المؤلفون: White, Marquitta J, Risse-Adams, O, Goddard, P, Contreras, MG, Adams, J, Hu, D, Eng, C, Oh, SS, Davis, A, Meade, K, Brigino-Buenaventura, E, LeNoir, MA, Bibbins-Domingo, K, Pino-Yanes, M, Burchard, EG

المصدر: Immunogenetics. 68(6-7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Immunology, Prevention, Clinical Research, Obesity, Genetics, Pediatric, Lung, Asthma, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Good Health and Well Being, Adolescent, Adult, Black or African American, Case-Control Studies, Child, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Precision Medicine, Risk Factors, San Francisco, White People, Young Adult, Health disparities, Children, GWAS

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3xx002h6

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المؤلفون: Herrera-Luis E; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain.; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Rosa-Baez C; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain., Huntsman S; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Eng C; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Beckman KB; University of Minnesota Genomics Center, Minneapolis, MN, USA., LeNoir MA; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain.; Bay Area Pediatrics, Oakland, CA, USA., Rodriguez-Santana JR; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain.; Centro de Neumología Pediátrica, San Juan, Puerto Rico., Villar J; Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.; Li Ka Shing Knowledge Institute at St Michael's Hospital, Toronto, ON, Canada., Laprise C; Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, QC, Canada.; Centre Intersectoriel en Santé Durable, Université du Québec à Chicoutimi, Saguenay, QC, Canada., Borrell LN; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA., Ziv E; Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.; Division of General Internal Medicine, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA., Burchard EG; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.; Division of General Internal Medicine, Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Instituto de Tecnologías Biomédicas, Universidad de La Laguna (ULL), La Laguna, Spain., Pino-Yanes M; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain mdelpino@ull.edu.es.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Tecnologías Biomédicas, Universidad de La Laguna (ULL), La Laguna, Spain.; These authors contributed equally as senior authors.

المصدر: The European respiratory journal [Eur Respir J] 2023 Dec 21; Vol. 62 (6). Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE

مواضيع طبية MeSH: Epigenome* , Asthma*/genetics, Child ; Humans ; Adolescent ; Epigenesis, Genetic ; DNA Methylation ; Gene Expression Profiling ; NADPH Dehydrogenase/genetics

المؤلفون: Kachuri L; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Population Health, Stanford University, Stanford, CA, USA., Mak ACY; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Hu D; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Eng C; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Huntsman S; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Elhawary JR; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Gupta N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Xiao S; Center for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI, USA., Keys KL; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Berkeley Institute for Data Science, University of California, Berkeley, Berkeley, CA, USA., Oni-Orisan A; Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA., Rodríguez-Santana JR; Centro de Neumología Pediátrica, San Juan, Puerto Rico., LeNoir MA; Bay Area Pediatrics, Oakland, CA, USA., Borrell LN; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY, USA., Zaitlen NA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Williams LK; Center for Individualized and Genomic Medicine Research, Henry Ford Health System, Detroit, MI, USA.; Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA., Gignoux CR; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Chris.Gignoux@cuanschutz.edu.; Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Chris.Gignoux@cuanschutz.edu., Burchard EG; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Esteban.Burchard@ucsf.edu.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. Esteban.Burchard@ucsf.edu., Ziv E; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Elad.Ziv@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. Elad.Ziv@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. Elad.Ziv@ucsf.edu.

المصدر: Nature genetics [Nat Genet] 2023 Jun; Vol. 55 (6), pp. 952-963. Date of Electronic Publication: 2023 May 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Black or African American*/genetics , Hispanic or Latino*/genetics , Mexican Americans*/genetics, Humans ; Genome-Wide Association Study ; Phenotype ; Polymorphism, Single Nucleotide ; Transcriptome

