المؤلفون: Sharifi, S, Saei, AA, Gharibi, H, Mahmoud, NN, Harkins, S, Dararatana, N, Lisabeth, EM, Serpooshan, V, Végvári, Á, Moore, A, Mahmoudi, M

المصدر: ACS applied bio materials. 5(6):2643-2663

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:235544705

المؤلفون: Staerz SD; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States., Lisabeth EM; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States., Njomen E; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States., Dexheimer TS; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States., Neubig RR; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States., Tepe JJ; Department of Chemistry, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, United States.

المصدر: ACS omega [ACS Omega] 2023 Apr 21; Vol. 8 (17), pp. 15650-15659. Date of Electronic Publication: 2023 Apr 21 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

المؤلفون: Ji Y; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (Y.J., E.M.L., R.R.N.) and Nicholas V. Perricone, MD, Division of Dermatology, Department of Medicine, College of Human Medicine, East Lansing, Michigan (R.R.N.)., Lisabeth EM; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (Y.J., E.M.L., R.R.N.) and Nicholas V. Perricone, MD, Division of Dermatology, Department of Medicine, College of Human Medicine, East Lansing, Michigan (R.R.N.)., Neubig RR; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan (Y.J., E.M.L., R.R.N.) and Nicholas V. Perricone, MD, Division of Dermatology, Department of Medicine, College of Human Medicine, East Lansing, Michigan (R.R.N.) rneubig@msu.edu.

المصدر: Molecular pharmacology [Mol Pharmacol] 2021 Aug; Vol. 100 (2), pp. 53-60. Date of Electronic Publication: 2021 May 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Lysophospholipids/*metabolism , Pulmonary Artery/*cytology , Signal Transduction/*drug effects , Sphingosine/*analogs & derivatives , Transforming Growth Factor beta1/*pharmacology, Actins/genetics ; Calcium-Binding Proteins/genetics ; Cells, Cultured ; Gene Expression Regulation/drug effects ; Humans ; Microfilament Proteins/genetics ; Muscle Contraction/drug effects ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Pulmonary Artery/drug effects ; Pulmonary Artery/metabolism ; Serum Response Factor/genetics ; Smad Proteins/genetics ; Smad Proteins/metabolism ; Sphingosine/metabolism ; Calponins

المؤلفون: Misek SA; Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA., Appleton KM; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA., Dexheimer TS; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA., Lisabeth EM; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA., Lo RS; Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, 90095, USA.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, 90095, USA.; David Geffen School of Medicine, University of California, Los Angeles, CA, 90095, USA., Larsen SD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA.; Vahlteich Medicinal Chemistry Core, University of Michigan, Ann Arbor, MI, 48109, USA., Gallo KA; Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA., Neubig RR; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824, USA. rneubig@msu.edu.; Nicholas V. Perricone, M.D., Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, 48824, MI, USA. rneubig@msu.edu.

المصدر: Oncogene [Oncogene] 2020 Feb; Vol. 39 (7), pp. 1466-1483. Date of Electronic Publication: 2019 Oct 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE

مواضيع طبية MeSH: Cell Dedifferentiation/*drug effects , Melanoma/*pathology , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins B-raf/*antagonists & inhibitors , Signal Transduction/*drug effects , rho-Associated Kinases/*metabolism, Adaptor Proteins, Signal Transducing/metabolism ; Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; Melanocytes/drug effects ; Melanocytes/pathology ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; YAP-Signaling Proteins

المؤلفون: Kahl DJ, Hutchings KM, Lisabeth EM; Department of Pharmacology and Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States., Haak AJ; Department of Pharmacology and Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States., Leipprandt JR; Department of Pharmacology and Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States., Dexheimer T; Department of Pharmacology and Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States., Khanna D; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence , University of Michigan Medical Center , Ann Arbor , Michigan 48109 , United States., Tsou PS; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence , University of Michigan Medical Center , Ann Arbor , Michigan 48109 , United States., Campbell PL; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence , University of Michigan Medical Center , Ann Arbor , Michigan 48109 , United States., Fox DA; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence , University of Michigan Medical Center , Ann Arbor , Michigan 48109 , United States., Wen B, Sun D, Bailie M; Michigan State University in Vivo Facility , East Lansing , Michigan 48824 , United States., Neubig RR; Department of Pharmacology and Toxicology , Michigan State University , East Lansing , Michigan 48824 , United States., Larsen SD

