المؤلفون: Alvarez Calderon F; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA.; Harvard Medical School, Boston, MA., Kang BH; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA., Kyrysyuk O; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Zheng S; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Wang H; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Mathewson ND; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Ning X; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA., Pyrdol J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA., Cao X; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Suvà ML; Department of Pathology and Center for Cancer Research, Massachusetts General Hospital, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Yuan GC; Department of Genetics and Genomic Sciences, Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY., Wittrup KD; Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.; Harvard Medical School, Boston, MA.; Department of Immunology, Harvard Medical School, Boston, MA.; Department of Neurology, Brigham and Women's Hospital, Boston, MA.

المصدر: Blood [Blood] 2024 Mar 21; Vol. 143 (12), pp. 1124-1138.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Hematologic Neoplasms*/genetics , Hematologic Neoplasms*/therapy , Neoplasms*, Animals ; Mice ; Humans ; CD4-Positive T-Lymphocytes ; Immunity, Cellular ; CD8-Positive T-Lymphocytes ; Antibodies, Monoclonal/pharmacology ; Antibodies, Monoclonal/therapeutic use ; NK Cell Lectin-Like Receptor Subfamily B/genetics

المؤلفون: Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Suo S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Guangzhou Laboratory, Guangzhou, Guangdong 510005, China. Electronic address: suo_shengbao@gzlab.ac.cn., Wang Y; TScan Therapeutics, Waltham, MA 02451, USA., Gunasti L; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Nabilsi N; TScan Therapeutics, Waltham, MA 02451, USA., Tadros J; TScan Therapeutics, Waltham, MA 02451, USA., Ferretti AP; TScan Therapeutics, Waltham, MA 02451, USA., Liao S; TScan Therapeutics, Waltham, MA 02451, USA., Gurer C; TScan Therapeutics, Waltham, MA 02451, USA., Chen YH; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Criscitiello S; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Ricker CA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Dionne D; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Uppaluri R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Haddad RI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ashenberg O; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Regev A; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute and Koch Institute of Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Van Allen EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., MacBeath G; TScan Therapeutics, Waltham, MA 02451, USA., Schoenfeld JD; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: jonathan_schoenfeld@dfci.harvard.edu., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.

المصدر: Cell [Cell] 2022 Aug 04; Vol. 185 (16), pp. 2918-2935.e29. Date of Electronic Publication: 2022 Jul 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/therapy , Programmed Cell Death 1 Receptor*, CD8-Positive T-Lymphocytes ; Humans ; Immunotherapy ; Lymphocytes, Tumor-Infiltrating ; Neoadjuvant Therapy ; Tumor Microenvironment

المؤلفون: Biermann J; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Program for Mathematical Genomics, Columbia University, New York, NY 10032, USA., Melms JC; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Amin AD; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Wang Y; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Program for Mathematical Genomics, Columbia University, New York, NY 10032, USA., Caprio LA; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Karz A; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Tagore S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA., Barrera I; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Ibarra-Arellano MA; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, 69120 Heidelberg, Germany., Andreatta M; Department of Oncology UNIL CHUV, Lausanne Branch, Ludwig Institute for Cancer Research Lausanne, CHUV and University of Lausanne, Lausanne, 1066 Épalinges, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Fullerton BT; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Gretarsson KH; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA., Sahu V; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA., Mangipudy VS; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA., Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA., Nair A; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Rogava M; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Ho P; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Koch PD; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Banu M; Department of Neurological Surgery, New York Presbyterian/Columbia University Irving Medical Center, New York, NY 10032, USA., Humala N; Department of Neurological Surgery, New York Presbyterian/Columbia University Irving Medical Center, New York, NY 10032, USA., Mahajan A; Department of Neurological Surgery, New York Presbyterian/Columbia University Irving Medical Center, New York, NY 10032, USA., Walsh ZH; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Shah SB; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Vaccaro DH; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Caldwell B; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Mu M; Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Wünnemann F; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, 69120 Heidelberg, Germany., Chazotte M; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, 69120 Heidelberg, Germany., Berhe S; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Center, Boston, MA 02215, USA., Driver J; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Ingham M; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Khan SA; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Rapisuwon S; Division of Hematology/Oncology, Medstar Washington Cancer Institute, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA., Slingluff CL Jr; Department of Surgery, University of Virginia, Charlottesville, VA, USA., Eigentler T; Department of Dermatology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany; Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, 10117, Berlin, Germany., Röcken M; Department of Dermatology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany., Carvajal R; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Atkins MB; Georgetown-Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA., Davies MA; Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA., Agustinus A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Graduate School, New York, NY 10065, USA., Bakhoum SF; Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Azizi E; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA; Irving Institute for Cancer Dynamics, Columbia University, New York, NY 10027, USA., Siegelin M; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA., Lu C; Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA., Carmona SJ; Department of Oncology UNIL CHUV, Lausanne Branch, Ludwig Institute for Cancer Research Lausanne, CHUV and University of Lausanne, Lausanne, 1066 Épalinges, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland., Hibshoosh H; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA., Ribas A; Department of Medicine, Jonsson Comprehensive Cancer Center, University of California, Los Angeles (UCLA), Los Angeles, CA 90024, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA., Bruce JN; Department of Neurological Surgery, New York Presbyterian/Columbia University Irving Medical Center, New York, NY 10032, USA., Bi WL; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Agrawal P; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA., Schapiro D; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, 69120 Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Hernando E; Department of Pathology, NYU Grossman School of Medicine, New York, NY 10016, USA., Macosko EZ; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA., Chen F; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Schwartz GK; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Izar B; Department of Medicine, Division of Hematology/Oncology, and Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Program for Mathematical Genomics, Columbia University, New York, NY 10032, USA; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address: bi2175@cumc.columbia.edu.

