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1دورية أكاديمية
المؤلفون: Tomi Rantamäki, Susanna Kemppainen, Henri Autio, Saara Stavén, Hennariikka Koivisto, Masami Kojima, Hanna Antila, Pasi O Miettinen, Elisa Kärkkäinen, Nina Karpova, Liisa Vesa, Lothar Lindemann, Marius C Hoener, Heikki Tanila, Eero Castrén
المصدر: PLoS ONE, Vol 8, Iss 7, p e68722 (2013)
وصف الملف: electronic resource
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المؤلفون: Lothar Lindemann, Giuseppe Palermo, Michael Derks, Marie-Laure Delporte, Stefan Sturm, Robert James Weikert, Salah Hadi, Georg Jaeschke, Scott Schobel
المصدر: British Journal of Clinical Pharmacology. 84:445-455
مصطلحات موضوعية: Pharmacology, business.industry, Nausea, Cmax, Context (language use), Placebo, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Tolerability, Pharmacokinetics, Vomiting, Medicine, Pharmacology (medical), medicine.symptom, business, Adverse effect, 030217 neurology & neurosurgery
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المؤلفون: Florian Von Raison, Randall L. Carpenter, Will Spooren, George Apostol, Jacqueline N. Crawley, Eva Loth, Elizabeth Berry-Kravis, Lothar Lindemann, Vincent des Portes, Farah Hossain, Mark F. Bear, Randi J Hagerman, Sebastian H. Scharf, Baltazar Gomez-Mancilla, Paul P. Wang, David R Hessl, Sébastien Jacquemont, Fabrizio Gasparini, Aia E. Jønch, Aurore Curie
المساهمون: Picower Institute for Learning and Memory
المصدر: Other repository
Berry-Kravis, E M, Lindemann, L, Jønch, A E, Apostol, G, Bear, M F, Carpenter, R L, Crawley, J N, Curie, A, Des Portes, V, Hossain, F, Gasparini, F, Gomez-Mancilla, B, Hessl, D, Loth, E, Scharf, S H, Wang, P P, Von Raison, F, Hagerman, R, Spooren, W & Jacquemont, S 2018, ' Drug development for neurodevelopmental disorders : lessons learned from fragile X syndrome ', Nature Reviews. Drug Discovery, vol. 17, no. 4, pp. 280–299 . https://doi.org/10.1038/nrd.2017.221
Nature reviews. Drug discovery, vol 17, iss 4مصطلحات موضوعية: 0301 basic medicine, Autism, Drug Evaluation, Preclinical, Review, Medical and Health Sciences, 0302 clinical medicine, Neurodevelopmental disorder, Drug Discovery, Intellectual disability, 2.1 Biological and endogenous factors, Pharmacology & Pharmacy, Aetiology, Randomized Controlled Trials as Topic, Pediatric, Clinical Trials as Topic, Neurotransmitter Agents, Metabotropic glutamate receptor 5, General Medicine, Biological Sciences, Preclinical, Fragile X syndrome, Mental Health, Drug development, 5.1 Pharmaceuticals, Neurological, Development of treatments and therapeutic interventions, congenital, hereditary, and neonatal diseases and abnormalities, Intellectual and Developmental Disabilities (IDD), Clinical Trials and Supportive Activities, Article, 03 medical and health sciences, Rare Diseases, Drug Development, Clinical Research, Behavioral and Social Science, Journal Article, medicine, Animals, Humans, Pharmacology, business.industry, Neurosciences, medicine.disease, FMR1, Brain Disorders, Clinical trial, Orphan Drug, 030104 developmental biology, Neurodevelopmental Disorders, Fragile X Syndrome, Drug Evaluation, business, Neuroscience, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Elyza Kelly, Jonathan O. Lipton, Samantha M. Schaeffer, Stephen H.T. Lammers, Jill L. Silverman, Chloe E. Super, Lothar Lindemann, Alexander Rotenberg, John R. Dreier, Meera E. Modi, Mustafa Sahin, Michael Honer, Sameer C. Dhamne, David J. Kwiatkowski, Georg Jaeschke
المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 43, iss 6
