المؤلفون: Hui Ao, Fei Tang, Jing Wang, Yu-Zhu Tan, Yan Wan, Lu Chen, Cheng Peng, Jin-feng Xu, Chao-long Rao

المصدر: Journal of Ginseng Research, Vol 45, Iss 6, Pp 617-630 (2021)
Journal of Ginseng Research

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Ginsenosides, AMO, Atractylodes macrocephala volatile oil, PG, ERK, extracellular signal-regulated kinases, PPD, protopanaxadiol, CY, cyclophosphamide, Review Article, AST, aspartate aminotransferase, Pharmacology, TNF-α, tumor necrosis factor-α, MKK4, mitogen activated protein kinase kinase 4, NQO, NAD (P) H quinone oxidoreductase, PGLF, PG leaf, Ginseng, Pharmacological effects, 0302 clinical medicine, RGE, red ginseng extract, Medicine, PGS, PG total saponins, Side effects, HO-1, heme oxygenase-1, CK, compound K, CIA, chemotherapy-induced hair loss, Kinase, PGFR, PG flower, PI3K, phosphatidylinositol 3-kinase, PGSD, PG seeds, FRG, probiotic-fermented eRG, NF-κB, nuclear factor-kappa B p65, BMNC, bone marrow nucleated cells, RG, red ginseng, 030220 oncology & carcinogenesis, Nrf2, nuclear factor erythroid related factor 2, PG, Panax ginseng, Mechanism, KG-KH, the mixture of ginsenosides Rk3 and Rh4, Signal transduction, PGRT, PG root, Biotechnology, ADM, Adriamycin, CYP2E1, Cytochrome P450 E1, eRG, 50% ethanol-extracted RG, ARE, antioxidant response element, mTOR, mammalian target of rapamycin, HEI-OC1, House Ear Institute-Organ of Corti 1, ERG, enzyme-treated eRG, Biochemistry, Genetics and Molecular Biology (miscellaneous), LLC-PK1, porcine renal proximal epithelial tubular, 03 medical and health sciences, ROS, reactive oxygen species, ALT, alanine aminotransferase, DAC, doses of docetaxel, doxorubicin as well as cyclophosphamide, GM-CSF, granulocyte macrophage colony-stimulating factor, LSK, Lin−Sca-1+c-kit+, Chemotherapy, Protein kinase A, Protein kinase B, PI3K/AKT/mTOR pathway, MDA, malonaldehyde, Cardiotoxicity, SREBP-1, sterol regulatory element binding protein 1, HSPCS, haematopoietic stem and progenitor cells, business.industry, Botany, wRG, water-extracted RG, PPT, protopanaxatriol, PGSM, PG stem, FRGE, fermented red ginseng extract, IL, interleukin, CP, cisplatin, AMPK, AMP-activated protein kinase, 030104 developmental biology, Complementary and alternative medicine, FBG, fermented black ginseng, QK1-989, JNK, c-jun N-terminal kinase, 5-FU, 5-fluorouracil, business, MAPK, mitogen-activated protein kinase, MEK, mitogen activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddba476a926baf2ffce4db535797ce9
https://doi.org/10.1016/j.jgr.2021.03.001

