المؤلفون: Zhang Y; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., He X; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., Gu L; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., Li S; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., Tang J; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., Ma R; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China., Yang H; Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: yang_hx430@csu.edu.cn., Peng Z; Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China; Hunan Key Lab of Organ Fibrosis, Changsha 410008, China; National International Collaborative Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: pengzhangzhe@csu.edu.cn.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Jul; Vol. 225, pp. 116267. Date of Electronic Publication: 2024 May 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Liver Failure, Acute*/drug therapy , Liver Failure, Acute*/chemically induced , Liver Failure, Acute*/metabolism , Liver Failure, Acute*/pathology , MAP Kinase Kinase 4*/metabolism , MAP Kinase Kinase 4*/antagonists & inhibitors , Pyridones*/pharmacology , Pyridones*/therapeutic use , Piperazines*/pharmacology , Piperazines*/therapeutic use, Animals ; Male ; Mice ; Cell Line ; Galactosamine/toxicity ; Lipopolysaccharides/toxicity ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Mice, Inbred C57BL ; Oxidative Stress/drug effects

المؤلفون: Hindson J; Nature Reviews Gastroenterology & Hepatology, . nrgasthep@springernature.com.

المصدر: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2024 Jun; Vol. 21 (6), pp. 376.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101500079 Publication Model: Print Cited Medium: Internet ISSN: 1759-5053 (Electronic) Linking ISSN: 17595045 NLM ISO Abbreviation: Nat Rev Gastroenterol Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Liver Regeneration*/drug effects , Liver Regeneration*/physiology , MAP Kinase Kinase 4*/metabolism , MAP Kinase Kinase 4*/antagonists & inhibitors , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacology, Animals ; Humans

المؤلفون: Zwirner S; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany; HepaRegeniX GmbH, Tübingen 72072, Germany., Abu Rmilah AA; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Klotz S; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Pfaffenroth B; Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen 72076, Germany., Kloevekorn P; Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen 72076, Germany., Moschopoulou AA; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Schuette S; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Haag M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart 70376, Germany., Selig R; HepaRegeniX GmbH, Tübingen 72072, Germany; Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen 72076, Germany., Li K; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Zhou W; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Nelson E; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Poso A; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany; School of Pharmacy, University of Eastern Finland, Kuopio 70211, Finland; iFIT Cluster of Excellence (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen 72076, Germany., Chen H; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Amiot B; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Jia Y; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Minshew A; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Michalak G; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Cui W; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Rist E; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Longerich T; Institute of Pathology, University Hospital Heidelberg, Heidelberg 69120, Germany., Jung B; HepaRegeniX GmbH, Tübingen 72072, Germany., Felgendreff P; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA., Trompak O; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Premsrirut PK; Mirimus Inc, 760 Parkside Ave, Brooklyn, NY 11226, USA., Gries K; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Muerdter TE; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart 70376, Germany., Heinkele G; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart 70376, Germany., Wuestefeld T; Laboratory for In Vivo Genetics & Gene Therapy, Genome Institute of Singapore, Agency for Science, Technology and Research (A(∗)STAR), Singapore 138672, Singapore; School of Biological Sciences, Nanyang Technological University of Singapore, Singapore 637551, Singapore., Shapiro D; HepaRegeniX GmbH, Tübingen 72072, Germany., Weissbach M; HepaRegeniX GmbH, Tübingen 72072, Germany., Koenigsrainer A; iFIT Cluster of Excellence (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen 72076, Germany; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Department of General-, Visceral, and Transplant Surgery, University Hospital Tübingen, Tübingen 72076, Germany., Sipos B; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany., Ab E; ZoBio B.V., Leiden 2333 CH, the Netherlands., Zacarias MO; ZoBio B.V., Leiden 2333 CH, the Netherlands., Theisgen S; ZoBio B.V., Leiden 2333 CH, the Netherlands., Gruenheit N; CeGaT GmbH, Tübingen 72076, Germany., Biskup S; CeGaT GmbH, Tübingen 72076, Germany., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart 70376, Germany; iFIT Cluster of Excellence (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen 72076, Germany; Department of Clinical Pharmacology, Pharmacy and Biochemistry, University of Tübingen, Tübingen 72076, Germany., Albrecht W; HepaRegeniX GmbH, Tübingen 72072, Germany., Laufer S; Department of Pharmaceutical Chemistry, University of Tübingen, Tübingen 72076, Germany; Tübingen Center for Academic Drug Discovery & Development (TüCAD(2)), Tübingen 72076, Germany. Electronic address: stefan.laufer@uni-tuebingen.de., Nyberg S; William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: nyberg.scott@mayo.edu., Zender L; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tübingen, Tübingen 72076, Germany; iFIT Cluster of Excellence (EXC 2180) 'Image-guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen 72076, Germany; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; Tübingen Center for Academic Drug Discovery & Development (TüCAD(2)), Tübingen 72076, Germany. Electronic address: lars.zender@med.uni-tuebingen.de.

