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المؤلفون: Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019مصطلحات موضوعية: 0301 basic medicine, LC-MS, liquid chromatography-mass spectrometry, DAVID, Database for Annotation, Visualization and Integrated Discovery, IGF1, insulin-like growth factor 1, AST, aspartate aminotransferase, RC799-869, muscular-atrophy phenotype, CS, citric synthase, animal-models, Mice, 0302 clinical medicine, iron, Fibrosis, Non-alcoholic Fatty Liver Disease, LDL, low-density lipoprotein, Nonalcoholic fatty liver disease, MCD, methionine and choline deficient diet, steatosis, Medicine, TNFR1, tumor necrosis factor receptor superfamily member 1A, defects, ANOVA, analysis of variance, Original Research, Mice, Knockout, P, postnatal day, FasR, Fas receptor, NEFA, non-esterified fatty acid, p53, tumor protein p53, TEAB, triethyl ammonium bicarbonate, Fatty liver, Gastroenterology, NASH, CPT1, carnitine palmitoyl transferase 1, p21, cyclin dependent kinase inhibitor 1A, Diseases of the digestive system. Gastroenterology, 3. Good health, ECM, extracellular matrix, SMN, TMT, tandem mass tagging, mouse-model, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, insulin, HDL, high-density lipoprotein, PBS, phosphate-buffered saline, steatohepatitis, Hypoglycemia, SMN1, survival motor neuron 1, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, VLDL, very low density lipoprotein, Internal medicine, ALT, alanine aminotransferase, NAFLD, mitochondrial dysfunction, Animals, MCL, Markov Clustering Algorithm, Hepatology, ALP, alkaline phosphatase, business.industry, T2DM, type 2 diabetes mellitus, IPA, ingenuity pathway analysis, medicine.disease, WT, wild-type, Survival of Motor Neuron 1 Protein, igfals, insulin-like growth factor binding protein acid labile subunit, digestive system diseases, Fatty Liver, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Metabolism, AAV9, adeno-associated virus 9, SMA, spinal muscular atrophy, network, Akt, protein kinase B, Hepatic stellate cell, NAFLD, nonalcoholic fatty liver disease, Steatosis, Steatohepatitis, business, Bax, BCL2 associated X protein, HFN4a, hepatic nuclear factor 4 alpha
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a717cf593f4034226b292cb0ee07cc
http://www.sciencedirect.com/science/article/pii/S2352345X21000254 -
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المؤلفون: Kai Lin, Han Zhao, Yingwei Zhu, Hong Tang, Gaojue Wu, Jingbin Ni, Jian Lu
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 653-664 (2021)مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Necrosis, Nonalcoholic Steatohepatitis, RC799-869, AST, aspartate aminotransferase, Choline, 0302 clinical medicine, Methionine, PCR, polymerase chain reaction, Fibrosis, Non-alcoholic Fatty Liver Disease, TNF-α, tumor necrosis factor α, Original Research, Liver injury, TGF-β, transforming growth factor β, Gastroenterology, Pyroptosis, NF-kappa B, Inflammasome, Diseases of the digestive system. Gastroenterology, Caspases, Initiator, mRNA, messenger RNA, Up-Regulation, Liver, Disease Progression, LPS, lipopolysaccharide, MCD, methionine- and choline-deficient diet, 030211 gastroenterology & hepatology, medicine.symptom, NF-κB, nuclear factor κB, NASH, nonalcoholic steatohepatitis, medicine.drug, Signal Transduction, Inflammation, Caspase-11, digestive system, 03 medical and health sciences, ALT, alanine aminotransferase, medicine, Animals, GSDMD, gasdermin D, Hepatology, business.industry, nutritional and metabolic diseases, medicine.disease, digestive system diseases, Diet, IL, interleukin, Mice, Inbred C57BL, 030104 developmental biology, GSDMD-N, N-terminal fragment of gasdermin D, Cancer research, Hepatocytes, α-SMA, α smooth muscle actin, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, business
