المؤلفون: Lyu, Jiankun, Jiang, Longyu, Yang, Chao, Wang, Shijie

المصدر: OCEANS 2022, Hampton Roads OCEANS Hampton Roads, 2022. :1-9 Oct, 2022

Relation: OCEANS 2022, Hampton Roads

المؤلفون: Fink, Elissa A, Bardine, Conner, Gahbauer, Stefan, Singh, Isha, Detomasi, Tyler C, White, Kris, Gu, Shuo, Wan, Xiaobo, Chen, Jun, Ary, Beatrice, Glenn, Isabella, O'Connell, Joseph, O'Donnell, Henry, Fajtová, Pavla, Lyu, Jiankun, Vigneron, Seth, Young, Nicholas J, Kondratov, Ivan S, Alisoltani, Arghavan, Simons, Lacy M, Lorenzo‐Redondo, Ramon, Ozer, Egon A, Hultquist, Judd F, O'Donoghue, Anthony J, Moroz, Yurii S, Taunton, Jack, Renslo, Adam R, Irwin, John J, García‐Sastre, Adolfo, Shoichet, Brian K, Craik, Charles S

المصدر: Protein Science. 32(8)

مصطلحات موضوعية: Medicinal and Biomolecular Chemistry, Chemical Sciences, Lung, Prevention, Emerging Infectious Diseases, Infectious Diseases, Vaccine Related, Biodefense, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Infection, Good Health and Well Being, Humans, COVID-19, SARS-CoV-2, Pandemics, Protease Inhibitors, Molecular Docking Simulation, Viral Nonstructural Proteins, Antiviral Agents, major protease, SARS-COV-2, structure-based inhibitor, discoverydockinganti-viral, Biochemistry and Cell Biology, Computation Theory and Mathematics, Other Information and Computing Sciences, Biophysics, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/61h336z6

المؤلفون: Lyu, Jiankun, Shoichet, Brian, Irwin, John

المصدر: Nature Chemical Biology. 19(6)

مصطلحات موضوعية: Libraries, Digital, Molecular Docking Simulation

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/4gr6p97x

المؤلفون: Alon, Assaf, Lyu, Jiankun, Braz, Joao M, Tummino, Tia A, Craik, Veronica, O’Meara, Matthew J, Webb, Chase M, Radchenko, Dmytro S, Moroz, Yurii S, Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L, Irwin, John J, Basbaum, Allan I, Shoichet, Brian K, Kruse, Andrew C

المصدر: Nature. 600(7890)

مصطلحات موضوعية: Peripheral Neuropathy, Pain Research, Chronic Pain, Neurosciences, Neurodegenerative, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Ligands, Mice, Neuralgia, Receptors, sigma, Structure-Activity Relationship, General Science & Technology

URL الوصول: https://escholarship.org/uc/item/9gp7838k

المؤلفون: Bender, Brian J, Gahbauer, Stefan, Luttens, Andreas, Lyu, Jiankun, Webb, Chase M, Stein, Reed M, Fink, Elissa A, Balius, Trent E, Carlsson, Jens, Irwin, John J, Shoichet, Brian K

المصدر: Nature Protocols. 16(10)

مصطلحات موضوعية: Brain Disorders, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Drug Design, Ligands, Molecular Docking Simulation, Software, Chemical Sciences, Biological Sciences, Medical and Health Sciences, Bioinformatics

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9hs932s0

المؤلفون: Tummino, Tia A, Rezelj, Veronica V, Fischer, Benoit, Fischer, Audrey, O'Meara, Matthew J, Monel, Blandine, Vallet, Thomas, White, Kris M, Zhang, Ziyang, Alon, Assaf, Schadt, Heiko, O'Donnell, Henry R, Lyu, Jiankun, Rosales, Romel, McGovern, Briana L, Rathnasinghe, Raveen, Jangra, Sonia, Schotsaert, Michael, Galarneau, Jean-René, Krogan, Nevan J, Urban, Laszlo, Shokat, Kevan M, Kruse, Andrew C, García-Sastre, Adolfo, Schwartz, Olivier, Moretti, Francesca, Vignuzzi, Marco, Pognan, Francois, Shoichet, Brian K

المصدر: Science. 373(6554)

مصطلحات موضوعية: Lung, Infectious Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Good Health and Well Being, A549 Cells, Animals, Antiviral Agents, COVID-19, Cations, Chlorocebus aethiops, Dose-Response Relationship, Drug, Drug Repositioning, Female, Humans, Lipidoses, Mice, Microbial Sensitivity Tests, Phospholipids, SARS-CoV-2, Surface-Active Agents, Vero Cells, Virus Replication, COVID-19 Drug Treatment, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/41h684bv

المؤلفون: Stein, Reed M, Yang, Ying, Balius, Trent E, O’Meara, Matt J, Lyu, Jiankun, Young, Jennifer, Tang, Khanh, Shoichet, Brian K, Irwin, John J

المصدر: Journal of Chemical Information and Modeling. 61(2)

مصطلحات موضوعية: Benchmarking, Ligands, Models, Molecular, Prospective Studies, Protein Binding, Medicinal and Biomolecular Chemistry, Theoretical and Computational Chemistry, Computation Theory and Mathematics, Medicinal & Biomolecular Chemistry

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7r785814

المؤلفون: Kim, Kuglae, Che, Tao, Panova, Ouliana, DiBerto, Jeffrey F, Lyu, Jiankun, Krumm, Brian E, Wacker, Daniel, Robertson, Michael J, Seven, Alpay B, Nichols, David E, Shoichet, Brian K, Skiniotis, Georgios, Roth, Bryan L

