يعرض 1 - 5 نتائج من 5 نتيجة بحث عن '"Lucia Salinaro"', وقت الاستعلام: 0.76s تنقيح النتائج
  1. 1
    Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

    المؤلفون: Bram Herpers, Berina Eppink, Mark I. James, Carme Cortina, Adrià Cañellas-Socias, Sylvia F. Boj, Xavier Hernando-Momblona, Dominik Glodzik, Rob C. Roovers, Marc van de Wetering, Carina Bartelink-Clements, Vanessa Zondag-van der Zande, Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh, Szabolcs Fatrai, David Maussang, Jeroen J. Lammerts van Bueren, Irene Chicote, Garazi Serna, Laia Cabellos, Lorena Ramírez, Paolo Nuciforo, Ramon Salazar, Cristina Santos, Alberto Villanueva, Camille Stephan-Otto Attolini, Elena Sancho, Hector G. Palmer, Josep Tabernero, Michael R. Stratton, John de Kruif, Ton Logtenberg, Hans Clevers, Leo S. Price, Robert G. J. Vries, Eduard Batlle, Mark Throsby

    المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research

    المصدر: Nature cancer, 3(4), 418-436

    مصطلحات موضوعية: Cancer Research, Glandular and Epithelial/metabolism, Drug development, Antibodies, Desenvolupament de medicaments, Receptors, G-Protein-Coupled, Neoplastic Stem Cells/metabolism, Càncer colorectal, Neoplasms, Antibodies, Bispecific, Receptors, Humans, Neoplasms, Glandular and Epithelial, Antibodies, Bispecific/pharmacology, G-Protein-Coupled/metabolism, ErbB Receptors/metabolism, Imidazoles, Receptors, G-Protein-Coupled/metabolism, Colorectal cancer, ErbB Receptors, Organoids, Oncology, Neoplasms, Glandular and Epithelial/metabolism, Pyrazines, Neoplastic Stem Cells, Bispecific/pharmacology

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6787d32a1a24821ce4603c0851f3e6
    https://pure.knaw.nl/portal/en/publications/06b7bea9-adb4-44dc-9013-631489b16e6a

    Find this article in full text from Springer Verlag.
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  2. 2
    Abstract 5562: A 3D image-based quantification of T cell-mediated killing of CRC organoids in the presence of immuno-modulators

    المؤلفون: Kuan Yan, Gera Goverse, Leo S. Price, Lidia Daszkiewicz, Mohamed Tleis, Mariusz Madej, Lucia Salinaro

    المصدر: Cancer Research. 78:5562-5562

    مصطلحات موضوعية: Cancer Research, Cell type, business.industry, medicine.medical_treatment, T cell, Cell, Immunotherapy, Peripheral blood mononuclear cell, medicine.anatomical_structure, Immune system, Oncology, Cancer immunotherapy, Cell culture, medicine, Cancer research, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::80af2fe1256db85feca1201d810274f8
    https://doi.org/10.1158/1538-7445.am2018-5562

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  3. 3
    A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

    المؤلفون: Bram Herpers, B. Ebbink, M.D. van de Wetering, Mark Throsby, Rob Roovers, Kuan Yan, W. De Lau, Leo S. Price, Hans Clevers, Robert R G Vries, Lucia Salinaro

    المصدر: European Journal of Cancer. 61:S130-S131

    مصطلحات موضوعية: Cancer Research, Specific antibody, Pathology, medicine.medical_specialty, Oncology, Colon carcinoma, 3d image, business.industry, Phenotypic screening, Organoid, Medicine, Stem cell, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::169a8b93a898e798c3695e5a525ac859
    https://doi.org/10.1016/s0959-8049(16)61462-4

    View record from ScienceDirect Full Text via ClinicalKey
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  4. 4
    Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids

    المؤلفون: Lex Bakker, Ingrid Kolfschoten, Robert P. de Vries, Marc van de Wetering, David Andre Baptiste Maussang-Detaille, Hans Clevers, Robert Doornbos, Lucia Salinaro, Leo S. Price, Mark Throsby, Carme Cortina, Mark James, Rob Roovers, Kuan Yan, Sylvia Boy, John de Kruif, Berina Eppink, Bram Herpers, Wim de Lau, Eduard Batlle

    المصدر: Cancer Research. 77:32-32

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, Cetuximab, Colorectal cancer, business.industry, LGR5, Wnt signaling pathway, medicine.disease_cause, medicine.disease, Molecular biology, 03 medical and health sciences, 0302 clinical medicine, Oncology, In vivo, medicine, Organoid, KRAS, business, 030215 immunology, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a0489206cfa657f3f0b4e95b882eb4
    https://doi.org/10.1158/1538-7445.am2017-32

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  5. 5
    Abstract PR05: A 3D image-based phenotypic screen of bi-specific antibodies targeting stem cells in a panel of patient derived colon carcinoma organoids

    المؤلفون: Berina Eppink, Bram Herpers, Rob Roovers, Robert P. de Vries, Wim de Lau, Lucia Salinaro, Mark Throsby, Leo S. Price, Marc van de Wetering, Hans Clevers, Kuan Yan

    المصدر: Clinical Cancer Research. 22:PR05-PR05

    مصطلحات موضوعية: Cancer Research, Pathology, medicine.medical_specialty, Colorectal cancer, Phenotypic screening, LGR5, Cancer, Biology, medicine.disease, Phenotype, Oncology, High-content screening, medicine, Organoid, Cancer research, Stem cell

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::797636dac5858f93e3262007e00d983a
    https://doi.org/10.1158/1557-3265.pdx16-pr05

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