المصدر: Cell [Cell] 2022 Jul 07; Vol. 185 (14), pp. 2591-2608.e30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms*/drug therapy , Brain Neoplasms*/secondary , Melanoma*, CD8-Positive T-Lymphocytes/pathology ; Ecosystem ; Humans ; RNA-Seq

المؤلفون: Qiu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Boufaied N; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada., Hallal T; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada., Feit A; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., de Polo A; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.; Division of Urology, Department of Surgery, McGill University, Montréal, QC, Canada., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Alahmadi W; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, QC, Canada., Larocque J; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, QC, Canada., Zadra G; Departments of Oncologic Pathology and Pathology, Dana-Farber Cancer Institute and Brigham's Women Hospital, Boston, MA, USA.; Institute of Molecular Genetics, National Research Council, Pavia, Italy., Xie Y; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Gu S; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Tang Q; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Zhang Y; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Syamala S; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Bell C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., O'Connor E; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Liu Y; Decipher Biosciences, San Diego, CA, USA., Schaeffer EM; Department of Urology, Northwestern University, Chicago, IL, USA., Jeffrey Karnes R; Department of Urology, Mayo Clinic, Rochester, MN, USA., Weinmann S; Center for Health Research, Kaiser Permanente Northwest, Portland, OR, USA., Davicioni E; Decipher Biosciences, San Diego, CA, USA., Morrissey C; Department of Urology, University of Washington, Seattle, WA, USA., Cejas P; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Ellis L; Division of Medical Oncology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Loda M; Department of Pathology and Laboratory Medicine, Weil Cornell Medicine, New York Presbyterian-Weill Cornell Campus, New York, NY, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Pomerantz MM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Spratt DE; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Corey E; Department of Urology, University of Washington, Seattle, WA, USA., Freedman ML; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA., Shirley Liu X; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Brown M; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Long HW; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. henry_long@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. henry_long@dfci.harvard.edu., Labbé DP; Cancer Research Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada. david.labbe@mcgill.ca.; Department of Anatomy and Cell Biology, McGill University, Montréal, QC, Canada. david.labbe@mcgill.ca.; Division of Urology, Department of Surgery, McGill University, Montréal, QC, Canada. david.labbe@mcgill.ca.; Division of Experimental Medicine, Department of Medicine, McGill University, Montréal, QC, Canada. david.labbe@mcgill.ca.

