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المؤلفون: Francine C. A. Gérard, Jean-Marie Bourhis, Caroline Mas, Anaïs Branchard, Duc Duy Vu, Sylvia Varhoshkova, Cédric Leyrat, Marc Jamin
المساهمون: Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Integrated Structural Biology Grenoble (ISBG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-European Molecular Biology Laboratory [Grenoble] (EMBL)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Graduate School (EUR) CBH—Chemistry, Biology, and Health, Grenoble Instruct-ERIC center (ISBG), European Synchrotron Radiation Facility, Synchrotron SOLEIL, ANR-12-BSV8-0025,NNViPol,Structure et fonction de la machine de transcription et réplication des virus à ARN non-segmenté de polarité négative(2012), ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017), ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), European Project: 263186,EC:FP7:SPA,FP7-SPACE-2010-1,GRAAL(2011), European Project: DEQ20170336754
المصدر: Viruses
Viruses, 2022, 14 (12), pp.2813. ⟨10.3390/v14122813⟩
Viruses; Volume 14; Issue 12; Pages: 2813مصطلحات موضوعية: [SDV]Life Sciences [q-bio], MESH: Phosphoproteins, nucleocapsid assembly, MESH: RNA, Virology, MESH: Protein Binding, rabies virus, X-ray crystallography, MESH: Nucleocapsid Proteins, Nucleocapsid Proteins, Phosphoproteins, phosphoprotein, MESH: Rabies virus, Infectious Diseases, Nucleoproteins, molecular dynamics simulation, MESH: RNA, Viral, small-angle X-ray scattering, MESH: Nucleoproteins, RNA, RNA, Viral, Mononegavirales, MESH: Molecular Chaperones, Protein Binding, Molecular Chaperones
وصف الملف: application/pdf
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المؤلفون: Hoa Thi My Vo, Alvino Maestri, Heidi Auerswald, Sopheak Sorn, Sokchea Lay, Heng Seng, Sotheary Sann, Nisa Ya, Polidy Pean, Philippe Dussart, Olivier Schwartz, Sovann Ly, Timothée Bruel, Sowath Ly, Veasna Duong, Erik A. Karlsson, Tineke Cantaert
المساهمون: Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Communicable Disease Department [Phnom Penh] (CDC MOH), Ministry of Health [Mozambique], Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Vaccine Research Institute [Créteil, France] (VRI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), The Howard Hughes Medical Institute (HHMI)–Wellcome Trust (208710/Z/17/Z to TC), « URGENCE COVID-19 » fundraising campaign of Institut Pasteur (TC, HA, and PD). HA is supported by the German Centre for International Migration and Development (CIM)., Virus et Immunité - Virus and immunity, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Vaccine Research Institute (VRI)
المصدر: Frontiers in Immunology, Vol 13 (2022)
Frontiers in Immunology
Frontiers in Immunology, 2022, 13, pp.817905. ⟨10.3389/fimmu.2022.817905⟩
Frontiers in Immunology, Frontiers, 2022, 13, pp.817905. ⟨10.3389/fimmu.2022.817905⟩مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Immunology, MESH: Spike Glycoprotein, Coronavirus, CD8-Positive T-Lymphocytes, B cell immunity, Antibodies, Viral, MESH: Phosphoproteins, long term immune response, MESH: Antibodies, Neutralizing, MESH: Immunity, Cellular, Immunology and Allergy, Coronavirus Nucleocapsid Proteins, Humans, MESH: COVID-19, MESH: Coronavirus Nucleocapsid Proteins, MESH: SARS-CoV-2, MESH: Immunity, Humoral, B-Lymphocytes, Immunity, Cellular, MESH: Humans, T cell immunity, SARS-CoV-2, MESH: Cambodia, COVID-19, MESH: CD4-Positive T-Lymphocytes, RC581-607, Phosphoproteins, Antibodies, Neutralizing, MESH: CD8-Positive T-Lymphocytes, Immunity, Humoral, antibody effector function, Spike Glycoprotein, Coronavirus, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, MESH: Immunologic Memory, Immunologic diseases. Allergy, Cambodia, Immunologic Memory, MESH: Antibodies, Viral
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2007694182814232276359818b79405
