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1دورية أكاديمية
المؤلفون: Lester J Lambert, Stefan Grotegut, Maria Celeridad, Palak Gosalia, Laurent JS De Backer, Andrey A Bobkov, Sumeet Salaniwal, Thomas DY Chung, Fu-Yue Zeng, Ian Pass, Paul J Lombroso, Nicholas DP Cosford, Lutz Tautz
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 9, p 4417 (2021)
مصطلحات موضوعية: protein tyrosine phosphatase, PTPN5, small-molecule screening, neurodegenerative disorders, Alzheimer’s disease, Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Lester J. Lambert, author1, Celeste Romero, author1, Douglas J. Sheffler, author1, Maria Celeridad, author1, Nicholas D. P. Cosford, author1, Lutz Tautz, author1
المصدر: Journal of Visualized Experiments. (161)
الإتاحة: http://www.jove.com/video/61457
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المؤلفون: Dhanya Raveendra-Panickar, Darren Finlay, Fabiana Izidro Layng, Lester J. Lambert, Maria Celeridad, Ming Zhao, Karina Barbosa, Laurent J.S. De Backer, Elizabeth Kwong, Palak Gosalia, Socorro Rodiles, John Holleran, Robert Ardecky, Stefan Grotegut, Steven Olson, John H. Hutchinson, Elena B. Pasquale, Kristiina Vuori, Aniruddha J. Deshpande, Nicholas D.P. Cosford, Lutz Tautz
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: PTS, protein thermal shift, Carcinogenesis, Protein Tyrosine Phosphatase, Non-Receptor Type 11, PTPN11, DMF, N,N-dimethylformamide, DMSO, dimethyl sulfoxide, protein tyrosine phosphatase, ERK, extracellular signal–regulated kinase, Biochemistry, AML, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, EtOAc, ethyl acetate, TBS-T, Tris-buffered saline–Tween-20, anticancer drug, Enzyme Inhibitors, AML, acute myeloid leukemia, STEP, striatal-enriched tyrosine phosphatase, AIC, Akaike's Information Criterion, ESI, electrospray ionization, SH2, Src-homology 2, leukemia, IRS-1, insulin receptor substrate 1, SHP2cat, SHP2 catalytic domain, inhibitor, Leukemia, Myeloid, Acute, Benzamides, RT, room temperature, RTK, receptor tyrosine kinase, PTP, protein tyrosine phosphatase, THF, tetrahydrofuran, Research Article, N-SH2, N-terminal SH2 domain, FGFR, fibroblast growth factor receptor, sgRNA, single-guide RNA, OMFP, 3-O-methylfluorescein phosphate, small molecule, chemical biology, TNBC, triple-negative breast cancer, breast cancer, FBS, fetal bovine serum, SAR, structure–activity relationship, SHP2, Src-homology 2 domain–containing phosphatase 2, Humans, EDC, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, Molecular Biology, RFU, relative fluorescence unit, pTyr, phosphotyrosine, SHP2-WT, full-length SHP2 WT, Cell Biology, Oncogenes, AICc, second-order corrected Akaike’s Information Criterion, SHP2, DIEA, N,N-diisopropylethylamine, p-ERK1/2, phospho-ERK1/2, HOBt, hydroxybenzotriazole
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29990762ad8fbd140f872fdc58a3cd6
http://europepmc.org/articles/PMC8760490 -
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المؤلفون: Allison S. Limpert, Lena M. Berger, Stefan Knapp, Lester J. Lambert, Nicholas D. P. Cosford, Fabiana I.A.L. Layng, Apirat Chaikuad, Cunxiang Yuan, Jing Dong, Li Wang, Maria Celeridad, Yi Peng, Douglas J. Sheffler, Nicole Bata, Guoxiong Liu, Nicole A Bakas
المصدر: J Med Chem
مصطلحات موضوعية: MST1, Hippo signaling pathway, Gene knockdown, Kinase, Chemistry, Cell growth, Intracellular Signaling Peptides and Proteins, Myeloid leukemia, Protein Serine-Threonine Kinases, Serine-Threonine Kinase 3, In vitro, Article, Serine, Mice, Inbred C57BL, Leukemia, Myeloid, Acute, Mice, Drug Discovery, Cancer research, Molecular Medicine, Animals, Humans, Female, Hippo Signaling Pathway, Protein Kinase Inhibitors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc05bd607eb905af295851148fa0764
https://europepmc.org/articles/PMC10149138/ -
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المؤلفون: Sumeet Salaniwal, Nicholas D. P. Cosford, Maria Celeridad, Andrey A. Bobkov, Paul J. Lombroso, Palak Gosalia, Fu Yue Zeng, Stefan Grotegut, Ian Pass, Laurent J.S. De Backer, Lutz Tautz, Thomas D.Y. Chung, Lester J. Lambert
