المؤلفون: Prescott NA; Tri-Institutional PhD Program in Chemical Biology; New York, NY 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA., Mansisidor A; Laboratory of Genome Architecture and Dynamics, The Rockefeller University; New York, NY 10065, USA.; These authors contributed equally., Bram Y; Division of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medicine; New York, NY 10065, USA.; These authors contributed equally., Biaco T; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA.; Department of Pharmacology, Weill Cornell Medicine; New York, NY 10065, USA.; These authors contributed equally., Rendleman J; Laboratory of Genome Architecture and Dynamics, The Rockefeller University; New York, NY 10065, USA., Faulkner SC; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA., Lemmon AA; Tri-Institutional PhD Program in Chemical Biology; New York, NY 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA., Lim C; Division of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medicine; New York, NY 10065, USA., Hamard PJ; Epigenetics Research Innovation Lab, Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA., Koche RP; Epigenetics Research Innovation Lab, Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA., Risca VI; Laboratory of Genome Architecture and Dynamics, The Rockefeller University; New York, NY 10065, USA., Schwartz RE; Division of Gastroenterology & Hepatology, Department of Medicine, Weill Cornell Medicine; New York, NY 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medicine; New York, NY 10065, USA., David Y; Tri-Institutional PhD Program in Chemical Biology; New York, NY 10065, USA.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, NY 10065, USA.; Department of Pharmacology, Weill Cornell Medicine; New York, NY 10065, USA.; Lead Contact.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Lee HG; Biochemistry, Structural Biology, Cell Biology, Developmental Biology and Molecular Biology (BCMB) Allied Program, Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10065.; Structural Biology Program, Sloan Kettering Institute, New York, NY 10065., Lemmon AA; Structural Biology Program, Sloan Kettering Institute, New York, NY 10065.; Tri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York NY 10065., Lima CD; Structural Biology Program, Sloan Kettering Institute, New York, NY 10065.; HHMI, New York, NY 10065.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 03; Vol. 120 (1), pp. e2213703120. Date of Electronic Publication: 2022 Dec 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Polyubiquitin*/metabolism , Saccharomyces cerevisiae Proteins*/metabolism, Valosin Containing Protein/genetics ; Valosin Containing Protein/metabolism ; Ubiquitin/metabolism ; Endoplasmic Reticulum/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism

المؤلفون: Patil K; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6315., Jordan EJ; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073., Park JH; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6073.; Department of Pharmacology, Yale University, New Haven, CT 06520.; Cancer Biology Institute, Yale University, West Haven, CT 06516., Suresh K; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321., Smith CM; Department of Pharmacology, Yale University, New Haven, CT 06520.; Cancer Biology Institute, Yale University, West Haven, CT 06516., Lemmon AA; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6073., Mossé YP; Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104., Lemmon MA; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073; mark.lemmon@yale.edu rradhak@seas.upenn.edu.; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104-6073.; Department of Pharmacology, Yale University, New Haven, CT 06520.; Cancer Biology Institute, Yale University, West Haven, CT 06516., Radhakrishnan R; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6315; mark.lemmon@yale.edu rradhak@seas.upenn.edu.; Graduate Group in Biochemistry and Molecular Biology, University of Pennsylvania, Philadelphia PA 19104-6073.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104-6321.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Mar 09; Vol. 118 (10).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Machine Learning* , Molecular Dynamics Simulation* , Mutation*, Anaplastic Lymphoma Kinase/*chemistry, Anaplastic Lymphoma Kinase/deficiency ; Enzyme Activation/genetics ; Humans ; Protein Conformation, alpha-Helical