المصدر: Cell [Cell] 2024 Mar 28; Vol. 187 (7), pp. 1666-1684.e26. Date of Electronic Publication: 2024 Mar 14.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Liver Failure*/drug therapy , Liver Failure*/prevention & control , MAP Kinase Kinase 4*/antagonists & inhibitors , Enzyme Inhibitors*/therapeutic use, Animals ; Humans ; Mice ; Hepatectomy/methods ; Hepatocytes ; Liver ; Liver Diseases/drug therapy ; Liver Regeneration ; Swine

المؤلفون: Tabanifar B; Divisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore 168583, Singapore., Moorthy A; Divisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore 168583, Singapore., Tsai HH; Queensland Health Forensic and Scientific Services, Coopers Plains, QLD 4108, Australia., Kannan S; Bioinformatics Institute, ASTAR, Singapore 138671, Singapore., Verma CS; Bioinformatics Institute, ASTAR, Singapore 138671, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore., Sabapathy K; Divisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore 168583, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore. Electronic address: kanaga.sabapathy@ntu.edu.sg.

المصدر: Cell reports [Cell Rep] 2023 Sep 26; Vol. 42 (9), pp. 113123. Date of Electronic Publication: 2023 Sep 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage* , Endonucleases* , MAP Kinase Kinase 4*/metabolism, Humans ; Cell Death ; Phosphorylation ; Ubiquitination

المؤلفون: Huang SW; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Hsu MJ; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan., Chen HC; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan., Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy., Cottiglia F; Department of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, Italy.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2024 Dec; Vol. 39 (1), pp. 2287420. Date of Electronic Publication: 2023 Dec 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Benzofurans*/pharmacology , Glycosides*/pharmacology, CCAAT-Enhancer-Binding Protein-beta/metabolism ; Cyclooxygenase 2/metabolism ; Lipopolysaccharides/pharmacology ; NF-kappa B/metabolism ; Phosphorylation ; p38 Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Kinase 4/metabolism ; Magnoliopsida/chemistry

المؤلفون: Yumura S; Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan., Kitagawa D; Carna Biosciences, Inc., 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan., Moritsugu K; Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan., Nakayama A; Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan., Shinada T; Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan., Sawa M; Carna Biosciences, Inc., 1-5-5 Minatojima-Minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan., Kinoshita T; Graduate School of Science, Osaka Metropolitan University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan. Electronic address: kinotk@omu.ac.jp.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 01; Vol. 112, pp. 129914. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Adenosine Triphosphate*/metabolism , Adenosine Triphosphate*/chemistry , Methionine*/chemistry , Methionine*/metabolism , Zearalenone*/analogs & derivatives , Zearalenone*/chemistry , Zearalenone*/pharmacology , Zearalenone*/metabolism , Zearalenone*/administration & dosage, Humans ; Binding Sites ; Mitogen-Activated Protein Kinase 7/metabolism ; Mitogen-Activated Protein Kinase 7/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 7/chemistry ; MAP Kinase Kinase 1/antagonists & inhibitors ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 7/metabolism ; MAP Kinase Kinase 7/antagonists & inhibitors ; MAP Kinase Kinase 7/chemistry ; Structure-Activity Relationship ; Molecular Dynamics Simulation ; Crystallography, X-Ray ; Molecular Structure ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Lactones ; Resorcinols ; MAP Kinase Kinase 4

المؤلفون: Kodous AS; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Taha EO; Petroleum Applications Department, Egyptian Petroleum Research Institute (EPRI), Cairo, Egypt., El-Maghraby DF; Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt., Hassana AA; Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. asmaabubakr98@yahoo.com., Atta MM; Radiation Physics Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt. mohatta2014@gmail.com.