المصدر: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4417, p 4417 (2021)مصطلحات موضوعية: QH301-705.5, High-throughput screening, PTPN5, Computational biology, Disease, Protein tyrosine phosphatase, protein tyrosine phosphatase, Article, Catalysis, Inorganic Chemistry, Drug Discovery, Protein-Tyrosine Kinases, Humans, Biology (General), Enzyme Inhibitors, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Spectroscopy, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, General Medicine, Protein Tyrosine Phosphatases, Non-Receptor, High-Throughput Screening Assays, Computer Science Applications, Synaptic function, neurodegenerative disorders, small-molecule screening, Tyrosine kinase, Alzheimer’s disease
وصف الملف: application/pdf
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المؤلفون: Nicole A Bakas, Lester J. Lambert, Nicholas D. P. Cosford, Mitchell Vamos, Huiyu Ren, Apirat Chaikuad, Reuben J. Shaw, Carina Wimer, Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Sonja N. Brun, Allison S. Limpert, Stefan Knapp
المصدر: J Med Chem
مصطلحات موضوعية: Cell Survival, Poly ADP ribose polymerase, Antineoplastic Agents, Apoptosis, Triple Negative Breast Neoplasms, Poly(ADP-ribose) Polymerase Inhibitors, Protein Serine-Threonine Kinases, Article, Piperazines, Olaparib, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Autophagy, Animals, Autophagy-Related Protein-1 Homolog, Humans, Protein Kinase Inhibitors, Triple-negative breast cancer, Cell Proliferation, Kinase, HEK 293 cells, Intracellular Signaling Peptides and Proteins, Drug Synergism, Mice, Inbred C57BL, HEK293 Cells, Pyrimidines, chemistry, Cell culture, PARP inhibitor, Cancer research, Molecular Medicine, Phthalazines, Female, Drug Screening Assays, Antitumor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4b2f1d43e7a3f43e170153e08bf32
https://europepmc.org/articles/PMC8064294/ -
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المؤلفون: Maria Celeridad, Douglas J. Sheffler, Lutz Tautz, Nicholas D. P. Cosford, Lester J. Lambert, Celeste Romero
المصدر: J Vis Exp
مصطلحات موضوعية: MAPK/ERK pathway, Cell signaling, biology, General Immunology and Microbiology, Drug discovery, T cell, General Chemical Engineering, General Neuroscience, Phosphatase, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Protein tyrosine phosphatase, Proto-Oncogene Mas, Article, Receptor tyrosine kinase, General Biochemistry, Genetics and Molecular Biology, medicine.anatomical_structure, Cancer research, biology.protein, medicine, Humans, Enzyme Inhibitors, Receptor, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8c9d5b1f6426e09045cc8543883b51
https://doi.org/10.3791/61457-v -
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المؤلفون: Eduard Sergienko, Lester J. Lambert, Celeste Romero, Socorro Rodiles, Laurent J.S. De Backer, Douglas J. Sheffler, Elena B. Pasquale, Lutz Tautz, Stefan Grotegut, Nicholas D. P. Cosford, Dhanya Raveendra-Panickar, John Holleran, Maria Celeridad
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cell signaling, Carcinogenesis, Allosteric regulation, Regulator, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Biochemistry, Proto-Oncogene Mas, Cell Line, 03 medical and health sciences, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, 030102 biochemistry & molecular biology, Drug discovery, Chemistry, Methods and Resources, Cell Biology, Immune checkpoint, 030104 developmental biology, Gain of Function Mutation, Cancer research, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729cacf596068112252fee6982355924
https://pubmed.ncbi.nlm.nih.gov/31953320 -
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المؤلفون: Allison S. Limpert, Malene Hansen, Nicole Bata, Apirat Chaikuad, Lester J. Lambert, Nicholas D. P. Cosford, Stefan Knapp
المصدر: Molecular Cancer Research. 18:B05-B05
مصطلحات موضوعية: Cancer Research, Hippo signaling pathway, MST1, Chemistry, Cell growth, Kinase, Autophagy, Cancer, Context (language use), medicine.disease, Oncology, Cancer research, medicine, Molecular Biology, Transcription factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ce3f63a44728be0caeffbe05076e7fc7
https://doi.org/10.1158/1557-3125.hippo19-b05 -
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المؤلفون: Tanja Mittag, Lester J. Lambert, James A. DeCaprio, Brenda A. Schulman, Jennifer L. Olszewski, Adriana E. Tron, David M. Duda, Michal Hammel, M. Brett Waddell
المصدر: Molecular Cell. 47(3):371-382
مصطلحات موضوعية: 0303 health sciences, biology, Cullin Proteins, Ubiquitin-Protein Ligases, Plasma protein binding, Cell Biology, Ubiquitin-conjugating enzyme, Ubiquitin ligase, Cell biology, 03 medical and health sciences, 0302 clinical medicine, biology.protein, CUL1, Protein folding, Binding site, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology