المؤلفون: Zou M; Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Chen W; Department of Orthopedics, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China., Li J; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Qi X; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Wang X; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Liu F; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Hu J; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China., Zhang Q; Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: qianshizhang@csu.edu.cn.

المصدر: The American journal of pathology [Am J Pathol] 2024 Sep; Vol. 194 (9), pp. 1737-1751. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis* , Cellular Senescence*/physiology , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc Degeneration*/metabolism , MAP Kinase Kinase Kinase 5*/metabolism , MAP Kinase Kinase Kinase 5*/genetics , Nucleus Pulposus*/pathology , Nucleus Pulposus*/metabolism, Adult ; Animals ; Female ; Humans ; Male ; Middle Aged ; Rats ; MAP Kinase Signaling System/physiology

المؤلفون: Shen J; Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China., Lai W; Division of Nanotechnology Development, National Center for Nanoscience and Technology, Beijing, 100190, China., Li Z; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China., Zhu W; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China., Bai X; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China., Yang Z; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China., Wang Q; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China. wangqingsong@pku.edu.cn., Ji J; State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, 100871, China. jijg@pku.edu.cn.

المصدر: Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2024 Sep; Vol. 73 (9), pp. 1547-1564. Date of Electronic Publication: 2024 Jul 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9508160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-908X (Electronic) Linking ISSN: 10233830 NLM ISO Abbreviation: Inflamm Res Subsets: MEDLINE

مواضيع طبية MeSH: Inflammation*/metabolism , MAP Kinase Kinase Kinase 5*/metabolism , MAP Kinase Kinase Kinase 5*/genetics , Microglia*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , Repressor Proteins*/genetics , Repressor Proteins*/metabolism, Animals ; Humans ; Mice ; Cell Line ; MAP Kinase Signaling System ; Signal Transduction

المؤلفون: Didan Y; School of Biomedical Science, Faculty of Medicine, University of Queensland; St Lucia, Brisbane, Australia., Ghomlaghi M; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Australia.; Biomedicine Discovery Institute, Monash University, Clayton, Australia., Nguyen LK; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Australia.; Biomedicine Discovery Institute, Monash University, Clayton, Australia., Ng DCH; School of Biomedical Science, Faculty of Medicine, University of Queensland; St Lucia, Brisbane, Australia. d.ng1@uq.edu.au.

المصدر: Nature communications [Nat Commun] 2024 Aug 05; Vol. 15 (1), pp. 6614. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Kinase Kinase 5*/metabolism , MAP Kinase Kinase Kinase 5*/genetics, Hydrogen-Ion Concentration ; Humans ; Mitogen-Activated Protein Kinase 9/metabolism ; Mitogen-Activated Protein Kinase 9/genetics ; Stress, Physiological ; Signal Transduction ; Animals ; Optogenetics ; MAP Kinase Signaling System

المؤلفون: Wan H; General practice medicine, Huanggang Central Hospital of Yangtze University, Huanggang, China., Zhang J; Department of central laboratory, Renmin hospital of Wuhan university, Wuhan, China., Liu Z; Department of Cardiology, Renmin hospital of Wuhan university, Wuhan, China., Dong B; Huanggang Institute of Translational Medicine, Huanggang, China., Tao Z; Department of Cardiology, Renmin hospital of Wuhan university, Wuhan, China., Wang G; Department of Cardiology, Huanggang Central Hospital of Yangtze University, Huanggang, China. 2285532569@qq.com., Wang C; Huanggang Disease Control Center, Huanggang, China. wangchihua@hgyy.org.cn.