المؤلفون: Perez-Garcia J; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain., Herrera-Luis E; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain., Li A; Department of Medicine, University of California, San Francisco, Calif., Mak ACY; Department of Medicine, University of California, San Francisco, Calif., Huntsman S; Department of Medicine, University of California, San Francisco, Calif., Oh SS; Department of Medicine, University of California, San Francisco, Calif., Elhawary JR; Department of Medicine, University of California, San Francisco, Calif., Eng C; Department of Medicine, University of California, San Francisco, Calif., Beckman KB; University of Minnesota Genomics Center, Minneapolis, Minn., Hu D; Department of Medicine, University of California, San Francisco, Calif., Lorenzo-Diaz F; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain; Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), ULL, Santa Cruz de Tenerife, Spain., Lenoir MA; Bay Area Pediatrics, Oakland, Calif., Rodriguez-Santana J; Centro de Neumología Pediátrica, San Juan, Puerto Rico., Zaitlen N; Department of Neurology, University of California, Los Angeles, Calif; Department of Computational Medicine, University of California, Los Angeles, Calif., Villar J; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain., Borrell LN; Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY., Burchard EG; Department of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif., Pino-Yanes M; Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna (ULL), La Laguna, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Instituto de Tecnologías Biomédicas, ULL, La Laguna, Spain. Electronic address: mdelpino@ull.edu.es.

المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2023 Jun; Vol. 151 (6), pp. 1503-1512. Date of Electronic Publication: 2023 Feb 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Bronchodilator Agents*/therapeutic use , Asthma*/drug therapy , Asthma*/genetics , Asthma*/metabolism, Child ; Young Adult ; Humans ; Adolescent ; Adult ; Epigenome ; Multiomics ; Albuterol/therapeutic use ; DNA Methylation ; Genome-Wide Association Study ; Fibrinogen/metabolism

المؤلفون: Wohlford EM; Division of Pediatric Allergy and Immunology, University of California San Francisco, San Francisco, Calif; Department of Medicine, University of California San Francisco, San Francisco, Calif., Huang PF; Department of Medicine, University of California San Francisco, San Francisco, Calif., Elhawary JR; Department of Medicine, University of California San Francisco, San Francisco, Calif. Electronic address: jennifer.elhawary@ucsf.edu., Millette LA; Genentech Inc, South San Francisco, Calif., Contreras MG; Department of Medicine, University of California San Francisco, San Francisco, Calif., Witonsky J; Division of Pediatric Allergy and Immunology, University of California San Francisco, San Francisco, Calif; Department of Medicine, University of California San Francisco, San Francisco, Calif., Holweg CTJ; Genentech Inc, South San Francisco, Calif., Oh SS; Department of Medicine, University of California San Francisco, San Francisco, Calif., Lee C; Office of Minority Health and Health Equity, US Food and Drug Administration, Silver Spring, Md., Merenda C; Office of Minority Health and Health Equity, US Food and Drug Administration, Silver Spring, Md., Rabin RL; Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Md., Araojo R; Office of Minority Health and Health Equity, US Food and Drug Administration, Silver Spring, Md., Mak ACY; Department of Medicine, University of California San Francisco, San Francisco, Calif., Eng CS; Department of Medicine, University of California San Francisco, San Francisco, Calif., Hu D; Department of Medicine, University of California San Francisco, San Francisco, Calif., Huntsman S; Department of Medicine, University of California San Francisco, San Francisco, Calif., LeNoir MA; Bay Area Pediatrics, Oakland, Calif., Rodríguez-Santana JR; Centro de Neumologia Pediátrica, Caguas, Puerto Rico., Borrell LN; Department of Epidemiology & Biostatistics, Graduate School of Public Health & Health Policy, City University of New York, New York, NY., Burchard EG; Department of Medicine, University of California San Francisco, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, Calif.

المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Nov; Vol. 148 (5), pp. 1324-1331.e12. Date of Electronic Publication: 2021 Sep 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Ethnicity* , Minority Groups* , Racial Groups*, Anti-Asthmatic Agents/*therapeutic use , Asthma/*epidemiology , Biological Products/*therapeutic use, Adolescent ; Asthma/therapy ; Case-Control Studies ; Child ; Eligibility Determination ; Female ; Humans ; Immunoglobulin E/blood ; Male ; Phenotype ; United States/epidemiology ; Young Adult