مصطلحات موضوعية: Male, 0301 basic medicine, Autism Spectrum Disorder, Pyridines, Autism, animal diseases, Neurodegenerative, Medical and Health Sciences, Transgenic, Mice, Tuberous sclerosis, Epilepsy, 0302 clinical medicine, Tuberous Sclerosis, 2.1 Biological and endogenous factors, Aetiology, Cells, Cultured, Pediatric, Psychiatry, Neurons, Cultured, Metabotropic glutamate receptor 5, Imidazoles, Brain, Long-term potentiation, Metabotropic Glutamate 5, Phenotype, Psychiatry and Mental health, Mental Health, Neurological, Original Article, Female, Receptor, Cells, Intellectual and Developmental Disabilities (IDD), Receptor, Metabotropic Glutamate 5, Allosteric regulation, Mice, Transgenic, Motor Activity, 03 medical and health sciences, Rare Diseases, Allosteric Regulation, Behavioral and Social Science, Tuberous Sclerosis Complex 2 Protein, mental disorders, medicine, Animals, Rats, Long-Evans, Excitatory Amino Acid Agents, Pharmacology, Animal, business.industry, Psychology and Cognitive Sciences, Neurosciences, Long-Evans, medicine.disease, Rats, Brain Disorders, Disease Models, Animal, 030104 developmental biology, nervous system, Disease Models, TSC2, business, Neuroscience, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Lothar Lindemann, Michal Stawarski, Ruth C. Werthmann, Jens Lamerz, Catherine Diener, Christophe Fischer, Thorsten Fritzius, Martin Gassmann, Angélique Augustin, Luca Trovò, Bernhard Bettler, Adi Raveh, Manuel Tzouros
المصدر: Neuropharmacology. 190:108426
مصطلحات موضوعية: 0301 basic medicine, G protein, Receptor, Metabotropic Glutamate 5, Allosteric regulation, Heterologous, Receptors, Metabotropic Glutamate, Hippocampus, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Allosteric Regulation, Tandem Mass Spectrometry, Animals, Receptor, G protein-coupled receptor, Mice, Knockout, Neurons, Pharmacology, Chemistry, Brain, Transfection, Cell biology, 030104 developmental biology, Metabotropic glutamate receptor, Protein Multimerization, Signal transduction, 030217 neurology & neurosurgery, Chromatography, Liquid, Signal Transduction
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المؤلفون: Luca Santarelli, Eriene A. Youssef, Jorge A. Quiroz, Christian Czech, Paulo Fontoura, Randi J Hagerman, Elizabeth Berry-Kravis, Russell Kinch, Lothar Lindemann, Michael Rabbia, Dennis Deptula, Rachel Langland, Chin Y Wong, Moritz Marcinowski, David R Hessl, Philip Drewitt, Carsten Horn, Amy John
المصدر: Neuropsychopharmacology
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Psychosis, Adolescent, Pyridines, Receptor, Metabotropic Glutamate 5, Placebo-controlled study, Placebo, law.invention, Fragile X Mental Retardation Protein, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, medicine, Humans, RNA, Messenger, Treatment Failure, Adverse effect, Pharmacology, Psychotropic Drugs, Imidazoles, DNA Methylation, Middle Aged, medicine.disease, FMR1, Clinical trial, Fragile X syndrome, Psychiatry and Mental health, 030104 developmental biology, Fragile X Syndrome, Physical therapy, Original Article, Female, Psychology, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery
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المؤلفون: Georg Jaeschke, Urs Niederhauser, Beatrice David, Eric Vieira, Will Spooren, Martin Kuratli, Jens-Uwe Peters, Michael Honer, Wolfgang Guba, Thomas Hartung, Daniel Tännler, Christoph Funk, Nadia Bitter-Stoll, Porter Richard Hugh Phillip, Bernd Büttelmann, Daniel Rueher, Paul Spurr, Jörg Huwyler, Nicole Clemann, Eric Prinssen, Joseph G. Wettstein, Axel Pähler, Simona M. Ceccarelli, Patrick Boissin, Theodor Stoll, Antonio Ricci, Jürgen Wichmann, Ann Petersen, Manfred Schneider, Marianne Rueher, Edilio Borroni, Sabine Kolczewski, Anthony Harrison, Lothar Lindemann
