المؤلفون: Lossio CF; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Osterne VJS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Pinto-Junior VR; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.; Department of Physics, Federal University of Ceara, Fortaleza 60440-970, Brazil., Chen S; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Oliveira MV; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Verduijn J; Nano-Biotechnology Group, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Verbeke I; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Serna S; Glycotechnology Lab, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain., Reichardt NC; Glycotechnology Lab, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain.; Centro de Investigación Biomédica en Red (CIBER-BBN), Paseo de Miramon 194, 20014 Donostia-San Sebastián, Spain., Skirtach A; Nano-Biotechnology Group, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Cavada BS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil., Van Damme EJM; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Nascimento KS; Laboratory of Biologically Active Molecules, Department of Biochemistry and Molecular Biology, Federal University of Ceara, Fortaleza 60440-970, Brazil.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 04; Vol. 24 (21). Date of Electronic Publication: 2023 Nov 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Lectins*/pharmacology , Lectins*/analysis , Canavalia*/metabolism, Molecular Docking Simulation ; Plant Lectins/metabolism ; Seeds/metabolism ; Carbohydrates/analysis ; Polysaccharides/analysis

المؤلفون: Oliveira MV; BioMol-Lab, Campus do Pici, Universidade Federal do Ceará, Fortaleza, Ceará 60.440-970, Brazil., Osterne VJS; BioMol-Lab, Campus do Pici, Universidade Federal do Ceará, Fortaleza, Ceará 60.440-970, Brazil; Laboratory for Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium., Lossio CF; BioMol-Lab, Campus do Pici, Universidade Federal do Ceará, Fortaleza, Ceará 60.440-970, Brazil., Serna S; Glycotechnology Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014 San Sebastian, Spain., Reichardt NC; Glycotechnology Laboratory, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo Miramón 182, 20014 San Sebastian, Spain; CIBER-BBN, Paseo Miramón 182, 20009 San Sebastian, Spain., Nascimento KS; BioMol-Lab, Campus do Pici, Universidade Federal do Ceará, Fortaleza, Ceará 60.440-970, Brazil., Van Damme EJM; Laboratory for Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, 9000 Ghent, Belgium. Electronic address: ElsJM.VanDamme@ugent.be., Cavada BS; BioMol-Lab, Campus do Pici, Universidade Federal do Ceará, Fortaleza, Ceará 60.440-970, Brazil. Electronic address: bscavada@ufc.br.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2021 Dec 15; Vol. 193 (Pt B), pp. 1562-1571. Date of Electronic Publication: 2021 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Fabaceae/*chemistry , Plant Lectins/*chemistry , Polysaccharides/*chemistry , Polysaccharides/*metabolism , Seeds/*chemistry, Amino Acid Sequence ; Animals ; Artemia/metabolism ; Glucose/metabolism ; Hemagglutination ; Mannose/metabolism

المؤلفون: Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: bscavada@ufc.br., Pinto-Junior VR; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Oliveira MV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil; Departamento de Nutrição, Universidade Estadual do Ceará, Fortaleza, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2021 Jun 30; Vol. 181, pp. 1104-1123. Date of Electronic Publication: 2021 Apr 22.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Carbohydrates/*chemistry , Lectins/*chemistry , Lectins/*isolation & purification , Vicia/*chemistry, Amino Acid Sequence/genetics ; Carbohydrates/genetics ; Lectins/genetics ; Lectins/ultrastructure

المؤلفون: Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: bscavada@ufc.br., Pinto-Junior VR; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil; Departamento de Nutrição, Universidade Estadual do Ceará, Fortaleza, Brazil., Oliveira MV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Silva MTL; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Bari AU; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lima LD; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Souza-Filho CHD; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 333-348. Date of Electronic Publication: 2020 Jun 20.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antifungal Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Antiviral Agents/*pharmacology , Bauhinia/*chemistry , Plant Lectins/*chemistry , Plant Lectins/*pharmacology, Amino Acid Sequence ; Anti-Inflammatory Agents/pharmacology ; Fabaceae/chemistry ; Metals/chemistry ; Molecular Conformation ; Phylogeny ; Plant Lectins/isolation & purification ; Plant Lectins/metabolism ; Protein Domains

المؤلفون: Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Silva MTL; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Pinto-Junior VR; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Madeira JC; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Brazil., Pereira MG; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Brazil., Leal RB; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Ferreira WP; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Assreuy AMS; Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, Brazil.

