المؤلفون: Fu MS; Department of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China., Pan SX; Department of Anesthesiology, Shanghai Fifth People's Hospital Fudan University, Shanghai 200240, China., Cai XQ; Department of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China., Lv CT; Central Laboratory, Shanghai Fifth People's Hospital Fudan University, Shanghai 200240, China., Pan QC; Department of Gastroenterology, Shanghai Fifth People's Hospital Fudan University, No. 801, Heqing Road, Minhang District, Shanghai 200240, China.

المصدر: Scientifica [Scientifica (Cairo)] 2024 Jun 06; Vol. 2024, pp. 5791613. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101589932 Publication Model: eCollection Cited Medium: Print ISSN: 2090-908X (Print) Linking ISSN: 2090908X NLM ISO Abbreviation: Scientifica (Cairo) Subsets: PubMed not MEDLINE

المؤلفون: Light V; Department of Psychiatry, McGill University (VL, SD), Douglas Mental Health University Institute, Montreal, QC, Canada; Integrated Program of Neuroscience (VL), McGill University, Montreal, QC, Canada., Jones SL; Douglas Research Centre (SLJ), Montreal, QC, Canada., Rahme E; Research Institute of the McGill University Health Centre (RI-MUHC) (ER), Montreal, QC, Canada., Rousseau K; Institut Universitaire en Santé Mentale de Montréal, Département de Psychiatrie (KR), Université de Montréal, Montreal, QC, Canada., de Boer S; Alzheimer Center Amsterdam, Department of Neurology (SB, YP), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; School of Psychology (SB), The University of Sydney, Sydney, NSW, Australia., Vermunt L; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC (LV, CT), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Soltaninejad M; McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology & Neurosurgery (MS, SD), McGill University, Montreal, QC, Canada., Teunissen C; Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC (LV, CT), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Pijnenburg Y; Alzheimer Center Amsterdam, Department of Neurology (SB, YP), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands., Ducharme S; Department of Psychiatry, McGill University (VL, SD), Douglas Mental Health University Institute, Montreal, QC, Canada; McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology & Neurosurgery (MS, SD), McGill University, Montreal, QC, Canada. Electronic address: simon.ducharme@mcgill.ca., Consortium FS and CCNA; Centre de Recherche de l'institut universitaire en santé mentale de Montréal (SC, CCNA), Montreal, QC, Canada.

المصدر: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2024 Aug; Vol. 32 (8), pp. 988-1001. Date of Electronic Publication: 2024 Mar 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9309609 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-7214 (Electronic) Linking ISSN: 10647481 NLM ISO Abbreviation: Am J Geriatr Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Frontotemporal Dementia*/blood , Frontotemporal Dementia*/diagnosis , Neurofilament Proteins*/blood , Biomarkers*/blood , Mental Disorders*/blood , Mental Disorders*/diagnosis, Humans ; Middle Aged ; Female ; Male ; Aged ; Adult ; Diagnosis, Differential ; Aged, 80 and over ; Age Factors ; Case-Control Studies ; ROC Curve

المؤلفون: Wang CM; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Liu CM; Department of Obstetrics, The Fourth Hospital of Shijiazhuang, Shijiazhuang, 050011, China., Jia XZ; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Zhao SB; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Nie ZY; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Lv CT; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Jiang Q; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China., Hao YL; Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Chang 'an District, Shijiazhuang, 050011, China. haoyali@hebmu.edu.cn.

المصدر: Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2024 Feb; Vol. 41 (2), pp. 363-370. Date of Electronic Publication: 2023 Dec 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 9206495 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7330 (Electronic) Linking ISSN: 10580468 NLM ISO Abbreviation: J Assist Reprod Genet Subsets: MEDLINE

مواضيع طبية MeSH: Fertilization in Vitro* , Infertility*/therapy , DNA-Binding Proteins* , Transcription Factors* , Mitochondrial Proteins*, Pregnancy ; Humans ; Female ; Granulosa Cells/metabolism ; Oocytes/metabolism ; RNA, Messenger/metabolism

المؤلفون: Li H; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Feng YH; College of Food Engineering, Anhui Science and Technology University, Chuzhou, Anhui, China., Xia C; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Chen Y; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Lu XY; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Wei Y; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Qian LL; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Zhu MY; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Gao GY; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Meng YF; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., You YL; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Tian Q; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Liang KQ; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Li YT; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Lv CT; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Rui XY; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China., Wei MY; School of Ecology, Resources and Environment, Dezhou University, Dezhou, Shandong, China., Zhang B; College of Food and Bio-engineering, Bengbu University, Bengbu, Anhui, China.

المصدر: Frontiers in nutrition [Front Nutr] 2024 Jan 05; Vol. 10, pp. 1321938. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE

المؤلفون: Li H; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Lv CT; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Li YT; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Gao GY; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Meng YF; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., You YL; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Tian Q; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Liang KQ; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Chen Y; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Chen H; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Xia C; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China., Rui XY; College of Food and Bio-Engineering, Bengbu University, Bengbu, Anhui, 233030, People's Republic of China. 965347604@qq.com., Zheng HL; Key Laboratory for Subtropical Wetland Ecosystem Research of MOE, College of the Environment and Ecology, Xiamen University, Xiamen, Fujian, 361005, People's Republic of China. zhenghl@xmu.edu.cn., Wei MY; School of Ecology, Resources and Environment, Dezhou University, DeZhou, Shandong, 253000, People's Republic of China. weimingyue@stu.xmu.edu.cn.

