المؤلفون: Nuria A. Tamayo, Matthew P. Bourbeau, Jennifer R. Allen, Kate S. Ashton, Jian Jeffrey Chen, Matthew R. Kaller, Thomas T. Nguyen, Nobuko Nishimura, Liping H. Pettus, Mary Walton, Brian Belmontes, Jodi Moriguchi, Kui Chen, John D. McCarter, Kelly Hanestad, Grace Chung, Maria Stefania S. Ninniri, Jan Sun, Leszek Poppe, Chris Spahr, John Hui, Lei Jia, Tian Wu, Upendra P. Dahal, Katheryne Z. Edson, Marc Payton

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: Cell Death, Tubulin, Neoplasms, Drug Discovery, Molecular Medicine, Humans, Kinesins, Mitosis, Spindle Apparatus

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b073c07dd2504a104516bc02d88ed4
https://pubmed.ncbi.nlm.nih.gov/35286090

المؤلفون: Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker, Jude Canon, Victor J. Cee, Frank Chavez, Yuping Chen, Heather Eastwood, Nadia Guerrero, Brad Herberich, Dean Hickman, Brian A. Lanman, Jimmy Laszlo, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, Liping H. Pettus, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Qiong Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker

المصدر: Journal of Medicinal Chemistry. 62:1523-1540

مصطلحات موضوعية: Molecular Structure, Swine, Antineoplastic Agents, Mice, SCID, Xenograft Model Antitumor Assays, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Hematologic Neoplasms, Drug Discovery, Animals, Humans, Molecular Medicine, Female, Pyrroles, Protein Kinase Inhibitors, Quinazolinones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3743f2a152bf3d38a985da1601967443
https://doi.org/10.1021/acs.jmedchem.8b01733

المؤلفون: Paul H. Wen, Stephen J. Wood, Qingyian Liu, Aaron C. Siegmund, Liping H. Pettus, Adrian Nanez, Matthew P. Bourbeau, Jennifer R. Allen, Michael D. Bartberger, Douglas A. Whittington, Jodi Bradley, James R. Manning, Kui Chen, Dean Hickman, Michael E. Johnson

المصدر: Journal of medicinal chemistry. 63(5)

مصطلحات موضوعية: Cyclopropanes, Male, Models, Molecular, Thiazines, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, In vivo, Alzheimer Disease, mental disorders, Drug Discovery, Amyloid precursor protein, medicine, Animals, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, IC50, 030304 developmental biology, Hypopigmentation, Melanosome, chemistry.chemical_classification, 0303 health sciences, Amyloid beta-Peptides, biology, Chemistry, Brain, Peptide Fragments, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Pharmacodynamics, biology.protein, Molecular Medicine, medicine.symptom, Amyloid Precursor Protein Secretases, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b282d5cda06e6b837c524c6d7c41050d
https://pubmed.ncbi.nlm.nih.gov/31589043

المؤلفون: Heather Eastwood, Andrew Tasker, Yuping Chen, David Powers, Nadia Guerrero, Christopher Mohr, Anthony B. Reed, Jimmy Laszlo, Paul Wang, Yihong Zhou, Ryan Wurz, Mark H. Norman, Karen Rex, Jeffrey T. Winston, Liping H. Pettus, Dean Hickman, Yang Xu, Brian A. Lanman, Tian Wu, Yen Nguyen, Kristin L. Andrews, J. Russell Lipford, Frank Chavez, Hui-Ling Wang, Christine Sastri, Matthew R. Lee, Bethany Mattson, Nuria A. Tamayo, Victor J. Cee, Jie Chen, Bradley J. Herberich, Bin Wu, Shon Booker

المصدر: Journal of Medicinal Chemistry. 59:6407-6430

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell, Administration, Oral, Antineoplastic Agents, Pharmacology, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Murine leukemia virus, medicine, Animals, Humans, Pyrroles, Kinase activity, Protein Kinase Inhibitors, Cell Proliferation, Quinazolinones, Dose-Response Relationship, Drug, Molecular Structure, biology, Cell growth, Chemistry, Drug discovery, Kinase, Neoplasms, Experimental, biology.organism_classification, Xenograft Model Antitumor Assays, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f85b2099ac31a14dc5abf0c6c20c999
https://doi.org/10.1021/acs.jmedchem.6b00610

