المؤلفون: Sean Irwin, Guo-Zhu Zheng, Sherri Smith, Craig Furman, Deepti Banka, Nathalie Rioux, Victoria Rimkunas, J Norris, Prashant Kumar, Nicholas A. Larsen, Y Yu, Anand Selvaraj, Sergei Agoulnik, Craig Karr, Andrew Hart, T Bowser, Lorna Helen Mitchell, Crystal MacKenzie, Huilan Yao, Pete Smith, Tarek Sahmoud, Peter Fekkes, Jiayi Wu, T-V Nguyen, Zhaojie Zhang, Frédéric H. Vaillancourt, Betty Chan, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Manav Korpal, Markus Warmuth, Ping Zhu, S Wardell, Amy K. Kim, Galina Kuznetsov, Sean Eckley, Allison Davis, Sudeep Prajapati, Jun Wang, Ming-Hong Hao, V. Subramanian, Naresh Kumar, Xiaoling Puyang, Lihua Yu, Jaya Julie Joshi, Reynolds Dominic, G W Lai

المصدر: Cancer Research. 78:P1-10

مصطلحات موضوعية: Cancer Research, Fulvestrant, Chemistry, Antagonist, Estrogen receptor, medicine.disease, Breast cancer, Oncology, Mechanism of action, Cancer research, medicine, medicine.symptom, Receptor, Estrogen receptor alpha, Tamoxifen, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07d855e8c12d90a391ebb18e38827bdf
https://doi.org/10.1158/1538-7445.sabcs17-p1-10-08

المؤلفون: Markus Warmuth, Manav Korpal, Deepti Banka, Peter Fekkes, Pavan Kumar, Andrew Hart, Lihua Yu, Ping Zhu, Lorna Helen Mitchell, Joyce Yang, W. George Lai, Amy Kim, Craig Karr, Pete Smith, Tarek Sahmoud, Xiaoling Puyang, Sherri Smith, Mike Thomas, Benjamin Caleb, O'shea Morgan Welzel, Victoria Rimkunas, Huilan Yao, Sean Eckley, Allison Davis, Silvia Buonamici, Crystal MacKenzie, V. Subramanian, Jeremy Wu, Zheng Guo Zhu, Christopher Rowbottom, Reynolds Dominic, Nicholas A. Larsen, Nathalie Rioux, Sean Irwin, Craig Furman

المصدر: Cancer Research. 77:DDT01-04

مصطلحات موضوعية: Cancer Research, Fulvestrant, business.industry, 010401 analytical chemistry, Cancer, Estrogen receptor, Pharmacology, medicine.disease, 01 natural sciences, 0104 chemical sciences, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Oncology, Nuclear receptor, Selective estrogen receptor modulator, 030220 oncology & carcinogenesis, Medicine, business, Estrogen receptor beta, Tamoxifen, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::71b5b0fa7e9d8e6795b2dcf66171548d
https://doi.org/10.1158/1538-7445.am2017-ddt01-04

المؤلفون: Jennifer Totman, Kevin Wayne Kuntz, Megan Alene Cloonan Foley, Lorna Helen Mitchell, Nathalie Rioux, Thomas V. Riera, James Edward John Mills, Suzanne L. Jacques, Robert A. Copeland, Tim J. Wigle, Alejandra Raimondi, Kip A. West, P. Ann Boriack-Sjodin, Sherri Smith, Margaret Porter Scott, Michael John Munchhof, Christine Klaus, Michael Thomenius, Nigel J. Waters, J. Joshua Smith, Richard Chesworth

المصدر: ACS Medicinal Chemistry Letters. 7:134-138

مصطلحات موضوعية: 0301 basic medicine, Chemistry, Organic Chemistry, Sulfonamide (medicine), Pharmacology, Biochemistry, Small molecule, In vitro, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, In vivo, Drug Discovery, medicine, Potency, Oxindole, Sulfamide, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2276a83671eb4bf0b31912fb398a2e24
https://doi.org/10.1021/acsmedchemlett.5b00272

