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المؤلفون: Rubinson DA; Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Tanaka N; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Fece de la Cruz F; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Kapner KS; Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Rosenthal MH; Dana Farber Cancer Institute and Brigham and Women's Hospital, Department of Radiology, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Norden BL; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Barnes H; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Ehnstrom S; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Morales-Giron AA; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Brais LK; Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts., Lemke CT; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Aguirre AJ; Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts.; The Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Corcoran RB; Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2024 May 01; Vol. 14 (5), pp. 727-736.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Membrane Proteins*/genetics , Membrane Proteins*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/antagonists & inhibitors , Pyridines*, Humans ; GTP Phosphohydrolases/genetics ; Mutation ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology ; Pyrimidines/therapeutic use ; Pyrimidines/pharmacology ; Piperazines/pharmacology ; Piperazines/therapeutic use

المؤلفون: Babbe H; Janssen Research and Development, LLC., Spring House, PA 19477., Sundberg TB; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Tichenor M; Janssen Research and Development, LLC., San Diego, CA 92121., Seierstad M; Janssen Research and Development, LLC., San Diego, CA 92121., Bacani G; Janssen Research and Development, LLC., San Diego, CA 92121., Berstler J; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Chai W; Janssen Research and Development, LLC., San Diego, CA 92121., Chang L; Janssen Research and Development, LLC., San Diego, CA 92121., Chung M; Janssen Research and Development, LLC., San Diego, CA 92121., Coe K; Janssen Research and Development, LLC., San Diego, CA 92121., Collins B; Janssen Research and Development, LLC., San Diego, CA 92121., Finley M; Janssen Research and Development, LLC., Spring House, PA 19477., Guletsky A; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Lemke CT; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Mak PA; Janssen Research and Development, LLC., San Diego, CA 92121., Mathur A; Janssen Research and Development, LLC., Spring House, PA 19477., Mercado-Marin EV; Janssen Research and Development, LLC., San Diego, CA 92121., Metkar S; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Raymond DD; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Rives ML; Janssen Research and Development, LLC., San Diego, CA 92121., Rizzolio M; Janssen Research and Development, LLC., San Diego, CA 92121., Shaffer PL; Janssen Research and Development, LLC., Spring House, PA 19477., Smith R; Janssen Research and Development, LLC., San Diego, CA 92121., Smith J; Janssen Research and Development, LLC., San Diego, CA 92121., Steele R; Janssen Research and Development, LLC., Spring House, PA 19477., Steffens H; Janssen Research and Development, LLC., San Diego, CA 92121., Suarez J; Janssen Research and Development, LLC., Spring House, PA 19477., Tian G; Janssen Research and Development, LLC., Spring House, PA 19477., Majewski N; Janssen Research and Development, LLC., Spring House, PA 19477., Volak LP; Janssen Research and Development, LLC., San Diego, CA 92121., Wei J; Janssen Research and Development, LLC., San Diego, CA 92121., Desai PT; Janssen Research and Development, LLC., Spring House, PA 19477., Ong LL; Janssen Research and Development, LLC., Spring House, PA 19477., Koudriakova T; Janssen Research and Development, LLC., San Diego, CA 92121., Goldberg SD; Janssen Research and Development, LLC., San Diego, CA 92121., Hirst G; Janssen Research and Development, LLC., San Diego, CA 92121., Kaushik VK; Broad Institute of MIT and Harvard, Center for the Development of Therapeutics, Cambridge, MA 02142., Ort T; Janssen Research and Development, LLC., Spring House, PA 19477., Seth N; Janssen Research and Development, LLC., Spring House, PA 19477., Graham DB; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Plevy S; Janssen Research and Development, LLC., Spring House, PA 19477., Venable JD; Janssen Research and Development, LLC., San Diego, CA 92121., Xavier RJ; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Towne JE; Janssen Research and Development, LLC., San Diego, CA 92121.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 02; Vol. 121 (1), pp. e2307086120. Date of Electronic Publication: 2023 Dec 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Protein Serine-Threonine Kinases*/metabolism , Cyclic AMP Response Element-Binding Protein*/metabolism, Mice ; Humans ; Animals ; Cytokines ; Inflammation/drug therapy ; Protein Isoforms ; Anti-Inflammatory Agents/pharmacology ; Immunity, Innate ; Transcription Factors

