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1
المؤلفون: Xiaotian Zhu, Dong Zou, Chester A. Metcalf, Raji Sundaramoorthi, Frank Wang, Feng Li, Jan Romero, John Iuliucci, Lois Commodore, Shuangying Liu, Wei-Sheng Huang, Lisi Cai, Qihong Xu, Jeff Keats, Tim Clackson, David C. Dalgarno, Joseph Snodgrass, Jiwei Qi, Yihan Wang, Victor M. Rivera, Mathew Thomas, Ingrid Chen, Tianjun Zhou, Yaoyu Ning, David Wen, Tomi K. Sawyer, Karin Russian, William C. Shakespeare, Marc I Broudy, Scott Wardwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3743-3748
مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Molecular Biology, Aniline Compounds, Molecular Structure, biology, Chemistry, Organic Chemistry, Ponatinib, Biological activity, medicine.disease, In vitro, Rats, Disease Models, Animal, Cyclization, Enzyme inhibitor, Alkynes, Mutation, biology.protein, Molecular Medicine, Linker, Toluene, Chronic myelogenous leukemia
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2
المؤلفون: Jeff Keats, Xiaotian Zhu, David C. Dalgarno, Tianjun Zhou, Victor M. Rivera, Lois Commodore, Tim Clackson, William C. Shakespeare, Wei-Sheng Huang, Yihan Wang, Qihong Xu, Mathew Thomas
المصدر: Chemical Biology & Drug Design. 77:1-11
مصطلحات موضوعية: Pharmacology, Mutation, Drug discovery, Organic Chemistry, Ponatinib, Myeloid leukemia, Imatinib, Biology, Gene mutation, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Imatinib mesylate, chemistry, Protein kinase domain, hemic and lymphatic diseases, Drug Discovery, medicine, Cancer research, Molecular Medicine, medicine.drug
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3
المؤلفون: Yaoyu Ning, Chester A. Metcalf, Lois Commodore, Jan Romero, Scott Wardwell, Tomi K. Sawyer, Yihan Wang, Qurish K. Mohemmad, Scott Paul Lentini, Ingrid Chen, Victor M. Rivera, Karin Russian, Geetha Banda, Sasmita Das, Narayana I. Narasimhan, Xiaotian Zhu, Raji Sundaramoorthi, Lisi Cai, Tianjun Zhou, Jeff Keats, Frank Wang, Tim Clackson, Qihong Xu, Jiwei Qi, David Wen, Joseph Snodgrass, Shuangying Liu, William C. Shakespeare, R. Mathew Thomas, Marc I Broudy, John Iuliucci, Wei-Sheng Huang, David C. Dalgarno, Dong Zou
المصدر: Journal of Medicinal Chemistry. 53:4701-4719
مصطلحات موضوعية: Models, Molecular, Mutant, Fusion Proteins, bcr-abl, Administration, Oral, Antineoplastic Agents, Mice, SCID, Pharmacology, Crystallography, X-Ray, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Kinase activity, Benzamide, Protein Kinase Inhibitors, ADME, Kinase, Chemistry, Imidazoles, breakpoint cluster region, Myeloid leukemia, medicine.disease, Rats, Pyridazines, Leukemia, Blood-Brain Barrier, Mutation, Molecular Medicine, Drug Screening Assays, Antitumor
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4
المؤلفون: Tim Clackson, Tomi K. Sawyer, William C. Shakespeare, Xiaotian Zhu, Wei-Sheng Huang, Yihan Wang, Lois Commodore, Tianjun Zhou, David C. Dalgarno
المصدر: Chemical Biology & Drug Design. 75:18-28
مصطلحات موضوعية: Drug Resistance, Fusion Proteins, bcr-abl, Biology, Biochemistry, Piperazines, Inhibitory Concentration 50, Structure-Activity Relationship, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Drug Discovery, medicine, Humans, Protein Kinase Inhibitors, Pharmacology, ABL, Drug discovery, Kinase, Organic Chemistry, Computational Biology, Imatinib, Protein-Tyrosine Kinases, Protein Structure, Tertiary, Pyrimidines, Nilotinib, Drug Resistance, Neoplasm, Purines, Drug Design, Benzamides, Imatinib Mesylate, Cancer research, Molecular Medicine, Kinase binding, K562 Cells, Tyrosine kinase, medicine.drug, Proto-oncogene tyrosine-protein kinase Src
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5
المؤلفون: Brian J. Druker, Amie S. Corbin, Yihan Wang, Yaoyu Ning, Huang Wei Sheng, Lois Commodore, Tomi K. Sawyer, Lauren T. Adrian, Xiaotian Zhu, Michael W. Deininger, David C. Dalgarno, Joseph Snodgrass, Jeffrey A. Keats, Raji Sundaramoorthi, William C. Shakespeare, Jeffrey W. Tyner, Christopher A. Eide, Thomas O'Hare, Marc M. Loriaux, Frank Wang, Scott Wardwell, Chester A. Metcalf, Dong Zhou, Victor M. Rivera, Qihong Xu, Mathew Thomas, Tim Clackson, Tianjun Zhou
المصدر: Cancer Cell. 16:401-412