المصدر: Cell. 182(6)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Brain Disorders, Mental Health, Depression, Substance Misuse, Aetiology, 2.1 Biological and endogenous factors, Mental health, Animals, Cryoelectron Microscopy, Crystallography, X-Ray, GTP-Binding Protein alpha Subunits, Gq-G11, Gene Expression, HEK293 Cells, Hallucinogens, Humans, Ligands, Lysergic Acid Diethylamide, Methiothepin, Models, Chemical, Mutation, Protein Conformation, alpha-Helical, Receptor, Serotonin, 5-HT2A, Recombinant Proteins, Serotonin, Spodoptera, GPCR, LSD, psychedelic, sertotonin receptor, signal transduction, structural biology, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/0wc7m3gg

المؤلفون: Gordon, David E, Jang, Gwendolyn M, Bouhaddou, Mehdi, Xu, Jiewei, Obernier, Kirsten, White, Kris M, O’Meara, Matthew J, Rezelj, Veronica V, Guo, Jeffrey Z, Swaney, Danielle L, Tummino, Tia A, Hüttenhain, Ruth, Kaake, Robyn M, Richards, Alicia L, Tutuncuoglu, Beril, Foussard, Helene, Batra, Jyoti, Haas, Kelsey, Modak, Maya, Kim, Minkyu, Haas, Paige, Polacco, Benjamin J, Braberg, Hannes, Fabius, Jacqueline M, Eckhardt, Manon, Soucheray, Margaret, Bennett, Melanie J, Cakir, Merve, McGregor, Michael J, Li, Qiongyu, Meyer, Bjoern, Roesch, Ferdinand, Vallet, Thomas, Mac Kain, Alice, Miorin, Lisa, Moreno, Elena, Naing, Zun Zar Chi, Zhou, Yuan, Peng, Shiming, Shi, Ying, Zhang, Ziyang, Shen, Wenqi, Kirby, Ilsa T, Melnyk, James E, Chorba, John S, Lou, Kevin, Dai, Shizhong A, Barrio-Hernandez, Inigo, Memon, Danish, Hernandez-Armenta, Claudia, Lyu, Jiankun, Mathy, Christopher JP, Perica, Tina, Pilla, Kala Bharath, Ganesan, Sai J, Saltzberg, Daniel J, Rakesh, Ramachandran, Liu, Xi, Rosenthal, Sara B, Calviello, Lorenzo, Venkataramanan, Srivats, Liboy-Lugo, Jose, Lin, Yizhu, Huang, Xi-Ping, Liu, YongFeng, Wankowicz, Stephanie A, Bohn, Markus, Safari, Maliheh, Ugur, Fatima S, Koh, Cassandra, Savar, Nastaran Sadat, Tran, Quang Dinh, Shengjuler, Djoshkun, Fletcher, Sabrina J, O’Neal, Michael C, Cai, Yiming, Chang, Jason CJ, Broadhurst, David J, Klippsten, Saker, Sharp, Phillip P, Wenzell, Nicole A, Kuzuoglu-Ozturk, Duygu, Wang, Hao-Yuan, Trenker, Raphael, Young, Janet M, Cavero, Devin A, Hiatt, Joseph, Roth, Theodore L, Rathore, Ujjwal, Subramanian, Advait, Noack, Julia, Hubert, Mathieu, Stroud, Robert M, Frankel, Alan D, Rosenberg, Oren S, Verba, Kliment A, Agard, David A, Ott, Melanie, Emerman, Michael, Jura, Natalia

المصدر: Nature. 583(7816)

مصطلحات موضوعية: Biological Sciences, Bioinformatics and Computational Biology, Biomedical and Clinical Sciences, Coronaviruses, Emerging Infectious Diseases, Infectious Diseases, Coronaviruses Therapeutics and Interventions, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Good Health and Well Being, Animals, Antiviral Agents, Betacoronavirus, COVID-19, Chlorocebus aethiops, Cloning, Molecular, Coronavirus Infections, Drug Evaluation, Preclinical, Drug Repositioning, HEK293 Cells, Host-Pathogen Interactions, Humans, Immunity, Innate, Mass Spectrometry, Molecular Targeted Therapy, Pandemics, Pneumonia, Viral, Protein Binding, Protein Biosynthesis, Protein Domains, Protein Interaction Mapping, Protein Interaction Maps, Receptors, sigma, SARS-CoV-2, SKP Cullin F-Box Protein Ligases, Vero Cells, Viral Proteins, COVID-19 Drug Treatment, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2gt3q50x
https://escholarship.org/content/qt2gt3q50x/qt2gt3q50x.pdf

المؤلفون: Lyu, Jiankun, Wang, Sheng, Balius, Trent E, Singh, Isha, Levit, Anat, Moroz, Yurii S, O’Meara, Matthew J, Che, Tao, Algaa, Enkhjargal, Tolmachova, Kateryna, Tolmachev, Andrey A, Shoichet, Brian K, Roth, Bryan L, Irwin, John J

المصدر: Nature. 566(7743)

مصطلحات موضوعية: Theory Of Computation, Medicinal and Biomolecular Chemistry, Chemical Sciences, Built Environment and Design, Information and Computing Sciences, Design, Neurosciences, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Bacterial Proteins, Crystallography, X-Ray, Dopamine Agonists, Humans, Ligands, Machine Learning, Molecular Docking Simulation, Observation, Receptors, Dopamine D4, Small Molecule Libraries, beta-Lactamase Inhibitors, beta-Lactamases, General Science & Technology

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/2k01p3zc