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المؤلفون: Giovanna Bergamini, Stefano Livia, Kenneth David Down, Marcus Bantscheff, Nick Barton, Friedrich B M Reinhard, Paola Grandi, Daniel Thomas, David N. Mallett, Paul Martin Gore, Sophie M. Bertrand, Z.A. Henley, Edith M. Hessel, James E. Rowedder, Mark Price, J. Nicole Hamblin, Birgit Dümpelfeld, Augustin Amour, Steve Keeling, Christina Rau, Máire A. Convery, Chris D. Edwards, Jonathan A. Taylor, Paul Rowland, Aoife C. Maxwell
المصدر: Journal of Medicinal Chemistry. 63:638-655
مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Cell membrane permeability, Class I Phosphatidylinositol 3-Kinases, Biological Availability, Class iii, Crystallography, X-Ray, Binding, Competitive, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Drug discovery, Chemistry, Class III Phosphatidylinositol 3-Kinases, Combinatorial chemistry, Rats, Bioavailability, Isoenzymes, Molecular Docking Simulation, Toxicity, Molecular Medicine, Selectivity
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المؤلفون: Sebastien Andre Campos, Sorif Uddin, Daniel Thomas, Paul Rowland, Birgit Duempelfeld, Douglas W. Thomson, Andrew Sharpe, James E. Rowedder, Kenneth David Down, Máire A. Convery, Augustin Amour, Michael Daniel Goldsmith, Grant A. McGonagle, David N. Mallett, Edith M. Hessel, Jana Krause, Kevin James Doyle, J. Nicole Hamblin, Srividya Sriskantharajah, Edward P. Cannons, Vipulkumar Kantibhai Patel, Chris D. Edwards, Cole Clissold, Nick Barton, Anderson Niall Andrew, John J. Coward
المصدر: Journal of medicinal chemistry. 64(18)
مصطلحات موضوعية: Male, Class I Phosphatidylinositol 3-Kinases, Crystallography, X-Ray, chemistry.chemical_compound, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Potency, Animals, Rats, Wistar, Phosphoinositide-3 Kinase Inhibitors, chemistry.chemical_classification, Mice, Inbred BALB C, Sulfonamides, Molecular Structure, Glutathione, Highly selective, Combinatorial chemistry, Sulfonamide, Bioavailability, chemistry, Molecular Medicine, Amine gas treating, Female, Selectivity, Protein Binding
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المؤلفون: Simon Peace, Gianpaolo Bravi, Máire A. Convery, Hannah Davies, Graham G. A. Inglis, Joanna M. Redmond, Sandeep Pal, Heather Hobbs, Declan Summers, Ian B. Campbell
المصدر: Journal of Medicinal Chemistry. 62:6972-6984
مصطلحات موضوعية: Pyrimidine, Stereochemistry, Isostere, Morpholines, 01 natural sciences, mTORC2, Bridged Bicyclo Compounds, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, chemistry.chemical_compound, Morpholine, Drug Discovery, Humans, Cycloheptanes, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Hydrogen bond, TOR Serine-Threonine Kinases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Molecular Medicine, Pharmacophore, Selectivity, Proto-Oncogene Proteins c-akt, Signal Transduction
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المؤلفون: Pamela A. Haile, Linda N. Casillas, Bartholomew J. Votta, Gren Z. Wang, Adam K. Charnley, Xiaoyang Dong, Michael J. Bury, Joseph J. Romano, John F. Mehlmann, Bryan W. King, Karl F. Erhard, Charles R. Hanning, David B. Lipshutz, Biva M. Desai, Carol A. Capriotti, Michelle C. Schaeffer, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Rakesh Nagilla, Elizabeth J. Rivera, Helen H. Sun, John K. Kenna, Allison M. Beal, Michael T. Ouellette, Mike Kelly, Gillian Stemp, Máire A. Convery, Anna Vossenkämper, Thomas T. MacDonald, Peter J. Gough, John Bertin, Robert W. Marquis
المصدر: Journal of Medicinal Chemistry. 62:6482-6494
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Máire A. Convery, Daniel Thomas, Chris D. Edwards, Craig Jamieson, James E. Rowedder, Ian Robert Baldwin, David N. Mallett, Chun-wa Chung, Charlotte J. Hardy, Nick Barton, Jonathan A. Spencer, Paul Rowland
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Phosphoinositide 3-kinase, biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, 01 natural sciences, Biochemistry, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, In vivo, Drug Discovery, biology.protein, Biophysics, QD, Surface plasmon resonance, Solubility
وصف الملف: application/pdf
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المؤلفون: Peter C. Ray, Margaret Huggett, Robert H. Bates, Paco De Dios Anton, Daniel A. Fletcher, Chun-wa Chung, Alfonso Mendoza-Losana, Simon Green, Jingkun Zeng, Fabio Zuccotto, David Barros, Lourdes Encinas, Paul G. Wyatt, Claire J. MacKenzie, Raquel Fernandez-Menendez, Máire A. Convery, Federica Prati
المصدر: Chemmedchem
