المؤلفون: Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein

المصدر: Journal of medicinal chemistry. 63(15)

مصطلحات موضوعية: Drug, Male, Proteases, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Factor XIa, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, Complement Factor D, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, 030304 developmental biology, ADME, media_common, Serine protease, 0303 health sciences, Protease, biology, Chemistry, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Coagulation, biology.protein, Molecular Medicine, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603

المؤلفون: Peter Gedeck, Louise Kirman, Jacob Aaron Klickstein, Lewis Whitehead, Melissa S. Grondine, Patrick McCarren, Susanne Glowienke, Herbert F. Schuster, Gregory Raymond Bebernitz

المصدر: Bioorganic & Medicinal Chemistry. 19:3173-3182

مصطلحات موضوعية: Quantitative structure–activity relationship, In silico, Clinical Biochemistry, Pharmaceutical Science, Hydrocarbons, Aromatic, Models, Biological, Biochemistry, Chemical reaction, Ames test, chemistry.chemical_compound, Computational chemistry, Drug Discovery, Humans, Organic chemistry, Computer Simulation, Amines, Molecular Biology, Drug discovery, Aryl, Organic Chemistry, Synthon, chemistry, Electrophile, Quantum Theory, Molecular Medicine, Mutagens

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517fdfc51e65d539d3e082b27334ca53
https://doi.org/10.1016/j.bmc.2011.03.066

المؤلفون: Siralee Munshi, Shari L. Caplan, Jinsheng Liang, Jiaping Gao, Bethany A Dale, Ramesh Chandra Gupta, Gregory Raymond Bebernitz, Michael Kavana, Brian Edward Vash, Paul Taslimi, Richard Deacon, Louise Kirman, Sunil Sadanand Nadkarni, Melissa S. Grondine, Valerie Beaulieu, Mesut Kakmak, Wieslawa Maniara, Irene St. Denny, Alokesh Duttaroy, Herbert F. Schuster, Travis Stams

المصدر: Journal of Medicinal Chemistry. 52:6142-6152

مصطلحات موضوعية: Blood Glucose, medicine.medical_specialty, Glucose uptake, Type 2 diabetes, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Glucokinase, Drug Discovery, medicine, Animals, Hypoglycemic Agents, Sulfonamides, Glucose tolerance test, medicine.diagnostic_test, Glycogen, Activator (genetics), Glucose Tolerance Test, medicine.disease, medicine.anatomical_structure, Endocrinology, Diabetes Mellitus, Type 2, Liver, chemistry, Hepatocyte, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f42388d9d384fa55ff534be29a734c9
https://doi.org/10.1021/jm900839k

المؤلفون: Nicola Elaine Press, Clive Mccarthy, Ian N. Bruce, Lewis Whitehead, Lilya Sviridenko, Mrinalini Sachin Oza, Gaynor Elizabeth Pilgrim, Darren Le Grand, Charles Owen, Louise Kirman, Graham Charles Bloomfield, Thomas H. Keller, Peter Finan, Judy Hayler, Mohammed Akhlaq, Denise Head, Emma Budd, Julia Hatto, Bernard Cuenoud, Peter Gedeck, Desmond O'Connor, Brian Cox, Catherine Leblanc

المصدر: Bioorganicmedicinal chemistry letters. 22(17)

مصطلحات موضوعية: Gene isoform, Models, Molecular, Cellular activity, Clinical Biochemistry, Pharmaceutical Science, Alpha (ethology), Bioinformatics, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Catalytic Domain, Drug Discovery, Animals, Humans, Protein Isoforms, PI3-Kinase Inhibitors, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Kinase, Chemistry, Organic Chemistry, SUPERFAMILY, Rats, Thiazoles, Molecular Medicine, Female, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e876bd0609cb94ac31c0d54a9c921ed8
https://pubmed.ncbi.nlm.nih.gov/22863202