Formation* , COVID-19*/genetics , COVID-19*/immunology , Lymphocyte Activation* , Mutation*, Antibodies, Viral/*immunology , CD4-Positive T-Lymphocytes/*immunology , Immunoglobulin G/*immunology, Humans ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology

المؤلفون: Shrock E; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Fujimura E; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA.; Chemical Biology Program, Harvard University, Cambridge, MA, USA., Kula T; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Timms RT; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Lee IH; Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Leng Y; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Robinson ML; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sie BM; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Li MZ; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA., Chen Y; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Logue J; Department of Medicine, University of Washington, Seattle, WA, USA., Zuiani A; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., McCulloch D; Department of Medicine, University of Washington, Seattle, WA, USA., Lelis FJN; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Henson S; Institute for Cell Engineering, Immunology Division, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Monaco DR; Institute for Cell Engineering, Immunology Division, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Travers M; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Habibi S; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Clarke WA; Division of Clinical Chemistry, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Caturegli P; Division of Immunology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Laeyendecker O; Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Division of Intramural Research, NIAID, NIH, Baltimore, MD, USA., Piechocka-Trocha A; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.; Howard Hughes Medical Institute, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Li JZ; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.; Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Khatri A; Endocrine Unit and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chu HY; Department of Medicine, University of Washington, Seattle, WA, USA., Villani AC; Massachusetts General Hospital Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, MA, USA., Kays K; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Goldberg MB; Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine and Microbiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Hacohen N; Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, MA, USA., Filbin MR; Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA., Yu XG; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.; Infectious Disease Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Walker BD; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.; Howard Hughes Medical Institute, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.; Centre for the AIDS Programme of Research in South Africa, Congella, South Africa., Wesemann DR; Division of Allergy and Immunology and Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Larman HB; Institute for Cell Engineering, Immunology Division, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA., Lederer JA; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Elledge SJ; Department of Genetics, Harvard Medical School, Boston, MA, USA. selledge@genetics.med.harvard.edu.; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Harvard Medical School, Boston, MA, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.

مؤلفون مشاركون: MGH COVID-19 Collection & Processing Team

المصدر: Science (New York, N.Y.) [Science] 2020 Nov 27; Vol. 370 (6520). Date of Electronic Publication: 2020 Sep 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Epitope Mapping* , Severity of Illness Index*, COVID-19/*immunology , Epitopes/*immunology , SARS-CoV-2/*immunology, Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibody Formation ; COVID-19/blood ; COVID-19 Serological Testing ; Cross Reactions ; Cryoelectron Microscopy ; Epitopes/chemistry ; Epitopes/genetics ; Female ; Humans ; Male ; Protein Conformation ; Seroconversion

المؤلفون: Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Tostanoski LH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Mercado NB; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., McMahan K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Mahrokhian SH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Liu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Li Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Loos C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Atyeo C; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Fischinger S; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Burke JS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Slein MD; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Chen Y; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zuiani A; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Lelis FJN; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Travers M; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Habibi S; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Pessaint L; Bioqual, Rockville, MD 20852, USA., Van Ry A; Bioqual, Rockville, MD 20852, USA., Blade K; Bioqual, Rockville, MD 20852, USA., Brown R; Bioqual, Rockville, MD 20852, USA., Cook A; Bioqual, Rockville, MD 20852, USA., Finneyfrock B; Bioqual, Rockville, MD 20852, USA., Dodson A; Bioqual, Rockville, MD 20852, USA., Teow E; Bioqual, Rockville, MD 20852, USA., Velasco J; Bioqual, Rockville, MD 20852, USA., Zahn R; Janssen Vaccines & Prevention BV, Leiden, Netherlands., Wegmann F; Janssen Vaccines & Prevention BV, Leiden, Netherlands., Bondzie EA; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Dagotto G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Gebre MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., He X; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Jacob-Dolan C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Kirilova M; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Kordana N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Lin Z; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Maxfield LF; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Nampanya F; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Nityanandam R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Ventura JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Wan H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Cai Y; Children's Hospital, Boston, MA 02115, USA., Chen B; Children's Hospital, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA., Schmidt AG; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA., Wesemann DR; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA., Andersen H; Bioqual, Rockville, MD 20852, USA., Lewis MG; Bioqual, Rockville, MD 20852, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. dbarouch@bidmc.harvard.edu.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA.