المؤلفون: Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: PE, R-phycoerythrin, Male, 0301 basic medicine, CL.CASP3, cleaved caspase 3, Aging, Cell cycle checkpoint, BrdU, 5-bromo-2′-deoxyuridine, DMSO, dimethyl sulfoxide, Mice, 0302 clinical medicine, APC, allophycocyanin, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, GEO, Gene Expression Omnibus, NES, normalized enrichment score, TRP53, transformation related protein 53, Wnt Signaling Pathway, Klotho, ANOVA, analysis of variance, Cellular Senescence, Original Research, SA-β-gal, senescence-associated beta-galactosidase, KIT, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Stomach, EdU, 5-ethynyl-2′-deoxyuridine, Gastroenterology, Wnt signaling pathway, MTS, methyltetrazolium salt, ICC, interstitial cells of Cajal, Middle Aged, CDKN1A, cyclin-dependent kinase inhibitor 1a, Up-Regulation, Cell biology, CTNNB1, catenin beta 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Models, Animal, symbols, Female, 030211 gastroenterology & hepatology, ANO1, anoctamin-1, RPKM, reads per kilobase of transcript per million mapped reads, Stem cell, Compliance, Senescence, SESN, sestrin, tsTAg, tsA58-mutant SV40 large T antigen, Adenomatous Polyposis Coli Protein, FDR Q, false discovery rate Q value, Mice, Transgenic, KLF4, Kruppel-like factor 4, Biology, DDR, DNA damage response, PI, propidium iodide, Young Adult, 03 medical and health sciences, symbols.namesake, Cyclin D1, RT-qPCR, real-time quantitative reverse-transcription polymerase chain reaction, Stem Cell, MEK, mitogen-activated protein kinase kinase, Animals, Humans, Kinase activity, lcsh:RC799-869, Klotho Proteins, CCND1, cyclin D1, Hepatology, WB, Western immunoblotting, RNA-seq, RNA sequencing, Cell Cycle Checkpoints, Interstitial Cells of Cajal, CDKN1B, cyclin-dependent kinase inhibitor 2B, WT, wild-type, Interstitial cell of Cajal, 030104 developmental biology, siRNA, small interfering RNA, ETV1, ets variant 1, ICC-SC, interstitial cells of Cajal stem cells, lcsh:Diseases of the digestive system. Gastroenterology, Tumor Suppressor Protein p53, MYC, myelocytomatosis oncogene, DAPI, 4′,6-diamidino-2-phenylindole

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1a15d90b0466d35d9517a3a039e81b
http://www.sciencedirect.com/science/article/pii/S2352345X2030117X

المؤلفون: Sara M. Dann, Zheng Zhou, Suxia Yao, Wenjing Yang, Anthony J. Bilotta, Yu Yu, Xiaojing Zhao, Chunyan Ma, Yingzi Cong, Yanbo Yu

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1023-1044 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, STAT3, signal transducer and activator of transcription 3, Cell, Video microscopy, HDAC, histone deacetylase, DMEM, Dulbecco’s modified Eagle’s medium, IEC, intestinal epithelial cell, Receptors, G-Protein-Coupled, STAT3, Mice, 0302 clinical medicine, HDAC, Propionate, MSIE, mouse small intestinal epithelial cell, OCR, oxygen consumption rate, TGFβ, transforming growth factor beta, IEC, Intestinal Mucosa, ANOVA, analysis of variance, HDACi, histone deacetylase inhibitor, Migration, Original Research, chemistry.chemical_classification, biology, Dextran Sulfate, Gastroenterology, Cell migration, gRNA, guide RNA, Colitis, Cell biology, medicine.anatomical_structure, SCFA, short-chain fatty acid, 030211 gastroenterology & hepatology, STAT3 Transcription Factor, TNFα, tumor necrosis factor alpha, mTOR, mammalian target of rapamycin, Histone Deacetylases, EGF, endothelial growth factor, 03 medical and health sciences, FBS, fetal bovine serum, DSS, dextran sulfate sodium, Intestinal epithelial cell migration, medicine, Animals, MSD, mean-squared displacement, lcsh:RC799-869, ECAR, extracellular acidification rate, KO, knockout, Hepatology, Epithelial Cells, Fatty Acids, Volatile, WT, wild-type, IL, interleukin, Histone Deacetylase Inhibitors, Mice, Inbred C57BL, 030104 developmental biology, chemistry, IFNγ, interferon gamma, Gene Expression Regulation, STAT protein, biology.protein, lcsh:Diseases of the digestive system. Gastroenterology, Propionates, Homeostasis, MEK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4114ca3e9339e1b8954fbfbdd4b9d
http://www.sciencedirect.com/science/article/pii/S2352345X20301909

المؤلفون: Marius Winkler, Juliane Friedrich, Cathinka Boedicker, Nadezda Dolgikh

المصدر: Translational Oncology, Vol 16, Iss, Pp 101313-(2022)
Translational Oncology

مصطلحات موضوعية: Cancer Research, (MEK), mitogen-activated protein kinase, (RIP1), receptor-interacting protein 1, (MULE), MCL-1 ubiquitin ligase E3, (FOXO1), forkhead box protein O1, (RMS), rhabdomyosarcoma, (PI), propidium iodide, (ERK), extracellular signal-regulated kinase, (FN), PAX3/7-FOXO1 fusion-negative, (DUSP6), dual specificity phosphatase 6, (FGF), fibroblast growth factor, ERK1/2 signaling, hemic and lymphatic diseases, (PARP), poly(ADP-ribose) polymerase, Apoptotic cell death, (CI), combination index, neoplasms, (RTK), receptor tyrosine kinase, RC254-282, Original Research, (PAX), paired box, (CAM), chicken chorioallantoic membrane, (FP), PAX3/7-FOXO1 fusion-positive, Ulixertinib, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, (IGF), insulin-like growth factor, RMS, (FCS), fetal calf serum, (Nec-1s), necrostatin-1s, (PBMCs), peripheral blood mononuclear cells, (CHX), cycloheximide, Oncology, (RSK), p90 ribosomal s6 kinase, S63845, (zVAD.fmk), N-benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone, biological phenomena, cell phenomena, and immunity, (EV), empty vector

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9f914981a207a50fa9cf51a7b0aef2
http://www.sciencedirect.com/science/article/pii/S1936523321003041

المؤلفون: Luigi Ricciardiello, Giulia Piazzi, Chiara Alquati, Anna Prossomariti

المساهمون: Prossomariti A., Piazzi G., Alquati C., Ricciardiello L.

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Colorectal cancer, Wnt/β-Catenin, Resistance, FZD, frizzled, mTORC1, Review, PI3K, phosphatidylinositol-3-kinase, DEPTOR, DEP domain-containing mTOR-interacting protein, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, GTPase, guanosine triphosphatase, Antineoplastic Combined Chemotherapy Protocols, Crosstalk, beta Catenin, Phosphoinositide-3 Kinase Inhibitors, Kinase, Gastroenterology, Wnt signaling pathway, mTORC1, mammalian target of rapamycin complex 1, APC, adenomatous polyposis coli, eIF4E, eukaryotic translation initiation factor 4E, FOXO3A, Forkhead box O3A, MNK, Mitogen-activated Protein kinase interacting kinases, Gene Expression Regulation, Neoplastic, Crosstalk (biology), PI3K/AKT/mTORC1, CRC, colorectal cancer, PORCN, Porcupine, 030211 gastroenterology & hepatology, Colorectal Neoplasms, RAS, Rat Sarcoma, Signal Transduction, Rheb, ras homolog enriched in brain, TSC, tuberous sclerosis, 4E-BP1, 4E binding protein 1, mTOR, mammalian target of rapamycin, RNF43, ring finger protein 43, Biology, Mechanistic Target of Rapamycin Complex 1, TNKSi, tankyrase inhibitors, AKT, protein kinase B, 03 medical and health sciences, eEF2K, elongation factor 2 kinase, MEK, Mitogen-activated protein kinase kinase, Cell Line, Tumor, medicine, GSK3, glycogen synthase kinase 3, Animals, Humans, FAP, familial adenomatous polyposis, lcsh:RC799-869, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, TNKS, tankyrase, Colorectal Cancer, Hepatology, ZNRF3, zinc/ring finger 3, medicine.disease, YAP, Yes-associated protein, EGFR, epidermal growth factor receptor, Wnt Proteins, Disease Models, Animal, 030104 developmental biology, DVL, Dishevelled, Drug Resistance, Neoplasm, Catenin, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Proto-Oncogene Proteins c-akt, LRP, low-density lipoprotein receptors 5 and 6, S6K, S6 Kinase

وصف الملف: STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515

المؤلفون: Michael D. Onken, Sarah E. Noda, Kevin M. Kaltenbronn, Cheryl Frankfater, Carol M. Makepeace, Nikki Fettig, Kisha D. Piggott, Philip L. Custer, Joseph E. Ippolito, Kendall J. Blumer

