المؤلفون: Ronaldson, PT, Bauer, B, El‐Kattan, AF, Shen, H, Salphati, L, Louie, SW

المصدر: Clinical Pharmacology & Therapeutics; Nov2016, Vol. 100 Issue 5, p419-422, 4p

مصطلحات موضوعية: CARRIER proteins, BLOOD-brain barrier, ORGANIC anion transporters, DRUG absorption, DRUGS, TRANSPORTATION

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المؤلفون: Subramanian R; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.) rajus@amgen.com., Zhu X; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Kerr SJ; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Esmay JD; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Louie SW; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Edson KZ; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Walter S; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Fitzsimmons M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Wagner M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Soto M; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Pham R; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Wilson SF; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.)., Skiles GL; Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California (R.S., X.Z, S.J.K., J.D.E., S.W.L., K.Z.E, S.W., M.W., M.S., R.P., S.F.W, G.L.S); and Covance Laboratories, Madison, Wisconsin (M.F.).

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2016 Aug; Vol. 44 (8), pp. 1319-31. Date of Electronic Publication: 2016 Feb 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Calcimimetic Agents/*pharmacokinetics , Peptides/*pharmacokinetics , Receptors, Calcium-Sensing/*agonists, Administration, Intravenous ; Animals ; Biotransformation ; Calcimimetic Agents/administration & dosage ; Calcimimetic Agents/blood ; Calcimimetic Agents/toxicity ; Cytochrome P-450 Enzyme System/metabolism ; Dogs ; Drug Interactions ; Female ; HEK293 Cells ; Humans ; Kidney/metabolism ; Liver/metabolism ; Male ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism ; Molecular Structure ; Peptides/administration & dosage ; Peptides/blood ; Peptides/toxicity ; Protein Binding ; Rats, Inbred BN ; Receptors, Calcium-Sensing/chemistry ; Receptors, Calcium-Sensing/metabolism ; Renal Elimination ; Risk Assessment ; Serum Albumin/metabolism ; Structure-Activity Relationship ; Tissue Distribution ; Transfection

المؤلفون: Bryan MC; Medicinal Chemistry Research Technologies, ‡Molecular Structure and Characterization, and §Pharmacokinetics and Drug Metabolism, Therapeutic Discovery, Amgen Inc. , One Amgen Center Drive, Thousand Oaks, California 91320, United States., Hein CD, Gao H, Xia X, Eastwood H, Bruenner BA, Louie SW, Doherty EM

المصدر: ACS combinatorial science [ACS Comb Sci] 2013 Sep 09; Vol. 15 (9), pp. 503-11. Date of Electronic Publication: 2013 Aug 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101540531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2156-8944 (Electronic) Linking ISSN: 21568944 NLM ISO Abbreviation: ACS Comb Sci Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , High-Throughput Screening Assays* , Molecular Dynamics Simulation*, Cell Membrane Permeability/*drug effects , Piperidines/*pharmacology , Small Molecule Libraries/*pharmacology, ATP Binding Cassette Transporter, Subfamily B/biosynthesis ; ATP Binding Cassette Transporter, Subfamily B/genetics ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; Algorithms ; Animals ; Cell Line ; Cell Membrane Permeability/physiology ; Humans ; Microsomes/chemistry ; Microsomes/metabolism ; Molecular Structure ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Rats ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Solubility ; Swine

المؤلفون: Rzasa RM; Department of Medicinal Chemistry, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. rrzasa@amgen.com, Hu E, Rumfelt S, Chen N, Andrews KL, Chmait S, Falsey JR, Zhong W, Jones AD, Porter A, Louie SW, Zhao X, Treanor JJ, Allen JR

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Dec 15; Vol. 22 (24), pp. 7371-5. Date of Electronic Publication: 2012 Oct 22.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism , Ethers/*metabolism , Ethers/*pharmacology , Phosphodiesterase Inhibitors/*metabolism , Phosphodiesterase Inhibitors/*pharmacology , Phosphoric Diester Hydrolases/*metabolism, Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Ethers/chemical synthesis ; Ethers/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Structure-Activity Relationship

المؤلفون: Cheng Y; Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA. yuanc@amgen.com, Judd TC, Bartberger MD, Brown J, Chen K, Fremeau RT Jr, Hickman D, Hitchcock SA, Jordan B, Li V, Lopez P, Louie SW, Luo Y, Michelsen K, Nixey T, Powers TS, Rattan C, Sickmier EA, St Jean DJ Jr, Wahl RC, Wen PH, Wood S

المصدر: Journal of medicinal chemistry [J Med Chem] 2011 Aug 25; Vol. 54 (16), pp. 5836-57. Date of Electronic Publication: 2011 Jul 29.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*chemical synthesis , Aminoquinolines/*pharmacology , Amyloid Precursor Protein Secretases/*antagonists & inhibitors , Aspartic Acid Endopeptidases/*antagonists & inhibitors, Aminoquinolines/chemistry ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/cerebrospinal fluid ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Biocatalysis/drug effects ; Brain/drug effects ; Brain/metabolism ; Catalytic Domain ; Cell Line ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Male ; Models, Chemical ; Models, Molecular ; Molecular Structure ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship

المؤلفون: Louie SW; Occupational Therapy Department, Tai Po Hospital, Tai Po, Hong Kong. louie stephanie@yahoo.com.hk, Wong SK, Wong CM

المصدر: NeuroRehabilitation [NeuroRehabilitation] 2009; Vol. 25 (2), pp. 129-35.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9113791 Publication Model: Print Cited Medium: Internet ISSN: 1878-6448 (Electronic) Linking ISSN: 10538135 NLM ISO Abbreviation: NeuroRehabilitation Subsets: MEDLINE

مواضيع طبية MeSH: Recovery of Function* , Stroke Rehabilitation*, Survivors/*classification, Adult ; Age Factors ; Aged ; Aged, 80 and over ; Analysis of Variance ; China ; Cluster Analysis ; Databases, Factual ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Neuropsychological Tests ; Rehabilitation Centers ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome

المؤلفون: Booth-Genthe CL; Department of Drug Metabolism, Merck Research Laboratories, West Point, PA 19486, USA. boothgenthe@verizon.net, Louie SW, Carlini EJ, Li B, Leake BF, Eisenhandler R, Hochman JH, Mei Q, Kim RB, Rushmore TH, Yamazaki M

المصدر: Journal of pharmacological and toxicological methods [J Pharmacol Toxicol Methods] 2006 Jul-Aug; Vol. 54 (1), pp. 78-89. Date of Electronic Publication: 2006 Mar 20.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9206091 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1056-8719 (Print) Linking ISSN: 10568719 NLM ISO Abbreviation: J Pharmacol Toxicol Methods Subsets: MEDLINE

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily B/*genetics , ATP Binding Cassette Transporter, Subfamily B/*metabolism , ATP-Binding Cassette Transporters/*genetics , ATP-Binding Cassette Transporters/*metabolism , LLC-PK1 Cells/*metabolism, ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Amino Acid Sequence ; Animals ; Cloning, Molecular ; Humans ; Mice ; Molecular Sequence Data ; Protein Transport/physiology ; Rats ; Rats, Sprague-Dawley ; Species Specificity