المؤلفون: Kristin L. Andrews, J. Russell Lipford, Christine Sastri, Victor J. Cee, Jeff Winston, Andrew Tasker, Liping H. Pettus, Ryan Wurz, Christopher Mohr, Matthew R. Lee, Brian A. Lanman, Bin Wu, Nadia Guerrero, Thomas Nixey, Anthony B. Reed, Hui-Ling Wang

المصدر: Bioorganic & Medicinal Chemistry Letters. 25:775-780

مصطلحات موضوعية: Models, Molecular, Gene isoform, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Potency, Structure–activity relationship, Amines, Protein Kinase Inhibitors, Molecular Biology, Drug discovery, Chemistry, Kinase, Organic Chemistry, Pim kinases, Molecular Medicine, Carcinogenesis, Carbolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4102f5f33a7997eb18aa2e1429e22aa2
https://doi.org/10.1016/j.bmcl.2014.12.091

المؤلفون: Andrew Tasker, Andreas Reichelt, Yi-Ling Hu, Deanna Mohn, John McCarter, Ben Fisher, Robert M. Rzasa, Yi Chen, Julio C. Medina, Gang Yu, Sharon Wannberg, Brian Lucas, Ron C. Kelly, Jennifer Seganish, Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Kristin L. Andrews, Douglas A. Whittington, Matthew Frank Brown, Dawei Zhang, Youngsook Shin, Mario G. Cardozo, Jason Duquette, Robert C. Wahl, Leeanne Zalameda, Daniela Metz, Vatee Pattaropong, Michael G. Johnson, Tisha San Miguel, Randall W. Hungate, John Whoriskey, Lawrence R. McGee, Timothy D. Cushing, Kirk Henne, Liping H. Pettus, Xiao He

المصدر: Journal of Medicinal Chemistry. 58:480-511

مصطلحات موضوعية: Models, Molecular, Adenosine, Class I Phosphatidylinositol 3-Kinases, Stereochemistry, Mice, Transgenic, Pharmacology, Crystallography, X-Ray, Autoimmune Diseases, Structure-Activity Relationship, In vivo, Drug Discovery, Sf9 Cells, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, IC50, Cells, Cultured, Whole blood, Inflammation, Autoimmune disease, Mice, Inbred BALB C, Molecular Structure, Drug discovery, Kinase, Chemistry, medicine.disease, Protein Structure, Tertiary, Disease Models, Animal, Models, Chemical, Rats, Inbred Lew, Quinolines, Molecular Medicine, Female, Amine gas treating, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f464b8458b3d559ce036ed30580e01
https://doi.org/10.1021/jm501624r

المؤلفون: Fang-Tsao Hong, Jian Jiang, Brian A. Lanman, Victor J. Cee, Liping H. Pettus, Paul E. Hughes, Nancy Zhang, Douglas A. Whittington, Tisha San Miguel, Anthony B. Reed, Ling Wang, Erin L. Mullady, Kristin L. Andrews, John D. McCarter, Andrew Tasker, Leeanne Zalameda, Mark H. Norman, Tian Wu, Ryan Wurz, Raju Subramanian

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:5630-5634

مصطلحات موضوعية: Male, Pyridines, Clinical Biochemistry, Molecular Conformation, Mice, Nude, Pharmaceutical Science, Alcohol, Biochemistry, Piperazines, Rats, Sprague-Dawley, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Piperazine, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Sulfonamides, Phosphoinositide 3-kinase, biology, Triazines, TOR Serine-Threonine Kinases, Organic Chemistry, In vitro, Rats, Sulfonamide, Liver, chemistry, Alcohols, biology.protein, Molecular Medicine, Phosphorylation, Female, Hepatocyte growth factor, Proto-Oncogene Proteins c-akt, Half-Life, Protein Binding, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac5698d5fbf21b4947041fb8e3a9326
https://doi.org/10.1016/j.bmcl.2014.10.085

