المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud

المصدر: Journal of Medicinal Chemistry. 63:512-528

مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293

المؤلفون: Youssef El-Ahmad, Laurence Fabien, Luc Bertin, Guillaume Dagousset, Christian Poma, Elsa Anselmi, Bruno Salgues, Victor Certal, Philippe Courtes, Anne-Laure Barthelemy, Emmanuel Magnier

المساهمون: Centre National de la Recherche Scientifique (CNRS), Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.704-712. ⟨10.1021/acs.oprd.9b00403⟩

مصطلحات موضوعية: Trifluoromethyl, Scale (ratio), 010405 organic chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Late stage, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, 3. Good health, chemistry.chemical_compound, chemistry, Group (periodic table), Reagent, Organic chemistry, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Gram

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0b114c3d1037db332e87d0c0a92fed
https://hal.archives-ouvertes.fr/hal-02992781

المؤلفون: Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Pierre-Yves Abecassis, Magali Mathieu, Thomas Bertrand, Tsiala Benard, Cédric Barrière, Samira El Batti, Jean-Philippe Letallec, Véronique Sonnefraud, Maurice Brollo, Laurence Delbarre, Véronique Loyau, Fabienne Pilorge, Luc Bertin, Patrick Richepin, Jérôme Arigon, Jean-Robert Labrosse, Jacques Clément, Florence Durand, Romain Combet, Pierre Perraut, Vincent Leroy, Frédéric Gay, Dominique Lefrançois, François Bretin, Jean-Pierre Marquette, Nadine Michot, Anne Caron, Christelle Castell, Laurent Schio, Gary McCort, Hélène Goulaouic, Carlos Garcia-Echeverria, Baptiste Ronan

المصدر: Journal of Medicinal Chemistry. 58:376-400

مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Molecular Sequence Data, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Neoplasms, Morpholine, Drug Discovery, Animals, Humans, Transferase, Amino Acid Sequence, Enzyme Inhibitors, Trifluoromethyl, Molecular Structure, Sequence Homology, Amino Acid, Drug discovery, Kinase, fungi, Synthon, Bridged Bicyclo Compounds, Heterocyclic, Class III Phosphatidylinositol 3-Kinases, Xenograft Model Antitumor Assays, Protein Structure, Tertiary, Models, Chemical, chemistry, Area Under Curve, Thermodynamics, Molecular Medicine, Caco-2 Cells, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f364d6dcf08b486db73cd403e73d3b1
https://doi.org/10.1021/jm5013352

المؤلفون: Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme

المصدر: Journal of Medicinal Chemistry. 57:903-920

مصطلحات موضوعية: Male, Cell Membrane Permeability, Indoles, Phosphatase, Molecular Conformation, Biological Availability, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Crystallography, X-Ray, Mice, Rats, Nude, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, PTEN Phosphohydrolase, Stereoisomerism, In vitro, Rats, Molecular Docking Simulation, Solubility, chemistry, Structural biology, Biochemistry, Indoline, Microsomes, Liver, biology.protein, Cancer research, Heterografts, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
https://doi.org/10.1021/jm401642q

المؤلفون: Wolfgang Amadeus Mozart

المساهمون: Debora Waldman, Olivia Doray, Joanna Malewski, Marc Scoffoni, Mayuko Yasuda, Luc Bertin-Hugault, Frédéric Longbois, Paris Chamber Orchestra, Orchestre de chambre de Paris

المؤلفون: Christoph Lengauer, Pierre Yves Abecassis, Luc Bertin, Véronique Charrier, Laurent Schio, Jean Christophe Carry, Patrick Richepin, Loic Vincent, Bruno Filoche-Romme, Florence Gruss-Leleu, Houlfa Guizani, Carlos Garcia-Echeverria, Angela Virone-Oddos, Andreas Karlsson, Jean Paul Nicolas, Victor Certal, Fabienne Pilorge, Frank Halley

