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المؤلفون: Xiaoxia Song, Feng Ren, Qian Liu, Yafei Huang, Wei Cai, Zhijun Xiang, Jia-Ning Xiang, Tang Ting, Qianqian Wu, Yingli Ma, Xichen Lin, Mercedes Lobera, Guifeng Zhang, Ling Zhou, Liming Shao, Ting Yang, Stewart Leung, Liuqing Yang, Wang Yonghui, Lisa A. Orband-Miller
المصدر: ACS Medicinal Chemistry Letters. 9:120-124
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Agonist, Stereochemistry, medicine.drug_class, Organic Chemistry, Peptide, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, RAR-related orphan receptor gamma, Amide, Drug Discovery, Coactivator, medicine, Moiety, Inverse agonist, Corepressor
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2
المؤلفون: Young Do, Lisa A. Orband-Miller, Anthony Shillings, Joelle Le, Caterina Musetti, Gordon Saxty, Beth Pietrak, Simon Teanby Hodgson, Petrov Kimberly, Daniel J. Price, Stephen A. Thomson, Eugene L. Stewart, Christie Schulte, Ashley Paul Hancock, Terrence L. Smalley, Michael R. Jeune, H. Fritz Kramer, Chuck Poole, Heather Hobbs, Kirsten M. Kahler, J. Darren Stuart, Paul N. Mortenson, Robert T. Nolte, Jason A. Holt, David N. Deaton, Don O. Somers, Elsie Diaz, Jeffrey Guss, Robert T. Gampe, Peckham Gregory
المصدر: Bioorganic & Medicinal Chemistry Letters. 47:128113
مصطلحات موضوعية: Imidazopyridine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Virtual screen, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Class (computer programming), Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Intramolecular Oxidoreductases, 010404 medicinal & biomolecular chemistry, Orally active, chemistry, Molecular Medicine
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المؤلفون: Chuck Poole, Alan R. Rendina, Andrew L. Larkin, Heather Hobbs, Helen F. Sneddon, Lee T. Schaller, Gordon Saxty, Jonathan P. Hutchinson, David N. Deaton, Jeffrey Guss, Young Do, Tianshun Xu, Karen Affleck, Simon Teanby Hodgson, Stephen A. Thomson, H. Fritz Kramer, Caterina Musetti, Peckham Gregory, Ian Edward David Smith, Melanie Leveridge, Harry Nicholls, Jason A. Holt, Don O. Somers, Ying Shen, J. Darren Stuart, Sorif Uddin, Anne Cleasby, Paul N. Mortenson, Caroline Richardson, Daniel J. Price, Lisa M. Shewchuk, Eugene L. Stewart, Michael R. Jeune, David Anders, Lisa A. Orband-Miller, Ashley Paul Hancock, Paris Ward, Joseph W. Wilson
المصدر: Bioorganicmedicinal chemistry. 27(8)
مصطلحات موضوعية: Male, Stereochemistry, Clinical Biochemistry, Fragment-based lead discovery, Pharmaceutical Science, Prostaglandin, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Pharmacokinetics, Hydrolase, Drug Discovery, Moiety, Animals, Humans, Enzyme Inhibitors, Molecular Biology, 010405 organic chemistry, Organic Chemistry, Quinoline, Degranulation, Lipocalins, 0104 chemical sciences, Intramolecular Oxidoreductases, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, chemistry, Quinolines, Molecular Medicine, Amine gas treating
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المؤلفون: Wei Zhang, Sijie Lu, Ling Zhou, Jia-Ning Xiang, Qian Liu, Yingli Ma, John D. Elliott, Stewart Leung, Yi Li, Liuqing Yang, Feng Ren, Kathleen Zhang, Wang Yonghui, Lisa A. Orband-Miller, Xichen Lin, Zhijun Xiang, Ziqiang Cheng, Qianqian Wu, Ting Yang
المصدر: Bioorganic & Medicinal Chemistry. 23:5293-5302
مصطلحات موضوعية: Drug Inverse Agonism, Stereochemistry, Cellular differentiation, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Partial agonist, Mice, chemistry.chemical_compound, RAR-related orphan receptor gamma, Drug Discovery, Animals, Humans, Inverse agonist, Molecular Biology, Liver microsomes, Cells, Cultured, Aryl, Organic Chemistry, Cell Differentiation, Nuclear Receptor Subfamily 1, Group F, Member 3, Amides, Combinatorial chemistry, Molecular Docking Simulation, Thiazoles, chemistry, Th17 Cells, Molecular Medicine
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المؤلفون: Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
المصدر: The Journal of Immunology. 192:2564-2575
مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Cellular differentiation, Immunology, Dermatitis, Biology, Heterocyclic Compounds, 4 or More Rings, Jurkat cells, Small Molecule Libraries, Interleukin 22, Jurkat Cells, Mice, Fluorescence Resonance Energy Transfer, Interleukin 23, Animals, Humans, Psoriasis, Immunology and Allergy, Cells, Cultured, Oligonucleotide Array Sequence Analysis, Skin, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, HEK 293 cells, Cell Differentiation, Nuclear Receptor Subfamily 1, Group F, Member 3, HEK293 Cells, Leukocytes, Mononuclear, Cancer research, Th17 Cells, Female, Interleukin 17, IL17A, Transcriptome, CD8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec65053b42fd78ff43551db09ab31607
