المؤلفون: de Cordova Kindermann S; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Caon G; Laboratório de Metabolismo e Endocrinologia Comparada, Departamento de Fisiologia, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, Brazil., Boeck CR; Mestrado em Ciências da Saúde e da Vida, Programa de Pós-graduação em Nanociências, Universidade Franciscana, Santa Maria, Brazil., de Oliveira Bauer C; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Dos Santos da Silva N; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Possamai OL; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Longaretti LM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Magenis ML; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., Damiani AP; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., de Oliveira Monteiro I; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil., de Andrade VM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina-UNESC, Criciúma, Brazil.

المصدر: Journal of the science of food and agriculture [J Sci Food Agric] 2024 Jul 08. Date of Electronic Publication: 2024 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE

المؤلفون: Magenis ML; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Damiani AP; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., de Bem Silveira G; Laboratory of Experimental Pathophysiology, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Dagostin LS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., de Marcos PS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., de Souza E; Course of Biomedicine, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., de Roch Casagrande L; Laboratory of Experimental Pathophysiology, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Longaretti LM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Silveira PCL; Laboratory of Experimental Pathophysiology, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., de Andrade VM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil.

المصدر: Journal of developmental origins of health and disease [J Dev Orig Health Dis] 2022 Aug; Vol. 13 (4), pp. 441-454. Date of Electronic Publication: 2021 Sep 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 101517692 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2040-1752 (Electronic) Linking ISSN: 20401744 NLM ISO Abbreviation: J Dev Orig Health Dis Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance* , Metabolic Diseases* , Prenatal Exposure Delayed Effects*/metabolism, Animals ; Breast Feeding ; Female ; Fructose/adverse effects ; Humans ; Lactation ; Male ; Mice ; Pregnancy

المؤلفون: Damiani AP; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Magenis ML; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Dagostin LS; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Beretta ÂCDL; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Sarter RJ; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Longaretti LM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Monteiro IO; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil., Andrade VM; Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina - UNESC, Criciúma, SC, Brazil. Electronic address: vmoraesdeandrade@yahoo.com.br.

المصدر: Mutation research [Mutat Res] 2022 Jul-Dec; Vol. 825, pp. 111796. Date of Electronic Publication: 2022 Aug 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0400763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-135X (Electronic) Linking ISSN: 00275107 NLM ISO Abbreviation: Mutat Res Subsets: MEDLINE

مواضيع طبية MeSH: Alkylating Agents*/toxicity , DNA Damage*, Mice ; Bees ; Animals ; Fatty Acids/pharmacology ; Comet Assay ; Methyl Methanesulfonate/toxicity ; Mutagens/toxicity

المؤلفون: Fagundes GE, Macan TP, Rohr P, Damiani AP, Da Rocha FR, Pereira M, Longaretti LM, Vilela TC, Ceretta LB, Mendes C, Silveira PCL, Teixeira JPF, de Andrade VM

المصدر: Mutagenesis [Mutagenesis] 2019 May 29; Vol. 34 (2), pp. 215.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print Cited Medium: Internet ISSN: 1464-3804 (Electronic) Linking ISSN: 02678357 NLM ISO Abbreviation: Mutagenesis Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Fagundes GE; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Macan TP; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Rohr P; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Damiani AP; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Da Rocha FR; Laboratory of Exercise Biochemistry and Physiology, Department of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Pereira M; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Longaretti LM; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Vilela TC; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Ceretta LB; Graduate Program in Public Health, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Mendes C; Laboratory of Exercise Biochemistry and Physiology, Department of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Silveira PCL; Laboratory of Exercise Biochemistry and Physiology, Department of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil., Teixeira JPF; Department of Environmental Health, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal., de Andrade VM; Translational Biomedicine Laboratory, Graduate Programme of Health Sciences, University of Southern Santa Catarina, UNESC, Criciúma, Santa Catarina, Brazil.

المصدر: Mutagenesis [Mutagenesis] 2019 May 29; Vol. 34 (2), pp. 135-145.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8707812 Publication Model: Print Cited Medium: Internet ISSN: 1464-3804 (Electronic) Linking ISSN: 02678357 NLM ISO Abbreviation: Mutagenesis Subsets: MEDLINE

مواضيع طبية MeSH: Cholecalciferol/*therapeutic use , Diabetes Mellitus, Type 2/*drug therapy , Hypoglycemic Agents/*therapeutic use, Aged ; Blood Glucose/drug effects ; Cholecalciferol/blood ; Cholesterol/blood ; DNA Damage/drug effects ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/enzymology ; Dietary Supplements ; Female ; Genomic Instability ; Glutathione/metabolism ; Humans ; Hypoglycemic Agents/blood ; Liver/enzymology ; Male ; Malondialdehyde/metabolism ; Middle Aged ; Nitric Oxide/metabolism ; Oxidative Stress/drug effects ; Triglycerides/blood

المؤلفون: Garcez ML; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., de Carvalho CA; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Mina F; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Bellettini-Santos T; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Schiavo GL; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., da Silva S; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Campos ACBF; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Varela RB; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Valvassori SS; Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Damiani AP; Laboratory of Translational Biomedicine, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Longaretti LM; Laboratory of Translational Biomedicine, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., de Andrade VM; Laboratory of Translational Biomedicine, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil., Budni J; Laboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. Electronic address: josiane.budni@unesc.net.