المؤلفون: Orsi DL; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ferrara SJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Siegel S; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Friberg A; Nuvisan ICB GmbH, 13353 Berlin, Germany., Bouché L; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Pook E; Research and Development, Pharmaceuticals, Bayer AG, 42113 Wuppertal, Germany., Lienau P; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Bluck JP; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Akcay G; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Stellfeld T; Nuvisan ICB GmbH, 13353 Berlin, Germany., Meyer H; Nuvisan ICB GmbH, 13353 Berlin, Germany., Pütter V; Nuvisan ICB GmbH, 13353 Berlin, Germany., Holton SJ; Nuvisan ICB GmbH, 13353 Berlin, Germany., Korr D; Nuvisan ICB GmbH, 13353 Berlin, Germany., Jerchel-Furau I; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Pantelidou C; Bayer US LLC, Research and Development Precision Molecular Oncology, Cambridge, MA 02142, USA., Strathdee CA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Meyerson M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics and Medicine, Harvard Medical School, Boston, MA 02115, USA., Eis K; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: jgold@broadinstitute.org.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2023 Jan 15; Vol. 78, pp. 117130. Date of Electronic Publication: 2022 Dec 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: PPAR gamma*/agonists , Urinary Bladder Neoplasms*, Humans ; Drug Inverse Agonism ; PPAR-gamma Agonists ; Gene Expression Regulation

المؤلفون: Orsi DL, Pook E, Bräuer N, Friberg A, Lienau P, Lemke CT, Stellfeld T, Brüggemeier U, Pütter V, Meyer H, Baco M, Tang S, Cherniack AD, Westlake L, Bender SA, Kocak M, Strathdee CA, Meyerson M, Eis K, Goldstein JT

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 1082. Date of Electronic Publication: 2022 Dec 21.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Orsi DL; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Pook E; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Bräuer N; Nuvisan ICB GmbH, 13353 Berlin, Germany., Friberg A; Nuvisan ICB GmbH, 13353 Berlin, Germany., Lienau P; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Stellfeld T; Nuvisan ICB GmbH, 13353 Berlin, Germany., Brüggemeier U; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Pütter V; Nuvisan ICB GmbH, 13353 Berlin, Germany., Meyer H; Nuvisan ICB GmbH, 13353 Berlin, Germany., Baco M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Tang S; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Cherniack AD; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States., Westlake L; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Bender SA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Kocak M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Strathdee CA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States., Meyerson M; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States.; Department of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States., Eis K; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Nov 10; Vol. 65 (21), pp. 14843-14863. Date of Electronic Publication: 2022 Oct 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: PPAR gamma*/metabolism, Ligands

المؤلفون: Kwon JJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Hajian B; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bian Y; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Young LC; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Amor AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller JR; Helix Biostructures, Indianapolis, IN, USA., Fraley CV; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sykes AM; Harvard Medical School, Boston, Massachusetts, USA.; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., So J; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Pan J; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Baker L; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee SJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Wheeler DB; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Mayhew DL; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, Massachusetts, USA., Persky NS; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang X; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Root DE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barsotti AM; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Stamford AW; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Perry CK; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burgin A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McCormick F; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; NCI RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA., Lemke CT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. clemke@broadinstitute.org., Hahn WC; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. william_hahn@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. william_hahn@dfci.harvard.edu.; Harvard Medical School, Boston, Massachusetts, USA. william_hahn@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. william_hahn@dfci.harvard.edu., Aguirre AJ; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. andrew_aguirre@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.; Harvard Medical School, Boston, Massachusetts, USA. andrew_aguirre@dfci.harvard.edu.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. andrew_aguirre@dfci.harvard.edu.

المصدر: Nature [Nature] 2022 Sep; Vol. 609 (7926), pp. 408-415. Date of Electronic Publication: 2022 Jul 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cryoelectron Microscopy* , Intracellular Signaling Peptides and Proteins*/chemistry , Intracellular Signaling Peptides and Proteins*/genetics , Intracellular Signaling Peptides and Proteins*/metabolism , Multiprotein Complexes*/chemistry , Multiprotein Complexes*/metabolism , Multiprotein Complexes*/ultrastructure , Protein Phosphatase 1*/chemistry , Protein Phosphatase 1*/metabolism , Protein Phosphatase 1*/ultrastructure , ras Proteins*/chemistry , ras Proteins*/metabolism , ras Proteins*/ultrastructure, Amino Acid Motifs ; Binding Sites ; Guanosine Triphosphate/metabolism ; Humans ; MAP Kinase Signaling System ; Mutation, Missense ; Phosphorylation ; Protein Binding ; Protein Stability ; raf Kinases