-
1Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma
المؤلفون: Alvaro C. Laga, John M. Asara, Howard Y. Chang, Justin L. Tan, Brian T. Do, Leonard I. Zon, Anne Bothmer, Richard M. White, David H. Price, Ng Shyh-Chang, Ryan A. Flynn, Nicole Pandell, Song Yang, Violaine Saint-André, Yoon Jung Kim, Zi Peng Fan, Koh Fujinaga, Elliott J. Hagedorn, Serine Avagyan, Tae Hoon Kim, Cristina Santoriello, B. Matija Peterlin, Ellen van Rooijen, John G. Clohessy, John E. Brogie, Richard A. Young, Celeste B. Greer, Yi Zhou, Pier Paolo Pandolfi, Rachel D. Fogley, Julien Ablain
المساهمون: Harvard Stem Cell Institute [Cambridge, USA] (HSCI), Harvard University, Howard Hughes Medical Institute [Boston] (HHMI), Howard Hughes Medical Institute (HHMI)-Harvard Medical School [Boston] (HMS), Boston Children's Hospital, Harvard Medical School [Boston] (HMS), Dana-Farber Cancer Institute [Boston], Center for Personal Dynamic Regulomes [Stanford] (CPDR), Stanford Medicine, Stanford University-Stanford University, Whitehead Institute, Massachusetts Institute of Technology (MIT), Department of Biology [MIT Cambridge, USA], Brigham & Women’s Hospital [Boston] (BWH), University of California [San Francisco] (UC San Francisco), University of California (UC), Yale School of Medicine [New Haven, Connecticut] (YSM), University of Texas at Dallas [Richardson] (UT Dallas), Beth Israel Deaconess Medical Center [Boston] (BIDMC), Cancer Research Institute [Boston, USA], Harvard Medical School [Boston] (HMS)-Harvard Medical School [Boston] (HMS), University of Iowa [Iowa City], Genome Institute of Singapore (GIS), Memorial Sloane Kettering Cancer Center [New York], Weill Medical College of Cornell University [New York], This work was supported by the Howard Hughes Medical Institute and the National Cancer Institute (NIH) R01CA103846 (to L.I.Z.). L.I.Z. is a founder and stockholder of Fate, Inc., Scholar Rock, and a scientific advisor for Stemgent. J.L.T. is an Agency for Science, Technology & Research, Singapore National Science Scholarship recipient. C.B.G. is a PhRMA Foundation predoctoral fellow. R.A.Y. is a founder and stockholder of Syros Pharmaceuticals. This work was partially supported by NIH grants 2P01CA120964 (to J.M.A.), 5P30CA006516 (to J.M.A.), R01CA140485 (to T.H.K.), R21AI107067 (to T.H.K.), R01-ES023168 (to H.Y.C), and R01-HG004361 (to H.Y.C), We thank Min Yuan for her help with the metabolomics studies and Dr. Telmo Henriques for his advice on RNA assays., Harvard University [Cambridge], University of California [San Francisco] (UCSF), University of California, Yale University School of Medicine, Massachusetts Institute of Technology. Department of Biology, Saint-André, Violaine, Fan, Zi Peng, Young, Richard A
المصدر: Molecular Cell
Molecular Cell, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
Molecular Cell, Elsevier, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
PMC
Molecular cell, vol 62, iss 1مصطلحات موضوعية: 0301 basic medicine, Transcription, Genetic, [SDV]Life Sciences [q-bio], Melanoma, Experimental, MESH: Oncogene Proteins / genetics, Medical and Health Sciences, Transcription (biology), MESH: Melanoma / genetics, Gene expression, Transcriptional regulation, 2.1 Biological and endogenous factors, MESH: Melanoma / pathology, Positive Transcriptional Elongation Factor B, MESH: Animals, Aetiology, Zebrafish, Melanoma, Cancer, Regulation of gene expression, Oncogene Proteins, MESH: RNA-Binding Proteins / genetics, Gene knockdown, Tumor, biology, Kinase, RNA-Binding Proteins, MESH: Gene Expression Regulation, Neoplastic, Biological Sciences, 3. Good health, MESH: RNA-Binding Proteins / metabolism, Gene Expression Regulation, Neoplastic, MESH: Melanoma, Experimental, MESH: Tumor Suppressor Proteins / genetics, Transcription, Biotechnology, MESH: Cell Line, Tumor, MESH: Zebrafish Proteins / metabolism, [SDV.CAN]Life Sciences [q-bio]/Cancer, Article, Cell Line, MESH: Zebrafish / genetics, 03 medical and health sciences, Experimental, Genetic, Cell Line, Tumor, medicine, Genetics, Animals, Humans, Molecular Biology, Neoplastic, MESH: Humans, Tumor Suppressor Proteins, MESH: Transcription, Genetic, Cell Biology, Zebrafish Proteins, biology.organism_classification, medicine.disease, MESH: Positive Transcriptional Elongation Factor B / genetics, 030104 developmental biology, Pyrimidines, Gene Expression Regulation, Cancer research, MESH: Pyrimidines / metabolism, MESH: Zebrafish Proteins / genetics, MESH: Melanoma / metabolism, Transcription Factors, Developmental Biology
وصف الملف: application/pdf
-
2دورية أكاديمية
المؤلفون: Ortega, Carlos A., Stevens, Madelyn N., Lewis, James S.Aff2, Aff3, Topf, Michael C.Aff2, IDs12105022014296_cor4
المصدر: Head and Neck Pathology. 16(3):942-946