https://www.frontiersin.org/articles/10.3389/fimmu.2022.817905/full -
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المؤلفون: Jean-François Eléouët, Monika Bajorek, Luis Checa Ruano, Marie Galloux, Jenna Fix, Charles-Adrien Richard, Hortense Decool, Olivier Sperandio, Irina Gutsche, Benjamin Bardiaux
المساهمون: Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Molécules Thérapeutiques in silico (MTI), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), ANR-19-CE11-0017, Agence Nationale de la Recherche, ANR, This work was carried out with the financial support of the French Agence Nationale de la Recherche, specific program ANR DecRisP, grant no. ANR-19-CE11-0017. We declare that we have no conflicts of interest with the contents of this article., ANR-19-CE11-0017,DecRisP,Décrypter les synthèses d'ARN par les pneumovirus(2019)
المصدر: J Virol
Journal of Virology
Journal of Virology, 2022, 96 (2), pp.e0090921. ⟨10.1128/JVI.00909-21⟩مصطلحات موضوعية: Models, Molecular, viruses, MESH: Cricetinae, Virus Replication, chemistry.chemical_compound, Protein-protein interaction, Transcription (biology), MESH: Metapneumovirus, RNA polymerase, Cricetinae, Structural modeling, MESH: Animals, Polymerase, Inclusion Bodies, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], HMPV, Nucleocapsid Proteins, Phosphoprotein, MESH: RNA, Viral, MESH: RNA-Dependent RNA Polymerase, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, RNA, Viral, MESH: Models, Molecular, Protein Binding, MESH: Mutation, Immunology, Biology, MESH: Phosphoproteins, Microbiology, Cell Line, Human metapneumovirus, Virology, MESH: Protein Binding, Animals, Protein Interaction Domains and Motifs, Nucleoprotein, MESH: Protein Interaction Domains and Motifs, Binding Sites, Structure and Assembly, MESH: Virus Replication, RNA, MESH: Nucleocapsid Proteins, biology.organism_classification, Phosphoproteins, RNA-Dependent RNA Polymerase, MESH: Inclusion Bodies, MESH: Cell Line, MESH: Binding Sites, Viral replication, chemistry, Insect Science, Mutation, biology.protein, Metapneumovirus
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7efcc80720167008066e4d77c332fd
https://europepmc.org/articles/PMC8791268/ -
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المؤلفون: Philippe Attias, Thomas Kofman, Nathanael Lapidus, Hamza Sakhi, Slim Fourati, Djamal Dahmane, Khalil El Karoui, Magali Bouvier
المساهمون: CHU Henri Mondor, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de santé publique [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), HAL-SU, Gestionnaire
المصدر: Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2021, 32 (5), pp.1033-1036. ⟨10.1681/ASN.2020111618⟩مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, 030232 urology & nephrology, serology, MESH: Spike Glycoprotein, Coronavirus, Antibodies, Viral, Gastroenterology, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Serology, 0302 clinical medicine, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Immunocompromised Host, Medicine, MESH: COVID-19, MESH: Coronavirus Nucleocapsid Proteins, MESH: Renal Dialysis, Aged, 80 and over, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Aged, MESH: Immunoglobulin G, education.field_of_study, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, hemodialysis, MESH: Middle Aged, biology, MESH: Kinetics, MESH: Paris, General Medicine, Middle Aged, 3. Good health, Titer, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Nephrology, MESH: Kidney Failure, Chronic, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, Spike Glycoprotein, Coronavirus, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Hemodialysis, Antibody, Adult, Paris, medicine.medical_specialty, MESH: Pandemics, MESH: Transplant Recipients, Population, MESH: Phosphoproteins, Immunocompromised Host, 03 medical and health sciences, Antigen, Renal Dialysis, Transplantation Immunology, Internal medicine, Coronavirus Nucleocapsid Proteins, Humans, MESH: SARS-CoV-2, Seroconversion, MESH: Transplantation Immunology, education, Pandemics, SARS-CoV-2 antibody, Aged, Retrospective Studies, MESH: Humans, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, Phosphoproteins, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Transplant Recipients, MESH: Male, Kinetics, 030104 developmental biology, Immunoglobulin G, biology.protein, Kidney Failure, Chronic, business, MESH: Female, MESH: Antibodies, Viral
