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المؤلفون: Fran Robson, Palma Rocchi, Sinem Demirbag, Thi Khanh Le, Khadija Shahed Khan, Clément Paris, Peter Barfuss, Wai-Lung Ng
المساهمون: University of Bristol [Bristol], The Chinese University of Hong Kong [Hong Kong], Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Hanoi University of Science and Technology (HUST), Sabanci University, Nanotechnology Research and Application Center, Sabanci University [Istanbul], Université Paris-Est (UPE), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Rocchi, Palma
المصدر: Molecular Cell
Molecular Cell, Elsevier, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩
Molecular Cell, 2020, 79 (5), pp.710-727. ⟨10.1016/j.molcel.2020.07.027⟩مصطلحات موضوعية: antisense oligonucleotide, Transcription, Genetic, MESH: Coronavirus Infections, viruses, [SDV]Life Sciences [q-bio], Cell, coronavirus, Cytidine, Viral Nonstructural Proteins, medicine.disease_cause, Virus Replication, Genome, Severity of Illness Index, 0302 clinical medicine, Transcription (biology), MESH: Molecular Targeted Therapy, MESH: COVID-19, Nucleotide, MESH: Adenosine Monophosphate, Molecular Targeted Therapy, Coronavirus, chemistry.chemical_classification, 0303 health sciences, Alanine, non-structural protein 14, virus diseases, ExoN, MESH: Amides, 3. Good health, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, 030220 oncology & carcinogenesis, MESH: Pyrazines, MESH: RNA, Viral, Pyrazines, Proofreading, MESH: Betacoronavirus, RNA, Viral, MESH: Genome, Viral, Coronavirus Infections, MESH: Cytidine, medicine.drug, MESH: Antiviral Agents, MESH: Pandemics, MESH: Mutation, exonuclease, MESH: Alanine, CoV, Pneumonia, Viral, antisense oligonucleotide (ASO), Computational biology, Genome, Viral, Biology, Therapeutic targeting, Hydroxylamines, Antiviral Agents, Article, ASO, 03 medical and health sciences, Betacoronavirus, MESH: Severity of Illness Index, Coronavirus (CoV), medicine, Humans, MESH: SARS-CoV-2, anti-coronavirus drugs, Molecular Biology, Pandemics, 030304 developmental biology, Exonuclease (ExoN), MESH: Ribonucleosides, MESH: Humans, Nucleoside analogue, SARS-CoV-2, MESH: Transcription, Genetic, MESH: Virus Replication, nucleoside analog, RNA, COVID-19, Correction, MESH: Hydroxylamines, Cell Biology, Amides, Adenosine Monophosphate, non-structural protein 14 (nsp14), respiratory tract diseases, nucleoside analogue (NA), Viral replication, chemistry, MESH: Pneumonia, Viral, Mutation, nsp14, MESH: Viral Nonstructural Proteins, NA, Ribonucleosides, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e7c3d34b3a0e2ab6d0db7eece5c7f1
https://pubmed.ncbi.nlm.nih.gov/33338403 -
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المؤلفون: Boris Guiu, Lucy Meunier, Cyril Fersing, François Quenet, Emmanuel Deshayes
المساهمون: Institut du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département radiologie diagnostique et interventionnelle Saint Eloi [CHRU Montpellier], Pôle Digestif [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)
المصدر: Clinical Nuclear Medicine
Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2020, 45 (2), pp.133-135. ⟨10.1097/RLU.0000000000002861⟩مصطلحات موضوعية: Cyclopropanes, Colorectal cancer, MESH: Drug Interactions, MESH: Sulfonamides, Hepacivirus, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Scintigraphy, medicine.disease_cause, Gastroenterology, 030218 nuclear medicine & medical imaging, Metastasis, 0302 clinical medicine, MESH: Cyclopropanes, MESH: Radionuclide Imaging, Medicine, Drug Interactions, MESH: Hepacivirus, Hypoalbuminemia, MESH: Imino Acids, Sulfonamides, Aniline Compounds, medicine.diagnostic_test, Imidazoles, General Medicine, Organotechnetium Compounds, MESH: Amides, 3. Good health, Grazoprevir, 030220 oncology & carcinogenesis, Female, MESH: Imidazoles, MESH: Radiopharmaceuticals, Adult, MESH: Antiviral Agents, medicine.medical_specialty, Elbasvir, Hepatitis C virus, Glycine, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Antiviral Agents, 03 medical and health sciences, MESH: Organotechnetium Compounds, MESH: Quinoxalines, Internal medicine, Quinoxalines, Humans, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, Benzofurans, MESH: Liver Failure, MESH: Humans, MESH: Carbamates, business.industry, Imino Acids, MESH: Benzofurans, MESH: Adult, medicine.disease, Amides, Liver function, Carbamates, Radiopharmaceuticals, business, MESH: Female, Liver Failure
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bebe2ff94a4c28fbeced4709ba214ff
https://hal.umontpellier.fr/hal-03384686 -
3Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
المؤلفون: Xavier Brazzolotto, Florian Nachon, Marko Živin, Jure Stojan, Maja Zorović, Damijan Knez, Jacques-Philippe Colletier, Urban Košak, Stanislav Gobec, Stane Pajk, Nicolas Coquelle
المساهمون: Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Laue-Langevin (ILL), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Institut de Recherche Biomédicale des Armées (IRBA), ILL, University of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia, Faculty of Pharmacy, University of Ljubljana, Département de Toxicologie et Risques Chimiques, Institute of Biochemistry, Faculty of Medicine
المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.498-505. ⟨10.1080/14756366.2019.1710502⟩
Journal of enzyme inhibition and medicinal chemistry, vol. 35, no. 1, pp. 498-505, 2020.
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)مصطلحات موضوعية: Models, Molecular, [SDV]Life Sciences [q-bio], Crystallography, X-Ray, 01 natural sciences, Mice, chemistry.chemical_compound, Drug Discovery, MESH: Animals, Butyrylcholinesterase, chemistry.chemical_classification, zaviralci, Molecular Structure, biology, MESH: Butyrylcholinesterase, General Medicine, MESH: Fluorescent Dyes, Fluorescence, Acetylcholinesterase, MESH: Amides, 3. Good health, inhibitor, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Fluorescence intensity, Biochemistry, butyrylcholinesterase, fluorescence, patogeneza Alzheimerjeve bolezni, MESH: Cholinesterase Inhibitors, MESH: Models, Molecular, Research Paper, MESH: Molecular Structure, Mixed inhibition, RM1-950, probe, butiriliholinesteraza, Hydrolase, Animals, Humans, [CHIM]Chemical Sciences, udc:616.894+616.892.3:615.2, MESH: Mice, Fluorescent Dyes, Pharmacology, MESH: Humans, 010405 organic chemistry, Active site, MESH: Crystallography, X-Ray, Amides, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, biology.protein, Therapeutics. Pharmacology, Cholinesterase Inhibitors
وصف الملف: application/pdf; text/url
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المؤلفون: Madelain, Vincent, Baize, Sylvain, Jacquot, Frédéric, Reynard, Stéphanie, Fizet, Alexandra, Barron, Stephane, Solas, Caroline, Lacarelle, Bruno, Carbonnelle, Caroline, Mentré, France, Raoul, Hervé, de Lamballerie, Xavier, Guedj, Jérémie
المساهمون: Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), Laboratoire P4 - Jean Mérieux, Centre Européen de Virologie/Immunologie-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Emergence des Pathologies Virales (EPV), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM), This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 666092, and from the St. Luke’s International University (Tokyo, Japan) in the framework of Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development (AMED)., European Project: 666092,H2020,H2020-Adhoc-2014-20,REACTION(2014), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), Baize, Sylvain, Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) duringEbola virus infection in non-human primates humans - REACTION - - H20202014-11-01 - 2016-10-31 - 666092 - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]