المصدر: Scientific reports [Sci Rep] 2023 May 10; Vol. 13 (1), pp. 7614. Date of Electronic Publication: 2023 May 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Avicennia*/metabolism, Animals ; Transcriptome ; Salinity ; Sodium Chloride/pharmacology ; Sodium Chloride/metabolism ; Gene Expression Profiling ; Epidermis ; Plant Leaves/genetics ; RNA/metabolism

المؤلفون: Li WX; Department of General Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200083, China., Tong HX; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Lv CT; Department of General Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200083, China., Yang H; Department of General Surgery, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200083, China., Zhao G; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Lu WQ; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China., Zhang Y; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. 13681971072@163.com.

المصدر: World journal of clinical cases [World J Clin Cases] 2022 Jan 21; Vol. 10 (3), pp. 811-819.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101618806 Publication Model: Print Cited Medium: Print ISSN: 2307-8960 (Print) Linking ISSN: 23078960 NLM ISO Abbreviation: World J Clin Cases Subsets: PubMed not MEDLINE

المؤلفون: Wang M; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Wu X; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Yu L; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Hu ZY; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Li X; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Meng X; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Lv CT; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Kim GY; Department of Marine Life Sciences, Jeju National University, Jeju, South Korea., Choi YH; Department of Biochemistry, College of Oriental Medicine, Dong-Eui University, Busan, South Korea., Wang Z; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Xu HW; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China., Jin CY; Key Laboratory of Advanced Technology for Drug Preparation, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, China.

المصدر: Frontiers in oncology [Front Oncol] 2021 Apr 16; Vol. 11, pp. 658608. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE

المؤلفون: Liu HM; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Suo FZ; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Li XB; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., You YH; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Lv CT; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Zheng CX; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Zhang GC; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Liu YJ; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Kang WT; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China., Zheng YC; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China; National Center for International Research of Micro-nano Molding Technology of Henan Province, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address: yichaozheng@zzu.edu.cn., Xu HW; Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, School of Pharmaceutical Science, Institute of Drug Discovery and Development, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan, 450001, China. Electronic address: xhwei01@zzu.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2019 Aug 01; Vol. 175, pp. 357-372. Date of Electronic Publication: 2019 Apr 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Enzyme Inhibitors/*chemical synthesis , Enzyme Inhibitors/*pharmacology , Histone Demethylases/*antagonists & inhibitors , Indoles/*chemical synthesis , Indoles/*pharmacology, Cell Line ; Cell Proliferation/drug effects ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Furans/chemistry ; High-Throughput Screening Assays ; Histone Demethylases/metabolism ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Inhibitory Concentration 50 ; Leukemia, Myeloid, Acute/pathology ; Recombinant Proteins/drug effects ; Recombinant Proteins/metabolism ; Structure-Activity Relationship

المؤلفون: Meng LH; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.; University of Chinese Academy of Sciences , Yuquan Road 19A, Beijing 100049, People's Republic of China., Li XM; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China., Lv CT; Department of Biochemistry and Molecular Biology, Second Military Medical University , Xiangyin Road 800, Shanghai 200433, People's Republic of China., Huang CG; Department of Biochemistry and Molecular Biology, Second Military Medical University , Xiangyin Road 800, Shanghai 200433, People's Republic of China., Wang BG; Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences , Nanhai Road 7, Qingdao 266071, People's Republic of China.

المصدر: Journal of natural products [J Nat Prod] 2014 Aug 22; Vol. 77 (8), pp. 1921-7.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*isolation & purification , Antineoplastic Agents/*pharmacology , Avicennia/*microbiology , Diketopiperazines/*isolation & purification , Diketopiperazines/*pharmacology , Penicillium/*chemistry, Antineoplastic Agents/chemistry ; China ; Crystallography, X-Ray ; Diketopiperazines/chemistry ; Drug Screening Assays, Antitumor ; Hep G2 Cells ; Humans ; Marine Biology ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular

المؤلفون: Wang LH; Department of Biochemistry and Molecular Biology, Second Military Medical University, Xiangyin Road No. 800, Shanghai, 200433, China., Ni CW, Lin YZ, Yin L, Jiang CB, Lv CT, Le Y, Lang Y, Zhao CY, Yang K, Jiao BH, Yin J

المصدر: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2014 Feb; Vol. 35 (2), pp. 1157-68. Date of Electronic Publication: 2013 Nov 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IOS Press Country of Publication: Netherlands NLM ID: 8409922 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0380 (Electronic) Linking ISSN: 10104283 NLM ISO Abbreviation: Tumour Biol Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms/*genetics , Glioblastoma/*genetics , Multidrug Resistance-Associated Proteins/*immunology , Recombinant Fusion Proteins/*genetics , TNF-Related Apoptosis-Inducing Ligand/*immunology, Antigens, Surface/genetics ; Antigens, Surface/immunology ; Apoptosis/genetics ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Jurkat Cells ; Multidrug Resistance-Associated Proteins/genetics ; Multidrug Resistance-Associated Proteins/therapeutic use ; Recombinant Fusion Proteins/immunology ; Recombinant Fusion Proteins/therapeutic use ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/immunology ; TNF-Related Apoptosis-Inducing Ligand/genetics ; TNF-Related Apoptosis-Inducing Ligand/therapeutic use