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1Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model
المؤلفون: Anna Axelsson Raja, Hiroko Wakimoto, Daniel M. DeLaughter, Daniel Reichart, Joshua Gorham, David A. Conner, Mingyue Lun, Clemens K. Probst, Norihiko Sakai, Rachel S. Knipe, Sydney B. Montesi, Barry Shea, Leonard P. Adam, Leslie A. Leinwand, William Wan, Esther Sue Choi, Eric L. Lindberg, Giannino Patone, Michela Noseda, Norbert Hübner, Christine E. Seidman, Andrew M. Tager, J. G. Seidman, Carolyn Y. Ho
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 119(28)
مصطلحات موضوعية: Disease Models, Animal, Mice, Multidisciplinary, Cardiovascular and Metabolic Diseases, Animals, Endothelial Cells, Hypertrophy, Cardiomyopathy, Hypertrophic, Receptors, Lysophosphatidic Acid, Carrier Proteins, Fibrosis
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff8adad5be76c820559ec05ac9a9e2d
https://pubmed.ncbi.nlm.nih.gov/35787042 -
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المؤلفون: Zilun Hu, Doree Sitkoff, Peter W. Glunz, Yan Zou, Cailan Wang, Jodi K. Muckelbauer, Leonard P. Adam, Ruth R. Wexler, Mimi L. Quan
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: History, Polymers and Plastics, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Business and International Management, Molecular Biology, Biochemistry, Industrial and Manufacturing Engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bd0491e080f2db50067a946e1fa19b
https://doi.org/10.2139/ssrn.4379816 -
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المؤلفون: Ji Jiang, Tammy C. Wang, Alice Ye A. Chen, Xiaohong Yin, Jennifer X. Qiao, Ming Chang, Muthoni G. Kamau, Julia Li, David S. Taylor, Leonard P. Adam, Lalgudi S. Harikrishnan, Xue-Qing Chen, Heather Finlay, R. Michael Lawrence, Richard Rampulla, Paul Levesque, Christine Huang, Paul G. Sleph, Carrie Xu, Ruth R. Wexler, Mark E. Salvati
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: biology, Chemistry, Organic Chemistry, Drug Discovery, Cholesterylester transfer protein, biology.protein, Pharmacology, Lead (electronics), Biochemistry, CETP inhibitor, Coronary heart disease
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4Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
المؤلفون: Xiaohong Ying, Joelle M. Onorato, Heather Finlay, Nathalie Toussaint, Tammy C. Wang, Yi-Xin Li, David S. Taylor, Ruth R. Wexler, Alice Y.A. Chen, Carol Hui Hu, Jennifer X. Qiao, Lauren Haque, Christine Huang, Lynn M. Abell, Leonard P. Adam, David A. Gordon, Hong Shen, Michael Galella
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3721-3725
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Endothelial lipase, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Pharmacology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Pharmacokinetics, Amide, Drug Discovery, Animals, Humans, Potency, Enzyme Inhibitors, Molecular Biology, 010405 organic chemistry, Chemistry, Cholesterol, HDL, Organic Chemistry, Lipase, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine
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المؤلفون: Yan-Shan Dai, Lisa Salvador, Paul Levesque, Uma Kavita, Qin C Ji, Wendy Miller, Yan J Zhang, Renuka Pillutla, Leonard P. Adam
المصدر: Human Gene Therapy Methods. 29:237-250
مصطلحات موضوعية: 0301 basic medicine, Serotype, Luminescence, Population, Enzyme-Linked Immunosorbent Assay, Antibodies, Viral, Serogroup, medicine.disease_cause, Sensitivity and Specificity, Applied Microbiology and Biotechnology, Epitope, Neutralization, Cell Line, law.invention, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Luciferases, Firefly, law, Cricetinae, Genetics, medicine, Animals, Humans, education, Adeno-associated virus, Genetics (clinical), Pharmacology, education.field_of_study, biology, Dependovirus, Antibodies, Neutralizing, Virology, In vitro, 030104 developmental biology, 030220 oncology & carcinogenesis, Recombinant DNA, biology.protein, Molecular Medicine, Antibody, Biomarkers
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88775e17f31316680262df4447b2c0e
https://doi.org/10.1089/hgtb.2018.131 -