المصدر: Nature Communications
Nature Communications, 2018, 9 (1), pp.4013. ⟨10.1038/s41467-018-06215-z⟩
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, Nature Publishing Group, 2018, 9, ⟨10.1038/s41467-018-06215-z⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4013. ⟨10.1038/s41467-018-06215-z⟩مصطلحات موضوعية: MESH: Antiviral Agents, Time Factors, [SDV]Life Sciences [q-bio], Science, viruses, Antiviral Agents, Article, Animals, MESH: Animals, MESH: Ebolavirus, lcsh:Science, MESH: Models, Theoretical, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Cytokines, MESH: Host-Pathogen Interactions, MESH: Macaca, MESH: Time Factors, Interferon-alpha, Hemorrhagic Fever, Ebola, Models, Theoretical, Viral Load, Ebolavirus, Amides, Survival Analysis, MESH: Amides, Disease Models, Animal, Pyrazines, MESH: Pyrazines, MESH: Survival Analysis, Host-Pathogen Interactions, MESH: Hemorrhagic Fever, Ebola, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Cytokines, Macaca, Female, lcsh:Q, MESH: Disease Models, Animal, MESH: Interferon-alpha, MESH: Viral Load, MESH: Female
وصف الملف: application/pdf
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المؤلفون: Maximilian J. Helf, James Sims, Jörn Piel, Brandon I. Morinaka, Anna L. Vagstad, Muriel Gugger, Shinichi Sunagawa, Marjan Verest, Edgars Lakis, Thibault Scalvenzi
المساهمون: Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Collection des Cyanobactéries, Institut Pasteur [Paris] (IP), J.P. thanks the Swiss National Science Foundation (31003A_146992/1) and the European Union (SYNPEPTIDE and European Research Council Advanced Grant 'SynPlex') for support. S.S. is grateful for financial support by the Helmut Horten Foundation. B.I.M. was the recipient of an Alexander von Humboldt Fellowship. A.L.V. was the recipient of an ETH Postdoctoral Fellowship., European Project: 613981,EC:FP7:KBBE,FP7-KBBE-2013-7-single-stage,SYNPEPTIDE(2013), Institut Pasteur [Paris]
المصدر: Science
Science, 2018, 359 (6377), pp.779-782. ⟨10.1126/science.aao0157⟩
Science, American Association for the Advancement of Science, 2018, 359 (6377), pp.779-782. ⟨10.1126/science.aao0157⟩مصطلحات موضوعية: 0301 basic medicine, MESH: Amino Acids, MESH: Mutation, Tyramine, MESH: Amino Acid Sequence, 010402 general chemistry, medicine.disease_cause, Cyanobacteria, 01 natural sciences, MESH: Genetic Loci, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Bacterial Proteins, Protein splicing, MESH: Protein Splicing, medicine, Escherichia coli, Protein Splicing, Amino Acid Sequence, Amino Acids, Peptide sequence, MESH: Bacterial Proteins, Bond cleavage, chemistry.chemical_classification, Multidisciplinary, Chemistry, MESH: Escherichia coli, MESH: Cyanobacteria, Ribosomal RNA, Amides, MESH: Amides, 0104 chemical sciences, Amino acid, 030104 developmental biology, Enzyme, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Biochemistry, Genetic Loci, MESH: Protein Processing, Post-Translational, Mutation, Protein Processing, Post-Translational, MESH: Tyramine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6a19830fe9433d8efaa92f9373eb42
https://hal-pasteur.archives-ouvertes.fr/pasteur-02044549 -
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المؤلفون: Mathy Froeyen, Leen Delang, Stéphanie Beaucourt, Bruno Canard, Ana Theresa Silveira de Morais, Isabelle Imbert, Johan Neyts, Marco Vignuzzi, Hervé Blanc, Pieter Leyssen, Rana Abdelnabi
