المؤلفون: Ogo Egbuna, Brandon Zimmerman, George Manos, Anne Fortier, Madalina C. Chirieac, Leslie A. Dakin, David J. Friedman, Kate Bramham, Kirk Campbell, Bertrand Knebelmann, Laura Barisoni, Ronald J. Falk, Debbie S. Gipson, Michael S. Lipkowitz, Akinlolu Ojo, Mark E. Bunnage, Martin R. Pollak, David Altshuler, Glenn M. Chertow

المصدر: New England Journal of Medicine. 388:969-979

مصطلحات موضوعية: General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::647a308969978ba8f826907be1073246
https://doi.org/10.1056/nejmoa2202396

المؤلفون: Amy Brault, Leslie Anthony Dakin, Fabien Vincent, Reto Horst, James F. Smith, John I. Trujillo, Darren Dumlao, Laura J. Byrnes, Daniel C. Schmitt, Suman Shanker, Justin Hall, Ann Aulabaugh, Jimson Wong, Matt Griffor, Hong Wang, Erik C. Ralph

المصدر: Protein Science. 26:2367-2380

مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Innate immune system, Cyclic GMP-AMP synthase, ATP synthase, Biology, Biochemistry, Small molecule, 03 medical and health sciences, A-site, 030104 developmental biology, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, Second messenger system, biology.protein, Transferase, Nucleotide, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e36cd1b5d0dd1efa348020467a71b031
https://doi.org/10.1002/pro.3304

المؤلفون: Lih-Ling Lin, Guoxing Wang, Joseph P. Gardner, Hong Wang, Suman Shanker, Eicke Latz, Jeffrey S. Culp, Bruce Allen Lefker, Frank Lovering, Daniel C. Schmitt, Dana Castro, Ann Aulabaugh, Ryan Nistler, Timothy A. Subashi, Jimson Wong, Ken Dower, Steven J. Hawrylik, Olga Plotnikova, Karen L. Leach, Wen Lin, Fabien Vincent, James F. Smith, Amy Brault, Darren Dumlao, David Hepworth, Justin Hall, Mark Horn, Shawn Weng, Jing Li, Nootaree Niljanskul, William B. Snyder, Edyta Tyminski, Douglas T. Golenbock, David W. Lin, Leslie Anthony Dakin, Dikran Aivazian, Lyn H. Jones, John I. Trujillo, Ming Chen, Betsy Pierce, Peter Jones

المصدر: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184843 (2017)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, GTP', Cell Lines, Druggability, lcsh:Medicine, Plasma protein binding, Biochemistry, Mass Spectrometry, 0302 clinical medicine, Spectrum Analysis Techniques, Drug Discovery, Enzyme-Linked Immunoassays, Enzyme Inhibitors, lcsh:Science, Genetic Interference, Multidisciplinary, ATP synthase, biology, Molecular Structure, Chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Nucleotidyltransferases, Enzymes, Bioassays and Physiological Analysis, Spectrophotometry, 030220 oncology & carcinogenesis, Second messenger system, Biological Cultures, Nucleotides, Cyclic, Research Article, Protein Binding, High-throughput screening, Fluorescence Polarization, Enzyme-Linked Immunosorbent Assay, Research and Analysis Methods, Antibodies, 03 medical and health sciences, Genetics, Humans, Immunoassays, Molecular Biology Techniques, Molecular Biology, Enzyme Assays, Molecular Biology Assays and Analysis Techniques, Hybridomas, Fluorimetry, lcsh:R, Biology and Life Sciences, Proteins, Molecular biology, High Throughput Screening, 030104 developmental biology, Pyrimidines, Phosphodiester bond, biology.protein, Immunologic Techniques, Enzymology, Pyrazoles, lcsh:Q, Biochemical Analysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b467aadfb55b2af9efbce775d0740c57
http://europepmc.org/articles/PMC5608272

المؤلفون: Li Xing, Jane M. Withka, Guoyun Bai, Mark E. Bunnage, Bruce Allen Lefker, Leslie Anthony Dakin, Sheng Tan, Shenping Liu, Mary Ellen Banker, Parag Sahasrabudhe, Ariamala Gopalsamy, Atli Thorarensen, Hua Xu, Jennifer A. Young, Joerg Bussenius, Boris A. Chrunyk, Jinshan M. Chen, Kieran F. Geoghegan, Stephen W. Wright, Suman Shanker, Jeremy T. Starr, Paul Balbo, Xiayang Qiu, Zuojun Guo, Wei Li, Lyn H. Jones, Fabien Vincent, Lise R. Hoth

المصدر: Scientific Reports

مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, Macrocyclic Compounds, Plasma protein binding, Molecular Dynamics Simulation, Pharmacology, Peptides, Cyclic, Article, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, Immune system, Humans, Structure–activity relationship, Binding site, Receptor, Cells, Cultured, Peptide ligand, Binding Sites, Multidisciplinary, biology, Interleukin-17, 030104 developmental biology, Drug Design, biology.protein, Interleukin 17, Antibody, Algorithms, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d84fd35679a6248c177be87226d5378

المؤلفون: Yongyun Wang, Yingjie Li, James E. Audia, F. Anthony Romero, Zhongguo Chen, Alexander M. Taylor, Robert J. Sims, Nico Cantone, Wenfeng Liu, Eneida Pardo, Alexandre Côté, Richard Pastor, Michael C. Hewitt, Steven Magnuson, Jeremy Murray, Steve Bellon, Richard T. Cummings, Jian Wang, Brian K. Albrecht, Hariharan Jayaram, Maureen Beresini, Leslie A. Dakin, Susan Kaufman, Henry Lu, Terry Crawford, Laura Zawadzke, Vickie Tsui, Xiaoqin Zhu, Gladys de Leon Boenig, Xiaoyu Zhu, Christopher G. Nasveschuk, Fen Yan, Yves Leblanc, Jiangpeng Liao, Andrew R. Conery, Zhaowu Xu, E. Megan Flynn, James R. Kiefer, Andrea G. Cochran, Dong Yu, Oscar W. Huang, Jeremy W. Setser, Tommy Lai, Patricia J. Keller

المصدر: ACS medicinal chemistry letters. 7(5)

مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, Chemistry, Organic Chemistry, Cell, Cellular pathways, Target engagement, Computational biology, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, Bromodomain, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Transcription (biology), Drug Discovery, medicine, Cancer research, EP300

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20779145f328a160a3abf779659b7000
https://pubmed.ncbi.nlm.nih.gov/27190605