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1Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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2
المؤلفون: Sachin Maniar, Anlai Wang, James Pribish, Shih-Min A. Huang, Andrew Hebert, Mikhail Levit, Jinyu Liu, Claude Barberis, Luke Fire, Elina Tserlin, Paul Erdman, Vinod F. Patel, Mark Czekaj, Joseph D. Batchelor, Frank Sun
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127625
مصطلحات موضوعية: Indoles, Pyrrolidines, Clinical Biochemistry, hERG, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Piperidines, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Tumor growth, Protein Kinase Inhibitors, Molecular Biology, PK/PD models, Aza Compounds, biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Permeability (electromagnetism), biology.protein, Cancer research, Molecular Medicine, Tumor growth inhibition, Protein Binding