المؤلفون: Leal TP; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Rao SC; The Parkinson's Foundation, Miami, Florida, USA., French-Kwawu JN; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA., Gouveia MH; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Borda V; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA., Bandres-Ciga S; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, Maryland, USA., Inca-Martinez M; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Mason EA; University of South Carolina School of Medicine, Columbia, South Carolina, USA., Horimoto ARVR; Division of Aging, Brigham and Women's Hospital, Boston, Massachusetts, USA., Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA., Sarihan EI; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA., Cornejo-Olivas MR; Neurogenetics Working Group, Universidad Científica del Sur, Lima, Peru.; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Torres LE; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Mazzetti-Soler PE; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.; Departamento de Medicina Humana, Universidad Nacional Mayor de San Marcos, Lima, Peru., Cosentino C; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Sarapura-Castro EH; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Rivera-Valdivia A; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Medina AC; Universidad Nacional del Altiplano, Puno, Peru., Dieguez EM; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Raggio VE; Department of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay., Lescano A; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Tumas V; Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil., Borges V; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Ferraz HB; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Rieder CR; Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Schumacher Schuh A; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Santos-Lobato BL; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil., Velez-Pardo C; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Jimenez-Del-Rio M; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Lopera F; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Moreno S; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia., Chana-Cuevas P; CETRAM, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile., Fernandez W; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda G; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda H; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda Bustos CE; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Yearout D; Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Neurology, University of Washington, Seattle, Washington, USA., Barbosa MT; Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Geriatric Medicine, Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, Brazil., Cardoso FEC; Movement Disorders Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Caramelli P; Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Cunningham MCQ; Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Movement Disorders Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Maia DP; Movement Disorders Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Lima-Costa MF; Instituto René Rachou da Fundação Oswaldo Cruz, Belo Horizonte, Brazil., Tarazona-Santos E; Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Zabetian CP; Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.; Department of Neurology, University of Washington, Seattle, Washington, USA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, Washington, USA., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Program in Health Equity and Population Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA., Mata IF; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

مؤلفون مشاركون: International Parkinson Disease Genomics Consortium (IPDGC), Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD)

المصدر: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2023 Sep; Vol. 38 (9), pp. 1625-1635. Date of Electronic Publication: 2023 Jul 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/genetics , Chromosomes, Human, X*/genetics, Female ; Humans ; Male ; Genome-Wide Association Study ; Hispanic or Latino ; Latin America ; Sex Factors ; Linkage Disequilibrium/genetics

المؤلفون: Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Horimoto ARVR; Department of Biostatistics, University of Washington, Seattle, WA, USA., Sarihan EI; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA., Inca-Martinez M; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA., Mason E; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA., Cornejo-Olivas M; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru., Torres L; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Mazzetti P; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Cosentino C; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Sarapura-Castro E; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Rivera-Valdivia A; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Medina AC; Universidad Nacional del Altiplano, Puno, Peru., Dieguez E; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Raggio V; Department of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay., Lescano A; Department of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay., Tumas V; Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil., Borges V; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Ferraz HB; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Rieder CR; Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Schumacher-Schuh A; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Brazil., Santos-Lobato BL; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil., Velez-Pardo C; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Antioquia, Colombia., Jimenez-Del-Rio M; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Antioquia, Colombia., Lopera F; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Antioquia, Colombia., Moreno S; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Antioquia, Colombia., Chana-Cuevas P; CETRAM, Facultad de ciencias Medicas, Universidad de Santiago de Chile, Chile., Fernandez W; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda G; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda H; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda-Bustos CE; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Yearout D; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA., Zabetian CP; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Mata IF; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Department of Neurology, University of Washington, Seattle, WA, USA. Electronic address: matai@ccf.org., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: timothydoconnor@gmail.com.

مؤلفون مشاركون: International Parkinson Disease Genomics Consortium (IPDGC), Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD)

المصدر: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2022 Sep; Vol. 102, pp. 7-15. Date of Electronic Publication: 2022 Jun 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study* , Parkinson Disease*/genetics, Genetic Predisposition to Disease/genetics ; Haplotypes ; Hispanic or Latino/genetics ; Humans ; Polymorphism, Single Nucleotide/genetics ; Risk Factors ; alpha-Synuclein/genetics

المؤلفون: Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Horimoto ARVR; Department of Biostatistics, University of Washington, Seattle, WA., Heilbron K; 23andMe, Inc., Sunnyvale, CA., Sarihan EI; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH., Inca-Martinez M; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH., Mason E; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH., Cornejo-Olivas M; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.; Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Peru., Torres L; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Mazzetti P; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Cosentino C; Movement Disorders Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru.; School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru., Sarapura-Castro E; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Rivera-Valdivia A; Neurogenetics Research Center, Instituto Nacional de Ciencias Neurologicas, Lima, Peru., Medina AC; Universidad Nacional del Altiplano, Puno, Peru., Dieguez E; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Raggio V; Department of Genetics, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay., Lescano A; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Tumas V; Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil., Borges V; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Ferraz HB; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Rieder CR; Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Schumacher-Schuh A; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Santos-Lobato BL; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil., Velez-Pardo C; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia., Jimenez-Del-Rio M; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia., Lopera F; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia., Moreno S; Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, Universidad de Antioquia (UdeA), Medellín, Colombia., Chana-Cuevas P; CETRAM, Facultad de ciencias Medicas, Universidad de Santiago de Chile, Santiago, Chile., Fernandez W; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda G; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda H; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Arboleda-Bustos CE; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogotá, Colombia., Yearout D; Veterans Affairs Puget Sound Health Care System, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA., Zabetian CP; Veterans Affairs Puget Sound Health Care System, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA., Cannon P; 23andMe, Inc., Sunnyvale, CA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD., Mata IF; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH.; Veterans Affairs Puget Sound Health Care System, Seattle, WA.; Department of Neurology, University of Washington, Seattle, WA.

مؤلفون مشاركون: 23andMe Research Team, Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD)

المصدر: Annals of neurology [Ann Neurol] 2021 Sep; Vol. 90 (3), pp. 353-365. Date of Electronic Publication: 2021 Jul 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Loci/*genetics , Genetic Variation/*genetics , Genome-Wide Association Study/*methods , Hispanic or Latino/*genetics , Parkinson Disease/*ethnology , Parkinson Disease/*genetics, Adult ; Aged ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/diagnosis ; Polymorphism, Single Nucleotide/genetics ; South America/ethnology

المؤلفون: Taliun D; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Harris DN; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Kessler MD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Carlson J; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Szpiech ZA; Department of Biology, Pennsylvania State University, University Park, PA, USA.; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA, USA., Torres R; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Taliun SAG; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Corvelo A; New York Genome Center, New York, NY, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kang HM; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Pitsillides AN; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., LeFaive J; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Lee SB; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Tian X; Department of Biostatistics, University of Washington, Seattle, WA, USA., Browning BL; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA., Das S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Emde AK; New York Genome Center, New York, NY, USA., Clarke WE; New York Genome Center, New York, NY, USA., Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Shetty AC; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Blackwell TW; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith AV; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA., Liu X; USF Genomics, College of Public Health, University of South Florida, Tampa, FL, USA., Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bobo DM; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aguet F; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Albert C; Massachusetts General Hospital, Boston, MA, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Ardlie KG; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Aslibekyan S; University of Alabama, Birmingham, AL, USA., Auer PL; Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, USA., Barnard J; Cleveland Clinic, Cleveland, OH, USA., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Department of Epidemiology, Columbia University Medical Center, New York, NY, USA., Barwick L; The Emmes Corporation, Rockville, MD, USA., Becker LC; Johns Hopkins University, Baltimore, MD, USA., Beer RL; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Benjamin EJ; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Boehnke M; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Brody JA; Department of Medicine, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Burchard EG; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Cade BE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Casella JF; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.; Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD, USA., Chalazan B; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Choi SH; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chung MK; Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA., Clish CB; Metabolomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Darbar D; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Daya M; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., de Andrade M; Mayo Clinic, Rochester, MN, USA., DeMeo DL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Dutcher SK; McDonnell Genome Institute, Washington University, St Louis, MO, USA.; Department of Genetics, Washington University, St Louis, MO, USA., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Eng C; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia., Fingerlin T; National Jewish Health, Center for Genes, Environment and Health, Denver, CO, USA., Forer L; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Fuchsberger C; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Fullerton SM; Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA., Germer S; New York Genome Center, New York, NY, USA., Gladwin MT; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gottlieb DJ; VA Boston Healthcare System, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., He J; Department of Epidemiology, Tulane University, New Orleans, LA, USA.; Tulane University Translational Science Institute, Tulane University, New Orleans, LA, USA., Heard-Costa NL; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Johnsen JM; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest Research Institute, Seattle, WA, USA., Johnson AD; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA, USA., Kaplan R; Albert Einstein College of Medicine, New York, NY, USA., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kelly T; Department of Epidemiology, Tulane University, New Orleans, LA, USA., Kelly S; Department of Epidemiology, Vitalant Research Institute, San Francisco, CA, USA.; Department of Pediatrics, UCSF Benioff Children's Hospital, Oakland, CA, USA.; Division of Pediatric Hematology, UCSF Benioff Children's Hospital, Oakland, CA, USA., Kenny EE; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kiel DP; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Klemmer R; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Konkle BA; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest Research Institute, Seattle, WA, USA., Kooperberg C; 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National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Mitchell BD; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Mohanty S; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Department of Internal Medicine, Dell Medical School, Austin, TX, USA., Montasser ME; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Montgomery C; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Murabito JM; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Natale A; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., O'Connell JR; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Peyser PA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Pleiness J; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Psaty BM; Department of Medicine, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Rao DC; Division of Biostatistics, Washington University in St Louis, St Louis, MO, USA., Redline S; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Roden D; Vanderbilt University Medical Center, Nashville, TN, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schoenherr S; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Schwartz DA; University of Colorado at Denver, Denver, CO, USA., Seo JS; Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Macrogen Inc, Seoul, Republic of Korea.; Gong Wu Genomic Medicine Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA., Sheehan VA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Sheu WH; Taichung Veterans General Hospital Taiwan, Taichung City, Taiwan., Shoemaker MB; Vanderbilt University Medical Center, Nashville, TN, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Sotoodehnia N; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Telen M; Duke University, Durham, NC, USA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Tracy RP; Department of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA., Van Den Berg DJ; Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Vasan RS; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc, San Diego, CA, USA., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Weeks DE; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Weir BS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Weiss ST; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., Weng LC; Massachusetts General Hospital, Boston, MA, USA., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zhao X; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Arnett DK; Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Boerwinkle E; University of Texas Health Science Center at Houston, Houston, TX, USA.; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Gabriel S; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gibbs R; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Qasba P; 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Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.; Framingham Heart Study, Framingham, MA, USA. adrienne@bu.edu., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA. cclaurie@uw.edu., Jaquish CE; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. jaquishc@nhlbi.nih.gov., Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. ryan.hernandez@mcgill.ca.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com., Abecasis GR; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. goncalo@umich.edu.

مؤلفون مشاركون: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

المصدر: Nature [Nature] 2021 Feb; Vol. 590 (7845), pp. 290-299. Date of Electronic Publication: 2021 Feb 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Genomics* , National Heart, Lung, and Blood Institute (U.S.)* , Precision Medicine*/standards, Genetic Variation/*genetics , Genome, Human/*genetics, Cytochrome P-450 CYP2D6/genetics ; Haplotypes/genetics ; Heterozygote ; Humans ; INDEL Mutation ; Loss of Function Mutation ; Mutagenesis ; Phenotype ; Polymorphism, Single Nucleotide ; Population Density ; Quality Control ; Sample Size ; United States ; Whole Genome Sequencing/standards