المصدر: Nature communications [Nat Commun] 2022 May 13; Vol. 13 (1), pp. 2559. Date of Electronic Publication: 2022 May 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms*/pathology , Receptors, Androgen*/genetics , Receptors, Androgen*/metabolism, Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic ; Genes, myc ; Humans ; Male ; Prostate/pathology ; Proto-Oncogene Proteins c-myc

المؤلفون: Melms JC; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Biermann J; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Huang H; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Wang Y; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Nair A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Tagore S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Katsyv I; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Rendeiro AF; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Amin AD; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Schapiro D; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Frangieh CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Center, Boston, MA, USA., Filliol A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Fang Y; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Ravichandran H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Clausi MG; Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY, USA., Alba GA; Department of Medicine, Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, USA., Rogava M; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Chen SW; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ho P; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Montoro DT; Cell Circuits, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Biology, Harvard Medical School, Boston, MA, USA., Kornberg AE; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Han AS; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Bakhoum MF; Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA., Anandasabapathy N; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Dermatology, Weill Cornell Medical College, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA., Suárez-Fariñas M; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bakhoum SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Borczuk A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Guo XV; Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY, USA., Lefkowitch JH; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Marboe C; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Lagana SM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Del Portillo A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Tsai EJ; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Zorn E; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Markowitz GS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Schwabe RF; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Institute of Human Nutrition, Columbia University, New York, NY, USA., Schwartz RE; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Elemento O; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Saqi A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Hibshoosh H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Que J; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu., Izar B; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Program for Mathematical Genomics, Columbia University, New York, NY, USA. bi2175@cumc.columbia.edu.

المصدر: Nature [Nature] 2021 Oct; Vol. 598 (7882), pp. E2.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Melms JC; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Biermann J; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Huang H; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Wang Y; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Nair A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Tagore S; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA., Katsyv I; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Rendeiro AF; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Amin AD; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Schapiro D; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Frangieh CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Center, Boston, MA, USA., Filliol A; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Fang Y; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Ravichandran H; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Clausi MG; Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY, USA., Alba GA; Department of Medicine, Division of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, MA, USA., Rogava M; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Chen SW; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ho P; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Montoro DT; Cell Circuits, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Systems Biology, Harvard Medical School, Boston, MA, USA., Kornberg AE; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Han AS; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Bakhoum MF; Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA., Anandasabapathy N; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Dermatology, Weill Cornell Medical College, New York, NY, USA.; Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA., Suárez-Fariñas M; Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Bakhoum SF; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bram Y; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Borczuk A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Guo XV; Human Immune Monitoring Core, Columbia University Irving Medical Center, New York, NY, USA., Lefkowitch JH; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Marboe C; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Lagana SM; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Del Portillo A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Tsai EJ; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Zorn E; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA., Markowitz GS; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Schwabe RF; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Institute of Human Nutrition, Columbia University, New York, NY, USA., Schwartz RE; Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Elemento O; Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA., Saqi A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Hibshoosh H; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Que J; Columbia Center for Human Development, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. jq2240@cumc.columbia.edu., Izar B; Department of Medicine, Division of Hematology/Oncology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Columbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Program for Mathematical Genomics, Columbia University, New York, NY, USA. bi2175@cumc.columbia.edu.

المصدر: Nature [Nature] 2021 Jul; Vol. 595 (7865), pp. 114-119. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Single-Cell Analysis*, COVID-19/*pathology , COVID-19/*virology , Lung/*pathology , SARS-CoV-2/*pathogenicity, Aged ; Aged, 80 and over ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Atlases as Topic ; Autopsy ; COVID-19/immunology ; Case-Control Studies ; Female ; Fibroblasts/pathology ; Fibrosis/pathology ; Fibrosis/virology ; Humans ; Inflammation/pathology ; Inflammation/virology ; Macrophages/pathology ; Macrophages/virology ; Macrophages, Alveolar/pathology ; Macrophages, Alveolar/virology ; Male ; Middle Aged ; Plasma Cells/immunology ; T-Lymphocytes/immunology

