نتائج البحث - "Lorraine Springuel"

المساهمون: UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre du cancer

المصدر: BIODRUGS
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, no. 5, p. 515-537 (2019)
Biodrugs
BioDrugs
BioDrugs, Vol. 33, no. 5, p. 515-537 (2019)

مصطلحات موضوعية: EXPRESSION, Stromal cell, BLOCKADE, T-Lymphocytes, ANTITUMOR-ACTIVITY, Biotechnologie, Cell- and Tissue-Based Therapy, Review Article, Pharmacologie, LYMPHOCYTES, THERAPY, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigen, Neoplasms, Tumor Microenvironment, medicine, Medicine and Health Sciences, Animals, Humans, DOSE-ESCALATION, Pharmacology (medical), ADOPTIVE IMMUNOTHERAPY, 030203 arthritis & rheumatology, Pharmacology, Clinical Trials as Topic, Tumor microenvironment, Receptors, Chimeric Antigen, biology, business.industry, Cancer, General Medicine, medicine.disease, CANCER, GENE, Chimeric antigen receptor, PHASE-I, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, Human medicine, Antibody, business, CHECKPOINT, Biotechnology

وصف الملف: Print; application/pdf; 1 full-text file(s): application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d4b739c3db93b42e03d57d5d8542f7
https://lirias.kuleuven.be/handle/123456789/641740

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5

The integrated stress response promotes B7H6 expression

المؤلفون: Noam Stern-Ginossar, Ofer Mandelboim, Einat Seidel, Lorraine Springuel, Julie Tai-Schmiedel, Boaz Tirosh, Eric Chevet, Miriam Shmuel, David E. Gilham, Mohamed Mahameed, Akram Obiedat, Yoav Charpak-Amikam, Tony Avril, Priya Dipta, Jennifer Bolsée

المساهمون: The Hebrew University of Jerusalem (HUJ), The Hebrew University Hadassah Medical School, Weizmann Institute of Science [Rehovot, Israël], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), 0, Ministry of Science and Technology, Israel, 721236, H2020 Marie Skłodowska-Curie Actions, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Journal of Molecular Medicine (Berlin, Germany)
Journal of Molecular Medicine
Journal of Molecular Medicine, 2020, 98 (1), pp.135-148. ⟨10.1007/s00109-019-01859-w⟩
Journal of Molecular Medicine, Springer Verlag, 2020, 98 (1), pp.135-148. ⟨10.1007/s00109-019-01859-w⟩

مصطلحات موضوعية: PERK, B7 Antigens, T-Lymphocytes, Eukaryotic Initiation Factor-2, [SDV.CAN]Life Sciences [q-bio]/Cancer, Blood Donors, UPR, Transfection, Immunotherapy, Adoptive, Lopinavir, 03 medical and health sciences, eIF-2 Kinase, 0302 clinical medicine, Downregulation and upregulation, Transduction, Genetic, Cell Line, Tumor, Drug Discovery, medicine, HIV Protease Inhibitor, Integrated stress response, Humans, Phosphorylation, Protein kinase A, B7H6, Genetics (clinical), 030304 developmental biology, 0303 health sciences, Nelfinavir, Receptors, Chimeric Antigen, Kinase, Chemistry, Endoplasmic reticulum, HIV Protease Inhibitors, Endoplasmic Reticulum Stress, 3. Good health, Cell biology, CAR-T, Killer Cells, Natural, 030220 oncology & carcinogenesis, Unfolded protein response, Unfolded Protein Response, Molecular Medicine, Original Article, medicine.drug, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::769961abc7e0dd57b9f81861fca4b01c
https://pubmed.ncbi.nlm.nih.gov/31838577

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6

Overcoming Target Driven Fratricide for T Cell Therapy

المؤلفون: Benjamin Violle, Céline Jacques-Hespel, Nancy Ramelot, Fanny Huberty, Eytan Breman, Peter De Waele, Sébastien Mauen, Alexandre Michaux, Lorraine Springuel, Benjamin Demoulin, Jérôme Marijsse, Thuy Nguyen, Céline Marchand, Dorothée Daro, Valérie Steenwinckel, Sophie Agaugue, David E. Gilham, Julien Houssa

المصدر: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology

مصطلحات موضوعية: Cytotoxicity, Immunologic, 0301 basic medicine, T-Lymphocytes, Cell, Ligands, Immunotherapy, Adoptive, NKG2D, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, NKG2D blocking antibody, Immunology and Allergy, LY294002, Enzyme Inhibitors, Cells, Cultured, Phosphoinositide-3 Kinase Inhibitors, Original Research, chimeric antigen receptor, biology, Chemistry, hemic and immune systems, people.cause_of_death, Cell biology, medicine.anatomical_structure, NK Cell Lectin-Like Receptor Subfamily K, Antibody, lcsh:Immunologic diseases. Allergy, Cell Survival, Morpholines, T cell, Immunology, Receptors, Antigen, T-Cell, T cells, chemical and pharmacologic phenomena, PI3K inhibitor, 03 medical and health sciences, CD314, Fratricide, Cell Line, Tumor, medicine, Humans, Antibodies, Blocking, Chimeric antigen receptor, Blockade, 030104 developmental biology, Chromones, biology.protein, K562 Cells, lcsh:RC581-607, people, fratricide