مصطلحات موضوعية: Models, Molecular, Cancer Research, HUMDISEASE, Fusion Proteins, bcr-abl, Mutagenesis (molecular biology technique), Antineoplastic Agents, Cell Growth Processes, Mice, SCID, Biology, Crystallography, X-Ray, Article, Mice, chemistry.chemical_compound, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, medicine, Animals, Humans, Proto-Oncogene Proteins c-abl, Protein Kinase Inhibitors, neoplasms, Ponatinib, Imidazoles, Myeloid leukemia, Imatinib, Cell Biology, medicine.disease, Pyridazines, Dasatinib, Leukemia, CHEMBIO, Oncology, chemistry, Nilotinib, Cancer research, Bosutinib, Signal Transduction, medicine.drug
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6
المؤلفون: Youde Mo, Barbara A. Seaton, Begoña Campos, John R. Dedman, Lois Commodore, Tanya R. Mealy, James F. Head
المصدر: Journal of Biological Chemistry. 278:2437-2443
مصطلحات موضوعية: Models, Molecular, Static Electricity, Phospholipid, Trimer, Plasma protein binding, Arginine, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Cell membrane, chemistry.chemical_compound, Fluorescence Resonance Energy Transfer, medicine, Animals, Annexin A5, Molecular Biology, Phospholipids, Dose-Response Relationship, Drug, Cell Membrane, Cell Biology, Recombinant Proteins, Rats, Kinetics, Membrane, medicine.anatomical_structure, chemistry, Liposomes, Mutation, Mutagenesis, Site-Directed, Biophysics, Phospholipid Binding, Calcium, Salt bridge, Dimerization, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56030759a69e6be207a732aae9a2cfa5
https://doi.org/10.1074/jbc.m210286200 -
7
المؤلفون: Sen Zhang, Yihan Wang, Feng Li, Rory Dodd, Lois Commodore, Anna Kohlmann, David C. Dalgarno, Victor M. Rivera, Matthew T. Greenfield, Tim Clackson, Jiwei Qi, William C. Shakespeare, Stephan G. Zech, Shuangying Liu, Juan J. Miret, Rachel M. Squillace, David Miller, Xiaohui Lu, R. Mathew Thomas, Wei-Sheng Huang, Xiaotian Zhu, Yongjin Xu, Tianjun Zhou, Rongsong Xu
المصدر: Journal of medicinal chemistry. 56(3)
مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Magnetic Resonance Spectroscopy, Protein Conformation, Lactate dehydrogenase A, Oxidative phosphorylation, Crystallography, X-Ray, Oxidative Phosphorylation, chemistry.chemical_compound, Lactate dehydrogenase, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Humans, Glycolysis, Enzyme Inhibitors, education, education.field_of_study, L-Lactate Dehydrogenase, Chemistry, Drug discovery, Ligand (biochemistry), Small molecule, Warburg effect, Biochemistry, Molecular Medicine
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8
المؤلفون: Tianjun, Zhou, Lois, Commodore, Wei-Sheng, Huang, Yihan, Wang, Mathew, Thomas, Jeff, Keats, Qihong, Xu, Victor M, Rivera, William C, Shakespeare, Tim, Clackson, David C, Dalgarno, Xiaotian, Zhu
المصدر: Chemical biologydrug design. 77(1)
مصطلحات موضوعية: Fluoroimmunoassay, Fusion Proteins, bcr-abl, Imidazoles, Crystallography, X-Ray, Piperazines, Pyridazines, Mice, Structure-Activity Relationship, Pyrimidines, Drug Resistance, Neoplasm, Cell Line, Tumor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Benzamides, Mutation, Imatinib Mesylate, Animals, Protein Kinase Inhibitors, Protein Binding
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9
المؤلفون: Matthew Thomas, David Delgarno, William C. Shakespeare, Anna Kohlmann, Yaoyu Ning, Xiaotian Zhu, Lois Commodore, Yongjin Xu, Tim Clackson, Jiwei Qi, Stephan G. Zech, Juan J. Miret, Rachel M. Squillace, Yihan Wang, Feng Li, Tianjun Zhou, Frank Wang, Victor M. Rivera, Matthew T. Greenfield, David Miller
المصدر: Cancer Research. 72:3236-3236
مصطلحات موضوعية: Cancer Research, Choline kinase, Cell growth, HEK 293 cells, Cancer, Biology, medicine.disease, chemistry.chemical_compound, Oncology, Biochemistry, chemistry, Apoptosis, Cancer cell, Cancer research, medicine, Signal transduction, Phosphocholine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e37b72eb57af7f0061a5f6e05adac50f
https://doi.org/10.1158/1538-7445.am2012-3236 -
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المؤلفون: Xiaotian Zhu, Yihan Wang, Lois Commodore, Raji Sundaramoorthi, William C. Shakespeare, Chester A. Metcalf, Mathew Thomas, Tianjun Zhou, Dong Zou, David C. Dalgarno, Tim Clackson, Tomi K. Sawyer, Wei-Sheng Huang
المصدر: Cancer Research. 70:2671-2671
مصطلحات موضوعية: Genetics, Cancer Research, ABL, Chemistry, Point mutation, Mutant, Wild type, Mutagenesis (molecular biology technique), Dasatinib, Oncology, Nilotinib, Protein kinase domain, hemic and lymphatic diseases, medicine, Cancer research, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::92dab09b3a08f42711f5f7b356bf2b5e
https://doi.org/10.1158/1538-7445.am10-2671
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