المؤلفون: Mallis RJ; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Department of Dermatology, Harvard Medical School, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Duke-Cohan JS; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Das DK; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Akitsu A; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Luoma AM; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Banik D; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Stephens HM; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Tetteh PW; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Castro CD; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Krahnke S; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637., Hussey RE; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115., Lawney B; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115., Brazin KN; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115., Reche PA; Department of Immunology, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain., Hwang W; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843.; Department of Physics and Astronomy, Texas A&M University, College Station, TX 77843.; School of Computational Sciences, Korea Institute for Advanced Study, 02455 Seoul, Korea., Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu., Lang MJ; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37235., Reinherz EL; Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, MA 02115; hwm@tamu.edu ejadams@uchicago.edu matt.lang@vanderbilt.edu ellis_reinherz@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.; Department of Medicine, Harvard Medical School, Boston, MA 02115.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jun 29; Vol. 118 (26).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Mechanotransduction, Cellular*, Receptors, Antigen, T-Cell, gamma-delta/*chemistry , Receptors, Antigen, T-Cell, gamma-delta/*metabolism, Amino Acid Sequence ; Animals ; Gene Expression Profiling ; Humans ; Ligands ; Mice ; Protein Domains ; Protein Stability ; Protein Structure, Secondary ; Receptors, Antigen, T-Cell, alpha-beta/chemistry ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Signal Transduction ; Single Molecule Imaging ; T-Lymphocytes/metabolism ; Thymocytes/metabolism ; Thymus Gland/metabolism ; Transcriptome/genetics

المؤلفون: Roehle K; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Qiang L; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Ventre KS; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Heid D; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Ali LR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Lenehan P; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Heckler M; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Crowley SJ; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Stump CT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Ro G; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Godicelj A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Bhuiyan AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Yang A; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Quiles Del Rey M; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Biary T; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Bruck PT; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tegethoff JF; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Nopper SL; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Li J; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Byrne KT; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Pelletier M; Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Stanger BZ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Akin JJ; Novartis Institute for Biomedical Research, Cambridge, MA 02139, USA., Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Agudo J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA., Dougan M; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. stephanie_dougan@dfci.harvard.edu.; Department of Immunology, Harvard Medical School, Boston, MA 02115, USA.

المصدر: Science translational medicine [Sci Transl Med] 2021 May 19; Vol. 13 (594).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Cellular Reprogramming* , Histocompatibility Antigens Class I* , Immunotherapy* , Phagocytes*, Inhibitor of Apoptosis Proteins/*antagonists & inhibitors , Neoplasms/*therapy , T-Lymphocytes/*immunology, Animals ; Humans ; Interferon-gamma ; Macrophages ; Mice ; NF-kappa B ; Neoplasms/immunology ; Signal Transduction

المؤلفون: Dougan M; Division of Gastroenterology and Department of Medicine, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA. Electronic address: mldougan@partners.org., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Dougan SK; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Department of Immunology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Neurology, Brigham & Women's Hospital and Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. Electronic address: kai_wucherpfennig@dfci.harvard.edu.

المصدر: Cell [Cell] 2021 Mar 18; Vol. 184 (6), pp. 1575-1588. Date of Electronic Publication: 2021 Mar 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Immunotherapy/*adverse effects , Inflammation/*etiology , Neoplasms/*immunology , Neoplasms/*therapy, Animals ; Cytokines/adverse effects ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immune Checkpoint Inhibitors/therapeutic use ; T-Lymphocytes/immunology

المؤلفون: Frangieh CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Melms JC; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Geiger-Schuller KR; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Ho P; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Cleary B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jerby-Arnon L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Malu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Immunitas Therapeutics, Waltham, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhao M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ager CR; Columbia Center for Translational Immunology, New York, NY, USA., Rogava M; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Hovey L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rotem A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca, Waltham, MA, USA., Bernatchez C; Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Schadendorf D; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Partner Site, Essen, Germany., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org., Izar B; Columbia Center for Translational Immunology, New York, NY, USA. bi2175@cumc.columbia.edu.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Program for Mathematical Genomics, Columbia University, New York, NY, USA. bi2175@cumc.columbia.edu.

المصدر: Nature genetics [Nat Genet] 2021 Mar; Vol. 53 (3), pp. 332-341. Date of Electronic Publication: 2021 Mar 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Escape*/genetics, CD58 Antigens/*immunology , Drug Resistance, Neoplasm/*immunology , Melanoma/*pathology , Single-Cell Analysis/*methods, CD58 Antigens/genetics ; CD58 Antigens/metabolism ; CRISPR-Cas Systems ; Coculture Techniques ; Computational Biology/methods ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epitopes/genetics ; Gene Knockout Techniques ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Melanoma/drug therapy ; Melanoma/immunology ; Sequence Analysis, RNA