المؤلفون: Michael T. McCabe, Ann Boriack-Sjodin, Richard Chesworth, Nathalie Rioux, Alejandra Raimondi, Suzanne L. Jacques, Gideon Shapiro, Ryan G. Kruger, Kenneth W. Duncan, Scott Ribich, Christopher J. Sneeringer, Oscar Moradei, Heidi M. Ott, Allison Drew, Mikel P. Moyer, Lorna Helen Mitchell, Nigel J. Waters, Jesse Smith, Margaret Porter Scott, Lei Jin, Jessica L. Handler, Robert A. Copeland, Christina J. Allain, Thomas V. Riera

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports

مصطلحات موضوعية: Male, 0301 basic medicine, CARM1, Cell, lcsh:Medicine, Antineoplastic Agents, In Vitro Techniques, medicine.disease_cause, Article, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Spiro Compounds, Enzyme Inhibitors, lcsh:Science, Multidisciplinary, Dose-Response Relationship, Drug, biology, Chemistry, lcsh:R, Isoxazoles, Methylation, In vitro, Cell biology, CARD Signaling Adaptor Proteins, Pyrimidines, 030104 developmental biology, Histone, medicine.anatomical_structure, Guanylate Cyclase, Histone methyltransferase, biology.protein, lcsh:Q, Multiple Myeloma, Carcinogenesis, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f066c3f03b15aa91bc786c3b08c2dc68
https://doi.org/10.1038/s41598-017-18446-z

المؤلفون: Cuyue Tang, Michael John Munchhof, Kat Cosmopoulos, Kip A. West, Mikel P. Moyer, Sherri Smith, Lorna Helen Mitchell, Margaret Porter Scott, Haris Jahic, Alexandra R. Grassian, Megan Alene Cloonan Foley, Thomas V. Riera, Darren Martin Harvey, Scott Ribich, P. Ann Boriack-Sjodin, Kevin Wayne Kuntz, Nigel J. Waters, Dorothy Brach, Christine Klaus, J. Joshua Smith, Robert A. Copeland, Trupti Lingaraj, Elizabeth A. Admirand, Jennifer Totman, Michael Thomenius, Christina R. Majer, Tim J. Wigle, Richard Chesworth, Alejandra Raimondi, Jodi Gureasko, Nathalie Rioux, James Edward John Mills, Suzanne L. Jacques, William P. Janzen

المصدر: PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0197372 (2018)

مصطلحات موضوعية: 0301 basic medicine, Methyltransferase, Carcinogenesis, lcsh:Medicine, Biochemistry, Synthetic Genome Editing, Genome Engineering, RNA interference, Medicine and Health Sciences, CRISPR, Enzyme Inhibitors, lcsh:Science, Multidisciplinary, Organic Compounds, Chemical Reactions, Crispr, Small molecule, Phenotype, Enzymes, Chemistry, Oncology, Cell Processes, Physical Sciences, Engineering and Technology, RNA Interference, Synthetic Biology, Research Article, Biotechnology, Mutagenesis (molecular biology technique), Adenocarcinoma of Lung, Bioengineering, Computational biology, Biology, Methylation, Small Molecule Libraries, 03 medical and health sciences, Humans, Cell Proliferation, Cell growth, Cas9, lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Proteins, Histone-Lysine N-Methyltransferase, Methyltransferases, Cell Biology, Synthetic Genomics, 030104 developmental biology, A549 Cells, Synthetic Bioengineering, Small Molecules, Enzymology, lcsh:Q, CRISPR-Cas Systems

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6179ff168da8f29fc3b07b8965b83d
https://pubmed.ncbi.nlm.nih.gov/29856759

المؤلفون: Maria Rico del Rosario Ferreira, Lorna Helen Mitchell, Yue Fang, Michael J. Neeb, Robert K. Boeckman, Shao Pengcheng Patrick

المصدر: Tetrahedron. 67:9787-9808

مصطلحات موضوعية: Annulation, Bicyclic molecule, Stereochemistry, Chemistry, Organic Chemistry, Absolute configuration, Total synthesis, Biochemistry, Article, Cycloaddition, Claisen rearrangement, Drug Discovery, Stereoselectivity, Lewis acids and bases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81c69df3f77873b626456feb322a1e3
https://doi.org/10.1016/j.tet.2011.09.067