المصدر: Bioorganicmedicinal chemistry letters. 24(6)

مصطلحات موضوعية: Male, Indoles, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Biochemistry, Permeability, Rats, Sprague-Dawley, chemistry.chemical_compound, Phosphatidylinositol 3-Kinases, Amide, Drug Discovery, Animals, Humans, Protein Isoforms, Thiazole, Molecular Biology, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Binding Sites, Organic Chemistry, Combinatorial chemistry, Amides, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Thiazoles, chemistry, Molecular Medicine, Caco-2 Cells, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a5914bd72703a797db886448147528
https://pubmed.ncbi.nlm.nih.gov/24560540

المؤلفون: Anne Thomas, Alexandre Rohaut, Annick Parent, Norbert Dereu, Luc Bertin, Hélène Goulaouic, Rosalia Arrebola, Patrick Mailliet, Alain Dupuy, Vincent Mikol, Victor Certal, Hervé Minoux, Chantal Carrez, Fabienne Pilorge, François Vallée, Stephane Guerif, Cécile Combeau, Jean-Marie Ruxer, Alain Jouanen, Jacques Dumas, Cécile Delorme, Thierry Gouyon, Paul Ferrari, Annabelle Lamberton, Florence Fassy, Fabienne Thompson, Claudine Grepin

المصدر: Journal of medicinal chemistry. 54(20)

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Pyridines, Stereoisomerism, Antineoplastic Agents, Crystallography, X-Ray, Chemical synthesis, Mice, Structure-Activity Relationship, Adenosine Triphosphate, Heat shock protein, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Animals, Humans, HSP90 Heat-Shock Proteins, Binding site, Virtual screening, Fluorenes, Binding Sites, Leukemia, biology, Chemistry, Imidazoles, Combinatorial chemistry, Hsp90, Chaperone (protein), biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce498d97ec879964cc10e7bb416991f
https://pubmed.ncbi.nlm.nih.gov/21972823

المؤلفون: Bruno Bescheron, Wolfgang Amadeus Mozart, Julie Scobeltzine, Victor Duclos

المساهمون: Kenneth Weiss, Julie Fuchs, Luc Bertin-Hugault, Sandrine Buendia, William Andrieux, Vannina Santoni, Nicolas Certenais, Chiara Skerath, Charlotte Dellion, Anna Reinhold, Students of the Department of Voice Disciplines of the Paris Conservatory, Zhe Chi, Guillaume Andrieux, Orchestre du Conservatoire national supérieur de musique et de danse de Paris, Elèves du Département des disciplines vocales du Conservatoire de Paris

المؤلفون: Leos Janácek, Jonathan Dove, Marie-Frédérique Fillion, Emilie Roy

المساهمون: Gaëlle Arquez, Abdellah Lasri, Yann Molénat, Anna Reinhold, Johanna Brault, Luc Bertin-Hugault, Heng Shi, Véronique Housseau, Natacha Figaro, Irina de Baghy, Orchestre du Conservatoire national supérieur de musique et de danse de Paris, Elèves du Département des disciplines vocales du Conservatoire de Paris

المؤلفون: François Vallée, Chantal Carrez, Fabienne Pilorge, Alain Dupuy, Annick Parent, Luc Bertin, Fabienne Thompson, Paul Ferrari, Florence Fassy, Annabelle Lamberton, Anne Thomas, Rosalia Arrebola, Stéphane Guerif, Alexandre Rohaut, Victor Certal, Jean-Marie Ruxer, Thierry Gouyon, Cécile Delorme, Alain Jouanen, Jacques Dumas, Claudine Grépin, Cécile Combeau, Hélène Goulaouic, Norbert Dereu, Vincent Mikol, Patrick Mailliet, Hervé Minoux

المصدر: Journal of Medicinal Chemistry. 55:564-564

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0a20f6c05a5a5278e6018ba12eb6681
https://doi.org/10.1021/jm201675k