المؤلفون: Borrell LN; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Elhawary JR; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Fuentes-Afflick E; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Witonsky J; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Bhakta N; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Wu AHB; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Bibbins-Domingo K; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Rodríguez-Santana JR; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Lenoir MA; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Gavin JR 3rd; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Kittles RA; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Zaitlen NA; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Wilkes DS; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Powe NR; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Ziv E; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.)., Burchard EG; From the Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York (L.N.B.); the Departments of Medicine (J.R.E., J.W., N.B., N.R.P., E.Z., E.G.B.), Pediatrics (E.F.-A., J.W.), Laboratory Medicine (A.H.B.W.), and Epidemiology and Biostatistics (K.B.-D.), Priscilla Chan and Mark Zuckerberg San Francisco General Hospital (K.B.-D., N.R.P.), the Division of General Internal Medicine and the Institute of Human Genetics, Helen Diller Family Comprehensive Cancer Center (E.Z.), and the Department of Bioengineering and Therapeutic Sciences (E.G.B.), University of California, San Francisco, San Francisco, Bay Area Pediatrics, Oakland (M.A.L.), the Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte (R.A.K.), and the Department of Neurogenetics, University of California, Los Angeles, Los Angeles (N.A.Z.) - all in California; the Centro de Neumología Pediátrica, San Juan, PR (J.R.R.-S.); Emory University School of Medicine, Atlanta (J.R.G.); and the School of Medicine, University of Virginia, Charlottesville (D.S.W.).

المصدر: The New England journal of medicine [N Engl J Med] 2021 Feb 04; Vol. 384 (5), pp. 474-480. Date of Electronic Publication: 2021 Jan 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Massachusetts Medical Society Country of Publication: United States NLM ID: 0255562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-4406 (Electronic) Linking ISSN: 00284793 NLM ISO Abbreviation: N Engl J Med Subsets: MEDLINE

مواضيع طبية MeSH: Medicine* , Racism*, Ethnicity/*genetics , Racial Groups/*genetics, Humans ; United States

المؤلفون: Keys KL; Department of Medicine, University of California, San Francisco, California, United States of America.; Berkeley Institute for Data Science, University of California, Berkeley, California, United States of America., Mak ACY; Department of Medicine, University of California, San Francisco, California, United States of America., White MJ; Department of Medicine, University of California, San Francisco, California, United States of America., Eckalbar WL; Department of Medicine, University of California, San Francisco, California, United States of America., Dahl AW; Department of Medicine, University of California, San Francisco, California, United States of America., Mefford J; Department of Medicine, University of California, San Francisco, California, United States of America., Mikhaylova AV; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Contreras MG; Department of Medicine, University of California, San Francisco, California, United States of America.; San Francisco State University, San Francisco, California, United States of America., Elhawary JR; Department of Medicine, University of California, San Francisco, California, United States of America., Eng C; Department of Medicine, University of California, San Francisco, California, United States of America., Hu D; Department of Medicine, University of California, San Francisco, California, United States of America., Huntsman S; Department of Medicine, University of California, San Francisco, California, United States of America., Oh SS; Department of Medicine, University of California, San Francisco, California, United States of America., Salazar S; Department of Medicine, University of California, San Francisco, California, United States of America., Lenoir MA; Bay Area Pediatrics, Oakland, California, United States of America., Ye JC; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Biosciences, University of California, San Francisco, California, United States of America., Thornton TA; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America., Zaitlen N; Department of Neurology, University of California, Los Angeles, California, United States of America., Burchard EG; Department of Medicine, University of California, San Francisco, California, United States of America.; Department of Bioengineering and Therapeutic Biosciences, University of California, San Francisco, California, United States of America., Gignoux CR; Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.; Department of Biostatistics and Informatics, School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

المصدر: PLoS genetics [PLoS Genet] 2020 Aug 14; Vol. 16 (8), pp. e1008927. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7404 (Electronic) Linking ISSN: 15537390 NLM ISO Abbreviation: PLoS Genet Subsets: MEDLINE

مواضيع طبية MeSH: Models, Genetic* , Transcriptome*, Black or African American/*genetics , Genome-Wide Association Study/*methods, Gene Expression Profiling/methods ; Gene Expression Profiling/standards ; Genome-Wide Association Study/standards ; Humans ; Quantitative Trait Loci ; RNA-Seq/methods ; RNA-Seq/standards ; Reference Standards