المؤلفون: Down K; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Amour A; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Baldwin IR; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Cooper AW; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Deakin AM; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Felton LM; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Guntrip SB; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Hardy C; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Harrison ZA; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Jones KL; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Jones P; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Keeling SE; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Le J; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Livia S; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Lucas F; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Lunniss CJ; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Parr NJ; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Robinson E; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Rowland P; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Smith S; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Thomas DA; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Vitulli G; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Washio Y; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K., Hamblin JN; Refractory Respiratory Inflammation DPU, and ‡Allergic Inflammation DPU, Respiratory Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Molecular Discovery Research, ∥Biological Sciences, and ⊥Computational Chemistry, Platform Technology & Science, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.; Experimental Medicine Unit, and ∇Epinova DPU, ImmunoInflammation Therapeutic Area, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

المصدر: Journal of medicinal chemistry [J Med Chem] 2015 Sep 24; Vol. 58 (18), pp. 7381-99. Date of Electronic Publication: 2015 Sep 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphoinositide-3 Kinase Inhibitors*, Indazoles/*chemistry , Oxazoles/*chemistry , Respiratory Tract Diseases/*drug therapy , Sulfonamides/*chemistry, Administration, Inhalation ; Animals ; Asthma/drug therapy ; Female ; Humans ; Indazoles/pharmacokinetics ; Indazoles/pharmacology ; Indoles ; Isoenzymes/antagonists & inhibitors ; Male ; Microsomes/metabolism ; Molecular Docking Simulation ; Ovalbumin/immunology ; Oxazoles/pharmacokinetics ; Oxazoles/pharmacology ; Piperazines ; Pneumonia/drug therapy ; Pneumonia/immunology ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Stereoisomerism ; Structure-Activity Relationship ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Th2 Cells/immunology

المؤلفون: Palmer JT; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia. Electronic address: j.palmer@biota.com.au., Axford LC; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Barker S; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Bennett JM; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Blair M; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Collins I; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Davies DT; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Ford L; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Gannon CT; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Lancett P; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Logan A; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Lunniss CJ; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Morton CJ; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Offermann DA; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Pitt GR; Biota Scientific Management, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia., Rao BN; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Singh AK; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Shukla T; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Srivastava A; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Stokes NR; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Thomaides-Brears HB; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom., Yadav A; Jubliant Chemsys Ltd, B-34, Sector 58, Noida 201301, India., Haydon DJ; Biota Europe Ltd, Begbroke Science Park, Begbroke, Oxfordshire OX51PF, United Kingdom.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Sep 01; Vol. 24 (17), pp. 4215-22. Date of Electronic Publication: 2014 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Benzothiazoles/*chemistry , Benzothiazoles/*pharmacology , DNA, Bacterial/*chemistry , DNA, Bacterial/*drug effects , DNA, Superhelical/*drug effects , Haemophilus influenzae/*drug effects, Alcohols/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Benzothiazoles/chemical synthesis ; Dose-Response Relationship, Drug ; Drug Discovery ; Microbial Sensitivity Tests ; Molecular Structure ; Staphylococcus ; Structure-Activity Relationship

المؤلفون: Axford LC; Biota Holdings Ltd, 10/585 Blackburn Road, Notting Hill, Victoria 3168, Australia. Electronic address: l.offermann@biota.com.au., Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Dec 15; Vol. 23 (24), pp. 6598-603. Date of Electronic Publication: 2013 Nov 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Benzothiazoles/*chemistry , Benzothiazoles/*pharmacology , DNA Topoisomerase IV/*antagonists & inhibitors , Isonipecotic Acids/*chemistry , Topoisomerase II Inhibitors/*chemical synthesis , Topoisomerase II Inhibitors/*pharmacology, Animals ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacokinetics ; Anti-Bacterial Agents/pharmacology ; Benzothiazoles/chemical synthesis ; DNA Gyrase/chemistry ; DNA Gyrase/metabolism ; DNA Topoisomerase IV/metabolism ; Enterococcus faecalis/drug effects ; Enterococcus faecalis/enzymology ; Enzyme Activation/drug effects ; Haemophilus influenzae/drug effects ; Haemophilus influenzae/enzymology ; Half-Life ; Mice ; Microbial Sensitivity Tests ; Rats ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/enzymology ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/enzymology ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacokinetics

المؤلفون: Stokes NR; Biota Europe Ltd., Begbroke, Oxfordshire, United Kingdom., Thomaides-Brears HB, Barker S, Bennett JM, Berry J, Collins I, Czaplewski LG, Gamble V, Lancett P, Logan A, Lunniss CJ, Peasley H, Pommier S, Price D, Smee C, Haydon DJ

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Dec; Vol. 57 (12), pp. 5977-86. Date of Electronic Publication: 2013 Sep 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacterial Proteins/*antagonists & inhibitors , Benzothiazoles/*pharmacology , DNA Topoisomerase IV/*antagonists & inhibitors , DNA Topoisomerases, Type II/*metabolism , Gram-Negative Bacteria/*drug effects , Gram-Positive Bacteria/*drug effects , Topoisomerase Inhibitors/*pharmacology , Urea/*analogs & derivatives, Adenosine Triphosphatases/antagonists & inhibitors ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacokinetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Benzothiazoles/chemistry ; Benzothiazoles/pharmacokinetics ; Cell Survival/drug effects ; DNA Topoisomerase IV/genetics ; DNA Topoisomerase IV/metabolism ; DNA Topoisomerases, Type II/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Gram-Negative Bacteria/enzymology ; Gram-Negative Bacteria/growth & development ; Gram-Positive Bacteria/enzymology ; Gram-Positive Bacteria/growth & development ; Hep G2 Cells ; Humans ; Interleukin-33 ; Interleukins ; Levofloxacin/pharmacology ; Male ; Microbial Sensitivity Tests ; Novobiocin/pharmacology ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Topoisomerase Inhibitors/chemistry ; Topoisomerase Inhibitors/pharmacokinetics ; Urea/chemistry ; Urea/pharmacokinetics ; Urea/pharmacology

المؤلفون: Lunniss CJ; GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, England., Cooper AW, Eldred CD, Kranz M, Lindvall M, Lucas FS, Neu M, Preston AG, Ranshaw LE, Redgrave AJ, Ed Robinson J, Shipley TJ, Solanke YE, Somers DO, Wiseman JO

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Mar 01; Vol. 19 (5), pp. 1380-5. Date of Electronic Publication: 2009 Jan 19.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Phosphodiesterase 4 Inhibitors*, Phosphodiesterase Inhibitors/*administration & dosage , Phosphodiesterase Inhibitors/*chemistry , Quinolines/*administration & dosage , Quinolines/*chemistry, Administration, Oral ; Animals ; Cattle ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Humans ; Male ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship