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المؤلفون: Lisa A. Westfield, Ara Metjian, Joshua Muia, Ayad Hamdan, Patricia Nieters, J. Evan Sadler, Anita Rodrigues, Ana G. Antun, Jeffrey I. Zwicker, Leili Dolatshahi
المصدر: Blood
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, medicine.medical_treatment, Immunology, Thrombotic thrombocytopenic purpura, Biochemistry, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, Medicine, In patient, Letter to Blood, business.industry, Low dose, Cell Biology, Hematology, respiratory system, medicine.disease, 030104 developmental biology, Multicenter study, Plasmapheresis, Rituximab, business, Adjuvant, Acquired TTP, 030215 immunology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35ec477cd0cb0f24279908456b9b288
https://doi.org/10.1182/blood.2019000795 -
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المؤلفون: Karen Vanhoorelbeke, Garima Gupta, Lisa A. Westfield, Jian Zhu, Joshua Muia, Niraj H. Tolia, J. Evan Sadler
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, PROTEASE, VON-WILLEBRAND-FACTOR, Immunology, Allosteric regulation, ADAMTS13 Protein, Plasma protein binding, 030204 cardiovascular system & hematology, Cleavage (embryo), Biochemistry, Thrombosis and Hemostasis, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Allosteric Regulation, DOMAIN, Catalytic Domain, hemic and lymphatic diseases, Scattering, Small Angle, von Willebrand Factor, Humans, Binding site, CONFORMATIONAL ACTIVATION, A2, Metalloproteinase, Binding Sites, Science & Technology, Chemistry, CLEAVAGE, RECOGNITION, Cell Biology, Hematology, Recombinant Proteins, ADAMTS13, Protein Structure, Tertiary, 030104 developmental biology, Mutagenesis, Mutation, Biophysics, CONTRIBUTE, BLOOD Commentary, Linker, Life Sciences & Biomedicine, Protein Binding
وصف الملف: Print-Electronic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007b7b6959f15a5ee803c2fafc51b68d
https://lirias.kuleuven.be/handle/123456789/648516 -
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المؤلفون: Jian Zhu, Lisa A. Westfield, Garima Gupta, Joshua Muia, Suellen Greco, Karen Vanhoorelbeke, J. Evan Sadler
مصطلحات موضوعية: 0301 basic medicine, PROTEASE, VON-WILLEBRAND-FACTOR, Immunology, Allosteric regulation, Plasma protein binding, 030204 cardiovascular system & hematology, Cleavage (embryo), Biochemistry, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, BINDING, Disintegrin, Protein precursor, Peptide sequence, CONFORMATIONAL ACTIVATION, Thrombospondin, Science & Technology, biology, Chemistry, CLEAVAGE, RECOGNITION, Cell Biology, Hematology, ADAMTS13, Cell biology, 030104 developmental biology, biology.protein, AUTOANTIBODIES, CONTRIBUTE, Life Sciences & Biomedicine
وصف الملف: Print-Electronic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a7816ae8cf9321bd0bfc252022440d
https://lirias.kuleuven.be/handle/123456789/648517 -
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المؤلفون: Joshua Muia, Sandra L. Haberichter, Lisa A. Westfield, Kenneth D. Friedman, Garima Gupta, John E. Heuser, Hendrik B. Feys, Jian Zhu, Niraj H. Tolia, Karen Vanhoorelbeke, J. Evan Sadler, Louis Deforche, Robyn Roth
المصدر: Proceedings of the National Academy of Sciences. 111:18584-18589
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Allosteric regulation, ADAMTS13 Protein, Plasma protein binding, Enzyme activator, Allosteric Regulation, Von Willebrand factor, Epidermal growth factor, hemic and lymphatic diseases, von Willebrand Factor, Humans, Platelet, Protein Structure, Quaternary, Multidisciplinary, biology, Chemistry, Biological Sciences, ADAM Proteins, ADAMTS13, Protein Structure, Tertiary, Cell biology, Enzyme Activation, cardiovascular system, biology.protein, circulatory and respiratory physiology, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe4813ee32c78ec9c759616b4e45641
https://doi.org/10.1073/pnas.1413282112 -
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المؤلفون: Joshua Muia, Anita Rodrigues, Ana G. Antun, Ara Metjian, Patricia Nieters, J. Evan Sadler, Lisa A. Westfield, Jeffrey I. Zwicker, Leili Dolatshahi
المصدر: Blood. 132:374-374
مصطلحات موضوعية: medicine.medical_specialty, Exacerbation, medicine.medical_treatment, Immunology, Thrombotic thrombocytopenic purpura, Hematopoietic stem cell transplantation, 030204 cardiovascular system & hematology, Biochemistry, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Prednisone, hemic and lymphatic diseases, Internal medicine, Clinical endpoint, medicine, business.industry, Surrogate endpoint, Cell Biology, Hematology, medicine.disease, Regimen, Rituximab, business, 030215 immunology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::340a4b819ebfacacb677910b300ccf40
