المؤلفون: Raghuram N; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, The University of Toronto, Toronto, ON, M5S 1A8, Canada., Temel EI; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, The University of Toronto, Toronto, ON, M5S 1A8, Canada., Kawamata T; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada., Kozma KJ; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada.; Department of Molecular Genetics, The University of Toronto, Toronto, ON, M5S 1A8, Canada., Loch AJ; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada., Wang W; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada., Adams JR; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada., Muller WJ; Department of Biochemistry and Department of Medicine, Rosalind and Morris Goodman Cancer Research Institute, McGill University, Montreal, QC, H3A 1A3, Canada., Egan SE; Program in Cell Biology, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Room 16-9703, Toronto, ON, M5G 0A4, Canada. segan@sickkids.ca.; Department of Molecular Genetics, The University of Toronto, Toronto, ON, M5S 1A8, Canada. segan@sickkids.ca.

المصدر: Breast cancer research : BCR [Breast Cancer Res] 2024 May 28; Vol. 26 (1), pp. 86. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100927353 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-542X (Electronic) Linking ISSN: 14655411 NLM ISO Abbreviation: Breast Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/genetics , Breast Neoplasms*/pathology , Class I Phosphatidylinositol 3-Kinases*/genetics , Class I Phosphatidylinositol 3-Kinases*/metabolism , Gene Expression Regulation, Neoplastic* , Phosphatidylinositol 3-Kinases*/metabolism , Phosphatidylinositol 3-Kinases*/genetics , Receptor, ErbB-2*/metabolism , Receptor, ErbB-2*/genetics , rhoC GTP-Binding Protein*/metabolism , rhoC GTP-Binding Protein*/genetics, Animals ; Female ; Humans ; Mice ; Epithelial-Mesenchymal Transition/genetics ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/pathology ; Mice, Transgenic ; Signal Transduction

المؤلفون: Schachter NF; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Adams JR; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Skowron P; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Kozma KJ; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Lee CA; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Raghuram N; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Yang J; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Loch AJ; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Wang W; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Kucharczuk A; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wright KL; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Quintana RM; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Natera, San Francisco, CA, USA., An Y; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Dotzko D; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Gorman JL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Wojtal D; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Shah JS; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Leon-Gomez P; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Pellecchia G; The Center for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada., Dupuy AJ; Department of Pathology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA., Perou CM; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC, 27599, USA., Ben-Porath I; Department of Developmental Biology and Cancer Research, Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel., Karni R; Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada (IMRIC), Hebrew University-Hadassah Medical School, Jerusalem, Israel., Zacksenhaus E; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, and Department of Medicine, University of Toronto, Toronto, ON, Canada., Woodgett JR; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Done SJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; The Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; The Laboratory Medicine Program, University Health Network, Toronto, ON, Canada., Garzia L; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Cancer Research Program, McGill University, Montreal, QC, Canada., Sorana Morrissy A; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Biochemistry and Molecular Biology, University of Calgary and Arnie Charbonneau Cancer Institute, Calgary, AB, Canada., Reimand J; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Taylor MD; Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Egan SE; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada. segan@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. segan@sickkids.ca.

المصدر: Nature communications [Nat Commun] 2021 Sep 02; Vol. 12 (1), pp. 5238. Date of Electronic Publication: 2021 Sep 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*genetics , Loss of Heterozygosity/*genetics, Animals ; Breast Neoplasms/pathology ; Cell Transformation, Neoplastic ; DNA Transposable Elements/genetics ; Female ; Genes, Tumor Suppressor ; Humans ; Mice ; Mutagenesis, Insertional ; Neoplasms, Experimental ; Signal Transduction

المؤلفون: An Y; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Adams JR; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Hollern DP; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Zhao A; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada., Chang SG; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada., Gams MS; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada., Chung PED; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, and Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., He X; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Jangra R; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Shah JS; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Yang J; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Beck LA; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Raghuram N; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Kozma KJ; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Loch AJ; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Wang W; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada., Fan C; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Done SJ; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre and The Laboratory Medicine Program, University Health Network, Toronto, ON, Canada., Zacksenhaus E; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, and Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Guidos CJ; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Immunology, University of Toronto, Toronto, ON, Canada., Perou CM; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: cperou@med.unc.edu., Egan SE; Program in Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G-0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. Electronic address: segan@sickkids.ca.

