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المؤلفون: Andrea Armirotti, Debora Russo, Andrea Nuzzi, Paolo Di Fruscia, Daniela Pizzirani, Chiara Pagliuca, Giovanni Bottegoni, Annalisa Fiasella, Ilaria Penna, Jose Antonio Ortega, Elisa Romeo, Francesca Giacomina, Sine Mandrup Bertozzi, Angelo Reggiani, Maria Summa, Anna Carbone, Roberta Giampà, Rosalia Bertorelli, Francesco Berti, Tiziano Bandiera, Luisa Mengatto, Stefano Ponzano, Glauco Tarozzo, Fabio Bertozzi
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, Stereochemistry, Anti-Inflammatory Agents, Peptides and proteins, Pyrazole, Article, Amidohydrolases, Amidase, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, N-Acylethanolamine, Drug Discovery, medicine, Animals, Humans, Sulfones, Enzyme Inhibitors, IC50, Inhibition, Inflammation, chemistry.chemical_classification, Palmitoylethanolamide, Molecular Structure, Inhibitors, Sulfonamide, Mice, Inbred C57BL, Molecular Docking Simulation, Mechanism of action, chemistry, Microsomes, Liver, Inhibitors,Inhibition,Sulfones,Peptides and proteins,Inflammation, Pyrazoles, Molecular Medicine, medicine.symptom, Protein Binding, Tropanes
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المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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المؤلفون: Valeria Capurro, Luisa Mengatto, Giorgio Tarzia, Andrea Armirotti, Angelo Reggiani, Guillermo Moreno-Sanz, Silvia Pontis, Elisa Romeo, Valerio Chiurchiù, Fabio Bertozzi, Daniele Piomelli, Alison Ribeiro, Mauro Maccarrone, Tiziano Bandiera, Marco Mor, Andrea Nuzzi, Annalisa Fiasella
المصدر: Ribeiro, A; Pontis, S; Mengatto, L; Armirotti, A; Chiurchiù, V; Capurro, V; et al.(2015). A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. ACS Chemical Biology, 10(8), 1838-1846. doi: 10.1021/acschembio.5b00114. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/53h085tr
مصطلحات موضوعية: Male, Anti-Inflammatory Agents, Inflammation, Biology, beta-Lactams, Biochemistry, Article, Amidohydrolases, Amidase, chemistry.chemical_compound, Oleoylethanolamide, Hydrolase, medicine, Animals, Humans, Enzyme Inhibitors, Receptor, chemistry.chemical_classification, Palmitoylethanolamide, Macrophages, General Medicine, Macrophage Activation, Mice, Inbred C57BL, Enzyme, chemistry, Molecular Medicine, medicine.symptom, Cysteine
وصف الملف: application/pdf
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المؤلفون: Tiziano Bandiera, Stefano Ponzano, Luisa Mengatto, Gianpiero Garau, Mauro Dionisi, Fabio Bertozzi, Claudia Karacsonyi, Daniele Piomelli, Glauco Tarozzo, Giorgio Tarzia, Elisa Romeo, Andrea Armirotti, Marco Mor, Angelo Reggiani
المصدر: Armirotti, A; Romeo, E; Ponzano, S; Mengatto, L; Dionisi, M; Karacsonyi, C; et al.(2012). β-Lactones inhibit N-acylethanolamine acid amidase by S-acylation of the catalytic N-terminal cysteine. ACS Medicinal Chemistry Letters, 3(5), 422-426. doi: 10.1021/ml300056y. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7c8692qz
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Stereochemistry, Organic Chemistry, S-acylation, Thioester, Biochemistry, Catalysis, Amidase, N-acylethanolamine acid amidase, Enzyme, Nucleophile, Drug Discovery, Organic chemistry, Cysteine
وصف الملف: application/pdf
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المؤلفون: Mauro Dionisi, Luisa Mengatto, Claudio Fiorelli, Glauco Tarozzo, Tiziano Bandiera, Andrea Cavalli, Daniele Piomelli, Stefano Ponzano, Marco Mor, Andrea Armirotti, Giorgio Tarzia, Fabio Bertozzi, Andrea Duranti, Anna Berteotti, Elisa Romeo, Angelo Reggiani
المساهمون: Stefano Ponzano, Fabio Bertozzi, Luisa Mengatto, Mauro Dionisi, Andrea Armirotti, Elisa Romeo, Anna Berteotti, Claudio Fiorelli, Glauco Tarozzo, Angelo Reggiani, Andrea Duranti, Giorgio Tarzia, Marco Mor, Andrea Cavalli, Daniele Piomelli, Tiziano Bandiera
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Stereochemistry, Amidase, Amidohydrolases, chemistry.chemical_compound, Oleoylethanolamide, Structure-Activity Relationship, INFLAMMATION, Tandem Mass Spectrometry, Drug Discovery, Hydrolase, Spectroscopy, Fourier Transform Infrared, Structure–activity relationship, Enzyme Inhibitors, IC50, DNA Primers, Palmitoylethanolamide, Base Sequence, PAIN, Peroxisome, chemistry, Biochemistry, Molecular Medicine, Carbamates, Cysteine
وصف الملف: STAMPA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780f434002621d5a8e8e158e9dd365b5
http://hdl.handle.net/11585/233075 -
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المؤلفون: Luisa Mengatto, Maria Summa, Chiara Pagliuca, Inga Bauer, Daniela Pizzirani, Anders Bach, Stefania Girotto, Alison Ribeiro, Daniele Piomelli, Andrea Armirotti, Natalia Realini, Marco De Vivo
المصدر: Angewandte Chemie International Edition.
