-
1
المؤلفون: Nicolas Solban, Alexander Pasternak, Qinglin Pu, Amy C. Doty, David Jonathan Bennett, Charles A. Lesburg, Wensheng Yu, Prasanthi Geda, Nunzio Sciammetta, J. Richard Miller, Hua Zhou, Xuelei Song, Yongxin Han, Lars Neumann, David L. Sloman, Mangeng Cheng, Heidi Ferguson, Karin M. Otte, Liangqin Guo, Hongjun Zhang, Alfred Lammens, Xavier Fradera, Meredeth A. McGowan
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Pentane, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Amide, Drug Discovery, Moiety, Potency, Bioisostere, Indoleamine 2,3-dioxygenase, Benzamide
-
2
المؤلفون: Harold B. Wood, Kunal Desai, Daming Feng, Jamie McCabe-Dunn, Yi-Heng Chen, Edward C. Sherer, Jane Y. Wu, Marc Poirier, Hong Li, Dongfang Meng, Ting Zhang, Kenneth P. Ellsworth, Liangqin Guo, Teruyuki Nishimura, Jiayi Xu, Tomokazu Hirabayashi, Sunita V. Dewnani, Patrick Andre, Louis-Charles Campeau, Richard Tschirret-Guth, Isao Sakurada, Paul Reichert, Cameron J. Smith, Robert K. Orr, Lisa M. Sonatore, Wayne M. Geissler, Thomas Bateman, Kazuto Araki, Joe Metzger, Alan Hruza, Richard A. Berger, Dann L. Parker, Tianying Jian
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:5437-5443
مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, High selectivity, Administration, Oral, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Thrombin generation, Factor IXa, Pharmacokinetics, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Molecular Biology, media_common, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Rats, Enzyme Activation, Human plasma, Drug Design, Pharmacodynamics, Molecular Medicine, Coagulation factor IXa, Heterocyclic Compounds, 3-Ring, Tricyclic
-
3دورية أكاديمية
المؤلفون: Qinglin Pu, Hongjun Zhang, Liangqin Guo, Mangeng Cheng, Doty, Amy C., Ferguson, Heidi, Fradera, Xavier, Lesburg, Charles A., McGowan, Meredeth A., Miller, J. Richard, Geda, Prasanthi, Xuelei Song, Otte, Karin, Nunzio Sciammetta, Solban, Nicolas, Wensheng Yu, Sloman, David L., Hua Zhou, Lammens, Alfred, Neumann, Lars
المصدر: ACS Medicinal Chemistry Letters; 8/13/2020, Vol. 11 Issue 8, p1548-1554, 7p
-
4
المؤلفون: Donald Nelson, Gary G. Chicchi, James Dellureficio, Ravi P. Nargund, Peter H. Dobbelaar, Liangqin Guo, Kwei-Lan Tsao, Janet S. Kerr, Bei Zhang, Zhong Lai, Patricia R. Bunting, Shrenik K. Shah, Raman K. Bakshi, Qingmei Hong, Hongbo Qi, Guillermo Fernandez, Mikhail Reibarkh, Qing Shao, Quang Truong, Koppara Samuel, Jian Liu, Sylvia Volksdorf, Zhixiong Ye, Yun-Ping Zhou, Margaret Wu, Cai Li, Stan Mitelman, Andrew D. Howard, Wu Du, Maria E. Trujillo, George J. Eiermann, Shuwen He, Vijay Bhasker G. Reddy, Tianying Jian, Pierre Morissette, Patrick Fitzgerald, Dorina Trusca, Sharon Tong, William K. Hagmann
المصدر: ACS Medicinal Chemistry Letters. 5:748-753
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, hERG, Antagonist, In vitro toxicology, Type 2 diabetes, Pharmacology, medicine.disease, Biochemistry, QT interval, Somatostatin, Drug Discovery, biology.protein, Medicine, cardiovascular diseases, Receptor, business, Antagonism
-
5
المؤلفون: John S. Debenham, Dann L. Parker, Birgit T. Priest, Ravi P. Nargund, Feroze Ujjainwalla, Randal M. Bugianesi, Michele Pachanski, Liangqin Guo, William K. Hagmann, George J. Eiermann, Yi Zang, Ramzi F. Sweis, Andrew D. Howard, Jenna L. Terebetski, Melissa Kirkland, Yue Feng, Gino Salituro, Derun Li, Christopher Joseph Sinz, Stan Mitelman, Maria E. Trujillo, Scott D. Edmondson, Karen H. Dingley, Jin Shang, Nicole Buist, Xiaofang Li, Weiguo Liu, Mary Ann Powles, Terri M. Kelly, Edward C. Sherer
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Organic Chemistry, Triazole, Type 2 Diabetes Mellitus, Glucose excursion, Type 2 diabetes, Metabolic stability, medicine.disease, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, chemistry, Internal medicine, Drug Discovery, medicine, Deficient mouse, Potency, Lead compound
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05666abdc0e69d7961b4edf099a12f0b
https://europepmc.org/articles/PMC5150677/ -
6
المؤلفون: Janet Kerr, Gary G. Chicchi, Margaret Wu, Cai Li, Shuwen He, Vijay Bhasker G. Reddy, Sharon Tong, William K. Hagmann, Patrick Fitzgerald, Guillermo Fernandez, Andrew D. Howard, Tianying Jian, Zhe Feng, Raman K. Bakshi, Dorina Trusca, Peter H. Dobbelaar, Donald Nelson, Mikhail Reibarkh, Qing Shao, Liangqin Guo, Yun-Ping Zhou, Ravi P. Nargund, Kwei-Lan Tsao, Edward C. Sherer, Stan Mitelman, Pierre Morissette, Maria E. Trujillo, Quang Truong, Zhixiong Ye, James D. Dellureficio, Hongbo Qi, Melissa Lin, Shrenik K. Shah, Sylvia Volksdorf, Jian Liu, Qingmei Hong, Koppara Samuel, Alexander Pasternak, George J. Eiermann, Patricia B. Bunting, Wu Du, Bei B. Zhang
المصدر: Bioorganicmedicinal chemistry letters. 26(6)
مصطلحات موضوعية: QTC PROLONGATION, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Biochemistry, hERG, Pharmaceutical Science, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Humans, cardiovascular diseases, Receptors, Somatostatin, Molecular Biology, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, 0104 chemical sciences, Rats, biology.protein, Molecular Medicine, Antagonism, Carbolines
-
7
المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin
-
8
المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405
مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine
-
9
المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110
مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding
-
10
المؤلفون: Heather L. Sings, Mark T. Goulet, Matthew J. Wyvratt, Iyassu K. Sebhat, Liangqin Guo, Rui Tang, Ravi P. Nargund, Qianping Peng, Euan Macintyre, Feroze Ujjainwalla, Constantin Tamvakopoulos, Zhixiong Ye, Lex H.T. Van der Ploeg, David H. Weinberg, Tanya MacNeil, John Huber
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3242-3247
مصطلحات موضوعية: Agonist, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Chemical synthesis, Pyrrolidine, Structure-Activity Relationship, chemistry.chemical_compound, Melanocortin receptor, Drug Discovery, medicine, Humans, Structure–activity relationship, Receptor, Telomerase, Molecular Biology, G protein-coupled receptor, Molecular Structure, digestive, oral, and skin physiology, Organic Chemistry, Stereoisomerism, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin