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1دورية أكاديمية
المؤلفون: Charles W. Wright, Naomi Li, Lynsey Shaffer, Armetta Hill, Nicolas Boyer, Stephen E. Alves, Sriraman Venkataraman, Kaustav Biswas, Linda A. Lieberman, Sina Mohammadi
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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المؤلفون: Charles W. Wright, Naomi Li, Lynsey Shaffer, Armetta Hill, Nicolas Boyer, Stephen Alves, Sriram Venkat, Kaustav Biswas, Linda A. Lieberman, Sina Mohammadi
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9a5c487ef12d61187d57398773a1b32a
https://doi.org/10.1101/2022.12.16.520780 -
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المؤلفون: Benjamin Wesley Trotter, Xavier Fradera, Stephen E. Alves, Meredeth A. McGowan, Peter Goldenblatt, Jason D. Katz, Yudith Garcia, Lynsey Shaffer, Michael D. Altman, Matthew Christopher, Kathryn Lipford, Charles A. Lesburg, Hyun-Hee Lee, Chaomin Li, Craig P. Chappell, Vincent Tong, Elaine M. Pinheiro, Armetta D. Hill, Ruban Mangado, Renu Jain, Robbie L. McLeod, Sanjiv J. Shah, Hongshi Yu, Abdelghani Achab, Dapeng Chen, Joey L. Methot, Sybill M G Williams, Hua Zhou, Neville J. Anthony
المصدر: Journal of medicinal chemistry. 64(8)
مصطلحات موضوعية: Purine, Antigens, Differentiation, T-Lymphocyte, Pyrrolidines, Class I Phosphatidylinositol 3-Kinases, Pharmacology, Molecular Dynamics Simulation, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, Antigens, CD, Drug Discovery, medicine, Bioluminescence imaging, Potency, Animals, Humans, Immunologic Factors, Lectins, C-Type, Rats, Wistar, Protein kinase B, PI3K/AKT/mTOR pathway, B-Lymphocytes, Binding Sites, Eosinophil, Duvelisib, Rhinitis, Allergic, Rats, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, chemistry, Molecular Medicine, Idelalisib, Proto-Oncogene Proteins c-akt, Half-Life, Signal Transduction
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المؤلفون: Michael D. Altman, Jason D. Katz, Hua Zhou, Joey L. Methot, Vincent Tong, Kevin J. Wilson, Yudith Garcia, Peter Goldenblatt, Abdelganhi Achab, Martin Augustin, Charles A. Lesburg, Qiaolin Deng, Solomon Kattar, Lynsey Shaffer, Xavier Fradera, Meredeth A. McGowan, Sanjiv J. Shah
المصدر: Bioorganicmedicinal chemistry letters. 42
مصطلحات موضوعية: Class I Phosphatidylinositol 3-Kinases, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Phthalimides, Computational biology, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Drug Discovery, Potency, Humans, Molecular Biology, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Virtual screening, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Ligand (biochemistry), 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Molecular Medicine, Cell signaling pathways
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المؤلفون: Joey L. Methot, Hua Zhou, Sam D. Kattar, Meredeth A. McGowan, Kevin Wilson, Yudith Garcia, Yongi Deng, Michael Altman, Xavier Fradera, Charles Lesburg, Thierry Fischmann, Chaomin Li, Steve Alves, Sanjiv Shah, Rafael Fernandez, Peter Goldenblatt, Armetta Hill, Lynsey Shaffer, Dapeng Chen, Vince Tong, Robbie L. McLeod, Hongshi Yu, Alan Bass, Ray Kemper, Nicholas T. Gatto, Lisa LaFranco-Scheuch, Benjamin Wesley Trotter, Timothy Guzi, Jason D. Katz
المصدر: Journal of Medicinal Chemistry. 62:4370-4382
مصطلحات موضوعية: Class Ia Phosphatidylinositol 3-Kinase, Male, Dogs, Pyrrolidines, Purines, Drug Design, Drug Discovery, Animals, Humans, Molecular Medicine, Rats, Wistar, Protein Kinase Inhibitors, HeLa Cells
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المؤلفون: Kevin W. Johnson, Peter Fuller, Sujal V. Deshmukh, Fang He, Peter Goldenblatt, Lauren Dorosh, Hongbo Zeng, Jason D. Brubaker, Luis E. Torres, Tony Siu, Fiona Elwood, Charles A. Lesburg, Sangita B. Patel, Duan Liu, Elma Kadic, Christopher J. Dinsmore, Xavier Fradera, Lynsey Shaffer, Jonathan R. Young, Lily Y. Moy, Feng Shi, Carla Alpert, Joel A. Klappenbach, Joshua Close, Rafael Fernandez, Hongshi Yu, Nathan Bays, Dawn M. Mampreian
المصدر: Journal of Medicinal Chemistry. 60:9676-9690
مصطلحات موضوعية: 0301 basic medicine, Halogenation, Stereochemistry, medicine.drug_class, Carboxamide, Pyrazole, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, Ligand efficiency, Chemistry, Drug discovery, Janus Kinase 1, Ligand (biochemistry), Rats, Bioavailability, Molecular Docking Simulation, 030104 developmental biology, Pyran, Pyrazoles, Molecular Medicine
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المؤلفون: Chaomin Li, Charles A. Lesburg, Jason D. Katz, Xavier Fradera, Robbie L. McLeod, Ruban Mangado, Elaine M. Pinheiro, Sybil M. G. Williams, Benjamin Wesley Trotter, Craig P. Chappell, Stephen E. Alves, Armetta D. Hill, Sanjiv J. Shah, Lynsey Shaffer, Michael D. Altman, Joey L. Methot, Hua Zhou, Renu Jain, Dapeng Chen, Hyun-Hee Lee, Meredith A. McGowan, Peter Goldenblatt
المصدر: Cancer Research. 79:2254-2254
مصطلحات موضوعية: Cancer Research, Tumor microenvironment, business.industry, Chronic lymphocytic leukemia, FOXP3, Cancer, medicine.disease, Lymphoma, Oncology, Cancer research, Medicine, Potency, Kinome, business, CD8
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::01203c857b786686ef70cf3c512ad5f8
https://doi.org/10.1158/1538-7445.am2019-2254
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