مصطلحات موضوعية: Acid Ceramidase, Ceramide, chemistry.chemical_compound, Enzyme inhibition, chemistry, Biochemistry, Stereochemistry, INT, Cover (algebra), General Chemistry, Sphingosine-1-phosphate, Catalysis, Intracellular
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المؤلفون: Luisa Mengatto, Andrea Cavalli, Anna Berteotti, Romina Vitale, Stefano Ponzano, Tiziano Bandiera, Fabio Bertozzi, Giovanni Bottegoni, Rita Petracca, Daniele Piomelli
المساهمون: Ponzano S, Berteotti A, Petracca R, Vitale R, Mengatto L, Bandiera T, Cavalli A, Piomelli D, Bertozzi F, Bottegoni G
المصدر: Ponzano, S; Berteotti, A; Petracca, R; Vitale, R; Mengatto, L; Bandiera, T; et al.(2014). Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of Medicinal Chemistry, 57(23), 10101-10111. doi: 10.1021/jm501455s. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4058m5gd
مصطلحات موضوعية: Models, Molecular, Quantitative structure–activity relationship, Stereochemistry, Chemistry, Drug discovery, Quantitative Structure-Activity Relationship, Esters, Amidase, Amidohydrolases, N-acylethanolamine acid amidase, chemistry.chemical_compound, Structure-Activity Relationship, Non-competitive inhibition, Carbamic acid, INFLAMMATION, Drug Discovery, Side chain, Molecular Medicine, Structure–activity relationship, Animals, Humans, Carbamates, Enzyme Inhibitors
وصف الملف: application/pdf; STAMPA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7172cc376699c5581178da5c0d22925a
https://hdl.handle.net/11576/2688382 -
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المؤلفون: Andrea Duranti, Luisa Mengatto, Marco Mor, Rosalia Bertorelli, Daniele Piomelli, Mauro Dionisi, Angelo Reggiani, Natalia Realini, Glauco Tarozzo, Guillermo Moreno-Sanz, Giorgio Tarzia, Oscar Sasso, Cataldo Martucci
المصدر: Sasso, O; Moreno-Sanz, G; Martucci, C; Realini, N; Dionisi, M; Mengatto, L; et al.(2013). Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain, 154(3), 350-360. doi: 10.1016/j.pain.2012.10.018. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0z4287q8
مصطلحات موضوعية: Male, Ultraviolet Rays, Recombinant Fusion Proteins, Drug Evaluation, Preclinical, Oleic Acids, Palmitic Acids, Pharmacology, Carrageenan, Article, Amidohydrolases, Proinflammatory cytokine, Mice, Oleoylethanolamide, chemistry.chemical_compound, Ethers, Cyclic, In vivo, medicine, Animals, Humans, PPAR alpha, Enzyme Inhibitors, Radiation Injuries, Mice, Knockout, Analgesics, Palmitoylethanolamide, Dose-Response Relationship, Drug, Chemistry, Pain Perception, Amides, Sciatic Nerve, Endocannabinoid system, Rats, Mice, Inbred C57BL, HEK293 Cells, Anesthesiology and Pain Medicine, Allodynia, Neurology, Biochemistry, Ethanolamines, Hyperalgesia, Tetradecanoylphorbol Acetate, Carbamates, Neurology (clinical), Sciatic nerve, medicine.symptom, Burns, Lysosomes, Endocannabinoids
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b75f0aa52e58372d0bd36d11d07c42b
https://hdl.handle.net/11576/2535261 -
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المؤلفون: Marco De Vivo, Natalia Realini, Daniele Piomelli, Stefania Girotto, Inga Bauer, Andrea Armirotti, Luisa Mengatto, Anders Bach, Chiara Pagliuca, Alison Ribeiro, Maria Summa, Daniela Pizzirani
المصدر: Angewandte Chemie. 127:374-374
مصطلحات موضوعية: Acid Ceramidase, Biochemistry, Chemistry, General Medicine, Intracellular
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