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1
المؤلفون: David F. Nakamura, Hing L. Sham, John-Michael Sauer, Dean R. Artis, Lany Ruslim, Ted Yednock, Michael A. Pleiss, Gary Probst, Marc Adler, Minghua Sun, Louis Brogley, Michael S. Dappen, Roy K. Hom, Michel Maillard, Nanhua Yao, Simeon Bowers, Andrei W. Konradi, Jay S. Tung, Raymond A. Ng, Andrea Gailunas, Wes Zmolek, Kevin P. Quinn, Fang Lawrence Y, Varghese John, R. Jeffrey Neitz, Michael P. Bova
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:4674-4679
مصطلحات موضوعية: Models, Molecular, Binding Sites, Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Design, Drug Discovery, Ethylamines, Aspartic Acid Endopeptidases, Molecular Medicine, Structure–activity relationship, Chromane, Amyloid Precursor Protein Secretases, Chromans, Enzyme Inhibitors, Selectivity, Molecular Biology, Cells, Cultured
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2
المؤلفون: Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4789-4794
مصطلحات موضوعية: Cell Membrane Permeability, Stereochemistry, Butanols, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Cns penetration, Structure-Activity Relationship, Acetamides, Drug Discovery, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Cyclohexylamines, Binding Sites, Chemistry, Cellular Assay, Organic Chemistry, Passive permeability, Permeability (electromagnetism), Biophysics, Molecular Medicine, Amyloid Precursor Protein Secretases
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3
المؤلفون: Nanhua Yao, Hing L. Sham, Hu Pan, Zhao Ren, Ted Yednock, Simeon Bowers, Gergely Toth, Louis Brogley, Anh P. Truong, Jing Wu, Martin L. Neitzel, Kevin P. Quinn, Frederique Bard, John-Michael Sauer, Dean R. Artis, Jennifer Sealy, Larry Fang, Kyle Powell, Gary Probst, Irene Griswold-Prenner, R. Jeffrey Neitz, Andrei W. Konradi, Roy K. Hom
المصدر: Bioorganicmedicinal chemistry letters. 20(24)
مصطلحات موضوعية: Stereochemistry, p38 mitogen-activated protein kinases, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Mitogen-Activated Protein Kinase 10, Drug Discovery, Thiophene, Animals, Humans, Mitogen-Activated Protein Kinase 8, Thiazole, Molecular Biology, Protein Kinase Inhibitors, biology, Kinase, Organic Chemistry, JNK Mitogen-Activated Protein Kinases, Thiazoles, chemistry, Mitogen-activated protein kinase, Drug Design, biology.protein, Microsomes, Liver, Quinolines, Molecular Medicine, Selectivity
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4
المؤلفون: Joseph B. Moon, Donna J. Paddock, Louis Brogley, and Sukanto Sinha, Nancy Jewett, Timothy E. Benson, Michael S. Dappen, John A. Tucker, Thomas L. Emmons, Roy K. Hom, Michel Maillard, Alfredo G. Tomasselli, Thorsett Eugene D, Shumeye Mamo, D. Bryan Prince, Varghese John, D. Danielle Woods, Michael J. Bienkowski
المصدر: Journal of medicinal chemistry. 50(4)
مصطلحات موضوعية: Models, Molecular, Peptidomimetic, Isostere, Stereochemistry, medicine.drug_class, Phthalic Acids, Carboxamide, Crystallography, X-Ray, Chemical synthesis, Cell Line, Amyloid beta-Protein Precursor, stomatognathic system, Drug Discovery, Hydrolase, Amyloid precursor protein, medicine, Humans, chemistry.chemical_classification, biology, Molecular Structure, Molecular Mimicry, Stereoisomerism, Enzyme, chemistry, Drug Design, biology.protein, Molecular Medicine, Amine gas treating, Amyloid Precursor Protein Secretases, Peptides
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5دورية أكاديمية
المؤلفون: Michel C. Maillard, Roy K. Hom, Timothy E. Benson, Joseph B. Moon, Shumeye Mamo, Michael Bienkowski, Alfredo G. Tomasselli, Danielle D. Woods, D. Bryan Prince, Donna J. Paddock, Thomas L. Emmons, John A. Tucker, Michael S. Dappen, Louis Brogley, Eugene D. Thorsett, Nancy Jewett, Sukanto Sinha, Varghese John
المصدر: Journal of Medicinal Chemistry; Feb2007, Vol. 50 Issue 4, p776-781, 6p
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6
المؤلفون: Robert Renthal, Louis Brogley, Juan C. Vila
المصدر: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 935:109-114
مصطلحات موضوعية: Halobacterium, Circular dichroism, Light, Protein Conformation, Retinal binding, Biophysics, Borohydrides, Ether, Biochemistry, chemistry.chemical_compound, Halobacteriaceae, Cyanogen Bromide, Chromatography, High Pressure Liquid, Chromatography, biology, Chemistry, Circular Dichroism, Bacteriorhodopsin, Biological membrane, Retinal, Cell Biology, Chromophore, biology.organism_classification, Peptide Fragments, Carbodiimides, Kinetics, Membrane, Dicyclohexylcarbodiimide, Spectrophotometry, Bacteriorhodopsins, biology.protein