نتائج البحث - "MDR reversers"

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 974-992 (2020)

مصطلحات موضوعية: Tariquidar, Antineoplastic Agents, ATP-binding cassette transporter, RM1-950, co-administration assay, cytotoxicity, MDR reversers, P-gp modulators, Tetrahydroisoquinoline, 01 natural sciences, Structure-Activity Relationship, chemistry.chemical_compound, Hydrolysis, Dogs, Neoplasms, Tetrahydroisoquinolines, Enzymatic hydrolysis, Amide, Drug Discovery, medicine, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Cells, Cultured, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Esters, General Medicine, Amides, Combinatorial chemistry, Drug Resistance, Multiple, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Doxorubicin, Drug Resistance, Neoplasm, Therapeutics. Pharmacology, Drug Screening Assays, Antitumor, Selectivity, Research Paper, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b642c35e6f90a3b77b4bcccb7ae2c
https://doi.org/10.1080/14756366.2020.1747449

PDF full text from Publisher

Find this article in full text from ProQuest

7

Dual P-Glycoprotein and CA XII Inhibitors: A New Strategy to Reverse the P-gp Mediated Multidrug Resistance (MDR) in Cancer Cells †

المؤلفون: Maria Novella Romanelli, Elisabetta Teodori, Dina Manetti, Claudiu T. Supuran, Gianluca Bartolucci, Marcella Coronnello, Laura Braconi, Silvia Bua, Andrea Lapucci, Silvia Dei

المصدر: Molecules
Volume 25
Issue 7
Molecules, Vol 25, Iss 1748, p 1748 (2020)

مصطلحات موضوعية: Pharmaceutical Science, hybrid compounds, Analytical Chemistry, 0302 clinical medicine, Drug Stability, Drug Discovery, Cytotoxicity, Carbonic Anhydrase Inhibitors, P-glycoprotein, Carbonic Anhydrases, 0303 health sciences, biology, Molecular Structure, Chemistry, Drug Resistance, Multiple, LoVo/DOX, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, selective chemosensitizers, Molecular Medicine, Efflux, MDR reversers, medicine.drug, circulatory and respiratory physiology, animal structures, PH reduction, Antineoplastic Agents, Article, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, medicine, Humans, Doxorubicin, cardiovascular diseases, ATP Binding Cassette Transporter, Subfamily B, Member 1, Physical and Theoretical Chemistry, 030304 developmental biology, CA XII inhibitors, Dual P-gp/CA XII inhibitory activity, Hybrid compounds, K562/DOX, Multitarget ligands, P-gp modulators, Selective chemosensitizers, multitarget ligands, Organic Chemistry, Biological Transport, Molecular biology, Multiple drug resistance, Drug Resistance, Neoplasm, Cancer cell, biology.protein, dual P-gp/CA XII inhibitory activity, K562 Cells, K562 cells

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629c7fc82ebb25f08fed2927a4aecb86
http://europepmc.org/articles/PMC7181201

Find this article in full text from ProQuest

8

Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug-resistance (MDR) modulators

المؤلفون: Ottavia Spiga, Niccolò Chiaramonte, Milena Salerno, Silvia Dei, Marta Menicatti, Laura Braconi, Chatchanok Udomtanakunchai, Marcella Coronnello, Marialessandra Contino, Maria Grazia Perrone, Gianluca Bartolucci, Nicola Antonio Colabufo, Elisabetta Teodori, Alfonso Trezza, Maria Novella Romanelli, Dina Manetti

