المؤلفون: Sanderson, P. E. J., Lyle, T. A., Cutrona, K. J., Dyer, D. L., Dorsey, B. D., McDonough, C. M., Naylor-Olsen, A. M., Chen, I-W., Chen, Z., Cook, J. J., Cooper, C. M., Gardell, S. J., Hare, T. R., Krueger, J. A., Lewis, S. D., Lin, J. H., Lucas, B. J., Jr., Lyle, E. A., Lynch, J. J., Jr., Stranieri, M. T., Vastag, K., Yan, Y., Shafer, J. A., Vacca, J. P.

المصدر: Journal of Medicinal Chemistry; November 5, 1998, Vol. 41 Issue: 23 p4466-4474, 9p

المؤلفون: Coburn CA; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. craig_coburn@merck.com, Rush DM, Williams PD, Homnick C, Lyle EA, Lewis SD, Lucas BJ Jr, Di Muzio-Mower JM, Juliano M, Krueger JA, Vastag K, Chen IW, Vacca JP

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2000 May 15; Vol. 10 (10), pp. 1069-72.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Acetamides/*chemistry , Acetamides/*pharmacology , Aminopyridines/*chemistry , Aminopyridines/*pharmacology , Anticoagulants/*chemistry , Anticoagulants/*pharmacology , Thrombin/*antagonists & inhibitors, Animals ; Anticoagulants/chemical synthesis ; Biological Availability ; Dipeptides/chemistry ; Dogs ; Drug Design ; Drug Evaluation, Preclinical/methods ; Humans ; Molecular Mimicry ; Pyridones/chemistry ; Pyridones/pharmacology ; Rats ; Structure-Activity Relationship ; Thrombosis/drug therapy

المؤلفون: Sanderson PE; Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA., Cutrona KJ, Dorsey BD, Dyer DL, McDonough CM, Naylor-Olsen AM, Chen IW, Chen Z, Cook JJ, Gardell SJ, Krueger JA, Lewis SD, Lin JH, Lucas BJ Jr, Lyle EA, Lynch JJ Jr, Stranieri MT, Vastag K, Shafer JA, Vacca JP

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1998 Apr 07; Vol. 8 (7), pp. 817-22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anticoagulants/*pharmacology , Pyridones/*pharmacology , Sulfonamides/*pharmacology , Thrombin/*antagonists & inhibitors, Administration, Oral ; Animals ; Anticoagulants/administration & dosage ; Anticoagulants/chemistry ; Biological Availability ; Chlorides ; Crystallography, X-Ray ; Dogs ; Ferric Compounds ; Kinetics ; Macaca fascicularis ; Models, Molecular ; Molecular Structure ; Pyridones/administration & dosage ; Pyridones/chemistry ; Rats ; Structure-Activity Relationship ; Sulfonamides/administration & dosage ; Sulfonamides/chemistry ; Thrombosis/drug therapy ; Trypsin/metabolism