المساهمون: Rega Institute for Medical Research [Leuven, België], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Architecture et fonction des macromolécules biologiques (AFMB), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Populations virales et Pathogenèse - Viral Populations and Pathogenesis, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the BELVIR project from BELSPO (IUAP), the EU-FP7/2011-2014 Project SILVER (GA 260644), and the EU-H2020 Innovative Training Network ANTIVIRALS (GA 642434). A.T.S.D.M. was supported by a postdoctoral fellowship from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico—Brasil). L.D. was supported by a postdoctoral fellowship from the FWO (Fund for Scientific Research of Flanders, Belgium)., European Project: 260644,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,SILVER(2010), European Project: 642434,H2020,H2020-MSCA-ITN-2014,ANTIVIRALS(2015), Pfeiffer, Julie K, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Virology
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩مصطلحات موضوعية: 0301 basic medicine, RdRp, viruses, Amino Acid Motifs, Virus Replication, Mice, chemistry.chemical_compound, MESH: Amino Acid Motifs, Japan, MESH: Chlorocebus aethiops, RNA polymerase, Chlorocebus aethiops, MESH: Animals, Polymerase, MESH: Microbial Viability, MESH: Mutagenesis, MESH: Japan, MESH: Drug Resistance, Viral, biology, MESH: Amides, Enterovirus B, Human, 3. Good health, Pyrazines, MESH: Pyrazines, MESH: RNA Replicase, Chikungunya virus, mutagenesis, MESH: Antiviral Agents, MESH: Mutation, Immunology, RNA-dependent RNA polymerase, MESH: Vero Cells, Favipiravir, favipiravir, Antiviral Agents, Microbiology, Virus, 03 medical and health sciences, Virology, Vaccines and Antiviral Agents, Drug Resistance, Viral, Animals, MESH: Lysine, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, CVB3, Vero Cells, MESH: Mice, Microbial Viability, Lysine, MESH: Virus Replication, RNA, MESH: Chikungunya virus, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Processivity, RNA-Dependent RNA Polymerase, Amides, 030104 developmental biology, fidelity, chemistry, Viral replication, MESH: Enterovirus B, Human, Insect Science, Mutation, biology.protein
وصف الملف: Electronic-Print
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ec8ca79e6936169943b98e6fae68ff
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928 -
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المؤلفون: Nguyen, Thi Huyen Tram, Guedj, Jérémie, Anglaret, Xavier, Laouénan, Cédric, Madelain, Vincent, Taburet, Anne-Marie, Baize, Sylvain, Sissoko, Daouda, Pastorino, Boris, Rodallec, Anne, Piorkowski, Géraldine, Carazo, Sara, Conde, Mamoudou N, Gala, Jean-Luc, Bore, Joseph Akoi, Carbonnelle, Caroline, Jacquot, Frédéric, Raoul, Hervé, Malvy, Denis, de Lamballerie, Xavier, Mentré, France, JIKI study group
المساهمون: Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Programme PAC-CI, ANRS France Recherche Nord & sud Sida-hiv hépatites, Laboratoire de Biotechnologie et Microbiologie Appliquée (LBMA), Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Emergence des Pathologies Virales (EPV), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Médecins Sans Frontières Belgique, The Alliance for International Medical Action [Dakar, Sénégal] (ONG ALIMA), Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratoire des Fièvres Hémorragiques en Guinée, Université Gamal Abdel Nasser de Conakry, Laboratoire P4 - Jean Mérieux, Centre Européen de Virologie/Immunologie-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM), The JIKI trial was supported by grants from the French National Agency for AIDS and viral hepatitis research (ANRS, Paris, France, http://www.anrs.fr/), the French Institute for Health Research (Inserm, Paris, France, http://www.inserm.fr/) and the European Commission (EU Horizon 2020 programme, grant N° 666092 - REACTION, http://ec.europa.eu/programmes/horizon2020/)., European Project: 666092,H2020,H2020-Adhoc-2014-20,REACTION(2014), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], MATEO, MATHIEU, Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) duringEbola virus infection in non-human primates humans - REACTION - - H20202014-11-01 - 2016-10-31 - 666092 - VALID, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - (SLuc) Centre de génétique médicale UCL, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Université Catholique de Louvain (UCL)
