المؤلفون: Julie Lorent, Maritza Jaramillo, Laia Masvidal, Tommy Alain, Ola Larsson, Visnu Chaparro, Bruno D. Fonseca, Tyson E. Graber, Léon C van Kempen, Maria Aguirre, Louis-Philippe Leroux

المساهمون: Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Karolinska Institutet [Stockholm], University of Ottawa [Ottawa], Jewish General Hospital, McGill University = Université McGill [Montréal, Canada], University Medical Center Groningen [Groningen] (UMCG), This work was supported by a Basil O'Connor starter scholar research award (5-FY14-78) and a research grant (6-FY16-151) from The March of Dimes Foundation to M.J. The Centre for Host-Parasite Interactions is supported by a Subvention de Regroupement Stratégique from the Fonds de Recherche du Québec en Nature et Technologies (FRQ-NT). M.J. is a recipient of a Bourse de Chercheur-Boursier Junior 1 from the Fonds de Recherche du Québec en Santé (FRQ-S) and a Subvention d'Établissement de Jeune Chercheur from the FRQ-S. V.C. is supported by a Ph.D. scholarship from the Fondation Universitaire Armand Frappier. Research in the laboratory of O.L. is supported by grants from the Swedish Research Council and the Wallenberg Academy Fellows program., We are grateful to Nahum Sonenberg for providing bone marrow from C57BL/6 s6k1−/− s6k2−/− mice (McGill University, Montreal, QC, Canada). We thank Medhi Jafarnejad (McGill University) for technical advice. We are thankful to Annie Sylvestre and Annik Lafrance for invaluable technical assistance. We acknowledge support from the Science for Life Laboratory, the National Genomics Infrastructure (NGI), and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure.

المصدر: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2018, 86 (9), pp.e00244-18. ⟨10.1128/IAI.00244-18⟩
Infection and Immunity, 86(9):ARTN e00244-18. AMER SOC MICROBIOLOGY

مصطلحات موضوعية: MESH: Signal Transduction, 0301 basic medicine, DIFFERENTIAL TRANSLATION, Protozoan Proteins, MESH: Toxoplasma/pathogenicity, RNA 5' Terminal Oligopyrimidine Sequence, MESH: Mice, Knockout, Mice, Poly(A)-binding protein, Protein biosynthesis, host-pathogen interactions, MESH: Animals, Cells, Cultured, Mice, Knockout, biology, IMMUNE-RESPONSES, TOR Serine-Threonine Kinases, translational control, Translation (biology), Cell biology, macrophages, Infectious Diseases, MESSENGER-RNA TRANSLATION, mTOR, PROTEIN-SYNTHESIS, MESH: Host-Parasite Interactions, [SDV.IMM]Life Sciences [q-bio]/Immunology, Toxoplasma, Signal Transduction, MESH: Cells, Cultured, Translational efficiency, Immunology, ENDOPLASMIC-RETICULUM, MESH: RNA 5' Terminal Oligopyrimidine Sequence, Toxoplasma gondii, Microbiology, DENDRITIC CELLS, Host-Parasite Interactions, POLY(A)-BINDING PROTEINS, Mitochondrial Proteins, 03 medical and health sciences, MESH: Protein Biosynthesis/genetics, MESH: Mice, Inbred C57BL, PARASITOPHOROUS VACUOLE MEMBRANE, parasitic diseases, Animals, MESH: Mice, Mechanistic target of rapamycin, Cellular Microbiology: Pathogen-Host Cell Molecular Interactions, 030102 biochemistry & molecular biology, Intracellular parasite, biology.organism_classification, MESH: Protozoan Proteins/immunology, Cytoplasm organization, Mice, Inbred C57BL, MESH: Mitochondrial Proteins/genetics, MAMMALIAN-TARGET, 030104 developmental biology, Protein Biosynthesis, MESH: TOR Serine-Threonine Kinases/genetics, biology.protein, INNATE IMMUNITY, MESH: Macrophages/parasitology, Parasitology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ebb9a78a49ce9a9e41a7e1dacffad
https://doi.org/10.1128/iai.00244-18

المؤلفون: B. Closs, Sylvie Bordes, Abdel Aouacheria, Célia Da Silva, Josselin Breugnot, Romain Jugé

المساهمون: SILAB, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE)

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6 (1), ⟨10.1038/srep35065⟩
Scientific Reports, 2016, 6 (1), ⟨10.1038/srep35065⟩

مصطلحات موضوعية: Keratinocytes, 0301 basic medicine, MESH: Keratinocytes/cytology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Cell, MESH: Microtubule-Associated Proteins/genetics, Apoptosis, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Mitochondrion, medicine.disease_cause, Mitochondrial Dynamics, MESH: Cell Survival/radiation effects, MESH: Mitochondria/genetics, MESH: Mitochondrial Proteins/genetics, GTP Phosphohydrolases, law.invention, 0302 clinical medicine, law, MESH: Microscopy, Confocal, MESH: Computational Biology/methods, MESH: Healthy Volunteers, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, skin and connective tissue diseases, Cells, Cultured, chemistry.chemical_classification, education.field_of_study, Microscopy, Confocal, Multidisciplinary, integumentary system, MESH: Keratinocytes/radiation effects, Healthy Volunteers, Mitochondria, 3. Good health, Cell biology, medicine.anatomical_structure, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], MESH: Mitochondria/radiation effects, Microtubule-Associated Proteins, MESH: Cells, Cultured, Dynamins, Cell Survival, DNA damage, Population, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Article, Mitochondrial Proteins, MESH: GTP Phosphohydrolases/genetics, 03 medical and health sciences, Confocal microscopy, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], medicine, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], education, MESH: Mitochondrial Dynamics/radiation effects, MESH: DNA Damage, Reactive oxygen species, MESH: Humans, MESH: Apoptosis, Computational Biology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, MESH: Reactive Oxygen Species/metabolism, MESH: Gene Knockdown Techniques, 030104 developmental biology, chemistry, Reactive Oxygen Species, Oxidative stress, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcf15385655ef23cec98f71cab15cff6