https://doi.org/10.1182/blood-2018-99-113677 -
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المؤلفون: Jian Zhu, Weiqiang Gao, Elodee A. Tuley, Lisa A. Westfield, J. Evan Sadler, Patricia J. Anderson
المصدر: Journal of Biological Chemistry. 287:26944-26952
مصطلحات موضوعية: Proteases, Von Willebrand factor type A domain, Proteolysis, Molecular Sequence Data, ADAMTS13 Protein, macromolecular substances, environment and public health, Biochemistry, Cell Line, Substrate Specificity, Catalytic Domain, hemic and lymphatic diseases, Cleave, von Willebrand Factor, medicine, Humans, Amino Acid Sequence, Molecular Biology, DNA Primers, Base Sequence, medicine.diagnostic_test, Chemistry, ADAMTS, Proteolytic enzymes, Cell Biology, ADAM Proteins, ADAMTS13, Cell biology, carbohydrates (lipids), enzymes and coenzymes (carbohydrates), health occupations, Enzymology, ADAMTS5 Protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a66d7e46a4fc49008b1ffb04e5ea568
https://doi.org/10.1074/jbc.m112.380535 -
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المؤلفون: J. Evan Sadler, Angie R. Purvis, Ren Huai Huang, Luke T. Dang, Lisa A. Westfield
المصدر: Journal of Biological Chemistry. 286:25763-25769
مصطلحات موضوعية: Von Willebrand factor type A domain, Molecular Sequence Data, Biochemistry, Cell Line, Conserved sequence, Residue (chemistry), Von Willebrand factor, hemic and lymphatic diseases, von Willebrand Factor, Animals, Humans, Histidine, Protein Structure, Quaternary, Protein precursor, Hemostatic function, Molecular Biology, Conserved Sequence, Phylogeny, Sequence Homology, Amino Acid, biology, Mutagenesis, Mucins, Cell Biology, Hydrogen-Ion Concentration, Protein Structure and Folding, biology.protein, Protein Multimerization, trans-Golgi Network
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d4e0663635f4b1b6a89b058e112005
https://doi.org/10.1074/jbc.m111.249151 -
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المؤلفون: Jin-Yu Shao, J. Evan Sadler, Junyi Ying, Lisa A. Westfield, Yingchen Ling
المصدر: Biophysical Journal. 98(8):1685-1693
مصطلحات موضوعية: Protein Folding, Optical Tweezers, Molecular Sequence Data, Biophysics, Context (language use), 030204 cardiovascular system & hematology, Cleavage (embryo), Cell Line, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Von Willebrand factor, von Willebrand Factor, Humans, Amino Acid Sequence, 030304 developmental biology, Polyproteins, 0303 health sciences, biology, Chemistry, Tension (physics), Protein, Biomechanical Phenomena, Protein Structure, Tertiary, Crystallography, Optical tweezers, Domain (ring theory), biology.protein, Protein folding, Protein Multimerization
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المؤلفون: Lisa A. Westfield, Kyuhwan Shim, J. Evan Sadler, Hongfa Zhu
المصدر: Blood. 104:415-419
مصطلحات موضوعية: Thrombomodulin, Immunology, Kidney, Fibrinogen, Biochemistry, Mice, Thrombin, Cricetinae, medicine, Animals, Platelet, Artery occlusion, Platelet activation, Cells, Cultured, Enzyme Precursors, business.industry, Thrombosis, Biological activity, Cell Biology, Hematology, Platelet Activation, Molecular biology, Mice, Mutant Strains, Recombinant Proteins, Disease Models, Animal, Mutagenesis, Acute Disease, Prothrombin, Carotid Artery Injuries, business, Protein C, circulatory and respiratory physiology, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be9e467c9be188bbeab4844a4bb75a4
https://doi.org/10.1182/blood-2004-02-0478 -
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المؤلفون: Joshua Muia, Jian Zhu, S. C. Covill, L. Dolatshahi, Sandra L. Haberichter, Weiqiang Gao, Kenneth D. Friedman, J E Sadler, Lisa A. Westfield
المصدر: Journal of thrombosis and haemostasis : JTH. 11(8)
مصطلحات موضوعية: Male, medicine.medical_specialty, Bilirubin, Recombinant Fusion Proteins, Thrombotic thrombocytopenic purpura, ADAMTS13 Protein, Sensitivity and Specificity, Article, Substrate Specificity, chemistry.chemical_compound, Von Willebrand factor, Internal medicine, von Willebrand Factor, medicine, Humans, Fluorescent Dyes, Chromatography, biology, Purpura, Thrombotic Thrombocytopenic, Thrombotic Microangiopathies, Barium chloride, Anticoagulants, Reproducibility of Results, Hematology, medicine.disease, Blood proteins, Thrombocytopenia, Low ionic strength, ADAMTS13, ADAM Proteins, Endocrinology, chemistry, Case-Control Studies, Mutation, biology.protein, Female, Hemoglobin, Peptides, Plasmids