المصدر: BMC cardiovascular disorders [BMC Cardiovasc Disord] 2024 Aug 05; Vol. 24 (1), pp. 406. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968539 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2261 (Electronic) Linking ISSN: 14712261 NLM ISO Abbreviation: BMC Cardiovasc Disord Subsets: MEDLINE

مواضيع طبية MeSH: Myocardial Infarction*/metabolism , Myocardial Infarction*/genetics , Myocardial Infarction*/pathology , MAP Kinase Kinase Kinase 5*/metabolism , MAP Kinase Kinase Kinase 5*/genetics , Myocytes, Cardiac*/metabolism , Myocytes, Cardiac*/pathology , Mice, Inbred C57BL* , Mice, Knockout* , Apoptosis* , Ubiquitin-Protein Ligases*/genetics , Ubiquitin-Protein Ligases*/metabolism , Disease Models, Animal* , Signal Transduction*, Animals ; Male ; Cells, Cultured ; Mice ; Ventricular Function, Left ; Cell Hypoxia ; Rats

المؤلفون: Peng Z; Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Wei G; Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Huang P; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Matta H; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Gao W; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., An P; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Zhao S; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Lin Y; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Tan L; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.; Center of Hepatopbiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Vaid K; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Skelton-Badlani D; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Nasser I; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., Budas G; Gilead Sciences, Inc., Foster City, California, USA., Lopez D; Gilead Sciences, Inc., Foster City, California, USA., Li L; Gilead Sciences, Inc., Foster City, California, USA., Breckenridge D; Gilead Sciences, Inc., Foster City, California, USA., Myers R; Gilead Sciences, Inc., Foster City, California, USA., McHutchison J; Gilead Sciences, Inc., Foster City, California, USA., Kuang M; Center of Hepatopbiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.; Division of Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Popov YV; Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2024 Aug 01; Vol. 80 (2), pp. 346-362. Date of Electronic Publication: 2024 Feb 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Kinase Kinase 5*/antagonists & inhibitors , MAP Kinase Kinase Kinase 5*/metabolism , Hepatocytes*/drug effects , Hepatocytes*/metabolism , Liver Cirrhosis*/drug therapy , Liver Cirrhosis*/pathology , Liver Cirrhosis*/metabolism , Disease Progression* , Liver Neoplasms*/drug therapy , Liver Neoplasms*/pathology , Liver Neoplasms*/metabolism , p38 Mitogen-Activated Protein Kinases*/metabolism , p38 Mitogen-Activated Protein Kinases*/antagonists & inhibitors , Mice, Inbred BALB C*, Animals ; Mice ; Male ; Thioacetamide/toxicity ; Mitochondria/drug effects ; Mitochondria/metabolism ; Disease Models, Animal

المؤلفون: Li X; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Guo Y; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Xing Z; Department of Hematology, Linfen Central Hospital, Linfen, Shanxi 041099, P.R. China., Gong T; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Yang L; Department of Pharmacology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Yang T; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Chang B; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Wang X; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Yu B; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China., Guo R; Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

المصدر: Oncology reports [Oncol Rep] 2024 Sep; Vol. 52 (3). Date of Electronic Publication: 2024 Jul 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cisplatin*/pharmacology , Drug Resistance, Neoplasm*/drug effects , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/pathology , Reactive Oxygen Species*/metabolism , MAP Kinase Kinase Kinase 5*/metabolism , Biphenyl Compounds*/pharmacology , MAP Kinase Signaling System*/drug effects , Sulfonamides*/pharmacology , Nitrophenols*/pharmacology , Piperazines*/pharmacology, Humans ; Female ; Cell Line, Tumor ; Apoptosis/drug effects ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; Antineoplastic Agents/pharmacology ; JNK Mitogen-Activated Protein Kinases/metabolism

المؤلفون: Wang B; Department of Integrated Chinese and Western Medicine, Jilin Cancer Hospital, Changchun 130103, China., Ma Y; Department of Integrated Chinese and Western Medicine, Jilin Cancer Hospital, Changchun 130103, China., Zhang Y; Department of Integrated Chinese and Western Medicine, Jilin Cancer Hospital, Changchun 130103, China. Electronic address: zhangyuejlcc@163.com., Yin X; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: xzyin@ciac.ac.cn.

المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Sep; Vol. 178, pp. 117214. Date of Electronic Publication: 2024 Jul 29.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Kinase Kinase 5*/metabolism , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Apoptosis/drug effects ; Signal Transduction/drug effects

المؤلفون: Kang K; School of Public Health, Fudan University, Shanghai, 200032, China.; Department of Research and Surveillance Evaluation, Shanghai Municipal Center for Health Promotion, Shanghai, 200040, China., Chen SH; Department of Radiation Oncology, Jiangxi Key Laboratory of Translational Cancer Research, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Cancer Institute, Nanchang, 330029, Jiangxi, China., Wang DP; Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. wdpboj@126.com.; Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, Shanghai, 200065, China. wdpboj@126.com., Chen F; Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, Shanghai, 200065, China. ndrchenf@163.com.

المصدر: Inflammation [Inflammation] 2024 Aug; Vol. 47 (4), pp. 1479-1490. Date of Electronic Publication: 2024 Feb 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7600105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2576 (Electronic) Linking ISSN: 03603997 NLM ISO Abbreviation: Inflammation Subsets: MEDLINE

مواضيع طبية MeSH: Endoplasmic Reticulum Stress*/drug effects , Endoplasmic Reticulum Stress*/physiology , TNF Receptor-Associated Factor 2*/metabolism , MAP Kinase Kinase Kinase 5*/metabolism , Protein Serine-Threonine Kinases*/metabolism , Apoptosis*/drug effects , Endoplasmic Reticulum Chaperone BiP* , Hippocampus*/metabolism , Hippocampus*/pathology , Endoribonucleases*/metabolism , Brain Ischemia*/metabolism , Brain Ischemia*/pathology , Brain Ischemia*/drug therapy, Animals ; Rats ; Mice ; Male ; Rats, Sprague-Dawley ; MAP Kinase Signaling System/physiology ; MAP Kinase Signaling System/drug effects ; Multienzyme Complexes

المؤلفون: Odawara T; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Yamauchi S; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. yamauchi-s@umin.ac.jp., Ichijo H; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. ichijo@g.ecc.u-tokyo.ac.jp.; Cell Signaling and Stress Responses Laboratory, Advanced Research Institute (ARIS), Tokyo Medical and Dental University, Tokyo, Japan. ichijo@g.ecc.u-tokyo.ac.jp.

المصدر: Communications biology [Commun Biol] 2024 Jun 05; Vol. 7 (1), pp. 691. Date of Electronic Publication: 2024 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE

مواضيع طبية MeSH: MAP Kinase Kinase Kinase 5*/metabolism , MAP Kinase Kinase Kinase 5*/genetics , Inflammation*/metabolism , Aging* , Cellular Senescence*, Animals ; Mice ; Humans ; Mice, Knockout ; Mice, Inbred C57BL ; Senescence-Associated Secretory Phenotype/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism ; p38 Mitogen-Activated Protein Kinases/genetics ; Cytokines/metabolism ; Cytokines/genetics

المؤلفون: He M; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Wang J; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Deng W; Fujian Provincial Key Laboratory of Hepatic Drug Research, Ningde 355300, PR China., Han X; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Wang X; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Pang L; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Huang J; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Lan P; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China., Wang T; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330006, PR China. Electronic address: iwangtiantian@126.com., Wang Z; College of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China. Electronic address: zengtaowang@126.com.

المصدر: Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107391. Date of Electronic Publication: 2024 Apr 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Indazoles*/pharmacology , Indazoles*/chemical synthesis , Indazoles*/chemistry , MAP Kinase Kinase Kinase 5*/antagonists & inhibitors , MAP Kinase Kinase Kinase 5*/metabolism , Molecular Docking Simulation* , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemical synthesis , Protein Kinase Inhibitors*/chemistry, Humans ; Apoptosis/drug effects ; Dose-Response Relationship, Drug ; Molecular Structure ; Non-alcoholic Fatty Liver Disease/drug therapy ; Structure-Activity Relationship ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/metabolism