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f23369c1c3791c5929d49aa06b81bb
https://hal.sorbonne-universite.fr/hal-03251712 -
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المؤلفون: Jean-Philippe Lavigne, Duarte Gouveia, Guylaine Miotello, Jean Charles Gaillard, Lucia Grenga, Albert Sotto, Fabrice Gallais, Laurent Bellanger, Olivier Pible, Jean Armengaud, Stéphanie Debroas
المساهمون: Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Salvy-Córdoba, Nathalie, ANR-17-CE18-0023,Phylopeptidomics,Identification rapide de bactéries pathogènes et résistances aux antibiotiques(2017)
المصدر: Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2020, 19 (11), pp.4407-4416. ⟨10.1021/acs.jproteome.0c00535⟩
Journal of Proteome Research, 2020, 19 (11), pp.4407-4416. ⟨10.1021/acs.jproteome.0c00535⟩مصطلحات موضوعية: 0301 basic medicine, Proteomics, MESH: Coronavirus Infections* / virology, MESH: Pneumonia, Viral* / virology, Shotgun, MESH: Coronavirus Infections* / diagnosis, MESH: Nasopharynx / virology, 02 engineering and technology, Tandem mass spectrometry, Biochemistry, Viral protein detection, COVID-19 Testing, Tandem Mass Spectrometry, viral protein detection, nasopharyngeal swab, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Nasopharynx, MESH: Coronavirus Nucleocapsid Proteins, MESH: Betacoronavirus / chemistry, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, 0303 health sciences, MESH: Pneumonia, Viral* / diagnosis, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Diagnostic test, Nucleocapsid Proteins, 021001 nanoscience & nanotechnology, 3. Good health, MESH: Tandem Mass Spectrometry / methods, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Nasopharyngeal swab, Coronavirus Infections, 0210 nano-technology, MESH: Pandemics, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Biology, Mass spectrometry, MESH: Phosphoproteins, Article, Virus, Betacoronavirus, 03 medical and health sciences, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Coronavirus Nucleocapsid Proteins, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Pandemics, 030304 developmental biology, Immunodiagnostics, 030102 biochemistry & molecular biology, Clinical Laboratory Techniques, SARS-CoV-2, COVID-19, General Chemistry, Phosphoproteins, Virology, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Peptides, MESH: Chromatography, Liquid, MESH: Clinical Laboratory Techniques / methods, Chromatography, Liquid
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المؤلفون: Maria Katsogiannou, Jean Baptiste Boyer, Luc Camoin, Laurence Calzone, Anaïs Baudot, Stéphane Audebert, Elisabeth Remy, Palma Rocchi, Alberto Valdeolivas
المساهمون: Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mathématiques de Luminy (IML), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Centre de recherche de l'Institut Curie [Paris], Institut Curie [Paris], Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Institut de Mathématiques de Marseille (I2M), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Hôpital Saint-Joseph [Marseille], Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), ProGeLife [Marseille], Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Rocchi, Palma
المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2019, 14 (11), pp.e0224148. ⟨10.1371/journal.pone.0224148⟩