المصدر: Cell reports [Cell Rep] 2018 Oct 16; Vol. 25 (3), pp. 702-714.e6.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , Mutation*, Cadherins/*physiology , Carcinoma, Lobular/*pathology , Mammary Neoplasms, Animal/*pathology , Phosphatidylinositol 3-Kinases/*physiology, Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Carcinoma, Lobular/immunology ; Carcinoma, Lobular/metabolism ; Cell Cycle Proteins/metabolism ; Class I Phosphatidylinositol 3-Kinases ; Female ; Mammary Neoplasms, Animal/immunology ; Mammary Neoplasms, Animal/metabolism ; Mice ; Mice, Knockout ; Myeloid Cells/immunology ; Myeloid Cells/metabolism ; Myeloid Cells/pathology ; Neoplasm Invasiveness ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Transcriptome ; YAP-Signaling Proteins ; rac GTP-Binding Proteins/metabolism

المؤلفون: Hammoud L; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada., Adams JR; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada., Loch AJ; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada., Marcellus RC; Drug Discovery Department, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Uehling DE; Drug Discovery Department, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Aman A; Drug Discovery Department, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Fladd C; SPARC BioCentre, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., McKee TD; Radiation Medicine Program, STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON M5G 1L7, Canada., Jo CEB; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada., Al-Awar R; Drug Discovery Department, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada., Egan SE; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Rossant J; Program in Developmental and Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: janet.rossant@sickkids.ca.

المصدر: Stem cell reports [Stem Cell Reports] 2016 Oct 11; Vol. 7 (4), pp. 787-801. Date of Electronic Publication: 2016 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*, Blood Vessels/*embryology , Blood Vessels/*metabolism , Cell Cycle Proteins/*metabolism , Embryonic Stem Cells/*cytology , Embryonic Stem Cells/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Protein-Tyrosine Kinases/*metabolism , Ribosomal Protein S6 Kinases/*metabolism, Angiogenesis Inhibitors/pharmacology ; Animals ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Line ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Discovery ; Female ; Humans ; Mice ; Morphogenesis ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic ; Neovascularization, Physiologic/drug effects ; Neovascularization, Physiologic/genetics ; Organogenesis ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Ribosomal Protein S6 Kinases/antagonists & inhibitors

المؤلفون: Wright KL; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Adams JR; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Liu JC; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Loch AJ; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Wong RG; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Jo CE; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Beck LA; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Santhanam DR; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Weiss L; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Mei X; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Lane TF; Department of Obstetrics and Gynecology and Department of Biological Chemistry, David Geffen School of Medicine and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California., Koralov SB; Department of Pathology, New York University Medical Center, New York, New York., Done SJ; Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, Ontario, Canada., Woodgett JR; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Zacksenhaus E; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Hu P; Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada., Egan SE; Program in Developmental and Stem Cell Biology, The Peter Gilgan Center for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. segan@sickkids.ca.

المصدر: Cancer research [Cancer Res] 2015 Nov 15; Vol. 75 (22), pp. 4960-72. Date of Electronic Publication: 2015 Sep 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*pathology , Neoplasm Invasiveness/*pathology , Signal Transduction/*physiology , ras Proteins/*metabolism, Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Disease-Free Survival ; Female ; Immunohistochemistry ; Kaplan-Meier Estimate ; Mice ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/pathology ; Oligonucleotide Array Sequence Analysis

المؤلفون: Zhang S; Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA., Loch AJ, Radtke F, Egan SE, Xu K

المصدر: Developmental dynamics : an official publication of the American Association of Anatomists [Dev Dyn] 2013 Jun; Vol. 242 (6), pp. 678-86. Date of Electronic Publication: 2013 Apr 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9201927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0177 (Electronic) Linking ISSN: 10588388 NLM ISO Abbreviation: Dev Dyn Subsets: MEDLINE