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 May 09; Vol. 62 (9), pp. 4350-4369. Date of Electronic Publication: 2019 Apr 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carboxylic Acids/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Fibrosis/*drug therapy , Oxadiazoles/*therapeutic use , Serum Response Factor/*antagonists & inhibitors , Trans-Activators/*antagonists & inhibitors, Animals ; Carboxylic Acids/chemical synthesis ; Carboxylic Acids/pharmacokinetics ; Connective Tissue Growth Factor/metabolism ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/pharmacokinetics ; Female ; Fibrosis/pathology ; Mice, Inbred C57BL ; Microsomes, Liver/drug effects ; Molecular Structure ; Oxadiazoles/chemical synthesis ; Oxadiazoles/pharmacokinetics ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/pathology ; Signal Transduction/drug effects ; Skin/pathology ; Structure-Activity Relationship ; Transcription, Genetic/drug effects ; rho GTP-Binding Proteins/antagonists & inhibitors

المؤلفون: Leal AS; Michigan State University, Department of Pharmacology & Toxicology, East Lansing, MI, USA., Misek SA; Department of Physiology, East Lansing, MI, USA., Lisabeth EM; Michigan State University, Department of Pharmacology & Toxicology, East Lansing, MI, USA., Neubig RR; Michigan State University, Department of Pharmacology & Toxicology, East Lansing, MI, USA., Liby KT; Michigan State University, Department of Pharmacology & Toxicology, East Lansing, MI, USA. liby.kare@msu.edu.

المصدر: Scientific reports [Sci Rep] 2019 May 08; Vol. 9 (1), pp. 7072. Date of Electronic Publication: 2019 May 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*metabolism , Pancreatic Neoplasms/*metabolism , Pancreatic Stellate Cells/*drug effects , Trans-Activators/*antagonists & inhibitors , Transcription Factors/*antagonists & inhibitors , rhoA GTP-Binding Protein/*antagonists & inhibitors , rhoC GTP-Binding Protein/*antagonists & inhibitors, Animals ; Disease Models, Animal ; Female ; Gene Knock-In Techniques ; Homeodomain Proteins/genetics ; Integrases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Pancreatic Stellate Cells/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; RAW 264.7 Cells ; Trans-Activators/genetics ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; rhoA GTP-Binding Protein/metabolism ; rhoC GTP-Binding Protein/metabolism

المؤلفون: Lisabeth EM; Department of Pharmacology & Toxicology and Michigan State University, East Lansing, Michigan, 48824, United States., Kahl D; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, United States., Gopallawa I; Department of Pharmacology & Toxicology and Michigan State University, East Lansing, Michigan, 48824, United States., Haynes SE; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, United States., Misek SA; Department of Pharmacology & Toxicology and Michigan State University, East Lansing, Michigan, 48824, United States., Campbell PL; Department of Internal Medicine, Division of Rheumatology, and University of Michigan, Ann Arbor, Michigan, 48109, United States., Dexheimer TS; Department of Pharmacology & Toxicology and Michigan State University, East Lansing, Michigan, 48824, United States., Khanna D; Department of Internal Medicine, Division of Rheumatology, and University of Michigan, Ann Arbor, Michigan, 48109, United States., Fox DA; Department of Internal Medicine, Division of Rheumatology, and University of Michigan, Ann Arbor, Michigan, 48109, United States., Jin X; Department of Biochemistry, Michigan State University, East Lansing, Michigan, 48824, United States., Martin BR; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, United States., Larsen SD; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan, 48109, United States.; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109, United States., Neubig RR; Department of Pharmacology & Toxicology and Michigan State University, East Lansing, Michigan, 48824, United States.