المصدر: Scientific reports [Sci Rep] 2024 May 21; Vol. 14 (1), pp. 11535. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Graphite*/chemistry , Graphite*/pharmacology , Nanocomposites*/chemistry , Hesperidin*/pharmacology , Hesperidin*/chemistry , Smad4 Protein*/metabolism , Matrix Metalloproteinase 2*/metabolism , Matrix Metalloproteinase 2*/genetics , Gamma Rays*, Humans ; Green Chemistry Technology/methods ; Signal Transduction/drug effects ; Caco-2 Cells ; Hep G2 Cells ; Cell Line, Tumor ; MAP Kinase Kinase 4/metabolism

المؤلفون: Ibraheem K; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK., Yhmed AMA; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.; Department of Medical Laboratory Sciences, Faculty of Medical Technology, Wadi Alshatti University, Wadi Alshatti P.O. Box 68, Libya., Nasef MM; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK., Georgopoulos NT; Department of Biological Sciences, School of Applied Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK.

المصدر: Cells [Cells] 2022 Oct 18; Vol. 11 (20). Date of Electronic Publication: 2022 Oct 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis* , CD40 Antigens*/metabolism , Reactive Oxygen Species*/metabolism , TNF Receptor-Associated Factor 3*/metabolism , TNF-Related Apoptosis-Inducing Ligand*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , MAP Kinase Kinase 4* , Colorectal Neoplasms*/metabolism , Colorectal Neoplasms*/pathology, Humans ; Caspase 10/metabolism ; CD40 Ligand/metabolism ; MAP Kinase Kinase Kinase 5/metabolism ; NADPH Oxidases/metabolism ; BH3 Interacting Domain Death Agonist Protein/metabolism

المؤلفون: Juchum M; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany., Pfaffenrot B; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany., Klövekorn P; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany., Selig R; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany; HepaRegenix GmbH, Eisenbahnstraße 63, 72072, Tuebingen, Germany., Albrecht W; HepaRegenix GmbH, Eisenbahnstraße 63, 72072, Tuebingen, Germany., Zender L; Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital Tuebingen, 72076, Tuebingen, DE, Germany; Cluster of Excellence 'Image Guided and Functionally Instructed Tumor Therapies' (iFIT), Eberhard Karls University of Tübingen, 72076, Tübingen, Germany; German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Laufer SA; Department of Pharmaceutical/Medicinal Chemistry, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany; Cluster of Excellence 'Image Guided and Functionally Instructed Tumor Therapies' (iFIT), Eberhard Karls University of Tübingen, 72076, Tübingen, Germany; German Consortium for Translational Cancer Research (DKTK), Partner Site Tübingen, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany; Tuebingen Center for Academic Drug Discovery, Auf der Morgenstelle 8, 72076, Tübingen, DE, Germany. Electronic address: stefan.laufer@uni-tuebingen.de.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2022 Oct 05; Vol. 240, pp. 114584. Date of Electronic Publication: 2022 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocytes*/metabolism , MAP Kinase Kinase 4*, Vemurafenib/pharmacology

المؤلفون: Yin S; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Pang A; Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China., Liu C; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Li Y; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Liu N; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Li S; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Li C; Department of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Sun H; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Fu Z; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Wang Y; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Zhang Y; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Yang M; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China. Electronic address: webfeng@126.com., Sun J; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China., Wang Y; Key Laboratory of Chemistry in Ethnic Medicinal Resources & Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Endophytes, State Ethnic Affairs Commission & Ministry of Education, School of Ethnic Medicine, Yunnan Minzu University, Kunming, Yunnan, China. Electronic address: wangying_814@163.com., Yang X; Department of Anatomy and Histology and Embryology, Faculty of Basic Medical Science, Kunming Medical University, Kunming, Yunnan, China. Electronic address: yangxinwanghp@163.com.

المصدر: The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102429. Date of Electronic Publication: 2022 Aug 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Astrocytes*/drug effects , Astrocytes*/metabolism , Oxidative Stress*/drug effects , Peptides*/pharmacology , Stroke*/prevention & control , Tryptophan Hydroxylase*/metabolism , Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I*/metabolism , MAP Kinase Kinase 4*/metabolism, Animals ; Rats