PLoS ONE, 2019, 14 (11), pp.e0224148. ⟨10.1371/journal.pone.0224148⟩
PLoS ONE, Vol 14, Iss 11, p e0224148 (2019)مصطلحات موضوعية: 0301 basic medicine, Proteomics, Male, MESH: Neoplasm Proteins, Proteomes, [SDV]Life Sciences [q-bio], Cell Membranes, Proteomic databases, Biochemistry, Mass Spectrometry, Androgen deprivation therapy, Prostate cancer, Database and Informatics Methods, 0302 clinical medicine, Stable isotope labeling by amino acids in cell culture, Membrane proteins, Transcriptional regulation, Medicine and Health Sciences, Post-Translational Modification, Phosphorylation, ComputingMilieux_MISCELLANEOUS, DU145 cells, 0303 health sciences, Multidisciplinary, MESH: Proteomics, Phosphoproteomics, Prostate Diseases, Prostate, MESH: Gene Expression Regulation, Neoplastic, 3. Good health, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, [SDV] Life Sciences [q-bio], Oncology, 030220 oncology & carcinogenesis, Proteome, Cell lines, Medicine, Cellular Structures and Organelles, Biological cultures, Research Article, MESH: Cell Line, Tumor, Urology, Science, [SDV.CAN]Life Sciences [q-bio]/Cancer, Computational biology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, MESH: Phosphoproteins, MESH: Prostate, 03 medical and health sciences, DU145, Cell Line, Tumor, LNCaP, medicine, Gene Expression and Vector Techniques, Humans, Molecular Biology Techniques, Molecular Biology, 030304 developmental biology, MESH: Mass Spectrometry, Molecular Biology Assays and Analysis Techniques, MESH: Humans, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Prostatic Neoplasms, Cell Biology, medicine.disease, Phosphoproteins, MESH: Male, Research and analysis methods, Genitourinary Tract Tumors, 030104 developmental biology, Biological Databases, MESH: Prostatic Neoplasms, MESH: Biomarkers, Protein expression, Biomarkers
وصف الملف: application/pdf
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المؤلفون: Hamon, Annaïg, Masson, Christel, Bitard, Juliette, Gieser, Linn, Roger, Jérôme E., Perron, Muriel
المساهمون: Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health [Bethesda] (NIH), Centre d'Etudes et de Recherche Thérapeutique en Ophtalmologie (CERTO), Association RETINA France, Partenaires INRAE-Partenaires INRAE
المصدر: Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2017, 58 (4), pp.1941-1953. ⟨10.1167/iovs.16-21366⟩مصطلحات موضوعية: MESH: Signal Transduction, retina, MESH: Retinal Degeneration, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Blotting, Western, Ependymoglial Cells, Hippo/YAP pathway, Cell Cycle Proteins, Real-Time Polymerase Chain Reaction, MESH: Phosphoproteins, Mice, MESH: Photoreceptor Cells, MESH: Mice, Inbred C57BL, MESH: Blotting, Western, Animals, MESH: Animals, Photoreceptor Cells, RNA, Messenger, MESH: Mice, MESH: Adaptor Proteins, Signal Transducing, MESH: RNA, Messenger, photoreceptor degeneration, Adaptor Proteins, Signal Transducing, Müller cells, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, MESH: Real-Time Polymerase Chain Reaction, Retinal Degeneration, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Nuclear Proteins, TEA Domain Transcription Factors, MESH: Immunohistochemistry, YAP-Signaling Proteins, MESH: Transcription Factors, MESH: Ependymoglial Cells, Phosphoproteins, MESH: Gene Expression Regulation, Immunohistochemistry, DNA-Binding Proteins, Mice, Inbred C57BL, Disease Models, Animal, Retinal Cell Biology, Gene Expression Regulation, sense organs, MESH: Disease Models, Animal, MESH: Nuclear Proteins, MESH: DNA-Binding Proteins, Signal Transduction, Transcription Factors
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a217c51fc5bff753b1a6a042c64ece31
http://europepmc.org/articles/PMC6024660 -