المصدر: Experimental gerontology [Exp Gerontol] 2018 Nov; Vol. 113, pp. 209-217. Date of Electronic Publication: 2018 Oct 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0047061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6815 (Electronic) Linking ISSN: 05315565 NLM ISO Abbreviation: Exp Gerontol

مواضيع طبية MeSH: Aging/*drug effects , Butyric Acid/*pharmacology , Galactose/*pharmacology , Histone Deacetylase Inhibitors/*pharmacology , Memory/*drug effects, Animals ; Brain/drug effects ; DNA Damage/drug effects ; Disease Models, Animal ; Male ; Maze Learning/drug effects ; Rats ; Rats, Wistar

المؤلفون: Leffa DD; Laboratory of Cellular and Molecular Biology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil. daniela_leffa@hotmail.com., Rezin GT; Laboratory of Clinical and Experimental Pathophysiology, Postgraduate Program in Health Sciences, Universidade do Sul de Santa Catarina, Av. José Acácio Moreira, 787, 88704-9000, Tubarão, SC, Brazil., Daumann F; Laboratory of Cellular and Molecular Biology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil., Longaretti LM; Laboratory of Cellular and Molecular Biology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil., Dajori AL; Laboratory of Cellular and Molecular Biology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil., Gomes LM; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000, Criciúma, SC, Brazil., Silva MC; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000, Criciúma, SC, Brazil., Streck EL; Laboratory of Experimental Physiopathology, Postgraduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000, Criciúma, SC, Brazil., de Andrade VM; Laboratory of Cellular and Molecular Biology, Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), Avenida Universitaria, 1105 Bloco S, Criciuma, SC, 88806-100, Brazil.

المصدر: Molecular neurobiology [Mol Neurobiol] 2017 Mar; Vol. 54 (2), pp. 954-963. Date of Electronic Publication: 2016 Jan 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

مواضيع طبية MeSH: Fruit and Vegetable Juices*, Brain/*metabolism , Diet, Western/*adverse effects , Energy Metabolism/*physiology , Malpighiaceae/*metabolism, Animals ; Antioxidants/administration & dosage ; Ascorbic Acid/administration & dosage ; Brain/drug effects ; Dietary Supplements ; Eating/physiology ; Energy Metabolism/drug effects ; Male ; Mice ; Obesity/diet therapy ; Obesity/etiology ; Obesity/metabolism ; Plant Extracts/administration & dosage ; Plant Extracts/metabolism ; Random Allocation

المؤلفون: Leffa DD; Laboratory for Molecular and Celular Biology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000, Criciúma, SC, Brazil, daniela_leffa@hotmail.com., dos Santos CE, Daumann F, Longaretti LM, Amaral L, Dias JF, da Silva J, Andrade VM

المصدر: Biological trace element research [Biol Trace Elem Res] 2015 Sep; Vol. 167 (1), pp. 70-6. Date of Electronic Publication: 2015 Feb 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE

مواضيع طبية MeSH: Diet* , Dietary Supplements* , Fruit and Vegetable Juices*, Kidney/*metabolism , Liver/*metabolism , Minerals/*metabolism, Analysis of Variance ; Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacology ; Ascorbic Acid/administration & dosage ; Ascorbic Acid/pharmacology ; Kidney/drug effects ; Liver/drug effects ; Male ; Malpighiaceae/chemistry ; Mice ; Rutin/administration & dosage ; Rutin/pharmacology

المؤلفون: Frizon TE; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil., Micheletto YM; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil., Westrup JL; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil., Wakabayashi PS; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil., Serafim FR; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil., Damiani AP; Laboratório de Biologia Celular e Molecular, PPGCS, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000 Criciúma, SC, Brazil., Longaretti LM; Laboratório de Biologia Celular e Molecular, PPGCS, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000 Criciúma, SC, Brazil., de Andrade VM; Laboratório de Biologia Celular e Molecular, PPGCS, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, 88806-000 Criciúma, SC, Brazil., Giacomelli FC; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09210-170 Santo André, SP, Brazil., Fort S; Univ Grenoble Alpes, CERMAV, F-38000 Grenoble, France., Dal Bó AG; Laboratório de Processamento de Polímeros Avançados - LAPPA, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil; Univ Grenoble Alpes, CERMAV, F-38000 Grenoble, France. Electronic address: adalbo@unesc.net.

المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2015 Sep 01; Vol. 133, pp. 323-30. Date of Electronic Publication: 2015 Jun 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE

مواضيع طبية MeSH: Acetylglucosamine/*chemistry , Poloxamer/*chemistry, Comet Assay ; Glycosylation ; Humans ; Micelles ; Microscopy, Electron, Transmission ; Scattering, Small Angle ; Spectrometry, Fluorescence ; Thermodynamics ; X-Ray Diffraction

المؤلفون: Giovanella F; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Ferreira GK; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., de Prá SD; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Carvalho-Silva M; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Gomes LM; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Scaini G; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Gonçalves RC; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR., Michels M; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR., Galant LS; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR., Longaretti LM; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Dajori AL; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Andrade VM; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., Dal-Pizzol F; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Porto Alegre, RS, BR., Streck EL; Universidade do Extremo Sul Catarinense, Criciúma, SC, BR., de Souza RP; Instituto de Ciências Biológicas, UFMG, Belo Horizonte, MG, BR.

المصدر: Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2015 Aug; Vol. 87 (2 Suppl), pp. 1487-96. Date of Electronic Publication: 2015 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Chloroquine/*pharmacology , DNA Damage/*drug effects , Oxidative Stress/*drug effects , Primaquine/*pharmacology, Animals ; Brain/drug effects ; Kidney/drug effects ; Liver/drug effects ; Male ; Rats ; Rats, Wistar ; Time Factors