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المؤلفون: Dennis S. Yamashita, Thaddeus A. Tomaszek, H.-J. Oh, M.W. Lark, S M Hwang, David J. Rickard, Ian E. James, Jae U. Jeong, Robert W. Marquis, George B. Stroup, M. Gowen, Shaji Kumar, Lauren Dare, Simon M. Blake, Daniel F. Veber, Janice A. Vasko-Moser
المصدر: Bone. 40:122-131
مصطلحات موضوعية: medicine.medical_specialty, Pathology, Histology, Physiology, Endocrinology, Diabetes and Metabolism, Cathepsin K, Osteoporosis, Administration, Oral, Osteoclasts, Collagen Type I, Bone resorption, Bone remodeling, chemistry.chemical_compound, In vivo, Internal medicine, medicine, Animals, Humans, Sulfones, Bone Resorption, Cells, Cultured, Cathepsin, Azepines, medicine.disease, Cathepsins, Disease Models, Animal, Macaca fascicularis, Endocrinology, chemistry, Ovariectomized rat, Peptides, Biomarkers, Odanacatib
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المؤلفون: Staffan Larsson, M.W. Lark, Michael A. Pratta, L.S. Lohmander, Shaji Kumar, André Struglics
المصدر: Osteoarthritis and Cartilage; 14(2), pp 101-113 (2006)
مصطلحات موضوعية: Cartilage, Articular, musculoskeletal diseases, matrix metalloproteinase, Knee Joint, Blotting, Western, Biomedical Engineering, Osteoarthritis, Matrix metalloproteinase, Glycosaminoglycan, synovial fluid, Rheumatology, Endopeptidases, medicine, Humans, Synovial fluid, Lectins, C-Type, Protease Inhibitors, Orthopedics and Sports Medicine, Aggrecans, cartilage, Aggrecan, Glycosaminoglycans, Rheumatology and Autoimmunity, Aggrecanase, Extracellular Matrix Proteins, Chemistry, Cartilage, aggrecanase, Antibodies, Monoclonal, musculoskeletal system, medicine.disease, Molecular biology, Matrix Metalloproteinases, Peptide Fragments, In vitro, carbohydrates (lipids), osteoarthritis, medicine.anatomical_structure, Chondroitin Sulfate Proteoglycans, aggrecan
وصف الملف: application/pdf
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المؤلفون: Ian E. James, Simon M. Blake, E. Berger, M.W. Lark, Alan J. Grodzinsky, Parth Patwari, Véronique Gaschen, Ernst B. Hunziker
المصدر: Osteoarthritis and Cartilage. 12:245-252
مصطلحات موضوعية: Cartilage, Articular, Pathology, medicine.medical_specialty, Programmed cell death, Cell, Biomedical Engineering, Apoptosis, Osteoarthritis, Cell morphology, Article, Chondrocyte, Rheumatology, Freezing, Electron microscopy, In Situ Nick-End Labeling, medicine, Animals, Orthopedics and Sports Medicine, TUNEL, TUNEL assay, Cell Death, business.industry, Cartilage, Mechanical injury, medicine.disease, Microscopy, Electron, medicine.anatomical_structure, Animals, Newborn, Cattle, Stress, Mechanical, business
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المؤلفون: Kevin L. Salyers, James Samanen, R. Curtis Haltiwanger, M.W. Lark, Leonard M. Azzarano, Irene N. Uzinskas, Karl F. Erhard, Robert N. Willette, Kyung O. Johanson, Catherine J. Gress, Stephen T Ross, Tian Li Yue, Keith W. Ward, William F. Huffman, Russell D. Cousins, Dirk A. Heerding, David J. Rieman, Shing Mei Hwang, Chet Kwon, Brian R. Smith, Ian E. James, William H. Miller, Catherine C.K. Yuan, Dennis T. Takata, Manley Peter J
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:1483-1486
مصطلحات موضوعية: Clinical Biochemistry, Integrin, Administration, Oral, Aminopyridines, Biological Availability, Pharmaceutical Science, Acetates, Pharmacology, Biochemistry, Phenylbutyrate, Cell Line, Oral administration, Drug Discovery, Cell Adhesion, Animals, Humans, Potency, Molecular Biology, biology, Chemistry, Organic Chemistry, Integrin alphaVbeta3, Phenylbutyrates, Small molecule, In vitro, Rats, Bioavailability, biology.protein, Molecular Medicine, Vitronectin, Half-Life
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المؤلفون: M.W. Lark, Karen E. Morrison
المصدر: Current Opinion in Pharmacology. 2:287-290
مصطلحات موضوعية: Pharmacology, medicine.medical_specialty, business.industry, Intervention (counseling), Drug Discovery, Physical therapy, Medicine, business
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المؤلفون: J.R. Connor, S.P. O'Brien, M.W. Lark, Ganesh M. Sathe, Shaji Kumar, P. Mui, J. Mooney, M. Gowen, P.R. Murdock
المصدر: Osteoarthritis and Cartilage. 9:727-737