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المؤلفون: Samuel T Workenhe, Akiko Yanagiya, Huy-Dung Hoang, Soroush Tahmasebi, Dana Pearl, Adrian Pelin, John C. Bell, Chadi Zakaria, Karen L. Mossman, Tyson E. Graber, Jaclyn Hearnden, Polen Sean, Tommy Alain, Jian-Jun Jia, Margaret Watson, Louis-Phillipe Leroux, Seyed Mehdi Jafarnejad, Jean-Simon Diallo, Nahum Sonenberg, Maritza Jaramillo, Nathaniel Robichaud, Vinh Tai Truong, Fabrice Le Boeuf
المساهمون: McGill University = Université McGill [Montréal, Canada], University of Ottawa [Ottawa], Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), McMaster University [Hamilton, Ontario], Ottawa Hospital Research Institute [Ottawa] (OHRI), This research was funded by grants from the Terry Fox Research Institute to NS and TA, and the CHEO Foundation, the Cancer Research Society / Stephen E. Drabin Research Fund, the Brain Tumour Foundation of Canada, and the Canadian Breast Cancer Foundation to TA. The funders had no role in study design, data collection and analysis, Decision to publish, or preparation of the manuscript, We thank Isabelle Harvey and Lynn Kyte for technical assistance, Xu Zhang and Sebastian Morales for help with experiments, and William Muller (McGill) for the mouse mammary epithelial cells.
المصدر: Zakaria, C, Sean, P, Hoang, H-D, Leroux, L-P, Watson, M, Workenhe, S T, Hearnden, J, Pearl, D, Truong, V T, Robichaud, N, Yanagiya, A, Tahmasebi, S, Jafarnejad, S M, Jia, J-J, Pelin, A, Diallo, J-S, Le Boeuf, F, Bell, J C, Mossman, K L, Graber, T E, Jaramillo, M, Sonenberg, N & Alain, T 2018, ' Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis ', PLoS Pathogens, vol. 14, no. 8, e1007264 . https://doi.org/10.1371/journal.ppat.1007264
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007264. ⟨10.1371/journal.ppat.1007264⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007264 (2018)مصطلحات موضوعية: 0301 basic medicine, Cell Cycle Proteins, mTORC1, Herpesvirus 1, Human, MESH: Eukaryotic Initiation Factor-4E/genetics, mTORC2, MESH: Immediate-Early Proteins/genetics, Mice, MESH: Immediate-Early Proteins/deficiency, MESH: Catalytic Domain/drug effects, Catalytic Domain, Neoplasms, MESH: Ubiquitin-Protein Ligases/genetics, Chlorocebus aethiops, MESH: Herpes Simplex/genetics, MESH: Ubiquitin-Protein Ligases/deficiency, MESH: Animals, MESH: Signal Transduction/genetics, Biology (General), MESH: Phosphoproteins/genetics, MESH: Eukaryotic Initiation Factor-4E/metabolism, Cells, Cultured, MESH: Phosphoproteins/metabolims, MESH: TOR Serine-Threonine Kinases/chemistry, TOR Serine-Threonine Kinases, MESH: Neoplasms/pathology, EIF4E, MESH: Herpes Simplex/complications, MESH: Herpes Simplex/pathology, 3. Good health, Gene Expression Regulation, Neoplastic, MESH: HEK293 Cells, MESH: Cells, Cultured, Signal Transduction, MESH: Organisms, Genetically Modified, QH301-705.5, Ubiquitin-Protein Ligases, Immunology, MESH: Gene Expression Regulation, Neoplastic/drug effects, MESH: Vero Cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Herpesvirus 1, Human/drug effects, Biology, MESH: Neoplasms/virology, Microbiology, MESH: TOR Serine-Threonine Kinases/antagonists & inhibitiors, Immediate-Early Proteins, MESH: Protein Kinase Inhibitors/pharmacology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Virology, Genetics, medicine, Animals, Humans, MESH: Mice, Molecular Biology, Protein Kinase Inhibitors, Vero Cells, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, MESH: Herpesvirus 1, Human/genetics, MESH: Adaptator Proteins, Signal Transducing/metabolism, MESH: Humans, Organisms, Genetically Modified, Cancer, Herpes Simplex, RC581-607, medicine.disease, Phosphoproteins, MESH: Cercopithecus aethiops, MESH: Neoplasms/complications, Oncolytic virus, 030104 developmental biology, Eukaryotic Initiation Factor-4E, HEK293 Cells, Viral replication, Cancer cell, Cancer research, Parasitology, Immunologic diseases. Allergy, MESH: Neoplasms/genetics, MESH: Adaptator Proteins, Signal Transducing/genetics
وصف الملف: application/pdf
