نتائج البحث - "Lisa Hooi"

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دورية أكاديمية

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

المصدر: Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Transforming growth factor-β, Precision-cut lung slice, Antifibrotic, αv integrin, PLN-74809, Diseases of the respiratory system, RC705-779

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1465-993X

URL الوصول: https://doaj.org/article/f75a5266ef724db48db905d69406f78e

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Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

المصدر: Respiratory research, vol 22, iss 1
Respiratory Research, Vol 22, Iss 1, Pp 1-14 (2021)

مصطلحات موضوعية: Precision-cut lung slice, Respiratory System, αv integrin, alpha(v) integrin, Cardiorespiratory Medicine and Haematology, Inbred C57BL, Mice, Idiopathic pulmonary fibrosis, chemistry.chemical_compound, Receptors, Pulmonary fibrosis, Phosphorylation, alpha 1 Chain, Lung, biology, Transforming growth factor-β, Pirfenidone, Transforming growth factor-beta, medicine.anatomical_structure, 5.1 Pharmaceuticals, Respiratory, Nintedanib, Antifibrotic Agents, Development of treatments and therapeutic interventions, Cell activation, Type I collagen, Signal Transduction, medicine.drug, Integrin, Clinical Sciences, Collagen Type I, Cell Line, Diseases of the respiratory system, Bleomycin, Rare Diseases, medicine, Animals, Humans, Vitronectin, Smad3 Protein, PLN-74809, RC705-779, Integrin alpha6beta1, Animal, Epithelial Cells, Fibroblasts, medicine.disease, Coculture Techniques, Idiopathic Pulmonary Fibrosis, chemistry, Disease Models, Cancer research, biology.protein, Antifibrotic

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8943da51a8a3553a1e3711bc9a9ed07
https://escholarship.org/uc/item/5q12m0vq

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Dual aVß6/aVß1 inhibitor PLN-74809 blocks multiple TGF-ß activation pathways associated with IPF

المصدر: Idiopathic interstitial pneumonias.

مصطلحات موضوعية: biology, Integrin Inhibition, business.industry, Integrin, Pirfenidone, respiratory system, Lung injury, medicine.disease, Bleomycin, respiratory tract diseases, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Fibrosis, biology.protein, Cancer research, Medicine, Nintedanib, business, Fibroblast, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38c605362d65a6584058ceae0e0ba3df
https://doi.org/10.1183/13993003.congress-2019.pa1286

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PS-091-Targeted disruption of TGF-B activation by an AVB1 integrin inhibitor significantly reduces liver fibrosis in CCl4 mice and Human NASH liver slices

المؤلفون: Patrick Andre, Vickram Rao, Martin Decaris, Irene Lepist, Lisa Hooi, Meghi Rexhepaj, Gail Lee, Shamra Martin, Perna Kotak, Katarina Leftheris, Maureen Reilly, Chun Chen, Johanna R. Schaub, Jake Cha, Scott Turner

المصدر: Journal of Hepatology. 70:e57-e58

مصطلحات موضوعية: Hepatology, biology, business.industry, Liver fibrosis, Integrin, biology.protein, Cancer research, Medicine, CCL4, Targeted disruption, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d5feefd54b1cda31ab12571881c0f192
https://doi.org/10.1016/s0618-8278(19)30103-3

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Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease

المؤلفون: Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski

المصدر: Antimicrobial Agents and Chemotherapy. 61

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e526d623aa25a82e039d51bfe79da1d8
https://doi.org/10.1128/aac.01569-16

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Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution

المؤلفون: Jin Hong, John B. Nicholas, Sharlene R. Lim, Eva Herrmann, Karl Kossen, Scott D. Seiwert, Xiaoli Qin, Patrick F. Smith, Bradford Williamson Ziegler, Christophe Sarrazin, Stefan Zeuzem, Isabel Najera, Ann Arfsten, Simone Susser, Christian M. Lange, Lisa Hooi

المصدر: Antimicrobial Agents and Chemotherapy. 56:271-279

مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Genotype, Lactams, Proline, Lactams, Macrocyclic, Hepatitis C virus, Hepacivirus, Population, Isoindoles, Viral Nonstructural Proteins, Virus Replication, medicine.disease_cause, Antiviral Agents, Drug Administration Schedule, Virus, Viral Proteins, Species Specificity, Recurrence, Drug Resistance, Viral, medicine, Humans, Protease Inhibitors, Pharmacology (medical), Protease inhibitor (pharmacology), education, Pharmacology, Sulfonamides, education.field_of_study, biology, Danoprevir, Hepatitis C, Hepatitis C, Chronic, Viral Load, medicine.disease, biology.organism_classification, Virology, Recombinant Proteins, Protein Structure, Tertiary, Molecular Typing, Infectious Diseases, Amino Acid Substitution, Mutation, RNA, Viral, Viral load

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b758ae33446d5e8fbf6755d5a4d60c
https://doi.org/10.1128/aac.05636-11

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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives

المصدر: Bioorganic & Medicinal Chemistry Letters. 19:4480-4483

مصطلحات موضوعية: Azoles, Magnetic Resonance Spectroscopy, Pyrimidine, Pyridines, Stereochemistry, Chemistry, Pharmaceutical, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, In Vitro Techniques, Viral Nonstructural Proteins, Benzothiadiazines, Antiviral Agents, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Animals, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Molecular Structure, biology, Bicyclic molecule, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Hepatitis C, digestive system diseases, Pyrimidines, Models, Chemical, chemistry, Benzothiadiazine, Enzyme inhibitor, Drug Design, biology.protein, Lactam, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000ef0a9262fe818849b255d0368b7bd
https://doi.org/10.1016/j.bmcl.2009.05.022

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HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives

المؤلفون: Shawn Misialek, Lisa Hooi, Guangyi Wang, Yanzhen He, Antitsa Dimitrova Stoycheva, Debasis Das, Mougang Hu, Jun Sun, Donald Ruhrmund, Leonid Beigelman, Scott D. Seiwert, Karl Kossen, Brad O. Buckman, Jianhua Huang, P. T. Ravi Rajagopalan

المصدر: Bioorganicmedicinal chemistry letters. 19(15)

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Stereochemistry, viruses, Hepatitis C virus, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Naphthols, In Vitro Techniques, Naphthalenes, Viral Nonstructural Proteins, medicine.disease_cause, Benzothiadiazines, Biochemistry, Chemical synthesis, Antiviral Agents, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Humans, Replicon, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Bicyclic molecule, biology, Molecular Structure, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Hepatitis C, digestive system diseases, In vitro, Enzyme, chemistry, Models, Chemical, Benzothiadiazine, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d69fbe4c653de9ca4152f58421e72cc
https://pubmed.ncbi.nlm.nih.gov/19502055

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HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives

المؤلفون: Shawn Misialek, P. T. Ravi Rajagopalan, Karl Kossen, Guangyi Wang, Xiaomin Wu, Laiguo Zhang, Debasis Das, Lisa Hooi, Donald Ruhrmund, Scott D. Seiwert, Brad O. Buckman, Leonid Beigelman

المصدر: Bioorganicmedicinal chemistry letters. 19(15)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0839e538c66f81e14d0adfb051849f1
https://pubmed.ncbi.nlm.nih.gov/19497737

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