مواضيع طبية MeSH: Cell Lineage* , Gene Expression Regulation, Developmental*, Calcium-Binding Proteins/*physiology , Intercellular Signaling Peptides and Proteins/*physiology , Lung/*embryology , Membrane Proteins/*physiology , Receptors, Notch/*metabolism, Animals ; Calcium-Binding Proteins/genetics ; Cell Differentiation ; Epithelial Cells/metabolism ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins/genetics ; Jagged-1 Protein ; Lung/metabolism ; Membrane Proteins/genetics ; Mice ; Mice, Transgenic ; Neuroendocrine Cells/metabolism ; Phenotype ; Serrate-Jagged Proteins ; Signal Transduction ; Time Factors

المؤلفون: Xu K; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Usary J; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Kousis PC; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Prat A; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Wang DY; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada., Adams JR; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada., Wang W; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Loch AJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Deng T; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON M5S 1A1, Canada., Zhao W; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Cardiff RD; Center for Comparative Medicine, University of California, Davis, CA 95616, USA., Yoon K; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Gaiano N; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ling V; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Beyene J; Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada., Zacksenhaus E; Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON M5S 1A1, Canada., Gridley T; Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA., Leong WL; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada., Guidos CJ; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A1, Canada., Perou CM; Lineberger Comprehensive Cancer Center, Departments of Genetics and Pathology, University of North Carolina, Chapel Hill, NC 27599, USA., Egan SE; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, M5G 1L7, Canada; The Campbell Family Cancer Research Institute and Surgical Oncology Princess Margaret Hospital, and the Department of General Surgery, University Health Network, Toronto, ON M5S 1A1, Canada. Electronic address: segan@sickkids.ca.

المصدر: Cancer cell [Cancer Cell] 2012 May 15; Vol. 21 (5), pp. 626-641.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*enzymology , Caveolins/*metabolism , Cell Transformation, Neoplastic/*metabolism , Glycosyltransferases/*metabolism , Mammary Glands, Animal/*enzymology , Mammary Neoplasms, Experimental/*enzymology , Neoplastic Stem Cells/*enzymology , Proto-Oncogene Proteins c-met/*metabolism, Animals ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Calcium-Binding Proteins/metabolism ; Caveolins/genetics ; Cell Proliferation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Cells, Cultured ; Claudins/metabolism ; Databases, Genetic ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Neoplastic ; Glycosyltransferases/deficiency ; Glycosyltransferases/genetics ; Humans ; Immunohistochemistry ; Intercellular Signaling Peptides and Proteins/metabolism ; Jagged-1 Protein ; Mammary Glands, Animal/growth & development ; Mammary Glands, Animal/pathology ; Mammary Glands, Animal/transplantation ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/pathology ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Middle Aged ; Neoplastic Stem Cells/pathology ; Neoplastic Stem Cells/transplantation ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-met/genetics ; Receptor, IGF Type 1/metabolism ; Receptors, Notch/metabolism ; Serrate-Jagged Proteins ; Signal Transduction

المؤلفون: Adams JR; Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Xu K, Liu JC, Agamez NM, Loch AJ, Wong RG, Wang W, Wright KL, Lane TF, Zacksenhaus E, Egan SE

المصدر: Cancer research [Cancer Res] 2011 Apr 01; Vol. 71 (7), pp. 2706-17. Date of Electronic Publication: 2011 Feb 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Mammary Neoplasms, Experimental/*genetics , Phosphatidylinositol 3-Kinases/*genetics , Tumor Suppressor Protein p53/*genetics, Alleles ; Animals ; Class I Phosphatidylinositol 3-Kinases ; Female ; Gene Knock-In Techniques ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Transgenic ; Phosphatidylinositol 3-Kinases/biosynthesis ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor Suppressor Protein p53/biosynthesis ; Tumor Suppressor Protein p53/deficiency