المؤلفون: Yevgeniya I. Orlovsky, Nicole Stowell, Anuk M. Das, David D. Christ, Kimberly A. Solomon, Dean A. Wacker, Douglas G. Batt, Lori L. Bostrom, Danielle M. Graden, Soo S. Ko, Erin McLaughlin, Carl P. Decicco, Gregory C. Houghton, Eric A. Wadman, Swamy Yeleswaram, Ilona Kariv, Percy H. Carter, Patricia K. Welch, Jeffrey G. Varnes, Robert C. Newton, Maryanne B. Covington, Paul Davies, James R. Pruitt, Shon K. Booker, Krishna Vaddi

المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2992-2997

مصطلحات موضوعية: Pan troglodytes, Stereochemistry, Receptors, CCR3, Clinical Biochemistry, Pharmaceutical Science, digestive system, Biochemistry, Cytochrome P-450 CYP2D6 Inhibitors, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, immune system diseases, Benzyl Compounds, Drug Discovery, Animals, Humans, Structure–activity relationship, skin and connective tissue diseases, Molecular Biology, Cells, Cultured, Phenylurea Compounds, Aryl, Organic Chemistry, Antagonist, hemic and immune systems, chemistry, Lipophilicity, Molecular Medicine, Biological Assay, Receptors, Chemokine, Cytochrome P-450 CYP2D6, Selectivity, CC chemokine receptors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1dd9c1a66cffc3a8a13b4d5ed114b4
https://doi.org/10.1016/j.bmcl.2007.03.065

المؤلفون: Brian Wayland, Brian M. Glass, Padmaja Polam, Wenyu Zhu, Amy Takvorian, Milton Hillman, Yanlong Li, Lucie Gonneville, Matthew L. Crawley, Brian Metcalf, Richard B. Sparks, Mary Becker-Pasha, Eddy W. Yue, Reid Huber, Laurine G. Galya, Erin McLaughlin, Dilip P. Modi, Richard Wynn, Brent Douty, Timothy Burn, Brian Reid, Michael J. Bower, Andrew P. Combs, Mei Li, Zelda Wasserman, Phillip Liu, Ronald M. Klabe, Min Wei, Karl F Blom, Paul J. Ala, James Russell Pruitt, Lori L. Bostrom, Gregory Hollis

المصدر: Journal of Medicinal Chemistry. 48:6544-6548

مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, In silico, Quantitative Structure-Activity Relationship, Peptide, Carboxamide, Protein tyrosine phosphatase, Crystallography, X-Ray, chemistry.chemical_compound, Drug Discovery, medicine, Peptide synthesis, Phosphotyrosine, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, Molecular Mimicry, Stereoisomerism, Dipeptides, Thiazoles, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3391b69bc36449813d723f802b9d79a
https://doi.org/10.1021/jm0504555

المؤلفون: James R. Pruitt, Robert Bruckner, Debra Burdick, Haiying Chen, Joseph M. Luettgen, Pancras C. Wong, Ruth R. Wexler, Lori L. Bostrom, Donald J. P. Pinto, Robert M. Knabb, Patrick Y.S. Lam, Matthew R. Wright, Robert A. Galemmo, Spencer Drummond, Karen A. Rossi, Steven Bai, Angela Smallwood, Brian Wells, Richard S. Alexander

المصدر: Journal of Medicinal Chemistry. 46:5298-5315

مصطلحات موضوعية: Serine protease, Proteases, medicine.drug_mechanism_of_action, biology, Stereochemistry, medicine.drug_class, Factor Xa Inhibitor, Carboxamide, Pyrazole, Serine, chemistry.chemical_compound, chemistry, Enzyme inhibitor, Drug Discovery, medicine, biology.protein, Molecular Medicine, Structure–activity relationship

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::65338656be43b312c6b74c7c75b3327b
https://doi.org/10.1021/jm030212h

المؤلفون: Chu-Biao Xue, John Wityak, Thais M. Sielecki, Donald J. Pinto, Douglas G. Batt, Gary A. Cain, Michael Sworin, Arlene L. Rockwell, John J. Roderick, Shuaige Wang, Michael J. Orwat, William E. Frietze, Lori L. Bostrom, Jie Liu, C. Anne Higley, F. Wayne Rankin, A. Ewa Tobin, George Emmett, George K. Lalka, Jean Y. Sze, Susan V. Di Meo, Shaker A. Mousa, Martin J. Thoolen, Adrienne L. Racanelli, Elizabeth A. Hausner, Thomas M. Reilly, William F. DeGrado, Ruth R. Wexler, Richard E. Olson