'ChemMedChem ', vol: 13, pages: 672-677 (2018)مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Tuberculosis, Fragment-based lead discovery, Antitubercular Agents, Computational biology, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Mycobacterium tuberculosis, Small Molecule Libraries, 03 medical and health sciences, Fragment (logic), InhA, Bacterial Proteins, Oxidoreductase, Drug Discovery, medicine, General Pharmacology, Toxicology and Pharmaceutics, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Ligand efficiency, biology, Molecular Structure, 010405 organic chemistry, Chemistry, INHA, Communication, Organic Chemistry, Surface Plasmon Resonance, medicine.disease, biology.organism_classification, fragment based drug discovery, Communications, 3. Good health, 0104 chemical sciences, 030104 developmental biology, functional group complexity, tuberculosis, Molecular Medicine, Oxidoreductases
وصف الملف: application/pdf
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المؤلفون: Angela Bridges, Sandrine Jayne, Jennifer Schofield, Ana Sousa Manso, Duncan S. Holmes, Xi-Ping Zhang, Larissa Lezina, Michael T. McCabe, Mark James Bamford, Anastasia Wyce, David Jonathan Hirst, Máire A. Convery, Tom Slocombe, Andrew C. Pearce, Don O. Somers, Simon D. Wagner, Paul Scott-Stevens, Ann Louise Walker, Jonathan P. Hutchinson, Constantinos Demetriou, Cassie Messenger, Melissa C. Musso, Sian Evans, Ruth C. Barber, Joanne Morley, Thomas Gobbetti
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Transcription, Genetic, SMRT, silencing mediator for retinoid or thyroid hormone receptor, Biochemistry, Immunoglobulin G, BCL6 inhibitor, immunology, SLE, systemic lupus erythematosus, Mice, hemic and lymphatic diseases, clPARP, cleaved poly(ADP-ribose) polymerase, Zinc finger, B-Lymphocytes, biology, Chemistry, autoimmunity, Zinc Fingers, BCL6, Cell biology, Proto-Oncogene Proteins c-bcl-6, GC, germinal center, DLBCL, diffuse large B-cell lymphoma, Hapten, Research Article, IgG, immunoglobulin G, lymphoma, lymphocyte, PK, pharmacokinetic, drug discovery, FBS, fetal bovine serum, Antigen, Animals, Humans, Molecular Biology, BTB, BR-C, ttk, and bab, BCL6, B-cell lymphoma 6, Thyroid hormone receptor, TNP, trinitrophenol, Germinal center, antibody response, Cell Biology, TE, target engagement, IL, interleukin, IgM, immunoglobulin M, biology.protein, CSB, cell-staining buffer, KLH, keyhole limpet hemocyanin, POZ, pox virus and zinc finger, Corepressor, Tfh, CD4+ T-cell subset follicular helper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c7e6fdf77eb69b9270c5b0a66260fc
https://doi.org/10.1016/j.jbc.2021.100928 -
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المؤلفون: Arthur Shu, Yiqian Lian, Huijie Li, Curt Dale Haffner, Terry Vincent Hughes, Ami S. Lakdawala, Julie A. Cox, Pamela A. Haile, Constantine Kreatsoulas, Beth Anne Knapp-Reed, Lisa M. Shewchuk, David B. Lipshutz, John F. Mehlmann, Michael T. Ouellette, Christopher J Aquino, Mark Elban, Nicole Cathleen Goodwin, Huiqiang Zhou, Adam Kenneth Charnley, Bartholomew J. Votta, Robert W. Marquis, Joseph J. Romano, Linda N. Casillas, Peter J. Gough, Máire A. Convery, John Bertin
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Bicyclic molecule, 010405 organic chemistry, Kinase, Chemistry, Organic Chemistry, Pyrazole, 01 natural sciences, Biochemistry, 0104 chemical sciences, RIPK2, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, NOD2, Drug Discovery, NOD1, Transferase, RECEPTOR-INTERACTING PROTEIN
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المؤلفون: Paul Rowland, Anthony William James Cooper, Kenneth David Down, Nick Barton, James E. Rowedder, Máire A. Convery, Natalie Wellaway, J. Nicole Hamblin, Jonathan A. Taylor, Simon Peace, Graham G. A. Inglis
المصدر: Journal of medicinal chemistry. 61(24)
مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, Stereochemistry, Drug Evaluation, Preclinical, Crystallography, X-Ray, Madin Darby Canine Kidney Cells, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Drug Discovery, Administration, Inhalation, Transferase, Structure–activity relationship, Animals, Enzyme Inhibitors, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Chemistry, Madin Darby canine kidney cell, Hydrogen Bonding, Isoquinolines, Rats, Class Ia Phosphatidylinositol 3-Kinase, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine
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المؤلفون: Catherine E. Peishoff, Donald O. Somers, Heather A. Carlson, Aqeel Ahmed, Michael Kranz, Kelly L. Damm-Ganamet, Richard D. Smith, Jeanne A. Stuckey, James B. Dunbar, Guanglei Cui, Millard H. Lambert, Patricia A. Elkins, Máire A. Convery
المصدر: Journal of Chemical Information and Modeling. 56:1063-1077
مصطلحات موضوعية: 0301 basic medicine, Databases, Pharmaceutical, Protein Conformation, Computer science, General Chemical Engineering, Computational biology, Library and Information Sciences, Ligands, computer.software_genre, Article, Structure-Activity Relationship, 03 medical and health sciences, Syk Kinase, tRNA Methyltransferases, Proteins, General Chemistry, Computer Science Applications, Molecular Docking Simulation, Benchmarking, 030104 developmental biology, Drug Design, Proteins metabolism, Factor Xa, Benchmark (computing), Data mining, computer, Large size
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