المصدر: Journal of molecular recognition : JMR [J Mol Recognit] 2020 Nov; Vol. 33 (11), pp. e2870. Date of Electronic Publication: 2020 Jul 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 9004580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1352 (Electronic) Linking ISSN: 09523499 NLM ISO Abbreviation: J Mol Recognit Subsets: MEDLINE

مواضيع طبية MeSH: Carbohydrates/*chemistry , Inflammation/*drug therapy , Mannose-Binding Lectins/*pharmacology , Plant Lectins/*pharmacokinetics, Animals ; Binding Sites ; Histamine/pharmacology ; Humans ; Inflammation/chemically induced ; Inflammation/pathology ; Mannose/chemistry ; Mannose-Binding Lectins/chemistry ; Mannosides/chemistry ; Plant Lectins/chemistry ; Plant Lectins/pharmacology ; Polysaccharides/chemistry ; Rats

المؤلفون: Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: bscavada@ufc.br., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Oliveira MV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Pinto-Junior VR; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil., Silva MTL; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Bari AU; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lima LD; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil., Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2020 Jul 01; Vol. 154, pp. 159-165. Date of Electronic Publication: 2020 Mar 14.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Fabaceae/*chemistry , Plant Lectins/*chemistry , Plant Lectins/*pharmacology, Chemical Phenomena

المؤلفون: Cavada BS; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil. Electronic address: bscavada@ufc.br., Bari AU; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Pinto-Junior VR; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Lossio CF; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Silva MTL; Laboratório de Neuroquímica 3 - Transdução de Sinal no SNC, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Souza LAG; Instituto Nacional de Pesquisas da Amazônia-INPA, Manaus, Amazonas, Brazil., Oliveira MV; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Souza-Filho CHD; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Correia SEG; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Vital APMS; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Lima LD; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Osterne VJS; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Nascimento KS; Laboratório de Moléculas Biologicamente Ativas (BioMol-Lab), Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2020 Feb 15; Vol. 145, pp. 845-855. Date of Electronic Publication: 2019 Nov 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Fabaceae/*chemistry , Plant Lectins/*chemistry , Seeds/*chemistry, Animals ; Artemia/chemistry ; Chromatography, Affinity/methods ; Glucose/chemistry ; Hydrogen-Ion Concentration ; Mannose/chemistry ; Temperature

المؤلفون: Nascimento KS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil. Electronic address: kyriasantiago@gmail.com., Silva MTL; Departamento de Bioquímica, Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Oliveira MV; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Lossio CF; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Pinto-Junior VR; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Osterne VJS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Cavada BS; Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil. Electronic address: bscavada@ufc.br.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2020 Feb 01; Vol. 144, pp. 509-526. Date of Electronic Publication: 2019 Dec 17.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Fabaceae/*chemistry , Plant Lectins/*chemistry , Plant Lectins/*therapeutic use, Binding Sites ; Carbohydrates/chemistry ; Protein Folding ; Structural Homology, Protein

المؤلفون: Cavada BS; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil. bscavada@ufc.br., Osterne VJS; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Pinto-Junior VR; Departmento de Fisica, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Souza LAG; Instituto Nacional de Pesquisa da Amazonia, Manaus, AM, Brazil., Lossio CF; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Silva MTL; Departamento de Bioquimica, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Correia-Neto C; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Oliveira MV; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Correia JLA; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Neco AHB; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil., Domingos JLC; Departmento de Fisica, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Ferreira WP; Departmento de Fisica, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Farias GA; Departmento de Fisica, Universidade Federal do Ceará, Fortaleza, CE, Brazil., Nascimento KS; Departmento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Mister Hull Avenue s/n. Campus do Pici, Bloco 907, Fortaleza, CE, 60455-970, Brazil. kyriasantiago@gmail.com.

المصدر: Journal of molecular modeling [J Mol Model] 2020 Jan 07; Vol. 26 (2), pp. 22. Date of Electronic Publication: 2020 Jan 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9806569 Publication Model: Electronic Cited Medium: Internet ISSN: 0948-5023 (Electronic) Linking ISSN: 09485023 NLM ISO Abbreviation: J Mol Model Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation*, Fabaceae/*chemistry , Plant Lectins/*chemistry, Humans ; Neoplasms ; Protein Domains

المؤلفون: Cavada BS; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil. Electronic address: bscavada@ufc.br., Osterne VJS; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Lossio CF; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Pinto-Junior VR; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Oliveira MV; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Silva MTL; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil., Leal RB; Universidade Federal de Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil., Nascimento KS; BioMol-Lab, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil. Electronic address: kyriasantiago@ufc.br.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2019 Aug 01; Vol. 134, pp. 901-911. Date of Electronic Publication: 2019 May 18.

نوع المنشور: Historical Article; Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Research*/history, Concanavalin A/*chemistry , Plant Lectins/*chemistry, Amino Acid Sequence ; Binding Sites ; Carbohydrates/chemistry ; Concanavalin A/pharmacology ; History, 20th Century ; History, 21st Century ; Models, Molecular ; Molecular Structure ; Plant Lectins/pharmacology ; Protein Binding ; Protein Multimerization ; Structure-Activity Relationship