المصدر: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (2), pp.e0005389. ⟨10.1371/journal.pntd.0005389⟩
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005389 (2017)
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 2017, 11 (2), pp.e0005389. ⟨10.1371/journal.pntd.0005389⟩
PLoS Neglected Tropical Diseases, Vol. 11, no.2, p. e0005389 [1-18] (2017)مصطلحات موضوعية: Male, Physiology, Blood plasma, Biochemistry, MESH: Child, Medicine and Health Sciences, Viral load, Child, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Aged, MESH: Guinea, MESH: Middle Aged, Pharmaceutics, lcsh:Public aspects of medicine, Hematology, Middle Aged, Ebolavirus, MESH: Amides, Body Fluids, Blood, MESH: Young Adult, Child, Preschool, Pyrazines, Creatinine, MESH: Pyrazines, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Drug therapy, Anatomy, Research Article, Adult, MESH: Antiviral Agents, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, Antiviral Agents, Microbiology, Young Adult, Virology, Albumins, Dose prediction methods, Humans, Pharmacokinetics, MESH: Ebolavirus, Aged, Pharmacology, MESH: Adolescent, MESH: Humans, MESH: Child, Preschool, Biology and Life Sciences, Proteins, lcsh:RA1-1270, MESH: Adult, Hemorrhagic Fever, Ebola, Amides, MESH: Male, MESH: Hemorrhagic Fever, Ebola, Guinea, MESH: Female, Biomarkers, Viral Transmission and Infection
وصف الملف: application/pdf
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المؤلفون: Célia S. Bonnet, Thorfinnur Gunnlaugsson, Marc Devocelle
المساهمون: Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Physiology and Medical Physics, School of Biochemistry and Immunology, Trinity College Dublin
المصدر: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10 (1), pp.126-33. ⟨10.1039/c1ob06567j⟩مصطلحات موضوعية: Lanthanide, Magnetic Resonance Spectroscopy, MESH: Europium, MULTIWAVELENGTH SPECTROSCOPIC DATA, chemistry.chemical_element, Terbium, Peptide, 010402 general chemistry, Photochemistry, Lanthanoid Series Elements, 01 natural sciences, Biochemistry, AQUEOUS-SOLUTION, HIGH-AFFINITY, Europium, CHARGE-TRANSFER, MESH: Lanthanoid Series Elements, MESH: Terbium, AMINO-ACIDS, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Physical and Theoretical Chemistry, chemistry.chemical_classification, METAL-ION BINDING, MESH: Magnetic Resonance Spectroscopy, MESH: Peptides, 010405 organic chemistry, Chemistry, fungi, Organic Chemistry, TRYPTOPHAN-CONTAINING PARVALBUMIN, Nuclear magnetic resonance spectroscopy, Chromophore, Amides, MESH: Amides, 0104 chemical sciences, MESH: Luminescent Measurements, Excited state, Luminescent Measurements, CALCIUM-BINDING, EQUILIBRIUM-CONSTANTS, Peptides, ENERGY-TRANSFER, Luminescence
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d04a32780a0f98ca8dcbe97c2cf300
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المؤلفون: Maté Biro, Annelie Oswald, Guillaume Salbreux, Jakub Sedzinski, Ewa K. Paluch, Jean-Yves Tinevez
المساهمون: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Max-Planck-Gesellschaft, International Institute of Molecular and Cell Biology [Warsaw] (IIMCB), Max Planck Institute for the Physics of Complex Systems (MPI-PKS), This work was supported by the Polish Ministry of Science and Higher Education and by the Max Planck Society., We thank J. S. Bois, A. G. Clark, S. W. Grill, C. P. Heisenberg, J. Howard, A. A. Hyman, J. F. Joanny, D. K. Lubensky, A. Oates, M. Piel, I. M. Tolic-Norrelykke, W. Zachariae and M. Zerial for discussions and comments on the manuscript, and J. Roensch and the Max Planck Institute of Molecular Cell Biology and Genetics Light Microscopy Facility for technical assistance.