المصدر: Journal of Medicinal Chemistry. 40:2064-2084

مصطلحات موضوعية: Blood Platelets, Male, Stereochemistry, medicine.drug_class, Administration, Oral, Carboxamide, Platelet Glycoprotein GPIIb-IIIa Complex, Chemical synthesis, Stereocenter, Amidine, chemistry.chemical_compound, Dogs, In vivo, Drug Discovery, medicine, Animals, Moiety, Potency, Isoxazoles, Macaca mulatta, Models, Chemical, chemistry, Drug Design, Molecular Medicine, Female, Glycoprotein IIb/IIIa, Platelet Aggregation Inhibitors, Papio

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9b542866bf589da6d073fd44e05bd5
https://doi.org/10.1021/jm960799i

المؤلفون: Brian L. Wells, Richard S. Alexander, Joseph Buriak, Joseph Cacciola, S.L. Lee, David J. Carini, Patricia C. Weber, Pieter F. W. Stouten, Matthew M. Abelman, John M. Fevig, Gregory Loyde Hillyer, Robert A. Galemmo, Ruth R. Wexler, Karen A. Rossi, Lori L. Bostrom, Charles A. Kettner, Richard Hilmer, Robert M. Knabb

المصدر: Bioorganic & Medicinal Chemistry Letters. 6:2913-2918

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, Aryl, Organic Chemistry, Clinical Biochemistry, Binding pocket, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Thrombin, Orally active, Binding conformation, Drug Discovery, medicine, Molecular Medicine, Molecular Biology, Alkyl, Discovery and development of direct thrombin inhibitors, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::69491b906e379ec101be8d95fd234caa
https://doi.org/10.1016/s0960-894x(96)00525-2

المؤلفون: Ronald L. Corbett, Susan R. Sherk, Ronald L. Magolda, Joseph J. Petraitis, Alicia M. Green, Lori L. Bostrom, Matthew M. Abelman, Rachel M. Kindt, Stephen W. Wright

المصدر: Bioorganic & Medicinal Chemistry Letters. 3:2875-2878

مصطلحات موضوعية: Chemistry, Cartilage, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Arthritis, Anatomy, Organ culture, medicine.disease, Biochemistry, In vitro, medicine.anatomical_structure, Drug Discovery, medicine, Biophysics, Molecular Medicine, Nasal cartilages, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c29d2782a0dc76761e0bb25547579bf
https://doi.org/10.1016/s0960-894x(01)80782-4

المؤلفون: Matthew M. Abelman, Lori L. Bostrom, R. L. Corbeltt, Stephen W. Wright

المصدر: ChemInform. 23

مصطلحات موضوعية: Chemistry, Halide, Organic chemistry, General Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::61e4995d05b1c01a4a18c402481e9042
https://doi.org/10.1002/chin.199232149

المؤلفون: Patricia C. Weber, R. A. Jun. Galemmo, Joseph Cacciola, R. Hilmer, Ruth R. Wexler, Matthew M. Abelman, Gregory Loyde Hillyer, Petrus Fredericus Wilhelmus Stouten, John M. Fevig, S.L. Lee, Richard S. Alexander, Charles A. Kettner, Brian L. Wells, J. Jun. Buriak, Robert M. Knabb, Karen A. Rossi, Lori L. Bostrom, David J. Carini

المصدر: ChemInform. 28

مصطلحات موضوعية: chemistry.chemical_classification, Stereochemistry, Chemistry, General Medicine, Combinatorial chemistry, Alkyl, Discovery and development of direct thrombin inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8acf5adfe57f4c0468eabe41b94f6a7c
https://doi.org/10.1002/chin.199723221

المؤلفون: Matthew R. Wright, James Russell Pruitt, Donald J. P. Pinto, Pancras C. Wong, Lori L. Bostrom, Robert M. Knabb, Melissa J. Estrella, Ruth R. Wexler

المصدر: ChemInform. 31

مصطلحات موضوعية: medicine.drug_mechanism_of_action, Chemistry, In vivo, Factor Xa Inhibitor, Antithrombotic, medicine, Potency, General Medicine, Pharmacology, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6456f5c53dfd666f93d1f18fe155e7c
https://doi.org/10.1002/chin.200030111

المؤلفون: Stephen W. Wright, Lori L. Bostrom, Ronald L. Corbett, Matthew M. Abelman

المصدر: Tetrahedron Letters. 33:153-156

مصطلحات موضوعية: chemistry.chemical_compound, Bicyclic molecule, Chemistry, Organic Chemistry, Drug Discovery, Halogen, Lactam, Halide, Benzisothiazolone, Biochemistry, Combinatorial chemistry, Antibacterial agent

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::08e405345c36d26cea3759ff5b23d638
https://doi.org/10.1016/0040-4039(92)88037-6