المؤلفون: K.K. Swinger, J.W Lampe, Tim J. Wigle, D Sadalge, P.A Boriack-Sjodin, Kevin Wayne Kuntz, Margaret Porter Scott, Richard Chesworth, Kenneth W. Duncan, Darren Martin Harvey, Robert A. Copeland, William P. Janzen, M.J Morrison, Lorna Helen Mitchell

المصدر: PLoS ONE, Vol 13, Iss 5, p e0197082 (2018)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Lysine, lcsh:Medicine, Sequence (biology), Peptide, Crystallography, X-Ray, Biochemistry, Histones, Database and Informatics Methods, Protein Structure Databases, 0302 clinical medicine, Neoplasms, Norleucine, Macromolecular Structure Analysis, Enzyme Inhibitors, Amino Acids, lcsh:Science, chemistry.chemical_classification, Multidisciplinary, Organic Compounds, Chemistry, Drug discovery, Peptide inhibitor, Enzymes, PR-SET Domains, 030220 oncology & carcinogenesis, Histone methyltransferase, Physical Sciences, Basic Amino Acids, Research Article, Protein Structure, Research and Analysis Methods, Histone H4, 03 medical and health sciences, Histone H3, DNA-binding proteins, Humans, Molecular Biology, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, Proteins, Histone-Lysine N-Methyltransferase, Methyltransferases, Repressor Proteins, Biological Databases, 030104 developmental biology, Enzyme Structure, Enzymology, lcsh:Q, Peptides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2590873f810a64888e3aa88bfd302a2
https://doi.org/10.1371/journal.pone.0197082

المؤلفون: Tim J. Wigle, O Moradei, Lorna Helen Mitchell, Scott Ribich, Nigel J. Waters, J. Joshua Smith, A.E Drew, K.K. Swinger, Nathalie Rioux, P.A Boriack-Sjodin, Lei Jin, Robert A. Copeland, Richard Chesworth, Thomas V. Riera, Mikel P. Moyer, Trupti Lingaraj, Suzanne L. Jacques, Margaret Porter-Scott

مصطلحات موضوعية: Methyltransferase, Arginine, Stereochemistry, Aryl, Organic Chemistry, Biology, Pyrazole, Biochemistry, Small molecule, Bioavailability, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Transferase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb8bd70cf4924862ed8a223aa633301
https://europepmc.org/articles/PMC4468411/

المؤلفون: Scott Ribich, Nathalie Rioux, Kerry Frost, Lorna Helen Mitchell, Robert A. Copeland, Philip Tiller, Joanne Shaw, Nigel J. Waters, Mikel P. Moyer, Katie Plant, Richard Chesworth

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 43(7)

مصطلحات موضوعية: Male, Protein-Arginine N-Methyltransferases, Arginine, Stereochemistry, Arylamine N-Acetyltransferase, Metabolite, Pharmaceutical Science, Gas Chromatography-Mass Spectrometry, Rats, Sprague-Dawley, chemistry.chemical_compound, Sulfation, Dogs, Animals, Bile, Humans, Amines, Enzyme Inhibitors, Biotransformation, Demethylation, Pharmacology, Substrate (chemistry), Ethylenediamines, In vitro, Rats, Isoenzymes, Kinetics, chemistry, Liver, Acetylation, Hepatocytes, Pyrazoles, Amine gas treating, Metabolic Networks and Pathways

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366455d22a7b2bcdf9a549600f3d753c
https://pubmed.ncbi.nlm.nih.gov/25887455

المؤلفون: Lorna Helen Mitchell, Brian Samas

المصدر: Synthetic Communications. 35:955-959

مصطلحات موضوعية: Crystallography, Stereochemistry, Chemistry, Yield (chemistry), Organic Chemistry, Crystal structure, Ring (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3071ec160407b84bd7f52adf0bc43697
https://doi.org/10.1081/scc-200051700