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المؤلفون: Lei Zhao, Peter Schafer, David A. Gordon, Payman Zamani, Yi Jia, Francisco Ramirez-Valle, Julio A. Chirinos, Zhaoqing Wang, Dietmar A. Seiffert, Ali Javaheri, Ernst Rietzschel, Thomas C. Hanff, Leonard P. Adam, Alice M. Walsh, Thomas P. Cappola, Stuart B. Prenner, Jordana B. Cohen, Mary Ellen Cvijic, Joseph Maranville
المصدر: JACC-BASIC TO TRANSLATIONAL SCIENCE
JACC: Basic to Translational Scienceمصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, medicine.medical_specialty, Apolipoprotein B, HFpEF, heart failure with preserved ejection fraction, heart failure, 030204 cardiovascular system & hematology, Cardiovascular death, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, proteomics, Clinical Research, Diabetes mellitus, Internal medicine, DM, diabetes mellitus, Medicine and Health Sciences, apolipoprotein M, Medicine, In patient, mediation analysis, Aldosterone, CILP2, cartilage intermediate layer protein 2, LASSO, least absolute shrinkage and selection operator, biology, diabetes, business.industry, medicine.disease, HR, hazard ratio, CI, confidence interval, 030104 developmental biology, chemistry, Heart failure, biology.protein, Cardiology, ApoM, apolipoprotein M, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business
وصف الملف: application/pdf
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المؤلفون: Doree F. Sitkoff, Alice Y. Chen, Hongwei Zhang, Anne Rose, Xue-Qing Chen, Cailan Wang, Leonard P. Adam, Mimi L. Quan, Nathan L. Cheadle, Zilun Hu, Lisa Zhang, David S. Taylor, Ruth R. Wexler, Songmei Xu, John S. Sack, Joseph E. Myers, Victor R. Guarino, James Hennan, Peter W. Glunz, Chunhong Yan, Julia Li
المصدر: Bioorganicmedicinal chemistry letters. 30(21)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Blood Pressure, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, In vivo, Amide, Drug Discovery, Molecule, Potency, Animals, Humans, Kinome, Molecular Biology, Protein Kinase Inhibitors, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Rho kinase inhibitor, Molecular Medicine, Pyrazoles, Selectivity
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المؤلفون: Jodi K. Muckelbauer, Mimi L. Quan, Zilun Hu, Cailan Wang, Nathan L. Cheadle, Ruth R. Wexler, Songmei Xu, Doree F. Sitkoff, Leonard P. Adam
المصدر: Bioorganicmedicinal chemistry letters. 30(21)
مصطلحات موضوعية: Models, Molecular, Pyrimidine, Stereochemistry, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Pyridine, Humans, Kinome, Molecular Biology, IC50, Protein Kinase Inhibitors, rho-Associated Kinases, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Kinase, Organic Chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Selectivity
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المؤلفون: David S. Taylor, Lei Zhao, Leonard P. Adam, David A. Gordon, Michael Basso, Alice Ye Chen, Eddie C.-K. Liu, Ji Jiang, Christian Caporuscio, Zulan Pi, James A. Johnson, Soong-Hoon Kim, Heather Finlay, John Lloyd, Joelle M. Onorato, Gregory A. Locke, George O. Tora, Ruth R. Wexler, Todd Kirshgessner, Lynn M. Abell, Xiaohong Yin, Hao Lu, Richard Yang, Sarah C. Traeger, Monique Phillips, Kamelia Behnia, Carol S. Ryan
المصدر: Journal of medicinal chemistry. 63(4)
مصطلحات موضوعية: Endothelial lipase, Male, Oxadiazoles, Molecular Structure, Chemistry, Cholesterol, Transgene, Reverse cholesterol transport, Cholesterol, HDL, Lipase, Pharmacology, Ketones, Small molecule, Mice, Inbred C57BL, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Molecular Medicine, Animals, lipids (amino acids, peptides, and proteins), Efflux, Enzyme Inhibitors, Lipoprotein
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المؤلفون: Ji Jiang, James Neels, David A. Gordon, Ruth R. Wexler, Alice Ye A. Chen, Michael Basso, Jon J. Hangeland, Leonard P. Adam, Heather Finlay, Paul G. Sleph, Lynn M. Abell, Richard Yang, Thomas Harrity, R. Michael Lawrence, David S. Taylor, Lauren Haque, Christine Huang, Xiaohong Yin, Todd J. Friends, Joelle M. Onorato
المصدر: ACS Medicinal Chemistry Letters. 9:673-678
مصطلحات موضوعية: 0301 basic medicine, Endothelial lipase, Lipoprotein lipase, Chemistry, Organic Chemistry, Substrate (chemistry), Plasma protein binding, 030204 cardiovascular system & hematology, Biochemistry, Molecular biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Drug Discovery, Lipase inhibitors, Hepatic lipase, IC50
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