مصطلحات موضوعية: Adult, Cartilage, Articular, Male, Pathology, medicine.medical_specialty, Microarray, Biomedical Engineering, In situ hybridization, Osteoarthritis, Biology, Chondrocyte, Rheumatology, medicine, Humans, Orthopedics and Sports Medicine, RNA, Messenger, In Situ Hybridization, Aged, Gene Library, Glycoproteins, Oligonucleotide Array Sequence Analysis, Aged, 80 and over, Clusterin, Reverse Transcriptase Polymerase Chain Reaction, cDNA library, Microarray analysis techniques, Cartilage, Middle Aged, medicine.disease, Clusterin, Osteoarthritis (OA), Cartilage, Chondrocyte, eye diseases, Up-Regulation, medicine.anatomical_structure, Case-Control Studies, biology.protein, Female, Proteoglycans, sense organs, Molecular Chaperones
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المؤلفون: M.W. Lark, John C. Lee, P. Agarwal, Alison M. Badger, M. Van Horn, Ganesh M. Sathe, M. Gowen, P. Mui, Joyce Mao, J.R. Connor, Wendy S. Halsey, Shaji Kumar, R.A. Dodds
المصدر: Osteoarthritis and Cartilage. 9(7):641-653
مصطلحات موضوعية: Adult, Cartilage, Articular, Molecular Sequence Data, Biomedical Engineering, Gene Expression, In situ hybridization, Biology, Rheumatology, Gene expression, medicine, Gene family, Humans, Orthopedics and Sports Medicine, Northern blot, Gene, In Situ Hybridization, Gene Library, Expressed Sequence Tags, Expressed sequence tag, cDNA library, Cartilage, Cartilage, Osteoarthritis (OA), cDNA libraries, Sequencing, Osteoarthritis, Knee, Blotting, Northern, Molecular biology, medicine.anatomical_structure, Case-Control Studies
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المؤلفون: J.R. Connor, M.W. Lark, Shaji Kumar, Alison M. Badger, Barbara A. Swift, A.K Roshak, M.N Cook, M. Gowen, K Carlson, T.M Newman-Tarr, John C. Lee
المصدر: Osteoarthritis and Cartilage. 8(6):434-443
مصطلحات موضوعية: Cartilage, Articular, Pyridines, p38 mitogen-activated protein kinases, Cell Culture Techniques, Biomedical Engineering, Nitric Oxide, p38 Mitogen-Activated Protein Kinases, Chondrocyte, Dinoprostone, Nitric oxide, chemistry.chemical_compound, Chondrocytes, Species Specificity, Rheumatology, Culture Techniques, medicine, Animals, Humans, Orthopedics and Sports Medicine, RNA, Messenger, Enzyme Inhibitors, Protein kinase A, Protein kinase C, biology, Cartilage, Nitric oxide, Proteoglycan, p38 kinase, CSAIDs, Imidazoles, Molecular biology, Nitric oxide synthase, medicine.anatomical_structure, chemistry, Gene Expression Regulation, biology.protein, Cattle, Proteoglycans, Mitogen-Activated Protein Kinases, Nitric Oxide Synthase, Tyrosine kinase, Interleukin-1
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المؤلفون: Barbara A. Swift, J.M Levin, M.W. Lark, Alison M. Badger, R.D Kapadia, R.W Coatney, A Bhattacharyya, R.A. Dodds
المصدر: Osteoarthritis and Cartilage. 8(5):374-377
مصطلحات موضوعية: Male, Aging, Pathology, medicine.medical_specialty, Guinea Pigs, Biomedical Engineering, Stifle joint, Osteoarthritis, Meniscus (anatomy), Menisci, Tibial, Bone remodeling, Rheumatology, medicine, Animals, Orthopedics and Sports Medicine, Osteoarthritis, Guinea-pig, Micro-CT, Bone, Cartilage, Meniscus, Lateral meniscus, business.industry, Ossification, Ossification, Heterotopic, Cartilage, Anatomy, medicine.disease, musculoskeletal system, Hindlimb, body regions, medicine.anatomical_structure, medicine.symptom, Tomography, X-Ray Computed, business, Cartilage Diseases, Medial meniscus
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المؤلفون: Ian E. James, M.W. Lark, F.-L. Wang, J.R. Connor, Shaji Kumar, M.E. Nuttall, C. Zou, M. Gowen, R.A. Dodds
المصدر: Osteoarthritis and Cartilage. 8:161-169
مصطلحات موضوعية: Adult, Cartilage, Articular, Genetic Markers, Male, Pathology, medicine.medical_specialty, Molecular Sequence Data, Biomedical Engineering, Down-Regulation, Gene Expression, Apoptosis, Osteoarthritis, Biology, Polymerase Chain Reaction, Chondrocyte, Immediate-Early Proteins, Pathogenesis, Chondrocytes, Rheumatology, Gene expression, medicine, Humans, Orthopedics and Sports Medicine, RNA, Messenger, In Situ Hybridization, Aged, Early Growth Response Protein 1, Differential display, Base Sequence, Cartilage, Middle Aged, Blotting, Northern, medicine.disease, DNA-Binding Proteins, body regions, medicine.anatomical_structure, Immunohistochemistry, Female, Differential display technique, Cell Division, hormones, hormone substitutes, and hormone antagonists, Transcription Factors, Egr-1, Chondrocyte, Apoptosis, Osteoarthritis, Cartilage, Differential display