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Antineoplastic Agents, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Tumor Cells, Cultured, ATP Binding Cassette Transporter, Subfamily G, Member 2, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Amines, 030304 developmental biology, P-glycoprotein, Pharmacology, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Aryl, Organic Chemistry, Esters, General Medicine, Drug Resistance, Multiple, 0104 chemical sciences, Neoplasm Proteins, Multiple drug resistance, chemistry, Docking (molecular), Drug Resistance, Neoplasm, biology.protein, Amine gas treating, Multidrug Resistance-Associated Protein 1, Efflux, Caco-2 Cells, Multidrug Resistance-Associated Proteins, K562 Cells, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimmide hydrochloride, 4-Dimethylaminopyridine, Apparent permeability, ATPase activity, BCRP, BCRP modulators, Breast cancer resistance protein, Caco-2 cells, Colorectal adenocarcinoma cells, DMAP, DOX, Doxorubicin, EDCI, Human plasma stability, KEE, Ketoprofen Ethyl Ester, Madin-Darby Canin Kidney, MDCK, MDR reversers, Molecular docking, MRP1, MRP1 modulators, Multidrug resistance associated protein 1, P-gp, P-gp modulators, PBS, PDB, Phosphate buffer solution, Pirarubicin uptake, Protein data bank, Rhd123, Rhodamine-123, Rhodamine-123 efflux, Topological polar surface area, TPSA, Linker, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a608570c490ee0bb2e3b1b660300c6
http://hdl.handle.net/2158/1152900

9

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

المؤلفون: Milena Salerno, Chiara Riganti, Ottavia Spiga, Elena Gazzano, Dina Manetti, Asimidis Athanasios, Gianluca Bartolucci, Maria Novella Romanelli, Marialessandra Contino, Laura Braconi, Silvia Dei, Elisabetta Teodori, Alfonso Trezza, Nicola Antonio Colabufo, Maria Grazia Perrone, Roberta Giampietro

مصطلحات موضوعية: 01 natural sciences, Madin Darby Canine Kidney Cells, Stereocenter, chemistry.chemical_compound, Drug Discovery, Structural isomer, Amines, Collateral sensitivity, Enantiomers, Human plasma stability, K562 cells, MDCK cells, MDR reversers, Molecular docking, P-gp modulators, Cells, Cultured, 0303 health sciences, Molecular Structure, Esters, Stereoisomerism, General Medicine, Drug Resistance, Multiple, Molecular Docking Simulation, Amine gas treating, Stereochemistry, Antineoplastic Agents, Structure-Activity Relationship, 03 medical and health sciences, Dogs, Animals, Humans, Cell Proliferation, 030304 developmental biology, Pharmacology, Dose-Response Relationship, Drug, 010405 organic chemistry, Aryl, Organic Chemistry, 0104 chemical sciences, Multiple drug resistance, chemistry, Drug Resistance, Neoplasm, Docking (molecular), Drug Design, Drug Screening Assays, Antitumor, Enantiomer, K562 Cells, Methyl group

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cf81100cf01c1230b4c3abea16f8cf
http://hdl.handle.net/2158/1175670

10

Design and synthesis of aminoester heterodimers containing flavone or chromone moieties as modulators of P-glycoprotein-based multidrug resistance (MDR)

المؤلفون: Marcella Coronnello, Elisabetta Teodori, Niccolò Chiaramonte, Maria Novella Romanelli, Milena Salerno, Dina Manetti, Silvia Dei

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, gp modulators, MDR reversers, heterodimers, flavonoids, doxorubicin-resistant human erythroleukemia K562 cells (K562/DOX), pirarubicin uptak, 03 medical and health sciences, chemistry.chemical_compound, Residue (chemistry), Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Tumor Cells, Cultured, Molecule, Moiety, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Amines, Molecular Biology, P-glycoprotein, biology, Dose-Response Relationship, Drug, Molecular Structure, Aryl, Organic Chemistry, Esters, Flavones, Drug Resistance, Multiple, Multiple drug resistance, 030104 developmental biology, chemistry, Chromones, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Drug Design, Chromone, biology.protein, Molecular Medicine, Amine gas treating, K562 Cells, Dimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2bbe60ffb410153698af31004d333c2
http://hdl.handle.net/2158/1106055

تنقيح النتائج