المصدر: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2019 Apr 12; Vol. 2 (2), pp. 92-100. Date of Electronic Publication: 2019 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

المؤلفون: Hutchings KM; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Lisabeth EM; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA., Rajeswaran W; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Wilson MW; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Sorenson RJ; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Campbell PL; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Ruth JH; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Amin A; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Tsou PS; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Leipprandt JR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA., Olson SR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA., Wen B; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Zhao T; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Sun D; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA., Khanna D; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Fox DA; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA., Neubig RR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA., Larsen SD; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sdlarsen@med.umich.edu.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Apr 15; Vol. 27 (8), pp. 1744-1749. Date of Electronic Publication: 2017 Mar 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Nipecotic Acids/*pharmacokinetics , Nipecotic Acids/*therapeutic use , Rho Factor/*antagonists & inhibitors , Scleroderma, Systemic/*drug therapy , Skin/*drug effects , Transcriptional Activation/*drug effects, Administration, Oral ; Animals ; Disease Models, Animal ; Fibrosis ; HEK293 Cells ; Humans ; Mice ; Nipecotic Acids/administration & dosage ; Nipecotic Acids/chemistry ; Rho Factor/metabolism ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/metabolism ; Scleroderma, Systemic/pathology ; Serum Response Element/drug effects ; Skin/metabolism ; Skin/pathology ; Trans-Activators/antagonists & inhibitors ; Trans-Activators/metabolism

المؤلفون: Yu-Wai-Man C; UCL Institute of Ophthalmology, London, UK. c.yu-wai-man@ucl.ac.uk.; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. c.yu-wai-man@ucl.ac.uk.; Signalling and Transcription Group, Francis Crick Institute, London, UK. c.yu-wai-man@ucl.ac.uk., Spencer-Dene B; Experimental Histopathology STP, Francis Crick Institute, London, UK., Lee RMH; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK., Hutchings K; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Lisabeth EM; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., Treisman R; Signalling and Transcription Group, Francis Crick Institute, London, UK., Bailly M; UCL Institute of Ophthalmology, London, UK., Larsen SD; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA., Neubig RR; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA., Khaw PT; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.

المصدر: Scientific reports [Sci Rep] 2017 Mar 31; Vol. 7 (1), pp. 518. Date of Electronic Publication: 2017 Mar 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cicatrix/*metabolism , Cicatrix/*pathology , Serum Response Factor/*antagonists & inhibitors , Serum Response Factor/*metabolism , Trans-Activators/*antagonists & inhibitors , Trans-Activators/*metabolism, Animals ; Cells, Cultured ; Cicatrix/prevention & control ; Collagen/metabolism ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Extracellular Matrix ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibrosis ; Humans ; Rabbits ; Signal Transduction/drug effects

المؤلفون: Haak AJ; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan., Appleton KM; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan., Lisabeth EM; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan., Misek SA; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan., Ji Y; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan., Wade SM; Department of Pharmacology, University of Michigan Medical Center, Ann Arbor, Michigan., Bell JL; Department of Medicinal Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan.; College of Pharmacy, University of Michigan Medical Center, Ann Arbor, Michigan., Rockwell CE; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan., Airik M; Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan., Krook MA; Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan., Larsen SD; Department of Medicinal Chemistry, University of Michigan Medical Center, Ann Arbor, Michigan.; College of Pharmacy, University of Michigan Medical Center, Ann Arbor, Michigan., Verhaegen M; Department of Dermatology, University of Michigan Medical Center, Ann Arbor, Michigan., Lawlor ER; Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan., Neubig RR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, Michigan. RNeubig@msu.edu.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2017 Jan; Vol. 16 (1), pp. 193-204. Date of Electronic Publication: 2016 Nov 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Lung Neoplasms/*secondary , Melanoma/*genetics , Melanoma/*metabolism , Signal Transduction/*drug effects , Trans-Activators/*antagonists & inhibitors , Trans-Activators/*metabolism , rho GTP-Binding Proteins/*genetics, Actins/metabolism ; Animals ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Disease Models, Animal ; Disease Progression ; Female ; Gene Expression ; Humans ; Melanoma/pathology ; Mice ; Neoplasm Metastasis ; Nipecotic Acids/pharmacology ; Transcription, Genetic ; Xenograft Model Antitumor Assays ; rhoC GTP-Binding Protein