المصدر: Science (New York, N.Y.) [Science] 2020 Aug 14; Vol. 369 (6505), pp. 806-811. Date of Electronic Publication: 2020 May 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Betacoronavirus/*immunology , Coronavirus Infections/*prevention & control , Pandemics/*prevention & control , Pneumonia, Viral/*prevention & control , Spike Glycoprotein, Coronavirus/*immunology , Vaccines, DNA/*immunology , Viral Vaccines/*immunology, Adjuvants, Immunologic ; Animals ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Betacoronavirus/physiology ; Bronchoalveolar Lavage Fluid/virology ; COVID-19 ; COVID-19 Vaccines ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Disease Models, Animal ; Female ; Humans ; Immunity, Cellular ; Immunity, Humoral ; Immunization, Secondary ; Immunogenicity, Vaccine ; Immunologic Memory ; Macaca mulatta ; Male ; Mutant Proteins/chemistry ; Mutant Proteins/immunology ; Nasal Mucosa/virology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Protein Domains ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Vaccination ; Vaccines, DNA/administration & dosage ; Viral Load ; Viral Vaccines/administration & dosage

المؤلفون: Jaufmann J; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, Tuebingen, Germany.; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Lelis FJN; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany.; Department of Medicine, Division of Rheumatology, Immunology and Allergy Brigham and Women's Hospital and Harvard Medical School, 60 Fenwood Road, Boston, MA, USA., Teschner AC; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Fromm K; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany.; Biozentrum, University of Basel, Infection Biology, Basel, Switzerland., Rieber N; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany.; Department of Pediatrics, Kinderklinik Muenchen Schwabing, Muenchen Klinik und Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Hartl D; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Beer-Hammer S; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, Tuebingen, Germany.

المصدر: European journal of immunology [Eur J Immunol] 2020 Jan; Vol. 50 (1), pp. 33-47. Date of Electronic Publication: 2019 Oct 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: B-Lymphocytes/*immunology , Myeloid-Derived Suppressor Cells/*immunology, B-Lymphocytes/metabolism ; Cell Proliferation/physiology ; Cells, Cultured ; Humans ; Lymphocyte Activation/immunology ; Myeloid-Derived Suppressor Cells/metabolism ; Phenotype

المؤلفون: Lelis FJN; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany; Department of Pediatrics, Department of Infectious Diseades, Boston Children's Hospital, Harvard Medical School,300 Longwood Avenue, Boston, MA 02115, USA., Jaufmann J; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074, Tuebingen, Germany., Singh A; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Fromm K; Biozentrum, University of Basel, Infection Biology, Klingelberstrasse 50/70, 4056 Basel, Switzerland., Teschner AC; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Pöschel S; University Women's Hospital, Core Facility Imagestream, University of Tuebingen, Tuebingen, Germany., Schäfer I; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany., Beer-Hammer S; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tuebingen, 72074, Tuebingen, Germany., Rieber N; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany; Department of Pediatrics, Kinderklinik München Schwabing, Klinikum Schwabing, StKM GmbH und Klinikum rechts der Isar, Technische Universität München, 80804 Munich, Germany., Hartl D; Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tuebingen, Tuebingen, Germany; Roche Pharma Research & Early Development (pRED), Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area, Switzerland. Electronic address: dominik.hartl@med.uni-tuebingen.de.

المصدر: Immunology letters [Immunol Lett] 2017 Aug; Vol. 188, pp. 108-115. Date of Electronic Publication: 2017 Jul 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7910006 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0542 (Electronic) Linking ISSN: 01652478 NLM ISO Abbreviation: Immunol Lett Subsets: MEDLINE

مواضيع طبية MeSH: Immunomodulation*, B-Lymphocytes/*immunology , B-Lymphocytes/*metabolism , Cell Communication/*immunology , Myeloid-Derived Suppressor Cells/*immunology , Myeloid-Derived Suppressor Cells/*metabolism, Antibody Formation/immunology ; Arginase/metabolism ; Biomarkers ; Cells, Cultured ; Humans ; Immunoglobulin M/immunology ; Lymphocyte Activation/immunology ; Neutrophils/immunology ; Neutrophils/metabolism ; Nitric Oxide/metabolism ; Reactive Oxygen Species/metabolism