https://doi.org/10.4049/jimmunol.1302190 -
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المؤلفون: Ling Zhou, Sijie Lu, Qianqian Wu, Yong-Gang Zhao, Zhong Zhong, Xichen Lin, Ruina Gao, Melanie Huxdorf, Shuai Wang, Wei Zhang, John D. Elliott, Ziqiang Cheng, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Zhijun Xiang, Ting Yang, Yan Xu, Jia-Ning Xiang, Stewart Leung, Wei Cai, Lisa A. Orband-Miller, Liuqing Yang, Guifeng Zhang, Jing Zhang
المصدر: Bioorganic & Medicinal Chemistry. 22:692-702
مصطلحات موضوعية: Encephalomyelitis, Autoimmune, Experimental, Ketone, Stereochemistry, Clinical Biochemistry, Retinoic acid, Administration, Oral, Pharmaceutical Science, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, RAR-related orphan receptor gamma, In vivo, Amide, Drug Discovery, Thiophene, medicine, Animals, Humans, Thiazole, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Arthritis, Organic Chemistry, Experimental autoimmune encephalomyelitis, Cell Differentiation, Nuclear Receptor Subfamily 1, Group F, Member 3, medicine.disease, Amides, Disease Models, Animal, Th17 Cells, Molecular Medicine, Collagen
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المؤلفون: Liuqing Yang, Zhijun Xiang, Zhong Zhong, Melanie Huxdorf, Stewart Leung, Xichen Lin, Ling Zhou, Yang Qiu, Ting Yang, Qianqian Wu, John D. Elliott, Wei Zhang, Jia-Ning Xiang, Wei Cai, Qian Liu, Yingli Ma, Yonghui Wang, Yaobang Cheng, Lisa A. Orband-Miller, Jing Zhang
المصدر: ACS Medicinal Chemistry Letters. 5:65-68
مصطلحات موضوعية: Indole test, Agonist, Orphan receptor, Tertiary amine, Chemistry, medicine.drug_class, Organic Chemistry, Rational design, Biochemistry, Combinatorial chemistry, RAR-related orphan receptor gamma, Drug Discovery, medicine, Inverse agonist, Linker
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المؤلفون: Timothy M. Willson, William J. Zuercher, Robert T. Nolte, Lisa A. Orband-Miller, Jon L. Collins, Aaron B. Miller, Donald P. McDonnell, Esther Y. Chao, Liping Wang, Stephanie Gaillard
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:821-824
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Estrogen receptor, Crystallography, X-Ray, Ligands, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Humans, Inverse agonist, Receptor, Molecular Biology, Binding selectivity, Orphan receptor, Binding Sites, Molecular Structure, Chemistry, Organic Chemistry, Estrogen Receptor alpha, Tamoxifen, Receptors, Estrogen, Nuclear receptor, Drug Design, Molecular Medicine, Selectivity, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Dana R Hohman, Lisa A. Orband-Miller, Susan L. Weaver, Eugene L. Stewart, Shawn P. Williams, John T. Moore, Thomas G. Consler, Paul Kenneth Spearing, Ning Go, Philip Stewart Turnbull, Millard H. Lambert, Ron L. Hale, Linda B. Moore, Stacey A. Jones, Amy T. Lu, Brad R. Henke, G. Bruce Wisely, Jean Shearin, R. Graham Robinett
المصدر: Journal of Medicinal Chemistry. 45:5492-5505
مصطلحات موضوعية: Models, Molecular, endocrine system, Transcription, Genetic, Estrogen receptor, Crystallography, X-Ray, Ligands, Partial agonist, Radioligand Assay, Structure-Activity Relationship, Genes, Reporter, Drug Discovery, Tumor Cells, Cultured, polycyclic compounds, Estrogen Receptor beta, Humans, Structure–activity relationship, Receptor, reproductive and urinary physiology, Estrogen receptor beta, Triazines, Chemistry, Ligand binding assay, Estrogen Receptor alpha, Stereoisomerism, Antiestrogen, Receptors, Estrogen, Biochemistry, Molecular Medicine, Estrogen receptor alpha, hormones, hormone substitutes, and hormone antagonists
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المؤلفون: Dennis Heyer, Lisa A. Orband-Miller, Frank Navas, David W. Gray, Shawn P. Williams, Adwoa Akwabi-Ameyaw, Jean Shearin, Jing Fang, Subba Reddy Katamreddy, Aaron B. Miller, Jonathan E. Britton
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:5075-5077
مصطلحات موضوعية: Selective Estrogen Receptor Modulators, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Ether, Naphthalenes, Ligands, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Estrogen Receptor Modulators, Drug Discovery, Combinatorial Chemistry Techniques, Estrogen Receptor beta, Humans, Structure–activity relationship, Molecular Biology, Alkyl, Estrogen receptor beta, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Estrogen Receptor alpha, Ligand (biochemistry), Receptors, Estrogen, chemistry, Molecular Medicine, Female, Estrogen receptor alpha
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