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Uveal Neoplasms, RRID, Research Resource Identifier, 2-DG6P, 2-deoxy-d-glucose-6-phosphate, oncogenes, Carcinogenesis, MST, Mito Stress Test, ROI, region of interest, TCA, tricarboxylic acid, DMSO, dimethyl sulfoxide, MEK, mitogen-activated protein kinase/extracellular signal–regulated kinase kinase, Biochemistry, OxPhos, oxidative phosphorylation, NSG, NOD scid gamma, 2-DG, 2-deoxyglucose, Erk, extracellular signal–regulated protein kinase, Cell Line, Tumor, Gq/11, Humans, OCR, oxygen consumption rate, TBST, Tris-buffered saline with Tween-20, Molecular Biology, Melanoma, PDX, patient-derived xenograft, 18F-FDG, 18F-fluorodeoxyglucose, ECAR, extracellular acidification rate, ATCC, American Type Culture Collection, BAP1, BRCA1-associated protein 1, GST, Glycolytic Stress Test, Gq/11, Gq or G11, I.I., integrated fluorescence intensities, MEKi, MEK inhibitor, Cell Biology, PKCi, PKC inhibitor, MEF, mouse embryonic fibroblast, GTP-Binding Protein alpha Subunits, BRAF, B-Raf proto-oncogene serine/threonine-protein kinase, CT, computed tomography, AMPK, AMP-activated protein kinase, mTORC1, mechanistic target of rapamycin complex 1, FR, FR900359, GTP-Binding Protein alpha Subunits, Gq-G11, FCCP, carbonyl cyanide-p-trifluoromethoxyphenylhydrazone, uveal melanoma, signaling, metabolism, Research Article, UM, uveal melanoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75e9c1da7a1bf50b5ce0880b781fb6f
http://europepmc.org/articles/PMC8761705

المؤلفون: Hemant Kumar, Yoav Peleg, Ariel Erijman, Julia M. Shifman, Ashish Noronha, Anamika Singh, Yosef Yarden

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: MAPK/ERK pathway, Ras inhibitors, Models, Molecular, Lung Neoplasms, Tumor suppressor gene, protein-protein interactions, SARAH, Salvador-RASSF-Hippo, Son of Sevenless, SPR, surface plasmon resonance, Adenocarcinoma of Lung, GTPase, RASSF5, Ras association domain family 5, Biochemistry, Nore1A, GEF, guanine nucleotide exchange factor, Ras effector protein, PLC, phospholipase C, APC, allophycocyanin, ERK, extracellular signal-regulated kinase, Protein Domains, FACS, fluorescence-activated cell sorting, Humans, SOS, son of sevenless, Genes, Tumor Suppressor, Molecular Biology, Adaptor Proteins, Signal Transducing, biology, Oncogene, RBD, RAS-binding domain, Chemistry, Effector, protein engineering, Cell Biology, YSD, yeast surface display, Cell biology, A549 Cells, Mitogen-activated protein kinase, Mutation, biology.protein, ras Proteins, RASSF5, Guanine nucleotide exchange factor, FITC, fluorescein isothiocyanate, Ras oncogene, Apoptosis Regulatory Proteins, MEK, mitogen-activated protein kinase, Research Article, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6e501be983b2ce2666c2a21b78ab3a
http://europepmc.org/articles/PMC8605244

المؤلفون: Sabine Wächter, Annette Wunderlich, Brandon H. Greene, Silvia Roth, Moritz Elxnat, Sebastian A. Fellinger, Frederik A. Verburg, Markus Luster, Detlef K. Bartsch, Pietro Di Fazio

المصدر: International Journal of Molecular Sciences, Vol 19, Iss 7, p 2077 (2018)

مصطلحات موضوعية: radioiodine refractory differentiated thyroid cancer, miRNAs, MEK (mitogen-activated protein kinase kinase) inhibitor, Biology (General), QH301-705.5, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: http://www.mdpi.com/1422-0067/19/7/2077; https://doaj.org/toc/1422-0067

URL الوصول: https://doaj.org/article/aaa78e7334f744e6b11c193ff96d9986

المؤلفون: Anaïs F. Bardet, Daniel Hess, Daniel Olivieri, Sébastien A. Smallwood, Ulrich Elling, Sujani Paramanathan, Joerg Betschinger

المساهمون: Friedrich Miescher Institute for Biomedical Research (FMI), Novartis Research Foundation, Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS), Institute of Molecular Biotechnology (IMBA), Austrian Academy of Sciences (OeAW)

المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100947. ⟨10.1016/j.jbc.2021.100947⟩
The Journal of Biological Chemistry

مصطلحات موضوعية: 2C, 2-cell embryo, TF, transcription factor, Aucun, BTB-link, extended BTB domain, Biochemistry, Ep400, chromatin remodeling, 0302 clinical medicine, i, inhibitor, Phylogeny, transcription factor, 2i, two inhibitors, Zinc finger, 0303 health sciences, LIF, leukemia inhibitory factor, bFGF, basic FGF, Zinc Fingers, KD, knock-down, Chromatin, Cell biology, N2B27, chemically defined base medium, Histone, BTB-POZ Domain, mESC, mouse embryonic stem cell, HiRA, histone regulator A, ChIP-seq, chromatin immunoprecipitation sequencing, EpiLC, epiblast-like cell, NuRD, nucleosome remodeling and deacetylase, Research Article, FDR, false discovery rate, Two-hybrid screening, DOX, doxycycline, Biology, Chromatin remodeling, 03 medical and health sciences, 2iLIF, N2B27 containing LIF, CHIR, and PD0325901, NuRD, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MEK, mitogen-activated protein kinase kinase, Humans, CHIR, CHIR99021, Nucleosome, Histone Chaperones, Epigenetics, AP-MS, affinity purification–MS, Molecular Biology, Transcription factor, 030304 developmental biology, epigenetics, LFQ, label-free quantification, GSK3, glycogen synthetase kinase 3, PBST, PBS–0.1% Tween-20, Cell Biology, Y2H, yeast-2-hybrid, embryonic stem cell, HiRA, FGF, fibroblast growth factor, Repressor Proteins, ZBTB2, serum-LIF, fetal calf serum–containing medium supplemented with LIF, histone chaperone, BTB, broad-complex, tramtrack, and bric-a-brac, biology.protein, qPCR, quantitative PCR, Znf, zinc-finger domain, 030217 neurology & neurosurgery, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026739c7c937a26878c6cad73fcd7ad9

المؤلفون: Jeffrey Rubens, David J. Clark, Lijun Chen, Antje Arnold, Micah J. Maxwell, Hui Zhang, Eric H. Raabe, Tung-Shing M. Lih, Michael Schnaubelt, Heather Sweeney, Charles G. Eberhart

المصدر: Molecular & Cellular Proteomics : MCP

مصطلحات موضوعية: MAPK/ERK pathway, Proteomics, HDAC, histone deacetylase, mTORC1, Mitogen-activated protein kinase kinase, Biochemistry, Analytical Chemistry, angiogenesis, IMAC, immobilized metal affinity chromatography, glioma, Antineoplastic Combined Chemotherapy Protocols, mTORC1/2, mammalian target of rapamycin complex 1/2, Sapanisertib, CDK, cyclin-dependent kinase, Trametinib, Benzoxazoles, trametinib, ESI, electrospray ionization, Chemistry, PSM, peptide-to-spectrum match, Brain Neoplasms, MEK inhibitor, TOR Serine-Threonine Kinases, phosphoproteome, apoptosis, tandem MS, VEGF, vascular endothelial growth factor, FAK, focal adhesion kinase, RT, room temperature, Female, Signal transduction, signal transduction, Proto-Oncogene Proteins B-raf, FDR, false discovery rate, Pyridones, Mice, Nude, mTOR, mammalian target of rapamycin, Pyrimidinones, Cell Line, Tumor, drug targets, MEK, mitogen-activated protein kinase kinase, Animals, Humans, mouse models, Molecular Biology, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Mitogen-Activated Protein Kinase Kinases, PCA, principal component analysis, PTK2, protein tyrosine kinase 2, Research, TAK228, TMT, tandem mass tag, ACN, acetonitrile, ERF, erythroblast transformation-specific 2 repressor factor, KSEA, kinase–substrate enrichment analysis, Phosphoproteins, FDA, Food and Drug Administration, EGFR, epidermal growth factor receptor, Pyrimidines, Cancer research, sapanisertib, BRAF, v-Raf murine sarcoma viral oncogene homolog B, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbad6edd54a95268217095d4ba24909d
http://europepmc.org/articles/PMC8363840