المصدر: Journal of Medicinal Chemistry. 58:1358-1371
مصطلحات موضوعية: Male, medicine.medical_specialty, Pyridines, Receptor, Metabotropic Glutamate 5, Allosteric regulation, Mice, Inbred Strains, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Rats, Wistar, Psychiatry, Receptor, Levodopa-induced dyskinesia, Dose-Response Relationship, Drug, Molecular Structure, Depression, Drug discovery, Metabotropic glutamate receptor 5, Chemistry, Imidazoles, medicine.disease, Macaca mulatta, Rats, Fragile X syndrome, Fragile X Syndrome, Molecular Medicine, Diazepam, medicine.drug
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المؤلفون: Marianne B. Müller, Georg Jaschke, Christoph W. Turck, Alexander S. Häusl, Mathias V. Schmidt, D. Harbich, Gengjing Zhao, Theo Rein, Sara Santarelli, Marcel Schieven, Christiana Labermaier, Joseph G. Wettstein, Nils C. Gassen, Klaus V. Wagner, Xiao-Dong Wang, Bianca Schmid, Jakob Hartmann, Natalie Matosin, Christine Kohl, Lothar Lindemann, Christian Webhofer
المصدر: Europe PubMed Central
مصطلحات موضوعية: Dominance-Subordination, Male, medicine.medical_specialty, Drug Inverse Agonism, Pyridines, Receptor, Metabotropic Glutamate 5, HOMER1, Social defeat, Mice, Homer Scaffolding Proteins, Internal medicine, medicine, Animals, Protein Isoforms, Inverse agonist, Chronic stress, RNA, Messenger, Mice, Knockout, Pharmacology, Social stress, Depressive Disorder, Metabotropic glutamate receptor 5, Imidazoles, Glutamate receptor, Brain, Resilience, Psychological, Mice, Inbred C57BL, Disease Models, Animal, Psychiatry and Mental health, Endocrinology, nervous system, Metabotropic glutamate receptor, Chronic Disease, Original Article, Carrier Proteins, Psychology, Excitatory Amino Acid Antagonists, Neuroscience, Stress, Psychological
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المؤلفون: Lothar Lindemann, Axel Ullrich, Frank O. Fackelmayer, Annette M. Hartmann, Heinrich Jasper, Stefan Stamm, Oliver Nayler, Wolf H. Strätling, Jean-Pierre Bourquin, Igor Stagljar
مصطلحات موضوعية: Chloramphenicol O-Acetyltransferase, Transcription, Genetic, RNA Splicing, RNA polymerase II, Saccharomyces cerevisiae, Biology, Cell Line, Mice, SR protein, Nuclear Matrix-Associated Proteins, Genes, Reporter, Transcription (biology), Gene expression, RNA Precursors, Genetics, Animals, Humans, Phosphorylation, Cell Nucleus, Binding Sites, Serine-Arginine Splicing Factors, fungi, Scaffold attachment factor B, Intron, Nuclear Proteins, Nucleic Acid Hybridization, RNA-Binding Proteins, 3T3 Cells, Matrix Attachment Region Binding Proteins, Phosphoproteins, Molecular biology, Rats, Chromatin, DNA-Binding Proteins, Receptors, Estrogen, RNA splicing, biology.protein, RNA Polymerase II, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0791f8b98efcaf5901bc6b24272990
http://doc.rero.ch/record/298399/files/26-15-3542.pdf -
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مصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Clinical study design, Disease, Pharmacology, Biology, Bioinformatics, medicine.disease, FMR1, Clinical trial, Fragile X syndrome, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Pharmacotherapy, chemistry, medicine, Mavoglurant, Trinucleotide repeat expansion, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::41d11383a7edbfdfb3992183236f7fb0
https://doi.org/10.1016/b978-0-12-804461-2.00018-4
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