المصدر: Nature
Nature, Nature Publishing Group, 2011, 476 (7361), pp.462-466. ⟨10.1038/nature10286⟩مصطلحات موضوعية: Cell division, Pyridines, [SDV]Life Sciences [q-bio], Cell, Biophysics, Nanotechnology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Cleavage (embryo), Models, Biological, Instability, Cell Line, Contractility, MESH: Cytokinesis / drug effects, MESH: Cytokinesis / physiology, MESH: Aneuploidy, medicine, Humans, Cleavage furrow, Cell Shape, Mitosis, Cell Size, Cytokinesis, MESH: Humans, Multidisciplinary, MESH: Cell Shape / drug effects, MESH: Amides / pharmacology, MESH: Models, Biological, Contractile proteins, Actomyosin, Aneuploidy, Amides, MESH: Cell Line, MESH: Cell Size / drug effects, MESH: Cell Shape / physiology, medicine.anatomical_structure, MESH: HeLa Cells, MESH: Actomyosin / metabolism, MESH: Pyridines / pharmacology, HeLa Cells
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المؤلفون: David Bec, Jean-Yves Bansard, Patrick Guinet, Pascal Lecorre, Eric Wodey, Jean-Pierre Estebe, Maja Ratajczak-Enselme, François Chevanne, Claude Ecoffey
المساهمون: Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anesthésie réanimation chirurgicale [Rennes], Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou, Laboratoire de Pharmacie Galenique, Biopharmacie et Pharmacie Clinique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Senhadji, Lotfi, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou, Laboratoire de Pharmacie Galenique, Biopharmacie et Pharmacie Clinique [Rennes], Université de Rennes (UR)
المصدر: Regional Anesthesia and Pain Medicine
Regional Anesthesia and Pain Medicine, Lippincott, Williams & Wilkins, 2009, 34 (1), pp.17-23. ⟨10.1097/AAP.0b013e31819338e2⟩
Regional Anesthesia and Pain Medicine, 2009, 34 (1), pp.17-23. ⟨10.1097/AAP.0b013e31819338e2⟩مصطلحات موضوعية: Tachycardia, Time Factors, Lidocaine, MESH: Myocardial Contraction, Blood Pressure, Ventricular tachycardia, Electrocardiography, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Heart Rate, 030202 anesthesiology, Cluster Analysis, Ropivacaine, MESH: Animals, Anesthetics, Local, MESH: Heart Rate, Infusions, Intravenous, Levobupivacaine, Principal Component Analysis, MESH: Anesthesia, General, MESH: Blood Pressure, General Medicine, Bupivacaine, MESH: Amides, 3. Good health, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Anesthesia, MESH: Bupivacaine, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, medicine.symptom, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, medicine.drug, MESH: Hemodynamics, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, MESH: Sheep, Anesthesia, General, MESH: Anesthetics, Local, QT interval, 03 medical and health sciences, QRS complex, medicine, Animals, cardiovascular diseases, MESH: Infusions, Intravenous, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, MESH: Principal Component Analysis, Models, Statistical, Sheep, business.industry, MESH: Time Factors, Hemodynamics, medicine.disease, Amides, Myocardial Contraction, MESH: Cluster Analysis, MESH: Electrocardiography, MESH: Lidocaine, Anesthesiology and Pain Medicine, Tachycardia, Ventricular, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH: Tachycardia, Ventricular, business, MESH: Female, MESH: Models, Statistical, 030217 neurology & neurosurgery
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