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المؤلفون: Louis Marie Bloyet, Sonia Longhi, Denis Gerlier, Stefano Gianni
المساهمون: Architecture et fonction des macromolécules biologiques ( AFMB ), Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ) -Institut National de la Recherche Agronomique ( INRA ), Centre International de Recherche en Infectiologie ( CIRI ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Chemistry [Cambridge, UK], University of Cambridge [UK] ( CAM ), Architecture et fonction des macromolécules biologiques (AFMB), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Immunobiologie des infections virales – Immunobiology of Viral Infections, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CNR, Dipartimento di Scienze Biochimiche, Università degli Studi di Roma 'La Sapienza' [Rome]-Istituto di Biologia e Patologia Molecolari, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Immunobiologie des infections virales – Immunobiology of Viral Infections (IbIV), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Istituto di Biologia e Patologia Molecolari, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-CNR Istituto di Biologia e Patologia Molecolari [Roma] (CNR | IBPM), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)-National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)
المصدر: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (17), pp.3091-3118. 〈10.1007/s00018-017-2556-3〉
Cellular and Molecular Life Sciences, Springer Verlag, 2017, 74 (17), pp.3091-3118. ⟨10.1007/s00018-017-2556-3⟩
Cellular and Molecular Life Sciences, 2017, 74 (17), pp.3091-3118. ⟨10.1007/s00018-017-2556-3⟩مصطلحات موضوعية: 0301 basic medicine, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, MESH: Protein Structure, Quaternary, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, viruses, Protein–protein interactions, [ SDV.MP.BAC ] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Virus Replication, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [ SDV.BBM.BC ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], Paramyxoviruses, nucleoprotein, phosphoprotein, intrinsic structural disorder, induced folding, fuzzy complexes, protein–protein interactions, antiviral approaches, Intrinsic structural disorder, Transcription (biology), [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Induced folding, MESH : Viral Proteins, [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], MESH: Evolution, Molecular, MESH: Intrinsically Disordered Proteins, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], [ SDV.MHEP.ME ] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Sendai virus, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], MESH : Antiviral Agents, MESH : Virus Replication, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM], [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: RNA, Viral, Phosphoprotein, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Paramyxoviridae, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Order and disorder, Molecular Medicine, Functional significance, RNA, Viral, MESH: Molecular Chaperones, MESH : Paramyxoviridae, MESH: Antiviral Agents, Computational biology, MESH : Nucleoproteins, Biology, Antiviral Agents, MESH: Phosphoproteins, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Protein–protein interaction, Evolution, Molecular, 03 medical and health sciences, Cellular and Molecular Neuroscience, Viral Proteins, MESH : Protein Structure, Quaternary, MESH : RNA, Viral, MESH : Evolution, Molecular, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Protein Structure, Quaternary, Molecular Biology, MESH : Intrinsically Disordered Proteins, Nucleoprotein, Pharmacology, [ SDV.IMM.II ] Life Sciences [q-bio]/Immunology/Innate immunity, 030102 biochemistry & molecular biology, MESH: Virus Replication, MESH : Molecular Chaperones, MESH: Paramyxoviridae, [ SDV.BIO ] Life Sciences [q-bio]/Biotechnology, [ SDV.SP.PHARMA ] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cell Biology, biology.organism_classification, Phosphoproteins, Virology, MESH: Viral Proteins, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Antiviral approaches, Intrinsically Disordered Proteins, 030104 developmental biology, Nucleoproteins, Fuzzy complexes, MESH: Nucleoproteins, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH : Phosphoproteins, Molecular Chaperones, [ SDV.BBM.BS ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
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المؤلفون: Mohamed Ouizougun-Oubari, Patrick England, Patrick Couvreur, Sylviane Hoos, Safa Lassoued, Jenna Fix, Félix A. Rey, Christina Sizun, M. Alejandra Tortorici, Bogdan Tarus, Jean-François Eléouët, François Bontems, Bruno Baron, Anny Slama-Schwok, Marie Galloux, N. Pereira, Stéphane Duquerroy, Didier Desmaële
المساهمون: Virologie Structurale - Structural Virology, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Protéopole, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Galien Paris-Sud (IGPS), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC), Université Paris-Sud - Paris 11 (UP11), This work was supported by the Agence Nationale de la Recherche (grant ANR 11 BSV8 024 02 to S.D., F.A.R., J.-F.E., and C.S.) and the Grand Equipement National de Calcul Intensif (grant 2012-076378 to A.S.-S. and B.T. for access to IDRIS HPC resources). Doctoral fellowships from Université Pierre et Marie Curie (Ecole Doctorale Iviv) to M.O.-O., Institut de Chimie des Substances Naturelles to N.P., and Région Ile-de-France DIM Malinf to S.L. are acknowledged., We thank the staffs at beam lines PROXIMA-1 at the Soleil synchrotron (St Aubin, France), ID14-4 at the European Synchrotron Radiation Facility (Grenoble, France), and PX06SA at the SLS synchrotron (Villigen, Switzerland), Ahmed Haouz and Patrick Weber (Protein Crystallization Platform, Institut Pasteur Paris), Origène Nyanguile and Vanessa Gaillard (HES-SO Valais-Wallis, Sion, Switzerland) for providing the P12 peptide, and Jacques Perrault (San Diego, CA) and Christophe Chevalier (Jouy-en-Josas, France) for providing and amplifying VSV-GFP, respectively., ANR-11-BSV8-0024,BRONCHIOLITEASER,Etude structurale et fonctionnelle du complexe polymérase du virus respiratoire syncytial et recherche d'inhibiteurs(2011), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
المصدر: Journal of Virology
Journal of Virology, American Society for Microbiology, 2015, 89 (21), pp.11129-11143. ⟨10.1128/JVI.01612-15⟩
Journal of Virology, 2015, 89 (21), pp.11129-11143. ⟨10.1128/JVI.01612-15⟩مصطلحات موضوعية: Models, Molecular, MESH: Antiviral Agents, Magnetic Resonance Spectroscopy, Protein Conformation, Viral protein, MESH: Nucleocapsid, [SDV]Life Sciences [q-bio], In silico, Immunology, Respiratory Syncytial Virus Infections, MESH: Respiratory Syncytial Virus, Human, Calorimetry, MESH: Drug Design, Biology, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, MESH: Phosphoproteins, Microbiology, Virus, MESH: Respiratory Syncytial Virus Infections, MESH: Protein Conformation, X-Ray Diffraction, Virology, medicine, Humans, Binding site, Nucleocapsid, MESH: Calorimetry, Polymerase, MESH: Humans, MESH: Magnetic Resonance Spectroscopy, Structure and Assembly, MESH: X-Ray Diffraction, Phosphoproteins, MESH: Crystallography, X-Ray, 3. Good health, Nucleoprotein, Luminescent Proteins, Viral replication, Drug Design, Respiratory Syncytial Virus, Human, Insect Science, Phosphoprotein, biology.protein, MESH: Luminescent Proteins, MESH: Models, Molecular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86554ccaf6f4bd9b41293f3b104e8ce1
https://doi.org/10.1128/jvi.01612-15
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