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المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 2, Iss 5, Pp 584-604 (2016)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: RT-PCR, reverse-transcription polymerase chain reaction, 0301 basic medicine, HFD, high-fat diet, Steatosis, ConA, concanavalin A, AST, aspartate aminotransferase, IEC, intestinal epithelial cell, Liver disease, DC, dendritic cell, CFU, colony-forming unit, Nonalcoholic fatty liver disease, KO, knock-out, TLR5, Original Research, Liver injury, Toll-like receptor, Hep, hepatocyte, Gastroenterology, mRNA, messenger RNA, Innate Immunity, 3. Good health, medicine.anatomical_structure, Hepatocyte, MCD, methionine- and choline-deficient diet, LPS, lipopolysaccharide, NASH, nonalcoholic steatohepatitis, TLR, Toll-like receptor, NLR, nod-like receptor, CCL4, carbon tetrachloride, PBS, phosphate-buffered saline, Biology, Proinflammatory cytokine, CXCL, chemokine (C-X-C motif) ligand 1, 03 medical and health sciences, ALT, alanine aminotransferase, medicine, lcsh:RC799-869, Inflammation, Hepatology, medicine.disease, WT, wild-type, IL, interleukin, 030104 developmental biology, Immunology, biology.protein, Hepatocytes, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, NPC, nonparenchymal cell, Flagellin
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المؤلفون: Nathan J. Cherrington, Michael Goedken, Joseph L. Jilek, Kevyn A. Jacobus, Wenxi He, Kayla Frost, Erica Toth
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3869-3878 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: Nonalcoholic steatohepatitis, ATPase, DT, drug transporter, Pharmacology, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, LC–MS/MS, liquid chromatography–tandem mass spectrometry, General Pharmacology, Toxicology and Pharmaceutics, Nephrotoxicity, OCT, organic cation transporter, 0303 health sciences, biology, Chemistry, CDDP, cisplatin, NASH, DDTC, diethyldithiocarbamate, CTR, copper transporter, 030220 oncology & carcinogenesis, Toxicity, MCD, methionine- and choline-deficient diet, Original Article, NASH, nonalcoholic steatohepatitis, MATE, multidrug and toxin extrusion protein, Biotechnology, medicine.drug, inorganic chemicals, Drug transporter, RM1-950, 03 medical and health sciences, Pharmacokinetics, Genetics, medicine, neoplasms, Molecular Biology, 030304 developmental biology, Cisplatin, Methionine, business.industry, GFR, glomerular filtration rate, ATP7, ATPase copper transporting protein, Transporter, P-gp, p-glycoprotein, Renal physiology, biology.protein, PK, pharmacokinetics, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, business
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المؤلفون: Takahiro Yamaura, Frank J. Gonzalez, Tadanobu Nagaya, Toshifumi Aoyama, Takefumi Kimura, Naoki Tanaka, Hiroyuki Kitabatake, Kenji Sano, Michiharu Komatsu, Naoyuki Fujimori, Eiji Tanaka, Takeji Umemura, Akira Horiuchi
المصدر: BBA Clinical
مصطلحات موضوعية: Nonalcoholic steatohepatitis, medicine.medical_treatment, BMI, body mass index, FASN, fatty acid synthase, PPAR, peroxisome proliferator-activated receptor, AST, aspartate aminotransferase, Gastroenterology, Nonalcoholic fatty liver disease, TNF, tumor necrosis factor α, CPT1A, carnitine palmitoyl-CoA transferase 1α, NAS, NAFLD activity score, TG, triglyceride, US, ultrasonography, MTTP, microsomal triglyceride transfer protein, SREBF1, sterol regulatory element-binding transcription factor 1, NASH, Regular Article, Hbv hepatitis b virus, FABP, fatty acid-binding protein, γGT, gamma-glutamyltransferase, Pancreaticoduodenectomy, CT, computed tomography, HADHA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase α, PPARGC, PPARγ co-activator, Alt alanine aminotransferase, CYBB, cytochrome b-245 β polypeptide, HCV, hepatitis C virus, Molecular Medicine, ACOX1, CYP, cytochrome P450, LPS, lipopolysaccharide, MCD, methionine- and choline-deficient diet, qPCR, quantitative polymerase chain reaction, DGAT, diacylglycerol acyltransferase, NASH, nonalcoholic steatohepatitis, VLDL, TLR, Toll-like receptor, CoA, coenzyme A, medicine.medical_specialty, RXR, retinoid X receptor, NAFLD - Nonalcoholic Fatty Liver Disease, digestive system, Pathology and Forensic Medicine, ROS, reactive oxygen