المؤلفون: Yunxin Bo, Tisha San Miguel, Nobuko Nishimura, Jian Jiang, Douglas A. Whittington, Paul E. Hughes, Sean Caenepeel, Mark H. Norman, John D. McCarter, Erin L. Mullady, Daniel J. Freeman, Kevin Yang, Ryan Wurz, Longbin Liu, Raju Subramanian, Kristin L. Andrews, Ling Wang, Liping H. Pettus, Nancy Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5714-5720

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Binding Sites, Phosphoinositide 3-kinase, biology, Triazines, Akt/PKB signaling pathway, Chemistry, TOR Serine-Threonine Kinases, Cellular Assay, Organic Chemistry, Rats, Molecular Docking Simulation, biology.protein, Molecular Medicine, Female, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62866028e9510797810acdca23680ada
https://doi.org/10.1016/j.bmcl.2012.06.078

المؤلفون: Bradley J. Herberich, Tian Wu, Paul E. Hughes, Claire L. M. Jackson, Nobuko Nishimura, Nancy Zhang, Ryan Wurz, Douglas A. Whittington, Shon Booker, Sean Caenepeel, Tisha San Miguel, Jian Jiang, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Brian A. Lanman, Andrew Tasker, Erin L. Mullady, John D. McCarter, Fang-Tsao Hong, Liping H. Pettus, Divesh Aidasani, Victor J. Cee, Ling Wang, Bin Wu, Mark H. Norman, Daniel J. Freeman, Kevin Yang, Longbin Liu, Leeanne Zalameda, Yunxin Y. Bo, Xiaochun Zhu, Kristin L. Andrews, Markian Stec, Nuria A. Tamayo, Raju Subramanian, Noel D'angelo

المصدر: Journal of Medicinal Chemistry. 55:7796-7816

مصطلحات موضوعية: Models, Molecular, Phosphoinositide 3-kinase, biology, Triazines, Chemistry, Cell growth, Pharmacology, Crystallography, X-Ray, medicine.disease, chemistry.chemical_compound, In vivo, Glioma, Drug Discovery, Second messenger system, medicine, biology.protein, Molecular Medicine, Phosphorylation, Phosphatidylinositol, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7379e5002efb24d810fb0e1f33a3641
https://doi.org/10.1021/jm300846z

المؤلفون: Yunxin Y. Bo, Leeanne Zalameda, Kevin Yang, Fang-Tsao Hong, Longbin Liu, Anthony B. Reed, Kristin L. Andrews, Tisha San Miguel, Brian A. Lanman, Paul E. Hughes, Noel D'angelo, Brad Herberich, Jian Jiang, Victor J. Cee, Claire L. M. Jackson, Ryan Wurz, Nobuko Nishimura, Raju Subramanian, Seifu Tadesse, Nancy Zhang, John D. McCarter, Daniel J. Freeman, Ling Wang, Nuria A. Tamayo, Erin L. Mullady, Mark H. Norman, Liping H. Pettus, Tian Wu, Douglas A. Whittington, Sean Caenepeel, Adrian L. Smith, Shon Booker

المصدر: Journal of Medicinal Chemistry. 55:5188-5219

مصطلحات موضوعية: Models, Molecular, Indazoles, Class I Phosphatidylinositol 3-Kinases, Pyridines, Biological Availability, Mice, Nude, Crystallography, X-Ray, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Sulfones, Phosphatidylinositol, PI3K/AKT/mTOR pathway, Sulfonamides, Triazines, Akt/PKB signaling pathway, Chemistry, Kinase, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, Rats, Cell biology, Pyrimidines, Biochemistry, Purines, Drug Design, Microsomes, Liver, Pyrazoles, Molecular Medicine, Female, Signal transduction, Proto-Oncogene Proteins c-akt, Signal Transduction, Phosphoinositide-dependent kinase-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e14c947647f0ff5c20164ffa4566dd
https://doi.org/10.1021/jm300184s