المؤلفون: Kessler MD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201., Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., Perry JA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., Heard-Costa NL; Department of Neurology, Boston University School of Medicine, Boston, MA 02118.; Framingham Heart Study, Framingham, MA 01702., Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI 48109., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Wang H; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142., Daya M; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Ziniti J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115., Datta S; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115., Celedón JC; Division of Pediatric Pulmonary Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213., Soto-Quiros ME; Department of Pediatrics, Hospital Nacional de Niños, 10103 San José, Costa Rica., Avila L; Department of Pediatrics, Hospital Nacional de Niños, 10103 San José, Costa Rica., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Barnes K; Department of Medicine, University of Colorado Denver, Aurora, CO 80045., Redline SS; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115.; Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215., Vasan RS; Framingham Heart Study, Framingham, MA 01702., Johnson AD; Framingham Heart Study, Framingham, MA 01702.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, The Framingham Heart Study, Framingham, MA 01702., Mathias RA; Division of Allergy and Clinical Immunology, The Johns Hopkins School of Medicine, Baltimore, MD 21224.; Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21218., Hernandez R; Quantitative Life Sciences, McGill University, Montreal, QC H3A OG4, Canada., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA 98195., Abecasis G; School of Public Health, University of Michigan, Ann Arbor, MI 48109., Browning SR; Department of Biostatistics, University of Washington, Seattle, WA 98195., Zöllner S; Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109.; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109., O'Connell JR; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD 21201., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201; timothydoconnor@gmail.com.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.; University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201.

مؤلفون مشاركون: National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Population Genetics Working Group

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Feb 04; Vol. 117 (5), pp. 2560-2569. Date of Electronic Publication: 2020 Jan 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Genome, Human*, Amish/*genetics, Adult ; Cohort Studies ; DNA Mutational Analysis ; Female ; Genetics, Population ; Heterozygote ; Humans ; Male ; Mutation ; Pedigree ; Whole Genome Sequencing ; Young Adult

المؤلفون: Deliz JR; Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA., Tanner CM; Weill Institute for Neurosciences, Department of Neurology, University of California -San Francisco, San Francisco, CA, USA., Gonzalez-Latapi P; Ken and Ruth Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. paulina.latapi@northwestern.edu.

المصدر: Current neurology and neuroscience reports [Curr Neurol Neurosci Rep] 2024 Jun; Vol. 24 (6), pp. 163-179. Date of Electronic Publication: 2024 Apr 20.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Current Science Inc Country of Publication: United States NLM ID: 100931790 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6293 (Electronic) Linking ISSN: 15284042 NLM ISO Abbreviation: Curr Neurol Neurosci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Parkinson Disease*/epidemiology, Humans ; Risk Factors

المؤلفون: Bhore, Noopur, Bogacki, Erin C., O'Callaghan, Benjamin, Plun-Favreau, Helene, Lewis, Patrick A., Herbst, Susanne

المصدر: Philosophical Transactions of the Royal Society B: Biological Sciences; 4/8/2024, Vol. 379 Issue 1899, p1-14, 14p

مصطلحات موضوعية: PARKINSON'S disease, GENOME-wide association studies, NEUROLOGICAL disorders, GENETIC disorders, IDENTIFICATION

المؤلفون: Karunakaran, Kalyani B., Jain, Sanjeev, Brahmachari, Samir K., Balakrishnan, N., Ganapathiraju, Madhavi K.

المصدر: Schizophrenia (2754-6993); 2/27/2024, Vol. 10 Issue 1, p1-12, 12p

المؤلفون: Sasani, Thomas A., Quinlan, Aaron R., Harris, Kelley

المصدر: eLife; 2/21/2024, p1-27, 27p

المؤلفون: Pankratz, Nathan, Cole, Benjamin R., Beutel, Kathleen M., Liao, Katherine P., Ashe, James

المصدر: Neurology: Genetics; Feb2024, Vol. 10 Issue 1, p1-9, 9p