species, SCD, stearoyl-CoA desaturase, PD, pancreaticoduodenectomy, Physiology (medical), Internal medicine, ALT, alanine aminotransferase, SOD, superoxide dismutase, HOMA-IR, homeostasis model assessment for insulin resistance, medicine, ApoB, apolipoprotein B, business.industry, Mechanism (biology), FA, fatty acid, ACACB, acetyl-CoA carboxylase β, nutritional and metabolic diseases, ACACA, acetyl-CoA carboxylase α, VLDL, very-low-density lipoprotein, ACADM, medium-chain acyl-CoA dehydrogenase, TGFB1, transforming growth factor β1, medicine.disease, Fatty acid, MyD88, digestive system diseases, Endocrinology, HBV, hepatitis B virus, ACOX1, acyl-CoA oxidase 1, NAFLD, nonalcoholic fatty liver disease, CAT, catalase, LXR, liver X receptor, business, MYD88, myeloid differentiation primary response 88
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6دورية أكاديمية
المؤلفون: Jilek JL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA., Frost KL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA., Jacobus KA; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA., He W; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA., Toth EL; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA., Goedken M; Rutgers Translational Sciences, Rutgers University, Piscataway, NJ 08901, USA., Cherrington NJ; Department of Pharmacology & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85724, USA.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Dec; Vol. 11 (12), pp. 3869-3878. Date of Electronic Publication: 2021 Jun 02.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE
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7دورية أكاديمية
المؤلفون: Etienne-Mesmin L; Center for Inflammation Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia., Vijay-Kumar M; Department of Nutritional Sciences and Medicine, Pennsylvania State University, University Park, Pennsylvania., Gewirtz AT; Center for Inflammation Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia., Chassaing B; Center for Inflammation Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
المصدر: Cellular and molecular gastroenterology and hepatology [Cell Mol Gastroenterol Hepatol] 2016 May 05; Vol. 2 (5), pp. 584-604. Date of Electronic Publication: 2016 May 05 (Print Publication: 2016).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Gastroenterological Association Country of Publication: United States NLM ID: 101648302 Publication Model: eCollection Cited Medium: Print ISSN: 2352-345X (Print) Linking ISSN: 2352345X NLM ISO Abbreviation: Cell Mol Gastroenterol Hepatol Subsets: PubMed not MEDLINE
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8دورية أكاديمية
المؤلفون: Nagaya T; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Tanaka N; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan ; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan., Kimura T; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Kitabatake H; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Fujimori N; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Komatsu M; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Horiuchi A; Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan., Yamaura T; Department of Gastroenterology, Iida Municipal Hospital, Iida, Japan., Umemura T; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan., Sano K; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan., Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States., Aoyama T; Department of Metabolic Regulation, Shinshu University Graduate School of Medicine, Matsumoto, Japan., Tanaka E; Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan.
المصدر: BBA clinical [BBA Clin] 2015 Feb 19; Vol. 3, pp. 168-74. Date of Electronic Publication: 2015 Feb 19 (Print Publication: 2015).
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101633879 Publication Model: eCollection Cited Medium: Print ISSN: 2214-6474 (Print) Linking ISSN: 22146474 NLM ISO Abbreviation: BBA Clin Subsets: PubMed not MEDLINE
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