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb734f27ae0d4c1bdf4f2b10e7770dc
https://doi.org/10.3389/fimmu.2018.02940

7

Single vector multiplexed shRNA provides a non-gene edited strategy to concurrently knockdown the expression of multiple genes in CAR T cells

المؤلفون: David E. Gilham, Panagiota A. Sotiropoulou, Alexandre Michaux, Eytan Breman, Mikhail Steklov, Simon Bornschein, Lorraine Springuel

المصدر: Journal of Clinical Oncology. 38:3103-3103

مصطلحات موضوعية: Small hairpin RNA, Cancer Research, Gene knockdown, Oncology, business.industry, Medicine, In patient, Vector (molecular biology), Car t cells, business, Gene, Chimeric antigen receptor, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c14763a83645d16fa4c45efac9fcc9e9
https://doi.org/10.1200/jco.2020.38.15_suppl.3103

8

Loss of mutL homolog-1 (MLH1) expression promotes acquisition of oncogenic and inhibitor-resistant point mutations in tyrosine kinases

المؤلفون: Béatrice Turcq, Elisabeth Losdyck, Lorraine Springuel, Pascale Saussoy, Laurent Knoops, Francois-Xavier Mahon, Jean-Christophe Renauld

المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biologie hématologique, UCL - (SLuc) Service d'hématologie, Centre National de la Recherche Scientifique (CNRS)

المصدر: Cellular and Molecular Life Sciences, Vol. 73, no. 24, p. 4739-4748 (2016)
Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2016, 73 (24), pp.4739-4748. ⟨10.1007/s00018-016-2310-2⟩

مصطلحات موضوعية: 0301 basic medicine, Genome instability, MESH: Oncogenes, DNA mismatch repair, Tyrosine kinase inhibitor, medicine.disease_cause, Tyrosine-kinase inhibitor, MESH: Down-Regulation, Mice, 0302 clinical medicine, MESH: DNA Methylation, RNA interference, MESH: RNA, Small Interfering, MESH: Janus Kinases, MESH: Protein Kinase Inhibitors, MESH: Animals, RNA, Small Interfering, Promoter Regions, Genetic, Oncogenic mutations, Mutation, Gene Expression Regulation, Leukemic, MESH: MutL Protein Homolog 1, MLH1, Myeloid leukemia, MESH: Drug Resistance, Neoplasm, 3. Good health, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, MESH: Gene Expression Regulation, Leukemic, Molecular Medicine, Intercellular Signaling Peptides and Proteins, MutL Protein Homolog 1, Tyrosine kinase, medicine.drug_class, Down-Regulation, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Cell Line, 03 medical and health sciences, Cellular and Molecular Neuroscience, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, MESH: Promoter Regions, Genetic, medicine, Animals, Humans, Point Mutation, MESH: Intercellular Signaling Peptides and Proteins, Molecular Biology, Protein Kinase Inhibitors, MESH: Mice, Janus Kinases, MESH: Point Mutation, Pharmacology, MESH: Humans, Point mutation, Janus kinase (JAK), MESH: Clone Cells, Cell Biology, Oncogenes, DNA Methylation, MESH: Gene Knockdown Techniques, Clone Cells, MESH: Cell Line, 030104 developmental biology, MESH: Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Drug Resistance, Neoplasm, Drug resistance, Cancer research, Ectopic expression

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2dfdb70f07ebca7d4b7954e8ac6d07
https://hdl.handle.net/2078.1/184342

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9

Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors

المؤلفون: Julien Devreux, Stefan N. Constantinescu, Lorraine Springuel, Tekla Hornakova, Alexandra Dusa, Jean-Christophe Renauld, Laurent Knoops

المساهمون: UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Service d'hématologie

المصدر: Haematologica : the hematology journal, Vol. 96, no. 6, p. 845-853 (2011)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a2d47471be86359d6c4f655be9c5a1
https://doi.org/10.3324/haematol.2010.036350

10

Distinct acute lymphoblastic leukemia (ALL)-associated Janus Kinase 3 (JAK3) mutants exhibit different cytokine-receptor requirements and JAK-inhibitor specificities

المؤلفون: Jean-Christophe Renauld, Elisabetta Flex, Sandrine Degryse, Jan Cools, Laurent Knoops, Tekla Hornakova, Marco Tartaglia, Elisabeth Losdyck, Stefan N. Constantinescu, Olga Gielen, Lorraine Springuel

المساهمون: UCL - (SLuc) Service d'hématologie, UCL - SSS/DDUV - Institut de Duve

المصدر: Journal of Biological Chemistry, Vol. 290, no. 48, p. 29022-29034 (2015)

وصف الملف: Print-Electronic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1deb3d95fd0dfca2ff6d4dc508b94953
https://hdl.handle.net/2078.1/166226

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